{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:53:05Z","timestamp":1793116385310,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bioactmat.2021.12.002","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T17:20:53Z","timestamp":1640020853000},"page":"355-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy"],"prefix":"10.1016","volume":"15","author":[{"given":"JunJie","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-0131","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2021.12.002_bib1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.canlet.2019.11.034","article-title":"Ultrasound nanotheranostics in fighting cancer: advances and prospects","volume":"470","author":"Zhou","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib2","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1039\/C9CS00648F","article-title":"Multifunctional sonosensitizers in sonodynamic cancer therapy","volume":"49","author":"Son","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib3","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1002\/adma.201602012","article-title":"Micro\/nanoparticle-augmented sonodynamic therapy (SDT): breaking the depth shallow of photoactivation","volume":"28","author":"Qian","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11427-017-9262-x","article-title":"Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics","volume":"61","author":"Pan","year":"2018","journal-title":"Sci. China: Life Sci."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2019.100773","article-title":"Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine","volume":"28","author":"Cui","year":"2019","journal-title":"Nano Today"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.drudis.2014.01.010","article-title":"Recent progress in development of new sonosensitizers for sonodynamic cancer therapy","volume":"19","author":"Chen","year":"2014","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib7","article-title":"Metalloporphyrin complex-based nanosonosensitizers for deep-tissue tumor theranostics by noninvasive sonodynamic therapy","volume":"15","author":"Ma","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib8","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/anie.201912768","article-title":"An ultrasound activated vesicle of janus Au-MnO nanoparticles for promoted tumor penetration and sono-chemodynamic therapy of orthotopic liver cancer","volume":"59","author":"Lin","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jconrel.2018.10.007","article-title":"Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses","volume":"290","author":"Liu","year":"2018","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib10","first-page":"235","article-title":"Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model","author":"Xu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2019.01.032","article-title":"Drug delivery systems targeting tumor-associated fibroblasts for cancer immunotherapy","volume":"448","author":"Liu","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib12","first-page":"230","article-title":"A pH\/Ultrasound dual-response biomimetic nanoplatform for nitric oxide gas-sonodynamic combined therapy and repeated ultrasound for relieving hypoxia","author":"An","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib13","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1021\/acs.nanolett.9b01595","article-title":"Intelligent hollow Pt-CuS janus architecture for synergistic catalysis-enhanced sonodynamic and photothermal cancer therapy","volume":"19","author":"Liang","year":"2019","journal-title":"Nano Lett"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib14","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1021\/acsnano.7b08225","article-title":"Oxygen-self-produced nanoplatform for relieving hypoxia and breaking resistance to sonodynamic treatment of pancreatic cancer","volume":"11","author":"Chen","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101305","article-title":"Fluorocarbon-driven photosensitizer assembly decodes energy conversion pathway for suppressing breast tumor","volume":"41","author":"Mei","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101065","article-title":"Switching reactive oxygen species into reactive nitrogen species by photocleaved O-2-Released nanoplatforms favors hypoxic tumor repression","volume":"8","author":"Luo","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-020-00755-7","article-title":"Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis","volume":"19","author":"Nosrati","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202000326","article-title":"Tumor metabolism-engineered composite nanoplatforms potentiate sonodynamic therapy via reshaping tumor microenvironment and facilitating electron-hole pairs' separation","volume":"30","author":"Guan","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.101009","article-title":"Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma","volume":"36","author":"Yin","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9785","article-title":"Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy","volume":"6","author":"Cheng","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib21","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/acs.nanolett.6b02365","article-title":"Ultrasound triggered tumor oxygenation with oxygen-shuttle nanoperfluorocarbon to overcome hypoxia-associated resistance in cancer therapies","volume":"16","author":"Song","year":"2016","journal-title":"Nano Lett"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib22","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1002\/adma.201601902","article-title":"Intelligent albumin-MnO2 nanoparticles as pH-\/H2O2-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy","volume":"28","author":"Chen","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib23","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1002\/adfm.201600676","article-title":"Modulation of hypoxia in solid tumor microenvironment with MnO2 nanoparticles to enhance photodynamic therapy","volume":"26","author":"Zhu","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202103134","article-title":"Engineering janus chemoreactive nanosonosensitizers for bilaterally augmented sonodynamic and chemodynamic cancer nanotherapy","volume":"31","author":"Xu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120278","article-title":"Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem","volume":"258","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201908598","article-title":"A novel Pt-TiO2 heterostructure with oxygen-deficient layer as bilaterally enhanced sonosensitizer for synergistic chemo-sonodynamic cancer therapy","volume":"30","author":"Liang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib27","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1021\/acsnano.9b08667","article-title":"Ultrasound-switchable nanozyme augments sonodynamic therapy against multidrug-resistant bacterial infection","volume":"14","author":"Sun","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib28","doi-asserted-by":"crossref","first-page":"12342","DOI":"10.1021\/acsnano.1c04280","article-title":"Upconverted metal-organic framework janus architecture for near-infrared and ultrasound Co-enhanced high performance tumor therapy","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-01060-7","article-title":"Intrinsic nucleus-targeted ultra-small metal-organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib30","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1002\/anie.201712027","article-title":"Simultaneous fenton-like ion delivery and glutathione depletion by MnO2-based nanoagent to enhance chemodynamic therapy","volume":"57","author":"Lin","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib31","doi-asserted-by":"crossref","first-page":"11546","DOI":"10.1021\/acsami.8b01960","article-title":"Artemisinin and AlEgen conjugate for mitochondria-targeted and image-guided chemo- and photodynamic cancer cell ablation","volume":"10","author":"Feng","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib32","doi-asserted-by":"crossref","first-page":"29490","DOI":"10.1021\/acsami.9b07390","article-title":"Artemisinin-based smart nanomedicines with self-supply of ferrous ion to enhance oxidative stress for specific and efficient cancer treatment","volume":"11","author":"Luo","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib33","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1002\/anie.201907388","article-title":"Programmed release of dihydroartemisinin for synergistic cancer therapy using CaCO3 mineralized metal-organic framework","volume":"58","author":"Wan","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejmech.2020.112044","article-title":"Artemisinin-derived hybrids and their anticancer activity","volume":"188","author":"Gao","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib36","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/med.21580","article-title":"Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives","volume":"39","author":"Sun","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.eng.2018.11.011","article-title":"Artemisinin, the magic drug discovered from traditional Chinese medicine","volume":"5","author":"Wang","year":"2019","journal-title":"Engineering"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib38","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/acsami.7b16999","article-title":"Localized Fe(II)-Induced cytotoxic reactive oxygen species generating nanosystem for enhanced anticancer therapy","volume":"10","author":"Ding","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pharmthera.2013.12.001","article-title":"Artemisinins: pharmacological actions beyond anti-malarial","volume":"142","author":"Ho","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcancer.2017.02.009","article-title":"From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy","volume":"46","author":"Efferth","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib41","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1039\/C5CC00927H","article-title":"Potential sonodynamic anticancer activities of artemether and liposome-encapsulated artemether","volume":"51","author":"Chen","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jconrel.2018.07.028","article-title":"Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy","volume":"286","author":"Wang","year":"2018","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib43","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2147\/OTT.S190208","article-title":"Lipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided, tumor-targeted chemotherapy","volume":"12","author":"Gao","year":"2019","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijbiomac.2017.02.094","article-title":"Characterization of the selective alkylation site in hemoglobin A by dihydroartemisinin with tandem mass spectrometry","volume":"99","author":"Tiensomjitr","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib45","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1021\/acsinfecdis.9b00264","article-title":"Stochastic protein alkylation by antimalarial peroxides","volume":"5","author":"Jourdan","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib46","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1039\/C9CC00531E","article-title":"A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species","volume":"55","author":"Chen","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib47","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1039\/c4tb00439f","article-title":"PEGylated poly(amine-co-ester) micelles as biodegradable non-viral gene vectors with enhanced stability, reduced toxicity and higher in vivo transfection efficacy","volume":"2","author":"Zhang","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib48","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1039\/C8TB02882F","article-title":"Enzymatic synthesis of PEG-poly(amine-co-thioether esters) as highly efficient pH and ROS dual-responsive nanocarriers for anticancer drug delivery","volume":"7","author":"Gong","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib49","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cclet.2019.01.003","article-title":"Histology and antitumor activity study of PTX-loaded micelle, a fluorescent drug delivery system prepared by PEG-TPP","volume":"30","author":"Li","year":"2019","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib50","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.cclet.2020.02.036","article-title":"Advances in aggregatable nanoparticles for tumor-targeted drug delivery","volume":"31","author":"Yu","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib51","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.carbpol.2017.12.047","article-title":"Redox\/enzyme sensitive chondroitin sulfate-based self-assembled nanoparticles loading docetaxel for the inhibition of metastasis and growth of melanoma","volume":"184","author":"Liu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib52","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.msec.2016.11.030","article-title":"Internal stimuli-responsive nanocarriers for drug delivery: design strategies and applications","volume":"71","author":"Liu","year":"2017","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib53","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/anie.201813702","article-title":"One-dimensional Fe2P acts as a fenton agent in response to NIR II light and ultrasound for deep tumor synergetic theranostics","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib54","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1039\/D0BM01734E","article-title":"One-for-all intelligent core-shell nanoparticles for tumor-specific photothermal-chemodynamic synergistic therapy","volume":"9","author":"Wu","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib55","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1021\/acs.chemmater.6b05215","article-title":"Core-shell metal-organic frameworks as Fe2+ suppliers for Fe2+-mediated cancer therapy under multimodality imaging","volume":"29","author":"Wang","year":"2017","journal-title":"Chem. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.002_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.biomaterials.2016.05.027","article-title":"Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo\/photothermal combinational cancer therapy","volume":"100","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.12.002_bib57","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.canlet.2016.07.033","article-title":"Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells","volume":"381","author":"Lin","year":"2016","journal-title":"Cancer Lett"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21005545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21005545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:04:24Z","timestamp":1762531464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21005545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":57,"alternative-id":["S2452199X21005545"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.12.002","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}