{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:29:29Z","timestamp":1780338569620,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51725302"],"award-info":[{"award-number":["51725302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52003270"],"award-info":[{"award-number":["52003270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20385"],"award-info":[{"award-number":["U20A20385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.bioactmat.2021.12.003","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:27:28Z","timestamp":1639704448000},"page":"110-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["An activated excretion-retarded tumor imaging strategy towards metabolic organs"],"prefix":"10.1016","volume":"14","author":[{"given":"Da-Yong","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan-Tian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Hai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-0787","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2021.12.003_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrclinonc.2017.171","article-title":"Surgical oncology for gliomas: the state of the art","volume":"15","author":"Sanai","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrclinonc.2017.194","article-title":"Perioperative events influence cancer recurrence risk after surgery","volume":"15","author":"Hiller","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ctm2.24","article-title":"Surgical trauma-induced immunosuppression in cancer: recent advances and the potential therapies","volume":"10","author":"Tang","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11060-018-03080-0","article-title":"The role of 5-aminolevulinic acid in spinal tumor surgery: a review","volume":"141","author":"Wainwright","year":"2019","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.wneu.2020.03.178","article-title":"The utility of 5-aminolevulinic acid for microsurgical resection of meningiomas","volume":"139","author":"Turcotte","year":"2020","journal-title":"World Neurosurg."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib6","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/cncr.31221","article-title":"Margins in breast cancer: how much is enough?","volume":"124","author":"Pilewskie","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib7","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jgh.14848","article-title":"Interaction between the tumor microenvironment and resection margin in different gross types of hepatocellular carcinoma","volume":"35","author":"Cha","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4048\/jbc.2017.20.2.176","article-title":"The usefulness of intraoperative circumferential frozen-section analysis of lumpectomy margins in breast-conserving surgery","volume":"20","author":"Ko","year":"2017","journal-title":"J. Breast Cancer"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jamcollsurg.2018.12.002","article-title":"Is frozen-section analysis during thyroid operation useful in the era of molecular testing?","volume":"228","author":"Mallick","year":"2019","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib10","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.euf.2017.04.008","article-title":"Intraoperative imaging techniques to support complete tumor resection in partial nephrectomy","volume":"4","author":"Hekman","year":"2018","journal-title":"Eur. Urol. Focus."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib11","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1007\/s00259-020-05104-2","article-title":"Liver tumor F-18 FDG-PET before and immediately after microwave ablation enables imaging and quantification of tumor tissue contraction","volume":"48","author":"Yan","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s11604-020-00961-1","article-title":"FDG-PET\/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background","volume":"38","author":"Ozaki","year":"2020","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrclinonc.2013.123","article-title":"Image-guided cancer surgery using near-infrared fluorescence","volume":"10","author":"Vahrmeijer","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib14","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1038\/s41467-018-05113-8","article-title":"NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41551-020-00616-6","article-title":"AND-gate contrast agents for enhanced fluorescence-guided surgery","volume":"5","author":"Widen","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib16","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/ac4038653","article-title":"Environment-sensitive fluorescent supramolecular nanofibers for imaging applications","volume":"86","author":"Cai","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/lsm.22933","article-title":"5-ALA in the management of malignant glioma","volume":"50","author":"Stepp","year":"2018","journal-title":"Laser Surg. Med."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41551-019-0494-0","article-title":"First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I\/II windows","volume":"4","author":"Hu","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S2468-1253(17)30216-9","article-title":"Indocyanine green fluorescence imaging in colorectal surgery: overview, applications, and future directions","volume":"2","author":"Keller","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib20","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.juro.2015.09.093","article-title":"Intraoperative molecular diagnostic imaging can identify renal cell carcinoma","volume":"195","author":"Guzzo","year":"2016","journal-title":"J. Urol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.suronc.2019.07.003","article-title":"Do we need to shift from dye injection to fluorescence in respective liver surgery?","volume":"33","author":"Takemura","year":"2020","journal-title":"Surg. Oncol."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nm.1854","article-title":"Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes","volume":"15","author":"Urano","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib23","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1073\/pnas.1610472113","article-title":"Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo","volume":"113","author":"Golijanin","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib24","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1039\/C4CS00161C","article-title":"Self-assembling small molecules for the detection of important analytes","volume":"43","author":"Ren","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib25","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1039\/C7CS90102J","article-title":"Supramolecular medicine","volume":"46","author":"Cui","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.addr.2016.08.010","article-title":"Activatable fluorescence: from small molecule to nanoparticle","volume":"113","author":"Luby","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/14737140.2018.1477593","article-title":"The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic","volume":"18","author":"Lwin","year":"2018","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/smll.201501700","article-title":"Recent advances in conjugated polymer materials for disease diagnosis","volume":"12","author":"Lv","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.addr.2016.05.015","article-title":"Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy","volume":"105","author":"Yang","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb7107","article-title":"Supramolecular nanosubstrate-mediated delivery system enables CRISPR-Cas9 knockin of hemoglobin beta gene for hemoglobinopathies","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib31","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1038\/s41467-019-12848-5","article-title":"A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging","volume":"10","author":"An","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib32","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1002\/adma.201502598","article-title":"In situ formation of nanofibers from purpurin18-peptide conjugates and the assembly induced retention effect in tumor sites","volume":"27","author":"Zhang","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2021.12.003_bib33","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/acsnano.9b08209","article-title":"A near-infrared peptide probe with tumor-specific excretion-retarded effect for image-guided surgery of renal cell carcinoma","volume":"14","author":"An","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib34","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1021\/acsnano.9b08693","article-title":"Tumor targeting by \u03b1(v)\u03b2(3)-Integrin-Specific lipid nanoparticles occurs via phagocyte hitchhiking","volume":"14","author":"Sofias","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1021\/acsami.9b16648","article-title":"Integrin \u03b1(v)\u03b2(3) receptor overexpressing on tumor-targeted positive MRI-guided chemotherapy","volume":"12","author":"Khatik","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib36","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7150\/thno.11139","article-title":"A prodrug-type, MMP-2-targeting nanoprobe for tumor detection and imaging","volume":"5","author":"Wang","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib37","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1039\/C8BM00593A","article-title":"MMP-2-responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging","volume":"6","author":"Sun","year":"2018","journal-title":"Biomater Sci"},{"key":"10.1016\/j.bioactmat.2021.12.003_bib38","doi-asserted-by":"crossref","first-page":"1807175","DOI":"10.1002\/adma.201807175","article-title":"Addressable peptide self-assembly on the cancer cell membrane for sensitizing chemotherapy of renal cell carcinoma","volume":"31","author":"Wang","year":"2019","journal-title":"Adv. Mater."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21005569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21005569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:03:31Z","timestamp":1762531411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21005569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":38,"alternative-id":["S2452199X21005569"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.12.003","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An activated excretion-retarded tumor imaging strategy towards metabolic organs","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}