{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:40:41Z","timestamp":1787895641742,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M683733"],"award-info":[{"award-number":["2020M683733"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2019031"],"award-info":[{"award-number":["2019031"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009580","name":"General Hospital of People\u2019s Liberation Army","doi-asserted-by":"publisher","award":["QNC19028"],"award-info":[{"award-number":["QNC19028"]}],"id":[{"id":"10.13039\/501100009580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21604093"],"award-info":[{"award-number":["21604093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973226"],"award-info":[{"award-number":["51973226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972081"],"award-info":[{"award-number":["81972081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bioactmat.2022.02.018","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:18:18Z","timestamp":1645705098000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity"],"prefix":"10.1016","volume":"16","author":[{"given":"Dawei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoke","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2022.02.018_bib1","first-page":"85","article-title":"Cysteine\/histidine-dependent amidohydrolase\/peptidase (CHAP)-Displayed nano phages: antimicrobial function against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"12","author":"Rahimzadeh","year":"2020","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib2","doi-asserted-by":"crossref","first-page":"110659","DOI":"10.1016\/j.msec.2020.110659","article-title":"A powerful combination of copper-cysteamine nanoparticles with potassium iodide for bacterial destruction","volume":"110","author":"Zhen","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/nm.4465","article-title":"The role of vaccines in preventing bacterial antimicrobial resistance","volume":"24","author":"Jansen","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib4","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/S0140-6736(18)31117-6","article-title":"Global governance of antimicrobial resistance","volume":"391","author":"Rochford","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nature06536","article-title":"Global trends in emerging infectious diseases","volume":"451","author":"Jones","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature17967","article-title":"A platform for the discovery of new macrolide antibiotics","volume":"533","author":"Seiple","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41587-019-0105-3","article-title":"Engineered toxin\u2212intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations","volume":"37","author":"Lopez-Igual","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib8","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/jps.24298","article-title":"Nanoengineered drug delivery systems for enhancing antibiotic therapy","volume":"104","author":"Kalhapure","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib9","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1001\/archinte.166.19.2138","article-title":"High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity","volume":"166","author":"Hidayat","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib10","doi-asserted-by":"crossref","first-page":"105103","DOI":"10.1088\/0957-4484\/21\/10\/105103","article-title":"Nanoconjugated vancomycin: new opportunities for the development of anti-VRSA agents","volume":"21","author":"Chakraborty","year":"2010","journal-title":"Nanotechnology"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib11","doi-asserted-by":"crossref","first-page":"1800334","DOI":"10.1002\/adhm.201800334","article-title":"Nanocellulose-based antibacterial materials","volume":"7","author":"Li","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib12","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.3390\/ijms15033519","article-title":"Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: in vitro and in vivo evaluation","volume":"15","author":"Wang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib14","first-page":"3207","article-title":"Virus-inspired surface-nanoengineered antimicrobial liposome: a potential system to simultaneously achieve high activity and selectivity","volume":"6","author":"Shi","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib15","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1021\/am508219g","article-title":"One-step synthesis of amine-functionalized hollow mesoporous silica nanoparticles as efficient antibacterial and anticancer materials","volume":"7","author":"Hao","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib16","first-page":"267","article-title":"Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics","volume":"8","author":"Kurian","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib17","first-page":"2281","article-title":"Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli (E. coli)","volume":"6","author":"Sun","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2018.01.024","article-title":"Bacteria-responsive intelligent wound dressing: simultaneous in situ detection and inhibition of bacterial infection for accelerated wound healing","volume":"161","author":"Zhou","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib19","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1039\/C9BM00606K","article-title":"Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery","volume":"7","author":"Wang","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib20","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1021\/acs.biomac.6b00744","article-title":"Fabrication of pH-responsive nanoparticles with an AIE feature for imaging intracellular drug delivery","volume":"17","author":"Wang","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib21","doi-asserted-by":"crossref","first-page":"102607","DOI":"10.1016\/j.jddst.2021.102607","article-title":"Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhancement of the antibacterial activity of vancomycin and 18\u03b2-glycyrrhetinic acid","volume":"64","author":"Jaglal","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.colsurfb.2017.07.049","article-title":"pH-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin","volume":"158","author":"Kalhapure","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118948","article-title":"AB2-type amphiphilic block copolymer containing a pH-cleavable hydrazone linkage for targeted antibiotic delivery","volume":"575","author":"Sonawane","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.actbio.2021.02.015","article-title":"Assembly of cationic and amphiphilic beta-sheet FKF tripeptide confers antibacterial activity","volume":"25","author":"Azoulay","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib25","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1039\/C6PY01618A","article-title":"Facile preparation of pH-responsive AIE-active POSS dendrimers for detection of trivalent cations and acid gases","volume":"7","author":"Zuo","year":"2016","journal-title":"Polym. Chem."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib26","doi-asserted-by":"crossref","first-page":"12674","DOI":"10.1021\/acsami.6b03235","article-title":"Synthesis and properties of hemostatic and bacteria-responsive in situ hydrogels for emergency treatment in critical situations","volume":"8","author":"Bu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib27","doi-asserted-by":"crossref","first-page":"656717","DOI":"10.3389\/fonc.2021.656717","article-title":"Schiff-linked PEGylated doxorubicin prodrug forming pH-responsive nanoparticles with high drug loading and effective anticancer therapy","volume":"11","author":"Song","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib28","first-page":"721","article-title":"Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis","volume":"6","author":"Liu","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00042-09","article-title":"Reduced vancomycin susceptibility in staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications","volume":"23","author":"Howden","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00003086-199903000-00008","article-title":"Antimicrobial treatment of chronic osteomyelitis","volume":"360","author":"Mader","year":"1999","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib31","doi-asserted-by":"crossref","first-page":"10874","DOI":"10.1021\/am403940d","article-title":"Vancomycin-modified mesoporous silica nanoparticles for selective recognition and killing of pathogenic gram-positive bacteria over macrophage-like cells","volume":"5","author":"Qi","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib32","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/ja909475m","article-title":"Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery","volume":"132","author":"Shen","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.msec.2017.08.063","article-title":"Acetal-linked pegylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery","volume":"82","author":"Huang","year":"2018","journal-title":"Mat. Sci. Eng. C"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib34","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.1021\/ja505212y","article-title":"Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy","volume":"136","author":"Huang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.reactfunctpolym.2019.04.013","article-title":"One-pot synthesis of bio-functionally water-soluble POSS derivatives via efficient click chemistry methodology","volume":"140","author":"Zhang","year":"2019","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib36","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/acs.biomac.9b01401","article-title":"Synergistic chemical and photodynamic antimicrobial therapy for enhanced wound healing mediated by multifunctional light-responsive nanoparticles","volume":"20","author":"Hu","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2022.02.018_bib37","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1038\/s41467-018-05142-3","article-title":"Dynamic and programmable morphology and size evolution via a living hierarchical self-assembly strategy","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2022.02.018_bib38","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1021\/acsnano.1c00894","article-title":"Rough Carbon\u2212iron oxide nanohybrids for near-infrared-II light-responsive synergistic antibacterial therapy","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22000901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22000901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:04:41Z","timestamp":1762531481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X22000901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":38,"alternative-id":["S2452199X22000901"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.02.018","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}