{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T19:41:15Z","timestamp":1786909275163,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bioactmat.2022.03.023","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T12:21:40Z","timestamp":1649161300000},"page":"75-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration"],"prefix":"10.1016","volume":"19","author":[{"given":"Lingbin","family":"Che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyong","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-3175","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bioactmat.2022.03.023_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1056\/NEJMoa1916525","article-title":"Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates","volume":"383","author":"Black","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bioactmat.2022.03.023_bib2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMra067395","article-title":"Mechanisms of anabolic therapies for osteoporosis","volume":"357","author":"Canalis","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"10169","key":"10.1016\/j.bioactmat.2022.03.023_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","volume":"393","author":"Compston","year":"2019","journal-title":"Osteoporosis, Lancet"},{"issue":"12","key":"10.1016\/j.bioactmat.2022.03.023_bib4","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"issue":"7","key":"10.1016\/j.bioactmat.2022.03.023_bib5","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00198-015-3093-2","article-title":"Projection of osteoporosis-related fractures and costs in China: 2010-2050","volume":"26","author":"Si","year":"2015","journal-title":"Osteoporos. Int."},{"issue":"50","key":"10.1016\/j.bioactmat.2022.03.023_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4704","article-title":"A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/ard.2008.092775","article-title":"Clinical subsequent fractures cluster in time after first fractures","volume":"68","author":"van Geel","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"19","key":"10.1016\/j.bioactmat.2022.03.023_bib8","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.bioactmat.2022.03.023_bib9","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10117","key":"10.1016\/j.bioactmat.2022.03.023_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(17)32137-2","article-title":"Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial","volume":"391","author":"Kendler","year":"2018","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.bioactmat.2022.03.023_bib11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"JAMA"},{"issue":"50","key":"10.1016\/j.bioactmat.2022.03.023_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4704","article-title":"A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.bioactmat.2022.03.023_bib13","first-page":"859","article-title":"Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats","volume":"5","author":"Zeng","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.10.049","article-title":"Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold","volume":"114","author":"Dang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib15","unstructured":"N. Amani, H.A. Javar, F.A. Dorkoosh, M.R. Rouini, M. Amini, M. Sharifzadeh, S. Boumi, Preparation and pulsatile release evaluation of teriparatide-loaded multilayer implant composed of polyanhydride-hydrogel layers using spin coating for the treatment of osteoporosis, J. Pharm. Innov. 22."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.addr.2018.07.002","article-title":"Drug delivery systems for programmed and on-demand release","volume":"132","author":"Davoodi","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"35","key":"10.1016\/j.bioactmat.2022.03.023_bib17","doi-asserted-by":"crossref","first-page":"22785","DOI":"10.1021\/acsami.6b03041","article-title":"Double-Walled microparticles-embedded self-cross-linked, injectable, and antibacterial hydrogel for controlled and sustained release of chemotherapeutic agents","volume":"8","author":"Davoodi","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jconrel.2014.12.004","article-title":"Coaxial electrohydrodynamic atomization: microparticles for drug delivery applications","volume":"205","author":"Davoodi","year":"2015","journal-title":"J. Contr. Release"},{"issue":"12","key":"10.1016\/j.bioactmat.2022.03.023_bib19","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/bit.26406","article-title":"Codelivery of anti-cancer agents via double-walled polymeric microparticles\/injectable hydrogel: a promising approach for treatment of triple negative breast cancer","volume":"114","author":"Davoodi","year":"2017","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jps.23773","article-title":"Emerging Research and clinical development trends of liposome and lipid nanoparticle drug delivery systems","volume":"103","author":"Kraft","year":"2014","journal-title":"J. Pharmaceut. Sci."},{"issue":"7","key":"10.1016\/j.bioactmat.2022.03.023_bib22","first-page":"3027","article-title":"Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature","volume":"61","author":"Kong","year":"2001","journal-title":"Cancer Res."},{"issue":"27","key":"10.1016\/j.bioactmat.2022.03.023_bib23","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1002\/adfm.201400279","article-title":"Stimuli-responsive materials for controlled release of theranostic agents","volume":"24","author":"Wang","year":"2014","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib24","first-page":"17","article-title":"Bioresponsive materials","volume":"2","author":"Lu","year":"2017","journal-title":"Nat. Rev. Mater."},{"issue":"15","key":"10.1016\/j.bioactmat.2022.03.023_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201705563","article-title":"Integration of phase-change materials with electrospun fibers for promoting neurite outgrowth under controlled release","volume":"28","author":"Xue","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib26","unstructured":"J.J. Xue, T. Wu, J.C. Qiu, Y.N. Xia, Spatiotemporally controlling the release of biological effectors enhances their effects on cell migration and neurite outgrowth, Small Methods 13."},{"issue":"14","key":"10.1016\/j.bioactmat.2022.03.023_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/adhm.202000200","article-title":"Controlling the release of neurotrophin-3 and chondroitinase ABC enhances the efficacy of nerve guidance conduits","volume":"9","author":"Donsante","year":"2020","journal-title":"Adv. Healthc. Mater."},{"issue":"25","key":"10.1016\/j.bioactmat.2022.03.023_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/adma.202000660","article-title":"Phase-change materials for controlled release and related applications","volume":"32","author":"Qiu","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib29","series-title":"Stimuli-responsive Polydopamine-Based Smart Materials","author":"Yang","year":"2021"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib30","article-title":"Mussel-inspired defect engineering of graphene liquid crystalline fibers for synergistic enhancement of mechanical strength and electrical conductivity","author":"Kim","year":"2018","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.bioactmat.2022.03.023_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/admi.201701254","article-title":"Mussel-inspired polymer-based universal spray coating for surface modification: fast fabrication of antibacterial and superhydrophobic surface coatings","volume":"5","author":"Schlaich","year":"2018","journal-title":"Adv. Mater. Interfac."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib32","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1038\/s41467-019-11455-8","article-title":"Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization","volume":"10","author":"Thrivikraman","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119552","article-title":"Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis","volume":"227","author":"Qiu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biomaterials.2018.06.035","article-title":"Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats","volume":"179","author":"Jiang","year":"2018","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bioactmat.2022.03.023_bib35","first-page":"445","article-title":"Secretomes of mesenchymal stem cells induce early bone regeneration by accelerating migration of stem cells","volume":"30","author":"Ogata","year":"2018","journal-title":"J. Oral Max Surg. Med."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bioactmat.2022.03.023_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100143","article-title":"Spatiotemporal immunomodulation using biomimetic scaffold promotes endochondral ossification-mediated bone healing","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.bioactmat.2022.03.023_bib38","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1021\/nn201010q","article-title":"Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods","volume":"5","author":"Agarwal","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.actbio.2015.12.006","article-title":"Bioinspired trimodal macro\/micro\/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect","volume":"32","author":"Tang","year":"2016","journal-title":"Acta Biomater"},{"issue":"2","key":"10.1016\/j.bioactmat.2022.03.023_bib40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2007.10.009","article-title":"Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: active ingredient and mediator of drug release","volume":"125","author":"Lindner","year":"2008","journal-title":"J. Contr. Release"},{"issue":"33","key":"10.1016\/j.bioactmat.2022.03.023_bib41","doi-asserted-by":"crossref","first-page":"36928","DOI":"10.1021\/acsami.0c09969","article-title":"Stellate plasmonic exosomes for penetrative targeting tumor NIR-II thermo-radiotherapy","volume":"12","author":"Zhu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"25","key":"10.1016\/j.bioactmat.2022.03.023_bib42","doi-asserted-by":"crossref","first-page":"22074","DOI":"10.1021\/acsami.7b00845","article-title":"Photocontrolled SiRNA delivery and biomarker-triggered luminogens of aggregation-induced emission by up-conversion NaYF4:Yb(3+)Tm(3+)@SiO2 nanoparticles for inducing and monitoring stem-cell differentiation","volume":"11","author":"Li","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib43","doi-asserted-by":"crossref","first-page":"120357","DOI":"10.1016\/j.biomaterials.2020.120357","article-title":"Nanocomposite hydrogel with NIR\/magnet\/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy","volume":"262","author":"Yuan","year":"2020","journal-title":"Biomaterials"},{"issue":"7822","key":"10.1016\/j.bioactmat.2022.03.023_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-020-2612-2","article-title":"Effects of extracellular matrix viscoelasticity on cellular behaviour","volume":"584","author":"Chaudhuri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib45","doi-asserted-by":"crossref","first-page":"115900","DOI":"10.1016\/j.bone.2021.115900","article-title":"Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations","volume":"146","author":"Fratzl-Zelman","year":"2021","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bioactmat.2022.03.023_bib46","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/endo-110-2-506","article-title":"Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration","volume":"110","author":"Tam","year":"1982","journal-title":"Endocrinology"},{"issue":"39","key":"10.1016\/j.bioactmat.2022.03.023_bib47","doi-asserted-by":"crossref","first-page":"1904450","DOI":"10.1002\/adfm.201904450","article-title":"A 3D printable and bioactive hydrogel scaffold to treat traumatic brain injury","volume":"29","author":"Che","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrm3254","article-title":"Building strong bones: molecular regulation of the osteoblast lineage","volume":"13","author":"Long","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.bioactmat.2022.03.023_bib49","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1210\/en.2011-1515","article-title":"An irradiation-altered bone marrow microenvironment impacts anabolic actions of PTH","volume":"152","author":"Koh","year":"2011","journal-title":"Endocrinology"},{"issue":"38","key":"10.1016\/j.bioactmat.2022.03.023_bib50","doi-asserted-by":"crossref","first-page":"10028","DOI":"10.1016\/j.biomaterials.2013.09.056","article-title":"Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics","volume":"34","author":"Lin","year":"2013","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.bioactmat.2022.03.023_bib51","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bioactmat.2020.03.008","article-title":"Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: in vitro and in vivo studies","volume":"5","author":"Zeng","year":"2020","journal-title":"Bioactive Materials"},{"issue":"sup2","key":"10.1016\/j.bioactmat.2022.03.023_bib52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/21691401.2018.1453825","article-title":"Alendronate delivery on amino modified mesoporous bioactive glass scaffolds to enhance bone regeneration in osteoporosis rats","volume":"46","author":"Wang","year":"2018","journal-title":"Artif. Cells Nanomed Biotechnol"},{"issue":"4","key":"10.1016\/j.bioactmat.2022.03.023_bib53","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bioactmat.2020.06.010","article-title":"Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats","volume":"5","author":"Zeng","year":"2020","journal-title":"Bioactive Materials"},{"issue":"2","key":"10.1016\/j.bioactmat.2022.03.023_bib54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbm.b.34396","article-title":"Composition control in biphasic silicate microspheres on stimulating new bone regeneration and repair of osteoporotic femoral bone defect","volume":"108","author":"Ghamor-Amegavi","year":"2020","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"47","key":"10.1016\/j.bioactmat.2022.03.023_bib55","doi-asserted-by":"crossref","first-page":"7974","DOI":"10.1039\/C8TB02526F","article-title":"Injectable strontium-doped hydroxyapatite integrated with phosphoserine-tethered poly(epsilon-lysine) dendrons for osteoporotic bone defect repair","volume":"6","author":"Yuan","year":"2018","journal-title":"J. Mater. Chem. B"},{"issue":"10","key":"10.1016\/j.bioactmat.2022.03.023_bib56","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1002\/jbm.a.35793","article-title":"Deferoxamine released from poly(lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis","volume":"104","author":"Jia","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"issue":"20","key":"10.1016\/j.bioactmat.2022.03.023_bib57","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1016\/j.biomaterials.2012.03.069","article-title":"The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats","volume":"33","author":"Cao","year":"2012","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bioactmat.2022.03.023_bib58","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bioactmat.2020.10.018","article-title":"Synergistic anti-inflammatory and osteogenic n-HA\/resveratrol\/chitosan composite microspheres for osteoporotic bone regeneration","volume":"6","author":"Li","year":"2021","journal-title":"Bioactive Materials"},{"issue":"30","key":"10.1016\/j.bioactmat.2022.03.023_bib59","doi-asserted-by":"crossref","first-page":"25547","DOI":"10.1021\/acsami.8b09879","article-title":"Chemical self-assembly of multifunctional hydroxyapatite with a coral-like nanostructure for osteoporotic bone reconstruction","volume":"10","author":"Quan","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.bioactmat.2022.03.023_bib60","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1039\/c2tb00138a","article-title":"Biomimetic preparation of trace element-codoped calcium phosphate for promoting osteoporotic bone defect repair","volume":"1","author":"Chen","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2022.03.023_bib61","doi-asserted-by":"crossref","DOI":"10.1007\/s00774-021-01240-3","article-title":"Selenium-modified calcium phosphate cement can accelerate bone regeneration of osteoporotic bone defect","author":"Li","year":"2021","journal-title":"J. Bone Miner. Metabol."},{"key":"10.1016\/j.bioactmat.2022.03.023_bib62","doi-asserted-by":"crossref","first-page":"106360","DOI":"10.1016\/j.ultras.2021.106360","article-title":"Longitudinal effects of low-intensity pulsed ultrasound on osteoporosis and osteoporotic bone defect in ovariectomized rats","volume":"113","author":"Sun","year":"2021","journal-title":"Ultrasonics"},{"issue":"3","key":"10.1016\/j.bioactmat.2022.03.023_bib63","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10529-016-2263-4","article-title":"Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits","volume":"39","author":"Chen","year":"2017","journal-title":"Biotechnol. Lett."},{"issue":"3","key":"10.1016\/j.bioactmat.2022.03.023_bib64","first-page":"952","article-title":"Co-modification of calcium phosphate cement to achieve rapid bone regeneration in osteoporotic femoral condyle defect with lithium and aspirin","volume":"13","author":"Tao","year":"2021","journal-title":"Am. J. Transl. Res."},{"issue":"11","key":"10.1016\/j.bioactmat.2022.03.023_bib65","first-page":"3839","article-title":"Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS","volume":"6","author":"Li","year":"2021","journal-title":"Bioact Mater"},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13018-020-02151-1","article-title":"Effect of alendronate on the femoral metaphyseal defect under carbamazepine in ovariectomized rats","volume":"16","author":"Zhang","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2022.03.023_bib67","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s13287-021-02303-y","article-title":"MSC-derived small extracellular vesicles overexpressing miR-20a promoted the osteointegration of porous titanium alloy by enhancing osteogenesis via targeting BAMBI","volume":"12","author":"Liu","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.bioactmat.2022.03.023_bib68","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1002\/jbm.a.36997","article-title":"Sustained delivery of alendronate by engineered collagen scaffold for the repair of osteoporotic bone defects and resistance to bone loss","volume":"108","author":"Zeng","year":"2020","journal-title":"J. Biomed. Mater. Res."},{"issue":"47","key":"10.1016\/j.bioactmat.2022.03.023_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202105383","article-title":"Injectable hydrogel with NIR light-responsive, dual-mode PTH release for osteoregeneration in osteoporosis","volume":"31","author":"Kuang","year":"2021","journal-title":"Adv. Funct. Mater."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22001402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22001402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:03:13Z","timestamp":1762531393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X22001402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":69,"alternative-id":["S2452199X22001402"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.03.023","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}