{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:46:19Z","timestamp":1790196379732,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bioactmat.2022.12.019","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T05:08:25Z","timestamp":1672636105000},"page":"387-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Mechano-responsive hydrogel for direct stem cell manufacturing to therapy"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-7567","authenticated-orcid":false,"given":"Yufeng","family":"Shou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-6001","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-5500","authenticated-orcid":false,"given":"Zhicheng","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-7377","authenticated-orcid":false,"given":"Khang Leng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-9477","authenticated-orcid":false,"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion Zhanyun","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-7935","authenticated-orcid":false,"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-1694","authenticated-orcid":false,"given":"Tong Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwee Teck","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-9515","authenticated-orcid":false,"given":"Andy","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2022.12.019_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3904\/kjim.2013.28.4.387","article-title":"Clinical applications of mesenchymal stem cells","volume":"28","author":"Kim","year":"2013","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0963689719837897","article-title":"The pros and cons of mesenchymal stem cell-based therapies","volume":"28","author":"Musia\u0142-Wysocka","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-8722-5-19","article-title":"Clinical applications of mesenchymal stem cells","volume":"5","author":"Wang","year":"2012","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"Npj Regen. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib5","first-page":"666","article-title":"Advancing application of mesenchymal stem cell-based bone tissue regeneration","volume":"6","author":"Shang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","article-title":"Mesenchymal stem cells current clinical applications: a systematic review","volume":"52","author":"Rodr\u00edguez-Fuentes","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.632717","article-title":"Therapeutic use of mesenchymal stromal cells: the need for inclusive characterization guidelines to accommodate all tissue sources and species","volume":"9","author":"Wright","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/01.moh.0000245697.54887.6f","article-title":"Mesenchymal stromal cells","volume":"13","author":"Keating","year":"2006","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008275","article-title":"Machine learning to predict mesenchymal stem cell efficacy for cartilage repair","volume":"16","author":"Liu","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.621748","article-title":"Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications","volume":"9","author":"Kouroupis","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib11","first-page":"1","article-title":"3D culture of bone marrow-derived mesenchymal stem cells (BMSCs) could improve bone regeneration in 3D-printed porous Ti6Al4V scaffolds","author":"Yu","year":"2018","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13287-020-02094-8","article-title":"Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells","volume":"12","author":"Bicer","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib13","article-title":"Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system, Mater","volume":"14","author":"Shou","year":"2022","journal-title":"Today Biogr."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/anbr.202000073","article-title":"Hydrogels for engineering the immune system","volume":"1","author":"Li","year":"2021","journal-title":"Adv. NanoBiomed Res."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.603408","article-title":"Influence of the mechanical environment on the regeneration of osteochondral defects","volume":"9","author":"Davis","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib16","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrm.2017.108","article-title":"Mechanical forces direct stem cell behaviour in development and regeneration","volume":"18","author":"Vining","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abp8163","article-title":"Navigating regulatory pathways for translation of biologic cartilage repair products","volume":"14","author":"Nordberg","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/ten.tea.2011.0391","article-title":"Improving viability of stem cells during syringe needle flow through the Design of hydrogel cell carriers","volume":"18","author":"Aguado","year":"2012","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41551-021-00729-6","article-title":"Therapeutic implications of transplanted-cell death","volume":"5","author":"Wagoner","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01228","article-title":"The necrobiology of mesenchymal stromal cells affects therapeutic efficacy","volume":"10","author":"Weiss","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7828","article-title":"Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation","volume":"9","author":"Galleu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib22","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1089\/scd.2016.0068","article-title":"Inactivated mesenchymal stem cells maintain immunomodulatory capacity","volume":"25","author":"Luk","year":"2016","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202107990","article-title":"Targeted therapeutics delivery by exploiting biophysical properties of senescent cells","volume":"32","author":"Low","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121802","article-title":"Dynamic gelatin-based hydrogels promote the proliferation and self-renewal of embryonic stem cells in long-term 3D culture","volume":"289","author":"xu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib25","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1021\/acsabm.0c01591","article-title":"Hyaluronic acid hydrogel with adjustable stiffness for mesenchymal stem cell 3D culture via related molecular mechanisms to maintain stemness and induce cartilage differentiation","volume":"4","author":"Ren","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actbio.2015.04.015","article-title":"Mechanical loading regulates human MSC differentiation in a multi-layer hydrogel for osteochondral tissue engineering","volume":"21","author":"Steinmetz","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib27","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1021\/acs.biomac.2c00176","article-title":"Sugar-assisted cryopreservation of stem cell-laden gellan gum\u2013collagen interpenetrating network hydrogels","volume":"23","author":"Ng","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib28","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1021\/acsnano.6b01765","article-title":"Dynamic surfaces for the study of mesenchymal stem cell growth through adhesion regulation","volume":"10","author":"Roberts","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib29","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.3390\/ijms20164024","article-title":"The effects of different dynamic culture systems on cell proliferation and osteogenic differentiation in human mesenchymal stem cells","volume":"20","author":"Tsai","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib30","article-title":"Combinatorial screen of dynamic mechanical stimuli for predictive control of MSC mechano-responsiveness","volume":"7","author":"Liu","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1039\/c1ib00056j","article-title":"(Micro)managing the mechanical microenvironment","volume":"3","author":"Moraes","year":"2011","journal-title":"Integr. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib32","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2013.0179","article-title":"Mesenchymal stem cell mechanobiology and emerging experimental platforms","volume":"10","author":"MacQueen","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41598-018-19804-1","article-title":"Magneto-active substrates for local mechanical stimulation of living cells","volume":"8","author":"Bidan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/srep45018","article-title":"Bioreactor mechanically guided 3D mesenchymal stem cell chondrogenesis using a biocompatible novel thermo-reversible methylcellulose-based hydrogel","volume":"7","author":"Cochis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13287-017-0672-5","article-title":"Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation","volume":"8","author":"Lin","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib36","article-title":"Engineering the viscoelasticity of gelatin methacryloyl (GelMA) hydrogels via small \u201cdynamic bridges\u201d to regulate BMSC behaviors for osteochondral regeneration","author":"Liu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib37","first-page":"1375","article-title":"Adaptable hydrogel with reversible linkages for regenerative medicine: dynamic mechanical microenvironment for cells","volume":"6","author":"Tong","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/bioengineering5030055","article-title":"Gelatin-methacryloyl (GelMA) hydrogels with defined degree of functionalization as a versatile toolkit for 3D cell culture and extrusion bioprinting","volume":"5","author":"Pepelanova","year":"2018","journal-title":"Bioengineering"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/srep31036","article-title":"Precise tuning of facile one-pot gelatin methacryloyl (GelMA) synthesis","volume":"6","author":"Shirahama","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/rb\/rbz050","article-title":"Preparation and characterization of methacrylated gelatin\/bacterial cellulose composite hydrogels for cartilage tissue engineering","volume":"7","author":"Gu","year":"2020","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib41","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1038\/s41598-019-42186-x","article-title":"Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency","volume":"9","author":"Zhu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib42","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.3390\/ijms20205061","article-title":"Effects of encapsulated cells on the physical\u2013mechanical properties and microstructure of gelatin methacrylate hydrogels","volume":"20","author":"Krishnamoorthy","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10118-021-2498-y","article-title":"Preparation and characterization of attractive poly(amino acid) hydrogels based on 2-ureido-4[1H]-pyrimidinone","volume":"39","author":"Shi","year":"2021","journal-title":"Chin. J. Polym. Sci."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib44","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1021\/acsapm.1c00017","article-title":"Toward renewable and functional biomedical polymers with tunable degradation rates based on itaconic acid and 1,8-octanediol","volume":"3","author":"Shou","year":"2021","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib45","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/j.biomaterials.2010.03.024","article-title":"The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening","volume":"31","author":"Chatterjee","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1089\/ten.tea.2012.0070","article-title":"Enhanced osteogenesis of human mesenchymal stem cells by periodic heat shock in self-assembling peptide hydrogel","volume":"19","author":"Chen","year":"2013","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900929","article-title":"Materials stiffness\u2010dependent redox metabolic reprogramming of mesenchymal stem cells for secretome\u2010based therapeutic angiogenesis","volume":"8","author":"Yang","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib48","first-page":"186","article-title":"Optimized fibrin gel bead assay for the study of angiogenesis","author":"Nakatsu","year":"2007","journal-title":"JoVE"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10856-018-6047-3","article-title":"Correction to: evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry","volume":"27","author":"Davidenko","year":"2018","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib50","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1016\/j.biomaterials.2011.02.029","article-title":"Advantages of RGD peptides for directing cell association with biomaterials","volume":"32","author":"Bellis","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/app.44380","article-title":"Photo-crosslinked poly(ethylene glycol) diacrylate (PEGDA) hydrogels from low molecular weight prepolymer: swelling and permeation studies","volume":"134","author":"Cavallo","year":"2017","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib52","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1002\/pc.24144","article-title":"Magnetic nanoparticle containing thiol-ene crosslinked hydrogels for controlled and targeted release of hydrophobic drugs","volume":"39","author":"Oktay","year":"2018","journal-title":"Polym. Compos."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib53","doi-asserted-by":"crossref","first-page":"11403","DOI":"10.1039\/C8RA01688G","article-title":"Oxygen insensitive thiol\u2013ene photo-click chemistry for direct imprint lithography of oxides","volume":"8","author":"Nagarjuna","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib54","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1039\/C4PY00030G","article-title":"Fully biodegradable antibacterial hydrogels via thiol\u2013ene \u201cclick\u201d chemistry","volume":"5","author":"Du","year":"2014","journal-title":"Polym. Chem."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib55","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1002\/smll.201600673","article-title":"The age of cortical neural networks affects their interactions with magnetic nanoparticles","volume":"12","author":"Tay","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib56","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/smll.200700595","article-title":"Cytotoxicity of nanoparticles","volume":"4","author":"Lewinski","year":"2008","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib57","doi-asserted-by":"crossref","first-page":"E3757","DOI":"10.1073\/pnas.1511304112","article-title":"Measuring dynamic cell\u2013material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels","volume":"112","author":"Schultz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib58","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1021\/ma102708b","article-title":"Cobalt ferrite nanoparticles as multifunctional cross-linkers in PAAm ferrohydrogels","volume":"44","author":"Messing","year":"2011","journal-title":"Macromolecules"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib59","doi-asserted-by":"crossref","first-page":"8423","DOI":"10.1021\/es9016975","article-title":"Size-, composition- and shape-dependent toxicological impact of metal oxide nanoparticles and carbon nanotubes toward bacteria","volume":"43","author":"Simon-Deckers","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib60","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3109\/17435390.2010.528847","article-title":"Toxicity of gold-nanoparticles: synergistic effects of shape and surface functionalization on micromotility of epithelial cells","volume":"5","author":"Tarantola","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib61","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1021\/acs.nanolett.1c00371","article-title":"Magnetic stiffening in 3D cell culture matrices","volume":"21","author":"Chen","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib62","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/s41556-020-0548-2","article-title":"Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures","volume":"22","author":"Massou","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib63","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2014.11.020","article-title":"Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions","volume":"13","author":"Kakinoki","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.actbio.2021.11.001","article-title":"Magnetic nanocomposite hydrogel with tunable stiffness for probing cellular responses to matrix stiffening","volume":"138","author":"Yan","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib65","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1021\/acs.nanolett.6b04958","article-title":"Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells","volume":"17","author":"Wong","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2206684119","article-title":"Gaussian curvature\u2013driven direction of cell fate toward osteogenesis with triply periodic minimal surface scaffolds","volume":"119","author":"Yang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib67","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1021\/acs.nanolett.7b03405","article-title":"Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo","volume":"17","author":"Kang","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib68","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/labinvest.2012.147","article-title":"\u03b21 integrin\u2013extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function","volume":"93","author":"Riopel","year":"2013","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib70","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/biores.2014.0055","article-title":"\u03b21 integrins mediate attachment of mesenchymal stem cells to cartilage lesions","volume":"4","author":"Zwolanek","year":"2015","journal-title":"BioResearch Open Access"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/6fdbd788-d918-4d42-ac57-fed8323f8508","article-title":"Large gradient high magnetic fields affect osteoblast ultrastructure and function by disrupting collagen I or fibronectin\/\u03b1\u03b21 integrin","volume":"8","author":"Qian","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib72","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3109\/09553002.2012.698365","article-title":"Large gradient high magnetic field affects FLG29.1 cells differentiation to form osteoclast-like cells","volume":"88","author":"Di","year":"2012","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121658","article-title":"Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: a potential regenerative medicine and food industry paradigm","volume":"287","author":"Wong","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13287-021-02137-8","article-title":"Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration","volume":"12","author":"Kadir","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib75","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3390\/ijms20081803","article-title":"The ERK MAPK pathway is essential for skeletal development and homeostasis","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib76","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1038\/s41598-019-43362-9","article-title":"Influence of cell spreading area on the osteogenic commitment and phenotype maintenance of mesenchymal stem cells","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib77","article-title":"Characterization of mechanics driven heterogeneity in mesenchymal stromal cells","author":"Kaonis","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.28","article-title":"Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells","volume":"46","author":"Han","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib79","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1089\/wound.2012.0420","article-title":"Mesenchymal stem cells in bone regeneration","volume":"2","author":"Knight","year":"2013","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib80","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12867-015-0036-6","article-title":"Mechanical stimulation of human tendon stem\/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1\/2 kinases","volume":"16","author":"Popov","year":"2015","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib81","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1096\/fj.201902377RR","article-title":"Tendon\u2010derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin\/transforming growth factor\u2010\u03b2 crosstalk\u2010mediated mechanism","volume":"34","author":"Wang","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib82","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.0903269107","article-title":"Geometric cues for directing the differentiation of mesenchymal stem cells","volume":"107","author":"Kilian","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib83","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/ten.teb.2012.0014","article-title":"Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways","volume":"18","author":"Mathieu","year":"2012","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib84","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/ten.tea.2019.0068","article-title":"The effects of ROCK inhibition on mesenchymal stem cell chondrogenesis are culture model dependent","volume":"26","author":"Gegg","year":"2020","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib85","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib86","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1021\/acsbiomaterials.8b00552","article-title":"Bilayered PLGA\/PLGA-HAp composite scaffold for osteochondral tissue engineering and tissue regeneration","volume":"4","author":"Liang","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib87","article-title":"Layer-specific stem cell differentiation in tri-layered tissue engineering biomaterials: towards development of a single-stage cell-based approach for osteochondral defect repair","volume":"12","author":"Levingstone","year":"2021","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib88","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1634\/stemcells.2006-0432","article-title":"Mesenchymal stem cells regulate angiogenesis according to their mechanical environment","volume":"25","author":"Kasper","year":"2007","journal-title":"Stem Cell."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib89","article-title":"Mechanical stimulation on mesenchymal stem cells and surrounding microenvironments in bone regeneration: regulations and applications","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib91","doi-asserted-by":"crossref","DOI":"10.1177\/2041731420943839","article-title":"Mesenchymal stem cells for cartilage regeneration","volume":"11","author":"Le","year":"2020","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib92","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/gels7040217","article-title":"Combinations of hydrogels and mesenchymal stromal cells (MSCs) for cartilage tissue engineering\u2014a review of the literature","volume":"7","author":"Wagenbrenner","year":"2021","journal-title":"Gels"},{"key":"10.1016\/j.bioactmat.2022.12.019_bib93","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13287-015-0228-5","article-title":"Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review","volume":"6","author":"Panchalingam","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/srep16570","article-title":"Optimization of human mesenchymal stem cell manufacturing: the effects of animal\/xeno-free media","volume":"5","author":"Oikonomopoulos","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib95","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1007\/s00253-018-8912-x","article-title":"Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges","volume":"102","author":"Jossen","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib96","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3727\/096368917X694831","article-title":"Effects of different cell-detaching methods on the viability and cell surface antigen expression of synovial mesenchymal stem cells","volume":"26","author":"Tsuji","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib97","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s42003-019-0638-5","article-title":"Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves","volume":"2","author":"Kurashina","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bioactmat.2022.12.019_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.650664","article-title":"The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy","volume":"9","author":"Garc\u00eda-Bernal","year":"2021","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22005072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X22005072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T14:34:42Z","timestamp":1762785282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X22005072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":97,"alternative-id":["S2452199X22005072"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.12.019","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechano-responsive hydrogel for direct stem cell manufacturing to therapy","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2022.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}