{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:58:40Z","timestamp":1788476320529,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bioactmat.2023.02.008","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T04:59:39Z","timestamp":1676869179000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration"],"prefix":"10.1016","volume":"26","author":[{"given":"Shi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-8409","authenticated-orcid":false,"given":"Zhengzhe","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Na","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-9678","authenticated-orcid":false,"given":"Yuanyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2023.02.008_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41578-020-0204-2","article-title":"Materials design for bone-tissue engineering","volume":"5","author":"Koons","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav7756","article-title":"Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration","volume":"11","author":"McDermott","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib3","first-page":"267","article-title":"Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201905220","article-title":"Biologization of allogeneic bone grafts with polyphosphate: a route to a biomimetic periosteum","volume":"29","author":"M\u0171ller","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax2476","article-title":"Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair","volume":"5","author":"Herberg","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib6","doi-asserted-by":"crossref","first-page":"343ra383","DOI":"10.1126\/scitranslmed.aad5904","article-title":"Tissue-engineered autologous grafts for facial bone reconstruction","volume":"8","author":"Bhumiratana","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biomaterials.2018.06.035","article-title":"Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats","volume":"179","author":"Jiang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib8","first-page":"120","article-title":"3D-printed bioactive ceramic scaffolds with biomimetic micro\/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone-implant interface in vivo","volume":"12","author":"Liu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib9","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1002\/adma.201600240","article-title":"Anisotropic materials for skeletal-muscle-tissue engineering","volume":"28","author":"Jana","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201870116","article-title":"Design and fabrication of a hierarchically structured scaffold for tendon-to-bone repair","volume":"30","author":"Zhu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/1043-2760(92)90169-2","article-title":"Pulsatile patterns in hormone secretion","volume":"3","author":"Brabant","year":"1992","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s40842-022-00137-y","article-title":"Role of pulsatile growth hormone (GH) secretion in the regulation of lipolysis in fasting humans","volume":"8","author":"Goldenberg","year":"2022","journal-title":"Clin. Diabet. Endocrinol."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib13","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1507\/endocrj.K09E-185","article-title":"GnRH pulsatility, the pituitary response and reproductive dysfunction","volume":"56","author":"Tsutsumi","year":"2009","journal-title":"Endocr. J."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00223-009-9222-1","article-title":"Differential regulation of RGS-2 by constant and oscillating PTH concentrations","volume":"84","author":"Homme","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib15","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1172\/JCI116483","article-title":"Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol","volume":"91","author":"Shen","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41574-020-0350-z","article-title":"Insights into parathyroid hormone secretion","volume":"16","author":"Starling","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13176","article-title":"SIKs control osteocyte responses to parathyroid hormone","volume":"7","author":"Wein","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1182\/blood.V118.21.722.722","article-title":"PTH stimulates osteoblastic VEGF-A production and remodels bone marrow micro-endothelial structures","volume":"118","author":"Smith","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/0022034512464779","article-title":"Parathyroid hormone applications in the craniofacial skeleton","volume":"92","author":"Chan","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib20","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nrendo.2015.139","article-title":"PTH receptor-1 signalling-mechanistic insights and therapeutic prospects","volume":"11","author":"Cheloha","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.10.049","article-title":"Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold","volume":"114","author":"Dang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib22","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1016\/j.biomaterials.2007.05.034","article-title":"Pulsatile release of parathyroid hormone from an implantable delivery system","volume":"28","author":"Liu","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201905876","article-title":"Parathyroid hormone derivative with reduced osteoclastic activity promoted bone regeneration via synergistic bone remodeling and angiogenesis","volume":"16","author":"Huang","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib24","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/8\/3\/035005","article-title":"Bone induction by surface-double-modified true bone ceramics in vitro and in vivo","volume":"8","author":"Li","year":"2013","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib25","doi-asserted-by":"crossref","first-page":"9586","DOI":"10.1016\/j.biomaterials.2010.08.020","article-title":"Enhancement of peptide coupling to hydroxyapatite and implant osseointegration through collagen mimetic peptide modified with a polyglutamate domain","volume":"31","author":"Culpepper","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202105383","article-title":"Injectable hydrogel with NIR light\u2010responsive, dual\u2010mode PTH release for osteoregeneration in osteoporosis","volume":"31","author":"Kuang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib27","article-title":"Dual-crosslinked dynamic hydrogel incorporating {Mo154 } with pH and NIR responsiveness for chemo-photothermal therapy","author":"Guedes","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib28","article-title":"Gold nanoclusters for NIR-II fluorescence imaging of bones","volume":"16","author":"Li","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.12.008","article-title":"Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant","volume":"193","author":"Tong","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1039\/C6CS00495D","article-title":"Silica\/organosilica cross-linked block copolymer micelles: a versatile theranostic platform","volume":"46","author":"Niu","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.scib.2020.07.035","article-title":"Block copolymer nanoparticle replicating strategy towards hierarchically mesoporous structured silica with predictable architectures","volume":"66","author":"Yang","year":"2021","journal-title":"Sci. Bull."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb6772","article-title":"Full-color fluorescent carbon quantum dots","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib33","article-title":"Excitation-dependent photoluminescence from single-carbon dots","volume":"13","author":"van Dam","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib34","first-page":"729","article-title":"Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer\/carbon dot nanohybrids","volume":"6","author":"Li","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib35","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1039\/C7CS00235A","article-title":"Carbon dots as photosensitisers for solar-driven catalysis","volume":"46","author":"Hutton","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib36","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1039\/C6CS00915H","article-title":"Raman spectroscopy of graphene-based materials and its applications in related devices","volume":"47","author":"Wu","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib37","doi-asserted-by":"crossref","DOI":"10.1063\/1.4928028","article-title":"Fluorescently tuned nitrogen-doped carbon dots from carbon source with different content of carboxyl groups","volume":"3","author":"Wang","year":"2015","journal-title":"Apl. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib38","doi-asserted-by":"crossref","first-page":"33936","DOI":"10.1021\/acsami.8b11175","article-title":"Mesoporous colloidal photonic crystal particles for intelligent drug delivery","volume":"10","author":"Gu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s003400100689","article-title":"An opto-mechanical nanoshell-polymer composite","volume":"73","author":"Sershen","year":"2001","journal-title":"Appl. Phys. B"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib40","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.eurpolymj.2005.04.038","article-title":"Studies on preparation and properties of NIPAAm\/hydrophobic monomer copolymeric hydrogels","volume":"41","author":"Lee","year":"2005","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib41","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1016\/j.polymer.2012.05.014","article-title":"Thermo-responsive nanofibers prepared from poly (N-isopropylacrylamide-co-N-methylol acrylamide)","volume":"53","author":"Chuang","year":"2012","journal-title":"Polymer"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib42","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1021\/ma00062a016","article-title":"Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers","volume":"26","author":"Herman","year":"1993","journal-title":"Macromolecules"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib43","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1021\/cr200157d","article-title":"Hydrogels for protein delivery","volume":"112","author":"Vermonden","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib44","article-title":"Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration Sci","volume":"6","author":"Zhang","year":"2016","journal-title":"For. Rep."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201700401","article-title":"3D printing of Lotus root-like biomimetic materials for cell delivery and tissue regeneration","volume":"4","author":"Feng","year":"2017","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib46","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1016\/j.biomaterials.2011.04.066","article-title":"The role of pore size on vascularization and tissue remodeling in PEG hydrogels","volume":"32","author":"Chiu","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib47","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1039\/C7TB00505A","article-title":"RhBMP-2 loaded MBG\/PEGylated poly(glycerol sebacate) composite scaffolds for rapid bone regeneration","volume":"5","author":"Chai","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib48","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.biomaterials.2017.11.011","article-title":"Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold","volume":"196","author":"Lin","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib49","first-page":"1921","article-title":"Mesoporous bioactive glass composition effects on degradation and bioactivity","volume":"6","author":"Schumacher","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2023.02.008_bib51","first-page":"446","article-title":"CD301b(+) macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN\/NFATc1\/VEGF axis","volume":"15","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib52","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/jbmr.4568","article-title":"Loss of parathyroid hormone receptor signaling in osteoprogenitors is associated with accumulation of multiple hematopoietic lineages in the bone marrow","volume":"37","author":"Kimura","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ange.200461119","article-title":"Core\/shell gold nanoparticles by self-assembly and crosslinking of micellar, block-copolymer shells","volume":"117","author":"Kang","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib54","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of Bioglass","volume":"17","author":"Hench","year":"2006","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioactmat.2023.02.008_bib55","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1002\/anie.200460598","article-title":"Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities","volume":"43","author":"Yan","year":"2004","journal-title":"Angew. Chem., Int. Ed. Engl."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23000464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23000464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T14:39:22Z","timestamp":1762785562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X23000464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":55,"alternative-id":["S2452199X23000464"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.02.008","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}