{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:36:23Z","timestamp":1793799383494,"version":"4.6.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T00:00:00Z","timestamp":1689984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009751","name":"School of Veterinary Medicine, University of California, Davis","doi-asserted-by":"publisher","award":["\/ NEI U24 EY029890"],"award-info":[{"award-number":["\/ NEI U24 EY029890"]}],"id":[{"id":"10.13039\/100009751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011106"],"award-info":[{"award-number":["P51OD011106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["U24 EY029890"],"award-info":[{"award-number":["U24 EY029890"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009429","name":"Israel National Road Safety Authority","doi-asserted-by":"publisher","award":["\/ NEI F30 EY031230"],"award-info":[{"award-number":["\/ NEI F30 EY031230"]}],"id":[{"id":"10.13039\/100009429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000262","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50HD105353"],"award-info":[{"award-number":["P50HD105353"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016026","name":"RRF Foundation for Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0655"],"award-info":[{"award-number":["W81XWH-20-1-0655"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bioactmat.2023.07.019","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T17:15:52Z","timestamp":1690823752000},"page":"142-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct"],"prefix":"10.1016","volume":"30","author":[{"given":"In-Kyu","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruosen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-2753","authenticated-orcid":false,"given":"Agustin","family":"Luz-Madrigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0761-6129","authenticated-orcid":false,"given":"Seunghwan","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-8379","authenticated-orcid":false,"given":"Jiahe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly L.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-2386","authenticated-orcid":false,"given":"M. Joseph","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3327-9795","authenticated-orcid":false,"given":"Allison L.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-613X","authenticated-orcid":false,"given":"David M.","family":"Gamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-1342","authenticated-orcid":false,"given":"Zhenqiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2023.07.019_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100846","article-title":"The cell biology of the retinal pigment epithelium","author":"Lakkaraju","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2016.00037","article-title":"Ocular immune privilege and transplantation","volume":"7","author":"Taylor","year":"2016","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.07.019_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/bjo.2005.086595","article-title":"Impact of age related macular degeneration on quality of life","volume":"90","author":"Hassell","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1001\/archophthalmol.2009.58","article-title":"Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments","volume":"127","author":"Rein","year":"2009","journal-title":"Arch. Ophthalmol."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2021.09.010","article-title":"The economic burden of vision loss and blindness in the United States","volume":"129","author":"Rein","year":"2022","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.bioactmat.2023.07.019_bib7","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Global Health"},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch's membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol. Aspect. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib9","first-page":"473","article-title":"Age-related macular degeneration","volume":"105","author":"Thomas","year":"2021","journal-title":"Med. Clin."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib10","first-page":"1","article-title":"Accidental self-inflicted handheld laser-induced maculopathy","author":"Narayanan","year":"2021","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.07.019_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/ICB.0000000000000935","article-title":"SELF-INFLICTED LASER-INDUCED MACULOPATHY MASQUERADING AS POSTERIOR UVEITIS IN A PATIENT WITH SUSPECTED IgG4-RELATED DISEASE","volume":"16","author":"Agarwal","year":"2022","journal-title":"Retin. Cases Brief Rep."},{"issue":"12","key":"10.1016\/j.bioactmat.2023.07.019_bib12","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1097\/IAE.0000000000000397","article-title":"Retinal injury after inadvertent handheld laser exposure","volume":"34","author":"Lee","year":"2014","journal-title":"Retina"},{"key":"10.1016\/j.bioactmat.2023.07.019_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-3-319-95046-4_27","article-title":"Stargardt disease","volume":"1085","author":"Tsang","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib14","article-title":"Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies","volume":"13","author":"Singh Grewal","year":"2021","journal-title":"Ther. Adv. Ophthalmol."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.07.019_bib15","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.ajo.2014.07.036","article-title":"Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration","volume":"158","author":"Rezende","year":"2014","journal-title":"Am. J. Ophthalmol."},{"issue":"19","key":"10.1016\/j.bioactmat.2023.07.019_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911769","article-title":"Therapeutic approaches for age-related macular degeneration","volume":"23","author":"Galindo-Camacho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.07.019_bib17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bioactmat.2023.07.019_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108391","article-title":"Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates","volume":"214","author":"Hughes","year":"2020","journal-title":"Clin. Immunol."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2\/3 trial","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bioactmat.2023.07.019_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101089","article-title":"Optogenetics for visual restoration: from proof of principle to translational challenges","volume":"91","author":"Lindner","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ophtha.2013.11.011","article-title":"NEI's audacious goals initiative","volume":"121","author":"Salowe","year":"2014","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.bioactmat.2023.07.019_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/tvst.10.10.15","article-title":"Outer retinal cell replacement: putting the pieces together","volume":"10","author":"Ludwig","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"6","key":"10.1016\/j.bioactmat.2023.07.019_bib23","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41591-022-01862-8","article-title":"Regenerative and restorative medicine for eye disease","volume":"28","author":"Van Gelder","year":"2022","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2022.02.003","article-title":"Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea","volume":"29","author":"Saha","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2023.07.019_bib25","article-title":"Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines","volume":"146","author":"Capowski","year":"2019","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.bioactmat.2023.07.019_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110827","article-title":"Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution","volume":"39","author":"Rempel","year":"2022","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.07.019_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213418120","article-title":"Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures","volume":"120","author":"Ludwig","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/hmg\/dds469","article-title":"iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration","volume":"22","author":"Singh","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.bioactmat.2023.07.019_bib29","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1167\/iovs.13-11943","article-title":"Functional analysis of serially expanded human iPS cell-derived RPE cultures","volume":"54","author":"Singh","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.07.019_bib30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajhg.2020.06.011","article-title":"Human iPSC modeling reveals mutation-specific responses to gene therapy in a genotypically diverse dominant maculopathy","volume":"107","author":"Sinha","year":"2020","journal-title":"Am. J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.bioactmat.2023.07.019_bib31","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1167\/iovs.14-14325","article-title":"Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation","volume":"55","author":"Carido","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.bioactmat.2023.07.019_bib32","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1167\/iovs.12-11239","article-title":"Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer","volume":"54","author":"Diniz","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.11.001","article-title":"Transplantation of photoreceptors into the degenerative retina: current state and future perspectives","volume":"69","author":"Gasparini","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100779","article-title":"Retinal stem cell transplantation: balancing safety and potential","volume":"75","author":"Singh","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/stcltm\/szac001","article-title":"Retinal cell transplantation, biomaterials, and in vitro models for developing next-generation therapies of age-related macular degeneration","volume":"11","author":"Rizzolo","year":"2022","journal-title":"Stem. Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.stemcr.2022.01.001","article-title":"Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration","volume":"17","author":"Kashani","year":"2022","journal-title":"Stem Cell Rep."},{"issue":"10","key":"10.1016\/j.bioactmat.2023.07.019_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.10.10.13","article-title":"One-Year follow-up in a phase 1\/2a clinical trial of an allogeneic RPE cell bioengineered implant for advanced dry age-related macular degeneration","volume":"10","author":"Kashani","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nbt.4114","article-title":"Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration","volume":"36","author":"da Cruz","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"475","key":"10.1016\/j.bioactmat.2023.07.019_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat5580","article-title":"Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs","volume":"11","author":"Sharma","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"40","key":"10.1016\/j.bioactmat.2023.07.019_bib40","doi-asserted-by":"crossref","first-page":"64631","DOI":"10.18632\/oncotarget.11502","article-title":"Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"issue":"39","key":"10.1016\/j.bioactmat.2023.07.019_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803550","article-title":"3D microstructured scaffolds to support photoreceptor polarization and maturation","volume":"30","author":"Jung","year":"2018","journal-title":"Adv. Mater."},{"issue":"17","key":"10.1016\/j.bioactmat.2023.07.019_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf0344","article-title":"Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction","volume":"7","author":"Lee","year":"2021","journal-title":"Sci. Adv."},{"issue":"20","key":"10.1016\/j.bioactmat.2023.07.019_bib43","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.biomaterials.2009.02.046","article-title":"Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation","volume":"30","author":"Redenti","year":"2009","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.bioactmat.2023.07.019_bib44","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.progpolymsci.2012.02.001","article-title":"Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): a review","volume":"37","author":"Rai","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib45","article-title":"Cell therapy for retinal dystrophies: from cell suspension formulation to complex retinal tissue bioengineering","volume":"2019","author":"Ben M'Barek","year":"2019","journal-title":"Stem Cell. Int."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.07.019_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/stem.2755","article-title":"A novel approach to single cell RNA-sequence analysis facilitates in silico gene reporting of human pluripotent stem cell-derived retinal cell types","volume":"36","author":"Phillips","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s005420050183","article-title":"Etching through silicon wafer in inductively coupled plasma","volume":"6","author":"Franssila","year":"2000","journal-title":"Microsyst. Technol."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.07.019_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1063\/1.3474652","article-title":"High aspect ratio silicon etch: a review","volume":"108","author":"Wu","year":"2010","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib49","series-title":"Handbook of Silicon Based MEMS Materials and Technologies","author":"Laermer","year":"2020"},{"issue":"6","key":"10.1016\/j.bioactmat.2023.07.019_bib50","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nbt0602-602","article-title":"A tough biodegradable elastomer","volume":"20","author":"Wang","year":"2002","journal-title":"Nat. Biotechnol."},{"issue":"39","key":"10.1016\/j.bioactmat.2023.07.019_bib51","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1039\/C5TB01048A","article-title":"Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications","volume":"3","author":"Loh","year":"2015","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"10.1016\/j.bioactmat.2023.07.019_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002026","article-title":"Poly(Glycerol sebacate) in biomedical applications-A review of the recent literature","volume":"10","author":"Vogt","year":"2021","journal-title":"Adv Healthc. Mater."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib53","article-title":"Synthesis, characterization and 3D micro-structuring via 2-photon polymerization of poly(glycerol sebacate)-methacrylate-an elastomeric degradable polymer","volume":"6","author":"Pashneh-Tala","year":"2018","journal-title":"Front Phys-Lausanne"},{"issue":"34","key":"10.1016\/j.bioactmat.2023.07.019_bib54","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1039\/C7PY00323D","article-title":"Norbornene-modified poly(glycerol sebacate) as a photocurable and biodegradable elastomer","volume":"8","author":"Yeh","year":"2017","journal-title":"Polym Chem-Uk"},{"issue":"4","key":"10.1016\/j.bioactmat.2023.07.019_bib55","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/8\/4\/045004","article-title":"3D printing of photocurable poly(glycerol sebacate) elastomers","volume":"8","author":"Yeh","year":"2016","journal-title":"Biofabrication"},{"issue":"48","key":"10.1016\/j.bioactmat.2023.07.019_bib56","doi-asserted-by":"crossref","first-page":"56988","DOI":"10.1021\/acsami.1c18250","article-title":"Injectable hydrogel capable of in situ covalent crosslinking for permanent embolization","volume":"13","author":"Xie","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.bioactmat.2023.07.019_bib57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12886-019-1296-6","article-title":"Thickness of individual layers at the macula and associated factors: the Beijing Eye Study 2011","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Ophthalmol."},{"issue":"421","key":"10.1016\/j.bioactmat.2023.07.019_bib58","article-title":"Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration","volume":"9","author":"Ben M'Barek","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"23","key":"10.1016\/j.bioactmat.2023.07.019_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800226","article-title":"The application of biomaterials to tissue engineering neural retina and retinal pigment epithelium","volume":"7","author":"Hunt","year":"2018","journal-title":"Adv Healthc. Mater."},{"issue":"435","key":"10.1016\/j.bioactmat.2023.07.019_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4097","article-title":"A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration","volume":"10","author":"Kashani","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2023.07.019_bib61","series-title":"Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated with Age-Related Macular Degeneration","year":"2023"},{"key":"10.1016\/j.bioactmat.2023.07.019_bib62","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev-pharmtox-010919-023245","article-title":"Retinal pigment epithelium replacement therapy for age-related macular degeneration: are we there yet?","volume":"60","author":"Sharma","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23002323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23002323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:06:07Z","timestamp":1778889967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X23002323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":62,"alternative-id":["S2452199X23002323"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.07.019","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}