{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:21:30Z","timestamp":1793413290552,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991502"],"award-info":[{"award-number":["81991502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991504"],"award-info":[{"award-number":["81991504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20220394"],"award-info":[{"award-number":["BX20220394"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["2023-ZDLSF-49"],"award-info":[{"award-number":["2023-ZDLSF-49"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bioactmat.2023.10.022","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T07:04:38Z","timestamp":1699513478000},"page":"85-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-0221","authenticated-orcid":false,"given":"Jiani","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-7636","authenticated-orcid":false,"given":"Geng","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanmin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji'an","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5474-702X","authenticated-orcid":false,"given":"Yimin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-4432","authenticated-orcid":false,"given":"Qianming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-2248","authenticated-orcid":false,"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"372","key":"10.1016\/j.bioactmat.2023.10.022_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag2809","article-title":"Pharmacological rescue of diabetic skeletal stem cell niches","volume":"9","author":"Tevlin","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"7915","key":"10.1016\/j.bioactmat.2023.10.022_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-022-04754-6","article-title":"Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes","volume":"606","author":"Maschalidi","year":"2022","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bioactmat.2023.10.022_bib3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/154405910608500606","article-title":"Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation","volume":"85","author":"Liu","year":"2006","journal-title":"J. Dent. Res."},{"issue":"9499","key":"10.1016\/j.bioactmat.2023.10.022_bib4","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.bioactmat.2023.10.022_bib5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/prd.12270","article-title":"Diabetes as a potential risk for periodontitis: association studies","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol. 2000"},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.7150\/thno.78878","article-title":"SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation resolution of diabetic periodontitis","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.bioactmat.2023.10.022_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2023.10.022_bib9","article-title":"Periodontal inflammation-triggered by periodontal ligament stem cell pyroptosis exacerbates periodontitis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010372","article-title":"Pyroptosis-mediated periodontal disease","volume":"23","author":"Sordi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jre.12689","article-title":"USF2 enhances the osteogenic differentiation of PDLCs by promoting ATF4 transcriptional activities","volume":"55","author":"Liu","year":"2020","journal-title":"J. Periodontal. Res."},{"issue":"11","key":"10.1016\/j.bioactmat.2023.10.022_bib12","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2337\/db17-1308","article-title":"Altered extracellular vesicle concentration, cargo, and function in diabetes","volume":"67","author":"Freeman","year":"2018","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1615820","article-title":"Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation","volume":"8","author":"Brahmer","year":"2019","journal-title":"J. Extracell. Vesicles"},{"issue":"12","key":"10.1016\/j.bioactmat.2023.10.022_bib14","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00125-019-05014-5","article-title":"Extracellular vesicles in metabolic disease","volume":"62","author":"Akbar","year":"2019","journal-title":"Diabetologia"},{"issue":"30","key":"10.1016\/j.bioactmat.2023.10.022_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba2987","article-title":"Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation","volume":"6","author":"Dou","year":"2020","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.bioactmat.2023.10.022_bib16","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1159\/000452512","article-title":"Cell-derived microparticles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"39","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.10.022_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201904044","article-title":"Circulating exosomal miR-20b-5p inhibition restores Wnt9b signaling and reverses diabetes-associated impaired wound healing","volume":"16","author":"Xiong","year":"2020","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tem.2016.10.003","article-title":"Extracellular vesicles: novel mediators of cell communication in metabolic disease","volume":"28","author":"Huang-Doran","year":"2017","journal-title":"Trends Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib19","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/s41467-021-26302-y","article-title":"Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors","volume":"12","author":"Xia","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bioactmat.2023.10.022_bib20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cmet.2022.08.004","article-title":"Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metabol."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.10.022_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2022.02.006","article-title":"Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression","volume":"34","author":"Lu","year":"2022","journal-title":"Cell Metabol."},{"issue":"7","key":"10.1016\/j.bioactmat.2023.10.022_bib22","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1172\/JCI72606","article-title":"Vitamin B(1)(2)-dependent taurine synthesis regulates growth and bone mass","volume":"124","author":"Roman-Garcia","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.10.022_bib23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2015.09.010","article-title":"A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Metabol."},{"issue":"18","key":"10.1016\/j.bioactmat.2023.10.022_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100275","article-title":"Emerging targets in type 2 diabetes and diabetic complications","volume":"8","author":"Demir","year":"2021","journal-title":"Adv. Sci."},{"issue":"9","key":"10.1016\/j.bioactmat.2023.10.022_bib25","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s42255-021-00444-1","article-title":"Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075","volume":"3","author":"Ji","year":"2021","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1","volume":"72","author":"Jiang","year":"2020","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.bioactmat.2023.10.022_bib27","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/1753-0407.13456","article-title":"The role of miRNAs carried by extracellular vesicles in type 2 diabetes and its complications","volume":"15","author":"Chao","year":"2023","journal-title":"J. Diabetes."},{"issue":"6","key":"10.1016\/j.bioactmat.2023.10.022_bib28","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s12031-022-01994-z","article-title":"Whole-transcriptome analysis of serum L1CAM-captured extracellular vesicles reveals neural and glycosylation changes in autism spectrum disorder","volume":"72","author":"Qin","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.bioactmat.2023.10.022_bib29","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41596-020-00466-1","article-title":"Isolation and characterization of extracellular vesicle subpopulations from tissues","volume":"16","author":"Crescitelli","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioactmat.2023.10.022_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/srep22519","article-title":"Cells release subpopulations of exosomes with distinct molecular and biological properties","volume":"6","author":"Willms","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.10.022_bib31","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/hep.32045","article-title":"Fatty acid synthase-suppressor screening identifies sorting nexin 8 as a therapeutic target for NAFLD","volume":"74","author":"Hu","year":"2021","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.bioactmat.2023.10.022_bib32","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat. Protoc."},{"issue":"9429","key":"10.1016\/j.bioactmat.2023.10.022_bib33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"issue":"7575","key":"10.1016\/j.bioactmat.2023.10.022_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bioactmat.2023.10.022_bib35","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/jcpe.13517","article-title":"Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging","volume":"48","author":"Zhao","year":"2021","journal-title":"J. Clin. Periodontol."},{"issue":"6","key":"10.1016\/j.bioactmat.2023.10.022_bib36","doi-asserted-by":"crossref","first-page":"C1189","DOI":"10.1152\/ajpcell.00536.2019","article-title":"Extracellular vesicles as signaling mediators in type 2 diabetes mellitus","volume":"318","author":"Noren Hooten","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"48","key":"10.1016\/j.bioactmat.2023.10.022_bib37","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Castano","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"10.1016\/j.bioactmat.2023.10.022_bib38","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.bbadis.2015.08.010","article-title":"Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction","volume":"1852","author":"Essandoh","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.bioactmat.2023.10.022_bib39","article-title":"Nanorepairers rescue inflammation-induced mitochondrial dysfunction in mesenchymal stem cells","volume":"9","author":"Zhai","year":"2022","journal-title":"Adv. Sci."},{"issue":"9","key":"10.1016\/j.bioactmat.2023.10.022_bib40","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00125-019-4959-1","article-title":"New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism","volume":"62","author":"Eid","year":"2019","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.bioactmat.2023.10.022_bib41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cmet.2012.06.013","article-title":"Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity","volume":"16","author":"Lodhi","year":"2012","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.10.022_bib42","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bioactmat.2023.10.022_bib43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2023.10.022_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152544","article-title":"Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production","volume":"443","author":"Kawata","year":"2020","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.bioactmat.2023.10.022_bib45","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.29605","article-title":"Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia\/reperfusion injury","volume":"67","author":"Yang","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.bioactmat.2023.10.022_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bioactmat.2023.10.022_bib47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12986-020-0434-8","article-title":"Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis","volume":"17","author":"Zeng","year":"2020","journal-title":"Nutr. Metab."},{"issue":"5","key":"10.1016\/j.bioactmat.2023.10.022_bib48","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.bioactmat.2023.10.022_bib49","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1600-0501.2012.02467.x","article-title":"Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: removal torque and histomorphometric analysis in rats","volume":"24","author":"de Molon","year":"2013","journal-title":"Clin. Oral Implants Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12235","article-title":"Periodontal complications of hyperglycemia\/diabetes mellitus: epidemiologic complexity and clinical challenge","volume":"78","author":"Kocher","year":"2018","journal-title":"Periodontol. 2000"},{"issue":"10","key":"10.1016\/j.bioactmat.2023.10.022_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102555","article-title":"Hepatic osteodystrophy-molecular mechanisms proposed to favor its development","volume":"20","author":"Ehnert","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bioactmat.2023.10.022_bib52","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00204-013-1191-5","article-title":"Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis","volume":"88","author":"Nussler","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.bioactmat.2023.10.022_bib53","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/JPER.22-0035","article-title":"Circulating small extracellular vesicles from patients with periodontitis contribute to development of insulin resistance","volume":"93","author":"Wang","year":"2022","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.10.022_bib54","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41419-023-05634-1","article-title":"Pyroptosis and degenerative diseases of the elderly","volume":"14","author":"Zhou","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib55","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1038\/s41598-018-20422-0","article-title":"Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells","volume":"8","author":"Pizato","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioactmat.2023.10.022_bib56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ijos.2015.2","article-title":"Diabetes mellitus related bone metabolism and periodontal disease","volume":"7","author":"Wu","year":"2015","journal-title":"Int. J. Oral Sci."},{"issue":"11","key":"10.1016\/j.bioactmat.2023.10.022_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202108430","article-title":"A logic-based diagnostic and therapeutic hydrogel with multistimuli responsiveness to orchestrate diabetic bone regeneration","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2023.10.022_bib58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-022-00177-1","article-title":"Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system","volume":"14","author":"Xin","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bioactmat.2023.10.022_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/5584_2018_333","article-title":"Stem cells derived from dental tissues","volume":"1144","author":"Aydin","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"31","key":"10.1016\/j.bioactmat.2023.10.022_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202101611","article-title":"Safeguarding osteointegration in diabetic patients: a potent \u201cChain Armor\u201d Coating for scavenging ROS and macrophage reprogramming in a microenvironment\u2010responsive manner","volume":"31","author":"He","year":"2021","journal-title":"Adv. Funct. Mater."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23003365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X23003365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T14:50:24Z","timestamp":1762786224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X23003365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":60,"alternative-id":["S2452199X23003365"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.10.022","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2023.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}