{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:17:12Z","timestamp":1790072232163,"version":"4.0.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipality Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016983","name":"Shanghai Clinical Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018920","name":"Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.bioactmat.2024.02.017","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:08:32Z","timestamp":1708492112000},"page":"517-533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy"],"prefix":"10.1016","volume":"35","author":[{"given":"Decui","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaozhi","family":"Liyin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoming","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-3637","authenticated-orcid":false,"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bioactmat.2024.02.017_bib1","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1016\/S2666-5247(23)00031-9","article-title":"Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study","volume":"4","author":"Liu","year":"2023","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib2","doi-asserted-by":"crossref","first-page":"107663","DOI":"10.1016\/j.pharmthera.2020.107663","article-title":"Updates on community acquired pneumonia management in the ICU","volume":"217","author":"Nair","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.34133\/research.0258","article-title":"DeepSecE: a deep-learning-based Framework for multiclass Prediction of secreted Proteins in gram-negative bacteria","volume":"6","author":"Zhang","year":"2023","journal-title":"Research"},{"issue":"8","key":"10.1016\/j.bioactmat.2024.02.017_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11080993","article-title":"Anti-Biofilm and antibacterial Activities of Cycas media R. Br secondary metabolites: in silico, in vitro, and in vivo approaches","volume":"11","author":"Attallah","year":"2022","journal-title":"Antibiotics"},{"issue":"7","key":"10.1016\/j.bioactmat.2024.02.017_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41579-023-00907-0","article-title":"Reviving colistin","volume":"21","author":"Taglialegna","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.02.017_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1473-3099(16)00006-2","article-title":"Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli","volume":"16","author":"Poirel","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1473-3099(16)00056-6","article-title":"Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae","volume":"16","author":"Du","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41426-018-0124-z","article-title":"Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae","volume":"7","author":"Wang","year":"2018","journal-title":"Emerg. Microb. Infect."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.02.017_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01932-17","article-title":"Rapid increase in prevalence of carbapenem-resistant Enterobacteriaceae (CRE) and emergence of colistin resistance gene mcr-1 in CRE in a hospital in henan, China","volume":"56","author":"Li","year":"2018","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.02.017_bib11","first-page":"711","article-title":"Colistin resistance in carbapenem-resistant Klebsiella pneumoniae: laboratory detection and impact on mortality","volume":"64","author":"Rojas","year":"2017","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.bioactmat.2024.02.017_bib12","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3201\/eid2209.160464","article-title":"Possible transmission of mcr-1-harboring Escherichia coli between companion animals and human","volume":"22","author":"Zhang","year":"2016","journal-title":"Emerg. Infect. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1473-3099(16)00009-8","article-title":"Colistin resistance gene mcr-1 in extended-spectrum \u03b2-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany","volume":"16","author":"Falgenhauer","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13099-018-0266-5","article-title":"Antimicrobial resistance in Enterobacteriaceae from healthy broilers in Egypt: emergence of colistin-resistant and extended-spectrum \u03b2-lactamase-producing Escherichia coli","volume":"10","author":"Moawad","year":"2018","journal-title":"Gut Pathog."},{"issue":"31","key":"10.1016\/j.bioactmat.2024.02.017_bib15","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.31.30586","article-title":"Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015","volume":"22","author":"Hern\u00e1ndez","year":"2017","journal-title":"Euro Surveill."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijantimicag.2017.11.010","article-title":"High prevalence of mcr-1, mcr-3 and mcr-5 in Escherichia coli derived from diseased pigs in Japan","volume":"51","author":"Fukuda","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijid.2018.05.011","article-title":"Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea","volume":"72","author":"Belaynehe","year":"2018","journal-title":"Int. J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.02.017_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00064-16","article-title":"Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms Encoded by Plasmids or chromosomes","volume":"30","author":"Poirel","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.02.017_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/jac\/18.5.557","article-title":"Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli","volume":"18","author":"Dixon","year":"1986","journal-title":"J. Antimicrob. Chemother."},{"issue":"12","key":"10.1016\/j.bioactmat.2024.02.017_bib20","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1074\/jbc.RA117.000924","article-title":"Mechanistic insights into transferable polymyxin resistance among gut bacteria","volume":"293","author":"Xu","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib21","first-page":"141","article-title":"Drug combinations: a strategy to extend the life of antibiotics in the 21st century. Nature Reviews","volume":"17","author":"Tyers","year":"2019","journal-title":"Microbiology"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib22","series-title":"Bacterial Infection Microenvironment-Responsive Porous Microspheres by Microfluidics for Promoting Anti-infective Therapy","author":"Gao","year":"2022"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bmt.2022.11.010","article-title":"Advances in the delivery systems for oral antibiotics","volume":"2","author":"Wang","year":"2023","journal-title":"Biomedical Technology"},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1473-3099(17)30747-8","article-title":"Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial","volume":"18","author":"Torres","year":"2018","journal-title":"Lancet Infect. Dis."},{"issue":"8","key":"10.1016\/j.bioactmat.2024.02.017_bib25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2018.0438","article-title":"Effect of meropenem-Vaborbactam vs piperacillin-Tazobactam on clinical Cure or Improvement and microbial Eradication in complicated urinary tract infection: the TANGO I randomized clinical trial","volume":"319","author":"Kaye","year":"2018","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.bioactmat.2024.02.017_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00775-022-01983-y","article-title":"Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria","volume":"28","author":"Zhang","year":"2023","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib27","article-title":"Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver","volume":"vol. 119","author":"Zhang","year":"2022"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib28","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/s41467-020-18939-y","article-title":"Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41467-018-02828-6","article-title":"Bismuth antimicrobial drugs serve as broad-spectrum metallo-\u03b2-lactamase inhibitors","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"issue":"30","key":"10.1016\/j.bioactmat.2024.02.017_bib30","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.2174\/1568026622666220919124104","article-title":"Mechanisms of metallic nanomaterials to induce an antibacterial effect","volume":"22","author":"Rodr\u00edguez-Barajas","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib31","doi-asserted-by":"crossref","first-page":"149287","DOI":"10.1016\/j.cej.2024.149287","article-title":"Combating drug-resistant helicobacter pylori infection with zinc peroxide-based nanoparticles: a ROS reservoir via photochemical reaction","volume":"483","author":"Wong","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib32","article-title":"Injectable nano-micro Composites with anti-bacterial and osteogenic Capabilities for minimally invasive Treatment of osteomyelitis","author":"Lu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib33","article-title":"Bio-responsive sliver peroxide-nanocarrier Serves as broad-spectrum metallo-\u03b2-lactamase Inhibitor for combating severe pneumonia","author":"Li","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib34","unstructured":"FDA,. Drugs@FDA: FDA-Approved Drugs. Available from:: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib35","doi-asserted-by":"crossref","first-page":"120628","DOI":"10.1016\/j.carbpol.2023.120628","article-title":"ROS-sensitive Crocin-loaded chitosan microspheres for lung targeting and attenuation of radiation-induced lung injury","volume":"307","author":"Wang","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.02.017_bib36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2010.02.043","article-title":"Anti-inflammatory agents: present and future","volume":"140","author":"Dinarello","year":"2010","journal-title":"Cell"},{"issue":"43","key":"10.1016\/j.bioactmat.2024.02.017_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803618","article-title":"Bioresponsive nanoparticles targeted to infectious microenvironments for sepsis management","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fcimb.2018.00163","article-title":"Chitosan microsphere used as an effective system to deliver a linked antigenic peptides vaccine protect mice against acute and chronic toxoplasmosis","volume":"8","author":"Guo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib39","series-title":"Performance Standards for Antimicrobial Susceptibility Testing, M100","year":"2021"},{"issue":"3","key":"10.1016\/j.bioactmat.2024.02.017_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-018-0141-x","article-title":"Drug combinations: a strategy to extend the life of antibiotics in the 21st century","volume":"17","author":"Tyers","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fcimb.2018.00163","article-title":"Chitosan microsphere used as an effective system to deliver a linked antigenic peptides vaccine protect mice against acute and chronic toxoplasmosis","volume":"8","author":"Guo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jmv.26235","article-title":"Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19","volume":"93","author":"Shi","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijbiomac.2017.01.109","article-title":"Inhalable bioresponsive chitosan microspheres of doxorubicin and soluble curcumin augmented drug delivery in lung cancer cells","volume":"98","author":"Jyoti","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib44","article-title":"Hypoxia and matrix metalloproteinase 13-responsive hydrogel microspheres alleviate osteoarthritis progression in vivo","author":"Zhou","year":"2023","journal-title":"Small"},{"issue":"10","key":"10.1016\/j.bioactmat.2024.02.017_bib45","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1021\/acsnano.1c06460","article-title":"Lung-targeting lysostaphin Microspheres for methicillin-resistant Staphylococcus aureus pneumonia Treatment and prevention","volume":"15","author":"Lin","year":"2021","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.bioactmat.2024.02.017_bib46","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1021\/acsnano.9b09773","article-title":"Monosized polymeric microspheres designed for passive lung targeting: biodistribution and pharmacokinetics after intravenous administration","volume":"14","author":"Agnoletti","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.addr.2014.05.017","article-title":"Delivery strategies for sustained drug release in the lungs","volume":"75","author":"Loira-Pastoriza","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.02.017_bib48","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.tibtech.2022.11.009","article-title":"Tuning chitosan's chemical structure for enhanced biological functions","volume":"41","author":"Aghbashlo","year":"2023","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib49","doi-asserted-by":"crossref","first-page":"118984","DOI":"10.1016\/j.carbpol.2021.118984","article-title":"Microstructure and properties of thermomechanically processed chitosan citrate-based materials","volume":"278","author":"Bezerra","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib50","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ijbiomac.2021.06.178","article-title":"Synthesis of chitosan-lysozyme microspheres, physicochemical characterization, enzymatic and antimicrobial activity","volume":"185","author":"Cer\u00f3n","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib51","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ijbiomac.2019.04.208","article-title":"Facile fabrication of functional chitosan microspheres and study on their effective cationic\/anionic dyes removal from aqueous solution","volume":"134","author":"Yu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib52","doi-asserted-by":"crossref","first-page":"119693","DOI":"10.1016\/j.carbpol.2022.119693","article-title":"Extracellular matrix-mimicking nanofibrous chitosan microspheres as cell micro-ark for tissue engineering","volume":"292","author":"Yang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib53","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.carbpol.2015.04.022","article-title":"Magnetic\/pH-responsive beads based on caboxymethyl chitosan and \u03ba-carrageenan and controlled drug release","volume":"128","author":"Mahdavinia","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2009.09.004","article-title":"Biodegradation, biodistribution and toxicity of chitosan","volume":"62","author":"Kean","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib55","doi-asserted-by":"crossref","first-page":"118698","DOI":"10.1016\/j.carbpol.2021.118698","article-title":"Modelling multiphasic starch digestograms with multiterm exponential and non-exponential equations","volume":"275","author":"Sopade","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib56","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jconrel.2020.11.055","article-title":"Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection","volume":"329","author":"Gao","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib57","doi-asserted-by":"crossref","first-page":"132437","DOI":"10.1016\/j.matlet.2022.132437","article-title":"Drug delivery system of green synthesized Ti-Cu nanocomposite","volume":"321","author":"Mart\u00edn-Camacho","year":"2022","journal-title":"Mater. Lett."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/02652048.2014.944951","article-title":"Polymer assisted entrapment of netilmicin in PLGA nanoparticles for sustained antibacterial activity","volume":"32","author":"Kolate","year":"2015","journal-title":"J. Microencapsul."},{"issue":"11","key":"10.1016\/j.bioactmat.2024.02.017_bib59","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1086\/647952","article-title":"Antimicrobial susceptibility testing: a review of general principles and contemporary practices","volume":"49","author":"Jorgensen","year":"2009","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib60","doi-asserted-by":"crossref","first-page":"100051","DOI":"10.1016\/j.engmic.2022.100051","article-title":"Two-component system GacS\/GacA, a global response regulator of bacterial physiological behaviors","volume":"3","author":"Song","year":"2023","journal-title":"Engineering Microbiology"},{"issue":"24","key":"10.1016\/j.bioactmat.2024.02.017_bib61","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1016\/j.jmb.2018.10.021","article-title":"The two-component system ZraPSR Is a novel ESR that Contributes to intrinsic antibiotic Tolerance in Escherichia coli","volume":"430","author":"Rome","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.017_bib62","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/BJ20111639","article-title":"ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSR","volume":"442","author":"Appia-Ayme","year":"2012","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.02.017_bib63","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1182\/blood-2010-11-317479","article-title":"MPO and neutrophils: a magnetic attraction","volume":"117","author":"Hickey","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2024.02.017_bib64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and Significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annual Review of Pathology"},{"issue":"2","key":"10.1016\/j.bioactmat.2024.02.017_bib65","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1039\/D1FO03768D","article-title":"Chitooligosaccharides alleviate hepatic fibrosis by regulating the polarization of M1 and M2 macrophages","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.bioactmat.2024.02.017_bib66","doi-asserted-by":"crossref","first-page":"108172","DOI":"10.1016\/j.biotechadv.2023.108172","article-title":"Current and emerging applications of saccharide-modified chitosan: a critical review","volume":"66","author":"Panahi, H","year":"2023","journal-title":"Biotechnol. Adv."},{"issue":"190","key":"10.1016\/j.bioactmat.2024.02.017_bib67","doi-asserted-by":"crossref","first-page":"190ra81","DOI":"10.1126\/scitranslmed.3006276","article-title":"Silver enhances antibiotic activity against gram-negative bacteria","volume":"5","author":"Morones-Ramirez","year":"2013","journal-title":"Sci. Transl. Med."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24000628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24000628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T04:04:06Z","timestamp":1715400246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X24000628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":67,"alternative-id":["S2452199X24000628"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.017","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}