{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:08:16Z","timestamp":1791212896469,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bioactmat.2024.03.027","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:18:17Z","timestamp":1714004297000},"page":"517-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["An orally administered bacterial membrane protein nanodrug ameliorates doxorubicin cardiotoxicity through alleviating impaired intestinal barrier"],"prefix":"10.1016","volume":"37","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyue","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-9272","authenticated-orcid":false,"given":"Xiaohan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-2715","authenticated-orcid":false,"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5306-1398","authenticated-orcid":false,"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bioactmat.2024.03.027_bib1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jchf.2018.08.005","article-title":"Frequency of transition from stage A to stage B heart failure after initiating potentially cardiotoxic chemotherapy","volume":"6","author":"Jones","year":"2018","journal-title":"JACC Heart Fail."},{"issue":"15","key":"10.1016\/j.bioactmat.2024.03.027_bib2","doi-asserted-by":"crossref","first-page":"e811","DOI":"10.1161\/CIR.0000000000001056","article-title":"Cardio-Oncology Committee of the Council on Clinical, C., Council on, G.; precision, M.; the council on peripheral vascular, D., cardio-oncology drug interactions: a scientific statement from the American heart association","volume":"145","author":"Beavers","year":"2022","journal-title":"Circulation."},{"key":"10.1016\/j.bioactmat.2024.03.027_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-pharmtox-030620-104842","article-title":"Preventing and treating anthracycline cardiotoxicity: new insights","volume":"61","author":"Sawicki","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"21","key":"10.1016\/j.bioactmat.2024.03.027_bib4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/eurheartj\/ehw022","article-title":"Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 x 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol","volume":"37","author":"Gulati","year":"2016","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.bioactmat.2024.03.027_bib5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrclinonc.2013.195","article-title":"Treatment-related cardiotoxicity in survivors of childhood cancer","volume":"10","author":"Lipshultz","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.03.027_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00100-22","article-title":"Bifidobacterium lactis probio-M8 adjuvant treatment confers added benefits to patients with coronary artery disease via target modulation of the gut-heart\/-brain axes","volume":"7","author":"Sun","year":"2022","journal-title":"mSystems."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.03.027_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/lam.13333","article-title":"Gut-organ axis: a microbial outreach and networking","volume":"72","author":"Ahlawat","year":"2021","journal-title":"Lett. Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib8","article-title":"The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases, Nat Commun","volume":"13","author":"Jiang","year":"2022"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s40168-022-01271-6","article-title":"Gut microbiome mediates the protective effects of exercise after myocardial infarction","volume":"10","author":"Zhou","year":"2022","journal-title":"Microbiome."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib10","first-page":"414","article-title":"Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis, Gut Microbes","volume":"7","author":"Rigby","year":"2016"},{"issue":"22","key":"10.1016\/j.bioactmat.2024.03.027_bib11","first-page":"6631","article-title":"Doxorubicin-induced systemic inflammation is driven by upregulation of toll-like receptor TLR4 and endotoxin LeakageGut flora promoted doxotubicin-induced","volume":"76","author":"Wang","year":"2016","journal-title":"Inflammation."},{"issue":"10","key":"10.1016\/j.bioactmat.2024.03.027_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.008220","article-title":"Yellow wine polyphenolic compound protects against doxorubicin-induced cardiotoxicity by modulating the composition and metabolic function of the gut microbiota","volume":"14","author":"Lin","year":"2021","journal-title":"Circ Heart Fail."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12916-022-02402-4","article-title":"Gut microbiota signatures of long-term and short-term plant-based dietary pattern and cardiometabolic health: a prospective cohort study","volume":"20","author":"Miao","year":"2022","journal-title":"BMC Med."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.03.027_bib14","first-page":"1388","article-title":"Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features, Cell","volume":"174","author":"Zmora","year":"2018"},{"key":"10.1016\/j.bioactmat.2024.03.027_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.908010","article-title":"The beneficial role of probiotic lactobacillus in respiratory diseases","volume":"13","author":"Du","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.03.027_bib16","first-page":"223","article-title":"The intestinal barrier\u2014shielding the body from nano-and microparticles in our diet, Metabolites","volume":"12","author":"Schwarzfischer","year":"2022"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.03.027_bib18","doi-asserted-by":"crossref","first-page":"H1227","DOI":"10.1152\/ajpheart.00612.2020","article-title":"Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease","volume":"319","author":"Lewis","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.bioactmat.2024.03.027_bib19","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41577-021-00538-7","article-title":"Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?","volume":"21","author":"Akdis","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib20","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","article-title":"Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis","volume":"11","author":"Tajik","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib21","article-title":"Dysregulated gut homeostasis observed prior to the accumulation of the brain amyloid-\u03b2 in Tg2576 mice, Int J Mol Sci","volume":"21","author":"Honarpisheh","year":"2020"},{"issue":"22","key":"10.1016\/j.bioactmat.2024.03.027_bib22","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1158\/0008-5472.CAN-15-3034","article-title":"Doxorubicin-induced systemic inflammation is driven by upregulation of toll-like receptor TLR4 and endotoxin leakage","volume":"76","author":"Wang","year":"2016","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bioactmat.2024.03.027_bib23","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1136\/gutjnl-2019-320105","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice","volume":"69","author":"Wang","year":"2020","journal-title":"Gut."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.03.027_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173004","article-title":"Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function","volume":"12","author":"Ottman","year":"2017","journal-title":"PLoS One."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.03.027_bib26","article-title":"Akkermansia muciniphila alleviates persistent inflammation, immunosuppression, and catabolism syndrome in mice. Metabolites","volume":"13","author":"Xu","year":"2023"},{"key":"10.1016\/j.bioactmat.2024.03.027_bib27","series-title":"Akkermansia Muciniphila Ameliorates the Host Response to Porphyromonas Gingivalis-Induced Experimental Periodontitis","author":"Mulhall","year":"2021"},{"issue":"8","key":"10.1016\/j.bioactmat.2024.03.027_bib28","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1039\/D1FO00115A","article-title":"The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid\u2013bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"issue":"7","key":"10.1016\/j.bioactmat.2024.03.027_bib30","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jacc.2017.06.030","article-title":"Biomarker-based risk model to predict cardiovascular mortality in patients with stable coronary disease","volume":"70","author":"Lindholm","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.03.027_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/CIRCULATIONAHA.122.059960","article-title":"Effect of intensive blood pressure control on troponin and natriuretic peptide levels: findings from SPRINT","volume":"147","author":"Berry","year":"2023","journal-title":"Circulation."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.03.027_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.23736\/S0026-4806.18.05787-7","article-title":"Serum zonulin in patients with inflammatory bowel disease: a pilot study","volume":"110","author":"Caviglia","year":"2019","journal-title":"Minerva Med."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib33","doi-asserted-by":"crossref","DOI":"10.4161\/tisb.27321","article-title":"The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease","volume":"1","author":"Vanuytsel","year":"2013","journal-title":"Tissue Barriers."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.03.027_bib34","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvz039","article-title":"Intestinal barrier dysfunction, LPS translocation, and disease development","volume":"4","author":"Ghosh","year":"2020","journal-title":"J. Endocrine Soc."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.03.027_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jgo.2017.04.001","article-title":"Cardio-oncology in the older adult","volume":"8","author":"Reddy","year":"2017","journal-title":"J. Geriatric Oncol."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.03.027_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1074248420968689","article-title":"Age-related considerations in cardio-oncology","volume":"26","author":"Screever","year":"2020","journal-title":"J. Cardiovasc. Pharmacol. Therapeut."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.03.027_bib37","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/path.3009","article-title":"Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways","volume":"226","author":"Kaczmarek","year":"2012","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/19490976.2016.1215806","article-title":"Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis","volume":"7","author":"Rigby","year":"2016","journal-title":"Gut Microb."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-016-1458-3","article-title":"The digestive tract as the origin of systemic inflammation","volume":"20","author":"de Jong","year":"2016","journal-title":"Crit. Care."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.03.027_bib40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41590-018-0064-8","article-title":"Innate immune responses to trauma","volume":"19","author":"Huber-Lang","year":"2018","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.bioactmat.2024.03.027_bib41","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1039\/C9FO01034C","article-title":"Zn(ii)-Curcumin supplementation alleviates gut dysbiosis and zinc dyshomeostasis during doxorubicin-induced cardiotoxicity in rats","volume":"10","author":"Wu","year":"2019","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.03.027_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.chom.2020.05.005","article-title":"microbe, Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity","volume":"28","author":"Sorbara","year":"2020","journal-title":"Cell Host Microbe."},{"issue":"6145","key":"10.1016\/j.bioactmat.2024.03.027_bib44","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science."},{"issue":"7480","key":"10.1016\/j.bioactmat.2024.03.027_bib45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.03.027_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.chom.2023.01.013","article-title":"Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance","volume":"31","author":"Zhang","year":"2023","journal-title":"Cell Host Microbe."},{"issue":"6516","key":"10.1016\/j.bioactmat.2024.03.027_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay9097","article-title":"Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites","volume":"370","author":"Guo","year":"2020","journal-title":"Science."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.03.027_bib48","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/ismej.2014.14","article-title":"Phylogenetic distribution of three pathways for propionate production within the human gut microbiota","volume":"8","author":"Reichardt","year":"2014","journal-title":"ISME J."},{"key":"10.1016\/j.bioactmat.2024.03.027_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173884","article-title":"Aldose reductase regulates doxorubicin-induced immune and inflammatory responses by activating mitochondrial biogenesis","volume":"895","author":"Sonowal","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.03.027_bib50","doi-asserted-by":"crossref","first-page":"H1091","DOI":"10.1152\/ajpheart.00290.2018","article-title":"Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium","volume":"315","author":"Jadapalli","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.03.027_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ Heart Fail."},{"issue":"8","key":"10.1016\/j.bioactmat.2024.03.027_bib52","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.ajpath.2019.04.009","article-title":"Heart inflammation: immune cell roles and roads to the heart","volume":"189","author":"Carrillo-Salinas","year":"2019","journal-title":"Am. J. Pathol."},{"issue":"1\u20133","key":"10.1016\/j.bioactmat.2024.03.027_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12026-014-8548-6","article-title":"The immune system and hypertension","volume":"59","author":"Singh","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bioactmat.2024.03.027_bib54","first-page":"391","volume":"26","author":"Estall","year":"2006"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24001087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24001087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T18:34:19Z","timestamp":1723314859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X24001087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"alternative-id":["S2452199X24001087"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.03.027","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An orally administered bacterial membrane protein nanodrug ameliorates doxorubicin cardiotoxicity through alleviating impaired intestinal barrier","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}