{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:52:33Z","timestamp":1792835553934,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974328"],"award-info":[{"award-number":["81974328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372358"],"award-info":[{"award-number":["82372358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372425"],"award-info":[{"award-number":["82372425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072443"],"award-info":[{"award-number":["82072443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018540","name":"Science Fund for Distinguished Young Scholars of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515020044"],"award-info":[{"award-number":["2022B1515020044"]}],"id":[{"id":"10.13039\/501100018540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bioactmat.2024.07.026","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T17:43:50Z","timestamp":1721756630000},"page":"221-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-8194","authenticated-orcid":false,"given":"Dong","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-5680","authenticated-orcid":false,"given":"Xinzhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2024.07.026_bib1","first-page":"287","article-title":"Regulation of rheumatoid arthritis microenvironment via a self-healing injectable hydrogel for improved inflammation elimination and bone repair","volume":"36","author":"Geng","year":"2024","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.07.026_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202380","article-title":"Nitric Oxide scavenging and hydrogen Sulfide production synergistically Treat rheumatoid arthritis","volume":"12","author":"Geng","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib3","doi-asserted-by":"crossref","first-page":"100015","DOI":"10.59717\/j.xinn-life.2023.100015","article-title":"Gasotransmitter delivery for bone diseases and regeneration","volume":"1","author":"Xu","year":"2023","journal-title":"The Innovation Life"},{"key":"10.1016\/j.bioactmat.2024.07.026_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121088","article-title":"A multifunctional nano-therapeutic platform based on octahedral yolk-shell Au NR@CuS: Photothermal\/photodynamic and targeted drug delivery tri-combined therapy for rheumatoid arthritis","volume":"277","author":"Huang","year":"2021","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.bioactmat.2024.07.026_bib5","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-023-01499-0","article-title":"Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms","volume":"8","author":"Jia","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103059","article-title":"A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization","volume":"70","author":"Li","year":"2024","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.bioactmat.2024.07.026_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","article-title":"Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis","volume":"12","author":"Fearon","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.bioactmat.2024.07.026_bib9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/ard.2009.119776","article-title":"Synovial tissue hypoxia and inflammation in vivo","volume":"69","author":"Ng","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.07.026_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2024.07.026_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.07.026_bib12","first-page":"945","article-title":"Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis","volume":"27","author":"Brouwer","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"issue":"6","key":"10.1016\/j.bioactmat.2024.07.026_bib13","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cmet.2012.05.008","article-title":"Polarizing macrophages through reprogramming of glucose metabolism","volume":"15","author":"Blagih","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120390","article-title":"Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization","volume":"264","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bioactmat.2024.07.026_bib15","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1161\/CIRCRESAHA.116.305420","article-title":"Maintaining ancient organelles: mitochondrial biogenesis and maturation","volume":"116","author":"Vega","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jconrel.2021.01.019","article-title":"Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells","volume":"331","author":"Kim","year":"2021","journal-title":"J. Contr. Release"},{"issue":"26","key":"10.1016\/j.bioactmat.2024.07.026_bib17","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1002\/anie.201602525","article-title":"Bilirubin nanoparticles as a nanomedicine for anti-inflammation therapy","volume":"55","author":"Lee","year":"2016","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"7","key":"10.1016\/j.bioactmat.2024.07.026_bib18","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1021\/acs.molpharmaceut.0c00337","article-title":"Bilirubin nanomedicines for the treatment of reactive oxygen species (ROS)-Mediated diseases","volume":"17","author":"Chen","year":"2020","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acsnano.7b07746","article-title":"Nanozyme decorated Metal-Organic Frameworks for enhanced photodynamic therapy","volume":"12","author":"Zhang","year":"2018","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.bioactmat.2024.07.026_bib20","article-title":"Biomimetic Liposomal Nanoplatinum for targeted cancer Chemophototherapy","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-022-00211-2","article-title":"FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis","volume":"10","author":"Guo","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.bioactmat.2024.07.026_bib22","first-page":"37","article-title":"Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment","volume":"24","author":"Shen","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13075-023-03198-1","article-title":"Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt\/\u03b2-catenin pathway","volume":"25","author":"Guo","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.04.011","article-title":"Bilirubin nanoparticle preconditioning protects against hepatic ischemia-reperfusion injury","volume":"133","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12929-016-0281-0","article-title":"Hypoxia and its implications in rheumatoid arthritis","volume":"23","author":"Qui\u00f1onez-Flores","year":"2016","journal-title":"J. Biomed. Sci."},{"issue":"8","key":"10.1016\/j.bioactmat.2024.07.026_bib26","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage heterogeneity in the context of rheumatoid arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.07.026_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204881","article-title":"Arthritic microenvironment Actuated Nanomotors for active rheumatoid arthritis therapy","volume":"10","author":"Xu","year":"2023","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.07.026_bib28","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/acsnano.8b08785","article-title":"Synergistic oxygen generation and reactive oxygen species scavenging by Manganese Ferrite\/Ceria Co-decorated nanoparticles for rheumatoid arthritis treatment","volume":"13","author":"Kim","year":"2019","journal-title":"ACS Nano"},{"issue":"10416","key":"10.1016\/j.bioactmat.2024.07.026_bib29","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bioactmat.2024.07.026_bib30","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1016\/S2665-9913(20)30445-8","article-title":"The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis","volume":"3","author":"Toes","year":"2021","journal-title":"Lancet Rheumatol"},{"issue":"6","key":"10.1016\/j.bioactmat.2024.07.026_bib31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/annrheumdis-2013-204105","article-title":"Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis","volume":"74","author":"Gao","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.07.026_bib32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrrheum.2011.205","article-title":"Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis","volume":"8","author":"Konisti","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"22","key":"10.1016\/j.bioactmat.2024.07.026_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228551","article-title":"The Importance of hypoxia-inducible factors (HIF-1 and HIF-2) for the Pathophysiology of inflammatory Bowel disease","volume":"21","author":"Kerber","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bioactmat.2024.07.026_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ani11102798","article-title":"Altered hypoxia-induced and Heat Shock protein immunostaining in secondary Hair Follicles associated with changes in Altitude and temperature in Tibetan Cashmere Goats","volume":"11","author":"He","year":"2021","journal-title":"Animals"},{"issue":"24","key":"10.1016\/j.bioactmat.2024.07.026_bib35","first-page":"5067","article-title":"The role of hypoxia inducible factor in nasal inflammations","volume":"20","author":"Cheng","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.bioactmat.2024.07.026_bib36","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/art.41701","article-title":"From angiogenesis to inflammation in rheumatoid arthritis","volume":"73","author":"Avouac","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.07.026_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41423-023-01108-8","article-title":"Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis","volume":"21","author":"Meyer","year":"2024","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.bioactmat.2024.07.026_bib39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00281-017-0619-z","article-title":"Selected cytokine pathways in rheumatoid arthritis","volume":"39","author":"Noack","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.07.026_bib40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3324\/haematol.2018.197210","article-title":"Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis","volume":"105","author":"Hernandez","year":"2020","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib41","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2017.06.018","article-title":"Hypoxia-sensitive COMMD1 Integrates signaling and cellular metabolism in human macrophages and Suppresses Osteoclastogenesis","volume":"47","author":"Murata","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","article-title":"Signaling pathways in rheumatoid arthritis: implications for targeted therapy","volume":"8","author":"Ding","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.07.026_bib43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/ard.2004.024430","article-title":"p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage","volume":"64","author":"Salvador","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib44","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jconrel.2022.01.029","article-title":"CaP-based anti-inflammatory HIF-1\u03b1 siRNA-encapsulating nanoparticle for rheumatoid arthritis therapy","volume":"343","author":"Liu","year":"2022","journal-title":"J. Contr. Release"},{"issue":"5","key":"10.1016\/j.bioactmat.2024.07.026_bib45","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35745-1","article-title":"HIF-2\u03b1, but not HIF-1\u03b1, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts","volume":"8","author":"Sasagawa","year":"2018","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.bioactmat.2024.07.026_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910701","article-title":"Chronic and cycling hypoxia: Drivers of cancer chronic inflammation through HIF-1 and NF-\u03baB activation: a review of the molecular mechanisms","volume":"22","author":"Korbecki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2024.07.026_bib48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","article-title":"Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bioactmat.2024.07.026_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13054-022-03893-6","article-title":"Immune effects of PI3K\/Akt\/HIF-1\u03b1-regulated glycolysis in polymorphonuclear neutrophils during sepsis","volume":"26","author":"Pan","year":"2022","journal-title":"Crit. Care"},{"issue":"11","key":"10.1016\/j.bioactmat.2024.07.026_bib50","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/annrheumdis-2018-213103","article-title":"Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis","volume":"77","author":"Bustamante","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101435","article-title":"Estrogenic control of mitochondrial function","volume":"31","author":"Klinge","year":"2020","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.bioactmat.2024.07.026_bib52","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.cmet.2021.09.002","article-title":"Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming","volume":"33","author":"Morrissey","year":"2021","journal-title":"Cell Metabol."},{"issue":"7444","key":"10.1016\/j.bioactmat.2024.07.026_bib53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bioactmat.2024.07.026_bib54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase supports metabolic Repurposing of Mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bioactmat.2024.07.026_bib55","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bioactmat.2024.07.026_bib56","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","article-title":"Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis","volume":"56","author":"Wculek","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.bioactmat.2024.07.026_bib57","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2023.02.035","article-title":"Nanomedicine is more than a supporting role in rheumatoid arthritis therapy","volume":"356","author":"Han","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2024.07.026_bib58","first-page":"83","article-title":"Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis","volume":"36","author":"Hua","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.07.026_bib59","first-page":"1","article-title":"Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment","volume":"18","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.bioactmat.2024.07.026_bib60","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1021\/acsnano.2c09127","article-title":"Redox homeostasis strategy for inflammatory macrophage reprogramming in rheumatoid arthritis based on Ceria Oxide nanozyme-Complexed Biopolymeric Micelles","volume":"17","author":"Zhou","year":"2023","journal-title":"ACS Nano"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24002974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24002974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:31:23Z","timestamp":1781350283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X24002974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":60,"alternative-id":["S2452199X24002974"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.07.026","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}