{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:49:52Z","timestamp":1794325792709,"version":"4.9.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A04J2314"],"award-info":[{"award-number":["2023A04J2314"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370497"],"award-info":[{"award-number":["82370497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12272164"],"award-info":[{"award-number":["12272164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["LC2019ZD001"],"award-info":[{"award-number":["LC2019ZD001"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2019CR016"],"award-info":[{"award-number":["2019CR016"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["003\/2022\/ALC"],"award-info":[{"award-number":["003\/2022\/ALC"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["0092\/2022\/A2,0144\/2022\/A3"],"award-info":[{"award-number":["0092\/2022\/A2,0144\/2022\/A3"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741563"],"award-info":[{"award-number":["2023M741563"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bioactmat.2024.08.018","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T07:44:05Z","timestamp":1724917445000},"page":"85-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect"],"prefix":"10.1016","volume":"42","author":[{"given":"Qinfeng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesheng","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geyang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-6314","authenticated-orcid":false,"given":"Xiaoqian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuofei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-1843","authenticated-orcid":false,"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2024.08.018_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121169","article-title":"Injectable Mussel\u2010Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration","volume":"278","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.11.028","article-title":"MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity","volume":"156","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","article-title":"The immune microenvironment in cartilage injury and repair","volume":"140","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-022-00269-w","article-title":"Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration","volume":"7","author":"Zeng","year":"2022","journal-title":"Npj Regen. Med."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib5","article-title":"Bioinspired gradient scaffolds for osteochondral tissue engineering","volume":"3","author":"Peng","year":"2023","journal-title":"Explorations"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/1947603515574286","article-title":"Treatment of hemophilic ankle arthrochipathy with one-step arthroscopic bone marrow\u2013derived cells transplantation","volume":"6","author":"Buda","year":"2015","journal-title":"Cartilage"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/hae.12659","article-title":"Experimental study on the role of intra-articular injection of MSCs on cartilage regeneration in haemophilia","volume":"21","author":"Ravanbod","year":"2015","journal-title":"Haemophilia"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib8","first-page":"1","article-title":"Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model","volume":"21","author":"Sogi","year":"2020","journal-title":"BMC Muscoskel. Disord."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib9","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/hae.14623","article-title":"FGF23 and SOX9 expression in haemophilic cartilage: in vitro studies of the effects of iron","volume":"28","author":"Zheng","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib10","article-title":"IL-6, IL-1\u03b2 and TNF-\u03b1 regulation of the chondrocyte phenotype: a possible mechanism of haemophilic cartilage destruction","volume":"28","author":"Zheng","year":"2023","journal-title":"Hematologia"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13020559","article-title":"Cartilage destruction by hemophilic arthropathy can Be prevented by inhibition of the ferroptosis pathway in human chondrocytes","volume":"13","author":"Wagener","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/hae.12208","article-title":"Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls","volume":"19","author":"Nieuwenhuizen","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib13","first-page":"1365","article-title":"Red blood cell exposure increases chondrocyte susceptibility to oxidative stress following hemarthrosis, Osteoarthr","volume":"31","author":"Lee","year":"2023","journal-title":"What Car?"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib14","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1039\/C7NR00352H","article-title":"Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration","volume":"9","author":"Liu","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib15","first-page":"120","article-title":"Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration","volume":"33","author":"Gan","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00441-016-2408-8","article-title":"Autologous chondrocytes as a novel source for neo-chondrogenesis in haemophiliacs","volume":"366","author":"Stocco","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib17","first-page":"1","article-title":"Dynamically adaptive scaffolds for cartilage tissue engineering, MedComm - biomater","volume":"2","author":"Peng","year":"2023","journal-title":"Appl."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib18","first-page":"145","article-title":"Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates\/promotes growth plate injury repair","volume":"10","author":"Guan","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib19","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/acsnano.3c00839","article-title":"Biotin-avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib20","article-title":"Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for cartilage protection","volume":"18","author":"Zeng","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib21","article-title":"Dentin-desensitizing biomaterials","volume":"34","author":"Wang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg0628","article-title":"Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy","volume":"7","author":"Hua","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib23","first-page":"1","article-title":"Injectable self-healing natural biopolymer-based hydrogel adhesive with thermoresponsive reversible adhesion for minimally invasive surgery","volume":"31","author":"Zhou","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib24","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.ijbiomac.2021.05.147","article-title":"Gelatin-based adhesive hydrogel with self-healing, hemostasis, and electrical conductivity","volume":"183","author":"Han","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib25","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1039\/D0BM02103B","article-title":"3D printed gelatin\/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair","volume":"9","author":"Huang","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib26","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1021\/acsbiomaterials.0c01414","article-title":"Tissue-adhesive chondroitin sulfate hydrogel for cartilage reconstruction","volume":"7","author":"Shin","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.202100109","article-title":"An engineered protein adhesive with properties of tissue integration and controlled release for efficient cartilage repair","volume":"10","author":"Zhang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/17474086.2016.1203780","article-title":"Intra-articular injections of mesenchymal stem cells (MSCs) as a treatment for hemophilic arthropathy","volume":"9","author":"Rodriguez-Merchan","year":"2016","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s13770-022-00437-5","article-title":"Thermosensitive hydrogel loaded with primary chondrocyte-derived exosomes promotes cartilage repair by regulating macrophage polarization in osteoarthritis","volume":"19","author":"Sang","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib30","article-title":"Exosomes derived from bone marrow mesenchymal stem cells alleviate rheumatoid arthritis symptoms via shuttling proteins","author":"Wang","year":"2023","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib31","article-title":"Biomaterials and nanomedicine for bone regeneration: progress and future prospects","volume":"1","author":"Zhou","year":"2021","journal-title":"Explorations"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.202105586","article-title":"Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth","volume":"9","author":"Fan","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib33","first-page":"194","article-title":"Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury","volume":"26","author":"Yang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib34","doi-asserted-by":"crossref","first-page":"13358","DOI":"10.1021\/acsnano.3c01612","article-title":"Cell-free osteoarthritis treatment with sustained-release of chondrocyte-targeting exosomes from umbilical cord-derived mesenchymal stem cells to rejuvenate aging chondrocytes","volume":"17","author":"Cao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib35","first-page":"317","article-title":"Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions","volume":"11","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0963689720968495","article-title":"Compositional variation and functional mechanism of exosomes in the articular microenvironment in knee osteoarthritis","volume":"29","author":"Li","year":"2020","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: roles and therapeutic potential in osteoarthritis","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-022-02738-5","article-title":"Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis","volume":"24","author":"Liu","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s10495-022-01787-0","article-title":"Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting microRNA -376c-3p and targeting the WNT-beta-catenin signaling axis","volume":"28","author":"Li","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-01086-x","article-title":"Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib41","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2018.02.050","article-title":"Characterization and application of size-sorted zonal chondrocytes for articular cartilage regeneration","volume":"165","author":"Yin","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib42","first-page":"890","article-title":"Hybrid gelatin\/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation","volume":"6","author":"Zhou","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib43","first-page":"273","article-title":"Triple-functional bone adhesive with enhanced internal fixation, bacteriostasis and osteoinductive properties for open fracture repair","volume":"25","author":"Yang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib44","first-page":"1","article-title":"Bone homeostasis modulating orthopedic adhesive for the closed-loop management of osteoporotic fractures","author":"Liu","year":"2023","journal-title":"Small. 2302704"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121530","article-title":"Injectable immunomodulation-based porous chitosan microspheres\/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regeneration","volume":"285","author":"Ji","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/smll.202306721","article-title":"Multifunctional injectable hydrogel microparticles loaded with miR-29a abundant BMSCs derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis","volume":"20","author":"Pan","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib47","doi-asserted-by":"crossref","first-page":"24308","DOI":"10.1021\/acsnano.3c10139","article-title":"Meniscus-Inspired self-lubricating and friction-responsive hydrogels for protecting articular cartilage and improving exercise","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib48","first-page":"1","article-title":"Injectable microgels with hybrid exosomes of chondrocyte-targeted FGF18 gene-editing and self-renewable lubrication for osteoarthritis therapy","volume":"36","author":"Chen","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.202207438","article-title":"Visualizable and lubricating hydrogel microspheres via NanoPOSS for cartilage regeneration","volume":"10","author":"Yao","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib50","first-page":"472","article-title":"Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis","volume":"16","author":"Lei","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib51","article-title":"Ropivacaine microsphere-loaded electroconductive nerve dressings for long-acting analgesia and functional recovery following diabetic peripheral nerve injury","volume":"21","author":"Liang","year":"2023","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21155227","article-title":"Extracellular nucleotides selectively induce migration of chondrocytes and expression of type ii collagen","volume":"21","author":"Szustak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib53","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1182\/blood.2019003824","article-title":"EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice","volume":"135","author":"Magisetty","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib54","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/jth.13328","article-title":"The F8\u2212\/\u2212 rat as a model of hemophilic arthropathy","volume":"14","author":"S\u00f8rensen","year":"2016","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib55","first-page":"1689","article-title":"Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib57","first-page":"1","article-title":"Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage","volume":"10","author":"Ma","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib58","article-title":"Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization","volume":"306","author":"Di Xu","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib59","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1021\/acsnano.2c10995","article-title":"Magnetic microcarriers with accurate localization and proliferation of mesenchymal stem cell for cartilage defects repairing","volume":"17","author":"Ma","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib60","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/jor.24559","article-title":"Amniotic suspension allograft modulates inflammation in a rat pain model of osteoarthritis","volume":"38","author":"Kimmerling","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.actbio.2023.01.021","article-title":"Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management","volume":"161","author":"Fang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib62","doi-asserted-by":"crossref","first-page":"18377","DOI":"10.1021\/acssuschemeng.0c04721","article-title":"Facile construction of chitin\/graphene nanocomposite sponges for efficient hemostasis","volume":"8","author":"Li","year":"2020","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adma.202211602","article-title":"Young exosome bio-nanoparticles restore aging-impaired tendon stem\/progenitor cell function and reparative capacity","volume":"35","author":"Jin","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib64","doi-asserted-by":"crossref","first-page":"13441","DOI":"10.1021\/acsnano.3c01713","article-title":"A redox homeostasis modulatory hydrogel with GLRX3+ extracellular vesicles attenuates disc degeneration by suppressing nucleus pulposus cell senescence","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib65","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.actbio.2021.02.039","article-title":"The tissue origin effect of extracellular vesicles on cartilage and bone regeneration","volume":"125","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib66","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1021\/acs.biomac.3c00351","article-title":"Post-implantation stiffening by a bioinspired, double-network, self-healing hydrogel facilitates minimally invasive cell delivery for cartilage regeneration","volume":"24","author":"Thomas","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.202302293","article-title":"Nanofiber composite microchannel-containing injectable hydrogels for cartilage tissue regeneration","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib68","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1021\/acs.biomac.8b01589","article-title":"Three-dimensional bioprinting of cell-laden constructs using polysaccharide-based self-healing hydrogels","volume":"20","author":"Kim","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119667","article-title":"A hyaluronic acid\/platelet-rich plasma hydrogel containing MnO2 nanozymes efficiently alleviates osteoarthritis in vivo","volume":"292","author":"Zhou","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib70","article-title":"Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics","volume":"23","author":"Hu","year":"2023","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib71","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.actbio.2016.04.019","article-title":"Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel","volume":"38","author":"Beck","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib72","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.actbio.2014.10.021","article-title":"Bilayered silk\/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and in vivo assessment of biological performance","volume":"12","author":"Yan","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib73","article-title":"3D printed cartilage-like tissue constructs with spatially controlled mechanical properties","volume":"29","author":"de Melo","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib74","article-title":"Hybrid bioprinting of zonally stratified human articular cartilage using scaffold-free tissue strands as building blocks","volume":"9","author":"Wu","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib75","article-title":"Engineered cell-laden thermosensitive poly(N-isopropylacrylamide)-immobilized gelatin microspheres as 3D cell carriers for regenerative medicine","volume":"15","author":"Yang","year":"2022","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111588","article-title":"Gelatin-polycaprolactone-nanohydroxyapatite electrospun nanocomposite scaffold for bone tissue engineering","volume":"119","author":"Gautam","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.carbpol.2018.11.086","article-title":"Chicken leg bone as a source of chondroitin sulfate","volume":"207","author":"Wang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118996","article-title":"Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing","volume":"278","author":"Wu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib79","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijbiomac.2021.01.089","article-title":"Hydroxypropyl chitosan-based dual self-healing hydrogel for adsorption of chromium ions","volume":"174","author":"Cao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib80","first-page":"98","article-title":"An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury","volume":"7","author":"Luo","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125680","article-title":"Characterization and bio-functional performance of chitosan\/poly (vinyl alcohol)\/trans-cinnamaldehyde ternary biopolymeric films","volume":"246","author":"Yan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib82","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001434","article-title":"Graphene oxide-doped gellan gum\u2013PEGDA bilayered hydrogel mimicking the mechanical and lubrication properties of articular cartilage","volume":"10","author":"Trucco","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adfm.202003451","article-title":"A synthetic hydrogel composite with the mechanical behavior and durability of cartilage","volume":"30","author":"Yang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119268","article-title":"A high strength, low friction, and biocompatible hydrogel from PVA, chitosan and sodium alginate for articular cartilage","volume":"286","author":"Luo","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib85","doi-asserted-by":"crossref","first-page":"46639","DOI":"10.1021\/acsami.3c09117","article-title":"Double-cross-linked hydrogel with long-lasting underwater adhesion: enhancement of maxillofacial in situ and onlay bone retention","volume":"15","author":"Yang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119336","article-title":"Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing","volume":"287","author":"Hao","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib87","article-title":"Nature-Inspired gelatin-based adhesive hydrogel: a rapid andUser-friendly solution for hemostatic applications","author":"Wang","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib88","author":"Ling"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib89","first-page":"1","volume":"vol. 2306289","author":"Lei","year":"2024"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib90","first-page":"41","article-title":"Biomimetic hybrid hydrogel for hemostasis, adhesion prevention and promoting regeneration after partial liver resection","volume":"11","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib91","doi-asserted-by":"crossref","first-page":"36166","DOI":"10.1021\/acsami.2c10202","article-title":"Tough wet adhesion of hydrogen-bond-based hydrogel with on-demand debonding and efficient hemostasis","volume":"14","author":"Wang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib92","author":"Guo"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib93","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.phrs.2016.11.032","article-title":"Pathophysiology of hemophilic arthropathy and potential targets for therapy","volume":"115","author":"Pulles","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib94","first-page":"588","article-title":"Rapid inflammation and early degeneration of bone and cartilage revealed in a time-course study of induced haemarthrosis in haemophilic rats","volume":"58","author":"Christensen","year":"2019","journal-title":"Rheumatol. (United Kingdom)."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib95","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1055\/s-0038-1641755","article-title":"Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice","volume":"118","author":"Cooke","year":"2018","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib96","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.jtha.2023.04.022","article-title":"Maladaptive lymphangiogenesis is associated with synovial iron accumulation and delayed clearance in factor VIII\u2013deficient mice after induced hemarthrosis","volume":"21","author":"Cooke","year":"2023","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib97","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1182\/blood.2021013119","article-title":"Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice","volume":"139","author":"Magisetty","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib98","first-page":"2754","article-title":"Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration","volume":"6","author":"Fan","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib99","article-title":"An all-silk-derived bilayer hydrogel for osteochondral tissue engineering","volume":"17","author":"Jiang","year":"2022","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155311","article-title":"Jolkinolide B ameliorates rheumatoid arthritis by regulating the JAK2\/STAT3 signaling pathway","volume":"124","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130098","article-title":"Effects of almond (Armeniaca Sibirica L. Lam) polysaccharides on gut microbiota and anti-inflammatory effects on LPS-induced RAW264.7 cells","volume":"263","author":"Peng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib102","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ijbiomac.2019.04.106","article-title":"Anti-inflammatory effects of vanadium-binding protein from Halocynthia roretzi in LPS-stimulated RAW264.7 macrophages through NF-\u03baB and MAPK pathways","volume":"133","author":"Kim","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153309","article-title":"Synergistic anti-inflammatory effects of silibinin and thymol combination on LPS-induced RAW264.7 cells by inhibition of NF-\u03baB and MAPK activation","volume":"78","author":"Chen","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136804","article-title":"Anti-inflammatory effect of two novel peptides derived from Binglangjiang buffalo whey protein in lipopolysaccharide-stimulated RAW264.7 macrophages","volume":"429","author":"Zhao","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2018.07.011","article-title":"Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes","volume":"180","author":"Dai","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111312","article-title":"Chondroitin sulfate modified 3D porous electrospun nanofiber scaffolds promote cartilage regeneration","volume":"118","author":"Chen","year":"2021","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib107","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib108","first-page":"1","article-title":"3D printed chondrogenic functionalized PGS bioactive scaffold for cartilage regeneration","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib109","article-title":"Materials Today Bio Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis","volume":"25","author":"Chen","year":"2024","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bioactmat.2024.08.018_bib110","author":"Satapathy"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib111","author":"Gong"},{"key":"10.1016\/j.bioactmat.2024.08.018_bib112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2017.11.003","article-title":"Cytokines in the pathogenesis of hemophilic arthropathy","volume":"39","author":"Wojdasiewicz","year":"2018","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24003566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X24003566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:08:39Z","timestamp":1778890119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X24003566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":112,"alternative-id":["S2452199X24003566"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.08.018","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}