{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:31:57Z","timestamp":1787319117359,"version":"build-2736575974"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"Sichuan University West China Hospital","doi-asserted-by":"publisher","award":["ZYGD23037"],"award-info":[{"award-number":["ZYGD23037"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752242"],"award-info":[{"award-number":["2024M752242"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272561"],"award-info":[{"award-number":["82272561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030377","name":"Missouri Society of Professional Surveyors","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC0002"],"award-info":[{"award-number":["2024NSFSC0002"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4606700"],"award-info":[{"award-number":["2023YFB4606700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bioactmat.2025.01.011","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T13:09:54Z","timestamp":1737205794000},"page":"100-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis"],"prefix":"10.1016","volume":"47","author":[{"given":"Mingyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-0853","authenticated-orcid":false,"given":"Hui-qi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.01.011_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.15585\/mmwr.mm6609e1","article-title":"Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2013-2015","volume":"66","author":"Barbour","year":"2017","journal-title":"MMWR. Morbidity Mortality Weekly Rep."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/rheumatology\/41.S1.3","article-title":"The prevalence and burden of arthritis","volume":"41","author":"Reginster","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41584-023-00966-w","article-title":"Matrix metalloproteinases in arthritis: towards precision medicine","volume":"19","author":"Grillet","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib6","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","article-title":"Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs","volume":"15","author":"Verma","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1073\/pnas.48.6.1014","article-title":"Collagenolytic activity in amphibian tissues: a tissue culture assay","volume":"48","author":"Gross","year":"1962","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib8","series-title":"Encyclopedia of Metalloproteins","first-page":"2454","author":"Nagase","year":"2013"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1183\/09031936.00146510","article-title":"Biological role of matrix metalloproteinases: a critical balance","volume":"38","author":"L\u00f6ffek","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci.-Landmark"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/biology12060843","article-title":"Involvement of matrix metalloproteinases in COVID-19: molecular targets, mechanisms, and insights for therapeutic interventions","volume":"12","author":"Salom\u00e3o","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13770-023-00536-x","article-title":"Development of matrix metalloproteinases-mediated extracellular matrix remodeling in regenerative medicine: a mini review","volume":"20","author":"Chen","year":"2023","journal-title":"Tissue Eng. Regen. MeD."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib16","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1126\/science.1067100","article-title":"Matrix metalloproteinase inhibitors and cancer: trials and tribulations","volume":"295","author":"Coussens","year":"2002","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib17","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1200\/JCO.2009.23.5556","article-title":"Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer","volume":"27","author":"Roy","year":"2009","journal-title":"J. Clin. Oncol. : Offic. J. Am. Soci. Clinic. Oncol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/1381612053382115","article-title":"Recent developments in the design of specific matrix metalloproteinase inhibitors aided by structural and computational studies","volume":"11","author":"Rao","year":"2005","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib19","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/art.11030","article-title":"Broad\u2010spectrum matrix metalloproteinase inhibitor marimastat\u2013induced musculoskeletal side effects in rats","volume":"48","author":"Renkiewicz","year":"2003","journal-title":"Arthritis Rheum.: Offic. J. Am. College Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1097-0282(1996)40:4<399::AID-BIP5>3.0.CO;2-R","article-title":"Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides","volume":"40","author":"Nagase","year":"1996","journal-title":"Biopolymers"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/90273","article-title":"Determination of protease cleavage site motifs using mixture-based oriented peptide libraries","volume":"19","author":"Turk","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib23","unstructured":"Tu, Y. & Zhu, L. in Smart Pharmaceutical Nanocarriers 83-116."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib24","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/sj.bjp.0701150","article-title":"Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo","volume":"121","author":"Lewis","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib25","doi-asserted-by":"crossref","first-page":"15579","DOI":"10.1016\/S0021-9258(18)98442-5","article-title":"Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins","volume":"266","author":"Fosang","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1471-2474-12-197","article-title":"Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"12","author":"Pickarski","year":"2011","journal-title":"BMC Muscoskel. Disord."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/03008207.2012.700346","article-title":"Early cartilage degeneration in a rat experimental model of developmental dysplasia of the hip","volume":"53","author":"Bo","year":"2012","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib29","doi-asserted-by":"crossref","first-page":"14811","DOI":"10.4238\/2015.November.18.46","article-title":"High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis","volume":"14","author":"Zeng","year":"2015","journal-title":"Genet. Mol. Res. : GMR"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joca.2009.12.002","article-title":"Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis","volume":"18","author":"Karlsson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/ard.2008.097139","article-title":"Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy","volume":"69","author":"Brew","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib32","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib33","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/ard.2010.133637","article-title":"Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis","volume":"70","author":"Rego-P\u00e9rez","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib34","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3390\/genes12070989","article-title":"Synovium-synovial fluid axis in osteoarthritis pathology: a key regulator of the cartilage degradation process","volume":"12","author":"Ingale","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5114\/reum\/168503","article-title":"Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review","volume":"61","author":"Pulik","year":"2023","journal-title":"Reumatologia"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib36","first-page":"1599","article-title":"Determination of stromelysin-1, 72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis","volume":"23","author":"Ishiguro","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib37","first-page":"593","article-title":"Characterization of type V collagenase (gelatinase) in synovial fluid of patients with inflammatory arthritis","volume":"19","author":"Hirose","year":"1992","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","article-title":"The multifactorial role of neutrophils in rheumatoid arthritis","volume":"10","author":"Wright","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib39","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1189\/jlb.69.6.851","article-title":"Gelatinase B functions as regulator and effector in leukocyte biology","volume":"69","author":"Opdenakker","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib40","doi-asserted-by":"crossref","first-page":"20262","DOI":"10.1073\/pnas.0706438104","article-title":"Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis","volume":"104","author":"Ardi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1471-4906(01)02023-3","article-title":"Gelatinase B: a tuner and amplifier of immune functions","volume":"22","author":"Opdenakker","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.2982211","article-title":"Oxidative autoactivation of latent collagenase by human neutrophils","volume":"227","author":"Weiss","year":"1985","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib43","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1021\/bi0493665","article-title":"Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B","volume":"43","author":"Van den Steen","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1096\/fj.01-0688com","article-title":"Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis","volume":"16","author":"Van den Steen","year":"2002","journal-title":"Faseb. J. : Offic. Pub. Federat. Am. Soci. Experim. Biol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib45","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood.V96.8.2673","article-title":"Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact","volume":"96","author":"Van den Steen","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib46","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/BOR.0000000000000917","article-title":"Advances in osteoarthritis imaging","volume":"35","author":"Chalian","year":"2023","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib48","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nrrheum.2012.223","article-title":"MRI-based semiquantitative scoring of joint pathology in osteoarthritis","volume":"9","author":"Guermazi","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41584-021-00673-4","article-title":"Early-stage symptomatic osteoarthritis of the knee \u2014 time for action","volume":"17","author":"Mahmoudian","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib50","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1021\/acs.analchem.7b01037","article-title":"Peptide microarray-based metal enhanced fluorescence assay for multiple profiling of matrix metalloproteinases activities","volume":"89","author":"Lei","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib51","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib52","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/ard.59.6.455","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis","volume":"59","author":"Yoshihara","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib53","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/bc100008b","article-title":"\u201cOne-step\u201d detection of matrix metalloproteinase activity using a fluorogenic peptide probe-immobilized diagnostic kit","volume":"21","author":"Ryu","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib54","doi-asserted-by":"crossref","first-page":"198","DOI":"10.7150\/thno.3477","article-title":"Measurement of MMP activity in synovial fluid in cases of osteoarthritis and acute inflammatory conditions of the knee joints using a fluorogenic peptide probe-immobilized diagnostic kit","volume":"2","author":"Ryu","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.05.019","article-title":"F\u00d6rster resonance energy transfer (FRET)-based biosensors for biological applications","volume":"138","author":"Zhang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-0716-2732-7_12","article-title":"Peptide array-based in situ fluorescence assay for profiling multiple matrix metalloproteinase activities","volume":"2578","author":"Lei","year":"2023","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib57","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1021\/bc800264z","article-title":"Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo","volume":"19","author":"Lee","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib58","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00726-010-0769-y","article-title":"Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging","volume":"41","author":"Ryu","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib59","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.joca.2014.04.006","article-title":"In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis","volume":"22","author":"Lim","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib60","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.38957","article-title":"Following the trajectory of osteoarthritis development through serial near infrared fluorescence imaging of MMP activities","volume":"67","author":"Leahy","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201802738","article-title":"In vivo imaging of MMP\u201013 activity using a specific polymer\u2010FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy","volume":"28","author":"Duro\u2010Castano","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib62","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/cbmi.3c00005","article-title":"Protease-activatable porphyrin molecular beacon for osteoarthritis management","volume":"1","author":"Walsh","year":"2023","journal-title":"Chem. Biomed. Imag."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib63","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1002\/art.30628","article-title":"Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3\u2013specific polymeric probe","volume":"63","author":"Ryu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib64","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1021\/bc4001273","article-title":"Detection of active matrix metalloproteinase-3 in serum and fibroblast-like synoviocytes of collagen-induced arthritis mice","volume":"24","author":"Lee","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib65","article-title":"Detection of matrix metallopeptidase 13 for monitoring stem cell differentiation and early diagnosis of osteoarthritis by fluorescent light\u2010up probes with aggregation\u2010induced emission characteristics","volume":"2","author":"Li","year":"2018","journal-title":"Advan. Biosyst."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib66","series-title":"Construction of a MMP Sensitive Array on Glass for MMP-13 Detection in Vitro","author":"Feng","year":"2019"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119520","article-title":"Cartilage-targeting and dual MMP-13\/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy","volume":"225","author":"Chen","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00666-7","article-title":"MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis","volume":"18","author":"Lan","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300962","article-title":"An MMP-2 responsive nanotheranostic probe enabled synergistic therapy of rheumatoid arthritis and MR\/CT assessment of therapeutic response in situ","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib70","first-page":"378","article-title":"MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis","volume":"37","author":"Zhou","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120797","article-title":"Recent advances in pH\/enzyme-responsive polysaccharide-small-molecule drug conjugates as nanotherapeutics","volume":"312","author":"Abbasi","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib72","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1039\/C5CS00798D","article-title":"Smart micro\/nanoparticles in stimulus-responsive drug\/gene delivery systems","volume":"45","author":"Karimi","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib73","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1021\/acs.bioconjchem.6b00027","article-title":"Tunable pH-sensitive linker for controlled release","volume":"27","author":"Choy","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jconrel.2019.07.031","article-title":"pH-responsive poly (lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis","volume":"309","author":"Zerrillo","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.128147","article-title":"Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo","volume":"409","author":"Zhang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib76","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/acsbiomaterials.6b00804","article-title":"Drug-free ROS sponge polymeric microspheres reduce tissue damage from ischemic and mechanical injury","volume":"4","author":"O'Grady","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib77","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1039\/c0sm00229a","article-title":"Long-term effects of hydrogel properties on human chondrocyte behavior","volume":"6","author":"Klein","year":"2010","journal-title":"Soft Matter"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib78","first-page":"1","article-title":"Towards an arthritis flare-responsive drug delivery system","volume":"9","author":"Joshi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib79","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1021\/acsabm.0c00242","article-title":"Matrix metalloproteinase-responsive PEGylated lipid nanoparticles for controlled drug delivery in the treatment of rheumatoid arthritis","volume":"3","author":"He","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib80","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261898","article-title":"Matrix metalloproteinases at a glance","volume":"137","author":"Hey","year":"2024","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310649","article-title":"Roles of matrix metalloproteinases and their natural inhibitors in metabolism: insights into health and disease","volume":"24","author":"Moli\u00e8re","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib82","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s13346-015-0234-2","article-title":"Particle-based technologies for osteoarthritis detection and therapy","volume":"6","author":"Kavanaugh","year":"2016","journal-title":"Drug Deliv.Translat. Res."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib83","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1039\/D0NR01648A","article-title":"Trigger-responsive engineered-nanocarriers and image-guided theranostics for rheumatoid arthritis","volume":"12","author":"Ahamad","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-022-01297-w","article-title":"Hierarchical functional nanoparticles boost osteoarthritis therapy by utilizing joint-resident mesenchymal stem cells","volume":"20","author":"Lu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121216","article-title":"3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model","volume":"279","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib86","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202213019","article-title":"A smart MMP13-responsive injectable hydrogel with inflammatory diagnostic logic and multiphase therapeutic ability to orchestrate cartilage regeneration","volume":"33","author":"Tianyuan","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2024.112966","article-title":"MMP13-responsive hydrogel microspheres for osteoarthritis treatment by precise delivery of celecoxib","volume":"241","author":"Xiang","year":"2024","journal-title":"Mater. Des."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib88","article-title":"Hypoxia and matrix metalloproteinase 13-responsive hydrogel microspheres alleviate osteoarthritis progression in vivo","volume":"20","author":"Zhou","year":"2024","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-22454-z","article-title":"Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis","volume":"12","author":"Deng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118625","article-title":"Targeted and MMP-2\/9 responsive peptides for the treatment of rheumatoid arthritis","volume":"569","author":"Li","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib91","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/10717544.2022.2032482","article-title":"Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis","volume":"29","author":"Yu","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib92","article-title":"Matrix metalloproteinase-sensitive size-shrinkable liposomes targeting activated macrophages for the treatment of rheumatoid arthritis","volume":"38","author":"Guo","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib93","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s42114-022-00493-4","article-title":"On-demand drug delivery of triptolide and celastrol by poly(lactic-co-glycolic acid) nanoparticle\/triglycerol monostearate-18 hydrogel composite for rheumatoid arthritis treatment","volume":"5","author":"Wang","year":"2022","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib94","article-title":"On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis","volume":"B","author":"Roy","year":"2024","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib95","doi-asserted-by":"crossref","first-page":"21076","DOI":"10.1021\/acsami.1c04953","article-title":"Dual-stimuli responsive polymeric micelles for the effective treatment of rheumatoid arthritis","volume":"13","author":"He","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib96","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.biomaterials.2010.10.009","article-title":"Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the various zones of articular cartilage","volume":"32","author":"Nguyen","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib97","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1016\/j.biomaterials.2011.06.014","article-title":"Engineering articular cartilage with spatially-varying matrix composition and mechanical properties from a single stem cell population using a multi-layered hydrogel","volume":"32","author":"Nguyen","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib98","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.jor.2017.05.001","article-title":"Current concepts in the articular cartilage repair and regeneration","volume":"14","author":"Karuppal","year":"2017","journal-title":"J. Orthop."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib99","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bmb\/ldn025","article-title":"Articular cartilage: structure, injuries and review of management","volume":"87","author":"Bhosale","year":"2008","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-021-00203-6","article-title":"The clinical potential of articular cartilage-derived progenitor cells: a systematic review","volume":"7","author":"Rikkers","year":"2022","journal-title":"npj Regen. Med."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib101","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.joca.2007.02.022","article-title":"Chondrocyte moves: clever strategies?","volume":"15","author":"Morales","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib102","first-page":"477","article-title":"Articular cartilage: tissue design and chondrocyte-matrix interactions","volume":"47","author":"Buckwalter","year":"1998","journal-title":"Instr. Course Lect."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib103","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/ard.60.4.305","article-title":"Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis","volume":"60","author":"Jorgensen","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib104","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00003086-197705000-00034","article-title":"Articular cartilage repair. Behavior of rabbit chondrocytes during tissue culture and subsequent allografting","volume":"124","author":"Green","year":"1977","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/mabi.201400335","article-title":"Tissue\u2010engineered cartilage: the crossroads of biomaterials, cells and stimulating factors","volume":"15","author":"Bhardwaj","year":"2015","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib106","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.joca.2022.07.012","article-title":"Cellular therapy and tissue engineering for cartilage repair","volume":"30","author":"Zelinka","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib107","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","article-title":"Repair and tissue engineering techniques for articular cartilage","volume":"11","author":"Makris","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib108","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.joca.2020.06.007","article-title":"Human articular cartilage is orthotropic where microstructure, micromechanics, and chemistry vary with depth and split-line orientation","volume":"28","author":"Fischenich","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib109","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/ten.teb.2011.0251","article-title":"Scaffold translation: barriers between concept and clinic","volume":"17","author":"Hollister","year":"2011","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib110","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/C6BM00068A","article-title":"Articular cartilage: from formation to tissue engineering","volume":"4","author":"Camarero-Espinosa","year":"2016","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib111","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1089\/scd.2008.0306","article-title":"Matrix metalloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro","volume":"18","author":"Bertram","year":"2009","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib112","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib113","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1096\/fj.10-165514","article-title":"A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells","volume":"25","author":"Bahney","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib114","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/bm060671a","article-title":"Material properties and cytocompatibility of injectable MMP degradable poly(lactide ethylene oxide fumarate) hydrogel as a carrier for marrow stromal cells","volume":"8","author":"He","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.eurpolymj.2019.02.024","article-title":"On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions","volume":"114","author":"Tsanaktsidou","year":"2019","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-017-5968-6","article-title":"Initiating human articular chondrocyte re-differentiation in a 3D system after 2D expansion","volume":"28","author":"Kudva","year":"2017","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib117","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.3390\/ijms19113341","article-title":"In vitro screening of molecularly engineered polyethylene glycol hydrogels for cartilage tissue engineering using periosteum-derived and ATDC5 cells","volume":"19","author":"Kudva","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib118","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.biomaterials.2007.11.046","article-title":"Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides\u2013a model for biofunctional scaffolds","volume":"29","author":"Chau","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib119","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1016\/j.biomaterials.2011.05.052","article-title":"Controlled biodegradation of Self-assembling \u03b2-hairpin Peptide hydrogels by proteolysis with matrix metalloproteinase-13","volume":"32","author":"Giano","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib120","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s10439-016-1608-4","article-title":"The in vitro and in vivo response to MMP-sensitive poly (ethylene glycol) hydrogels","volume":"44","author":"Amer","year":"2016","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib121","unstructured":"Park, Y., Lutolf, M., Hubbell, J., Hunziker, E. & Wong, M. in TRANSACTIONS OF THE ANNUAL MEETING-ORTHOPAEDIC RESEARCH SOCIETY. 296."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib122","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biomaterials.2015.02.079","article-title":"Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration","volume":"54","author":"Parmar","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib123","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/adhm.201400695","article-title":"Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition","volume":"4","author":"Sridhar","year":"2015","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib124","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.3390\/polym12071598","article-title":"Biomimetic cell-laden MeHA hydrogels for the regeneration of cartilage tissue","volume":"12","author":"Tsanaktsidou","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib125","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/107632704323061870","article-title":"Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly (ethylene glycol)-based hydrogels as a scaffold for cartilage repair","volume":"10","author":"Park","year":"2004","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib126","article-title":"Cell-mediated degradation regulates human mesenchymal stem cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels","volume":"9","author":"Feng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib127","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/ten.tea.2013.0519","article-title":"GFOGER-modified MMP-sensitive polyethylene glycol hydrogels induce chondrogenic differentiation of human mesenchymal stem cells","volume":"20","author":"Mhanna","year":"2014","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib128","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.biomaterials.2008.01.035","article-title":"The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities","volume":"29","author":"Salinas","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib129","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actbio.2017.01.028","article-title":"Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels","volume":"51","author":"Parmar","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.actbio.2019.03.046","article-title":"An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly (ethylene glycol) hydrogels with localized transforming growth factor \u03b23","volume":"93","author":"Schneider","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib131","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0363546518808012","article-title":"Photopolymerizable injectable cartilage mimetic hydrogel for the treatment of focal chondral lesions: a proof of concept study in a rabbit animal model","volume":"47","author":"Pascual-Garrido","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib132","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1007\/s10856-008-3469-3","article-title":"Synthesis and characterization of matrix metalloprotease sensitive-low molecular weight hyaluronic acid based hydrogels","volume":"19","author":"Kim","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib133","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/biot.201400635","article-title":"Inkjet\u2010bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging","volume":"10","author":"Gao","year":"2015","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib134","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/acsbiomaterials.6b00378","article-title":"Factor XIII cross-linked hyaluronan hydrogels for cartilage tissue engineering","volume":"2","author":"Broguiere","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2016.05.011","article-title":"Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells","volume":"99","author":"Parmar","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib136","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/jbm.a.36412","article-title":"A MMP7\u2010sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage","volume":"106","author":"Aisenbrey","year":"2018","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib137","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/term.2404","article-title":"Peptide\u2010functionalized starPEG\/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo","volume":"12","author":"Hesse","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110276","article-title":"A collagen mimetic peptide-modified hyaluronic acid hydrogel system with enzymatically mediated degradation for mesenchymal stem cell differentiation","volume":"108","author":"Ren","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib139","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1021\/acsabm.3c00082","article-title":"Impact of inter- and intra-donor variability by age on the gel-to-tissue transition in MMP-sensitive PEG hydrogels for cartilage regeneration","volume":"6","author":"Maples","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib140","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.joca.2023.01.516","article-title":"Biomimetic and bioactive hydrogels with tethered growth factors for cartilage regeneration","volume":"31","author":"Stefani","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib141","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2519\/jospt.1998.28.4.203","article-title":"Composition and dynamics of articular cartilage: structure, function, and maintaining healthy state","volume":"28","author":"Cohen","year":"1998","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib142","doi-asserted-by":"crossref","DOI":"10.3390\/md17040223","article-title":"Isolation and characterisation of major and minor collagens from hyaline cartilage of hoki (Macruronus novaezelandiae)","volume":"17","author":"Cumming","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib143","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.biomaterials.2009.12.040","article-title":"A Streptococcus pyogenes derived collagen-like protein as a non-cytotoxic and non-immunogenic cross-linkable biomaterial","volume":"31","author":"Peng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib144","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biomaterials.2015.02.079","article-title":"Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration","volume":"54","author":"Parmar","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib145","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/adhm.201600136","article-title":"Harnessing the versatility of bacterial collagen to improve the chondrogenic potential of porous collagen scaffolds","volume":"5","author":"Parmar","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib146","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1002\/smll.201500169","article-title":"Beta\u2010sheet\u2010forming, self\u2010assembled peptide nanomaterials towards optical, energy, and healthcare applications","volume":"11","author":"Kim","year":"2015","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib147","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.joca.2013.12.009","article-title":"A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis","volume":"22","author":"Snelling","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib148","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.joca.2016.03.007","article-title":"Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses","volume":"24","author":"Dunn","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib149","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/art.21638","article-title":"Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage","volume":"54","author":"Sato","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib150","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.orthres.2004.12.016","article-title":"Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype","volume":"23","author":"Yagi","year":"2005","journal-title":"J. Orthop. Res. : Offic. Pub. Orthopaedic Res. Soci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib151","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/art.1780401120","article-title":"Osteoarthritic lesions: involvement of three different collagenases","volume":"40","author":"Shlopov","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib152","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/mt.2016.151","article-title":"The TMSB4 pseudogene LncRNA functions as a competing endogenous RNA to promote cartilage degradation in human osteoarthritis","volume":"24","author":"Liu","year":"2016","journal-title":"Mol. Ther. : J. Am. Soci. Gene Ther."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib153","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/art.23504","article-title":"Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes","volume":"58","author":"Ijiri","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib154","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/1529-0131(200103)44:3<585::AID-ANR107>3.0.CO;2-C","article-title":"Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes","volume":"44","author":"Tetlow","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib155","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/ard.56.9.542","article-title":"Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific","volume":"56","author":"Freemont","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib156","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.115.227330","article-title":"Matrix metalloproteinases as regulators of vein structure and function: implications in chronic venous disease","volume":"355","author":"MacColl","year":"2015","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib157","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2174\/092986708785747490","article-title":"Structural bases for substrate and inhibitor recognition by matrix metalloproteinases","volume":"15","author":"Aureli","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib158","doi-asserted-by":"crossref","first-page":"51646","DOI":"10.1074\/jbc.M310109200","article-title":"The intermediate S1' pocket of the endometase\/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling","volume":"278","author":"Park","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib159","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/sj.bjc.6603043","article-title":"Towards third generation matrix metalloproteinase inhibitors for cancer therapy","volume":"94","author":"Overall","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/6657","article-title":"Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors","volume":"6","author":"Lovejoy","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib161","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/138920009789895499","article-title":"Pharmacokinetics of biotech drugs: peptides, proteins and monoclonal antibodies","volume":"10","author":"Lin","year":"2009","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib162","doi-asserted-by":"crossref","DOI":"10.1002\/bip.23069","article-title":"The polypeptide biophysics of proline\/alanine-rich sequences (PAS): recombinant biopolymers with PEG-like properties","volume":"109","author":"Breibeck","year":"2018","journal-title":"Biopolymers"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib163","article-title":"Recent advances in clinical translation of intra-articular osteoarthritis drug delivery systems","volume":"4","author":"DeJulius","year":"2021","journal-title":"Advan. Therapeutics"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib164","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ejpb.2007.03.023","article-title":"MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin","volume":"67","author":"Lee","year":"2007","journal-title":"Eur. J. Pharm. Biopharm. : Offic.J. Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib165","doi-asserted-by":"crossref","first-page":"17047","DOI":"10.1073\/pnas.1304987110","article-title":"Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib166","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jconrel.2012.05.035","article-title":"Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases","volume":"161","author":"Erster","year":"2012","journal-title":"J. Contr. Release : Offic. J. Control. Release Soci."},{"key":"10.1016\/j.bioactmat.2025.01.011_bib167","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1021\/nn300524f","article-title":"Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting","volume":"6","author":"Zhu","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib168","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1021\/nn200161v","article-title":"Manipulating the power of an additional phase: a flower-like Au-Fe3O4 optical nanosensor for imaging protease expressions in vivo","volume":"5","author":"Xie","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib169","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1126\/science.aay8276","article-title":"Cartilage-inspired, lipid-based boundary-lubricated hydrogels","volume":"370","author":"Lin","year":"2020","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib170","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41586-023-06037-0","article-title":"Cartilage-like protein hydrogels engineered via entanglement","volume":"618","author":"Fu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2025.01.011_bib171","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf7075","article-title":"Strong and tough fibrous hydrogels reinforced by multiscale hierarchical structures with multimechanisms","volume":"9","author":"Guo","year":"2023","journal-title":"Sci. Adv."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:25:20Z","timestamp":1785169520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X2500012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":171,"alternative-id":["S2452199X2500012X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.01.011","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}