{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:08:12Z","timestamp":1778278092061,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","award":["2024XAKJ010009"],"award-info":[{"award-number":["2024XAKJ010009"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010166","name":"Xiamen City Department of Science and Technology","doi-asserted-by":"publisher","award":["3502Z20224028"],"award-info":[{"award-number":["3502Z20224028"]}],"id":[{"id":"10.13039\/100010166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bioactmat.2025.04.023","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T16:28:34Z","timestamp":1746980914000},"page":"138-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-7192","authenticated-orcid":false,"given":"Hongwei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bozhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-2472","authenticated-orcid":false,"given":"Ling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.04.023_bib1","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1111\/odi.14289","article-title":"Global prevalence of gingival recession: a systematic review and meta-analysis","volume":"29","author":"Yadav","year":"2023","journal-title":"Oral Dis."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1902\/jop.2010.090701","article-title":"Predetermination of root coverage","volume":"81","author":"Zucchelli","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib3","doi-asserted-by":"crossref","first-page":"138899","DOI":"10.1016\/j.cej.2022.138899","article-title":"Porous polydroxyalkanoates (PHA) scaffolds with antibacterial property for oral soft tissue regeneration","volume":"451","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/prd.12059","article-title":"Periodontal plastic surgery","volume":"68","author":"Zucchelli","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/JPER.19-0350","article-title":"Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction","volume":"91","author":"Zucchelli","year":"2020","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib6","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00784-018-2608-6","article-title":"Free gingival graft adjunct with low-level laser therapy: a randomized placebo-controlled parallel group study","volume":"23","author":"Yildiz","year":"2019","journal-title":"Clin. Oral Invest."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/dj10060109","article-title":"A 3D digital analysis of the hard palate wound healing after free gingival graft harvest: a pilot study in the short term","volume":"10","author":"Marques","year":"2022","journal-title":"Dent. J."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4103\/jisp.jisp_515_20","article-title":"Autologous Platelet Concentrate of 2(nd) and 3(rd) generations efficacy in the surgical treatment of gingival recession: an overview of systematic reviews","volume":"25","author":"Fernandes","year":"2021","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib9","first-page":"756","article-title":"Clinical and histomorphometric soft tissue assessment comparing free gingival graft and a collagen matrix as alveolar-sealer materials: a randomized controlled pilot clinical trial","volume":"54","author":"Maffei","year":"2023","journal-title":"Quintessence Int."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib10","doi-asserted-by":"crossref","first-page":"2105348","DOI":"10.1002\/adfm.202105348","article-title":"Biomimetic lamellar chitosan scaffold for soft gingival tissue regeneration","volume":"31","author":"Feng","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/prd.12468","article-title":"Complications and treatment errors in root coverage procedures","volume":"92","author":"Mazzotti","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.aav9750","article-title":"Multivascular networks and functional intravascular topologies within biocompatible hydrogels","volume":"364","author":"Grigoryan","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib13","doi-asserted-by":"crossref","first-page":"2308848","DOI":"10.1002\/advs.202308848","article-title":"From basic science to clinical practice: a review of current periodontal\/mucogingival regenerative biomaterials","volume":"11","author":"De Lauretis","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib14","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1902\/jop.1998.69.11.1271","article-title":"Subpedicle connective tissue graft versus guided tissue regeneration with bioabsorbable membrane in the treatment of human gingival recession defects","volume":"69","author":"Trombelli","year":"1998","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib15","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1034\/j.1600-051X.2003.00397.x","article-title":"Bilaminar techniques for the treatment of recession-type defects. A comparative clinical study","volume":"30","author":"Zucchelli","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib16","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/jbm.a.34525","article-title":"Stimuli responsive deswelling of radiation synthesized collagen hydrogel in simulated physiological environment","volume":"101","author":"Zhang","year":"2013","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib17","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.1038\/s41598-023-33372-z","article-title":"Qualitative study on diabetic cutaneous wound healing with radiation crosslinked bilayer collagen scaffold in rat model","volume":"13","author":"Li","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib18","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/jbm.a.34243","article-title":"Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by \u03b3-irradiation","volume":"100","author":"Zhang","year":"2012","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib19","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/jbm.a.37723","article-title":"Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket","volume":"112","author":"Li","year":"2024","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.actbio.2019.05.070","article-title":"Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying","volume":"94","author":"Grenier","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib21","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/jbm.a.34938","article-title":"Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by \u03b3-irradiation","volume":"102","author":"Zhang","year":"2014","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12018-023-09286-9","article-title":"The macrophage's role on bone remodeling and osteogenesis: a systematic review","volume":"21","author":"Orvalho","year":"2023","journal-title":"Clin. Rev. Bone Miner. Metabol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/09205063.2014.985023","article-title":"Radiation cross-linked collagen\/dextran dermal scaffolds: effects of dextran on cross-linking and degradation","volume":"26","author":"Zhang","year":"2015","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib24","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1360\/SSC-2020-0102","article-title":"Research progress of radiation synthesis and application of hydrogels","volume":"50","author":"M","year":"2020","journal-title":"Scientia Sinica Chimica"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib25","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1039\/D0BM00055H","article-title":"Rational design and latest advances of polysaccharide-based hydrogels for wound healing","volume":"8","author":"Hu","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.reactfunctpolym.2006.09.003","article-title":"Effect of method of preparation on properties of temperature and pH-sensitive gels: chemical crosslinking versus irradiation with e-beam","volume":"67","author":"Lugo-Medina","year":"2007","journal-title":"Reactive Funct. Polym."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib27","doi-asserted-by":"crossref","first-page":"109287","DOI":"10.1016\/j.radphyschem.2020.109287","article-title":"Application of radiation crosslinking technique to development of gelatin scaffold for tissue engineering","volume":"180","author":"Kimura","year":"2021","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/JPER.19-0351","article-title":"Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration","volume":"91","author":"Tavelli","year":"2020","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib29","first-page":"68","article-title":"Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction","volume":"15","author":"Gu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12477","article-title":"Minimal invasiveness in gingival augmentation and root coverage procedures","volume":"91","author":"Cairo","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib32","doi-asserted-by":"crossref","first-page":"1801651","DOI":"10.1002\/adma.201801651","article-title":"The collagen suprafamily: from biosynthesis to advanced biomaterial development","volume":"31","author":"Sorushanova","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib33","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1111\/odi.14802","article-title":"Low-dose TNF-\u03b1 promotes angiogenesis of oral squamous cell carcinoma cells via TNFR2\/Akt\/mTOR axis","volume":"30","author":"Li","year":"2024","journal-title":"Oral Dis."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s12967-024-05214-7","article-title":"PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib35","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1111\/ejn.13297","article-title":"Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis","volume":"44","author":"Rollinson","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/ard-2023-224129","article-title":"Ablation of integrin-mediated cell-collagen communication alleviates fibrosis","volume":"82","author":"Sawant","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41580-023-00583-1","article-title":"Cell-extracellular matrix mechanotransduction in 3D","volume":"24","author":"Saraswathibhatla","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib39","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib40","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1016\/j.biomaterials.2014.03.078","article-title":"The effect of thick fibers and large pores of electrospun poly(\u03b5-caprolactone) vascular grafts on macrophage polarization and arterial regeneration","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib41","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1016\/j.biomaterials.2014.03.025","article-title":"The effect of scaffold macroporosity on angiogenesis and cell survival in tissue-engineered smooth muscle","volume":"35","author":"Walthers","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s42003-020-01606-9","article-title":"BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways","volume":"4","author":"Geng","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","article-title":"Targeting integrin pathways: mechanisms and advances in therapy","volume":"8","author":"Pang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41536-022-00253-4","article-title":"Integrin-specific hydrogels for growth factor-free vasculogenesis","volume":"7","author":"Moreira","year":"2022","journal-title":"NPJ Regen. Med."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib46","doi-asserted-by":"crossref","first-page":"100732","DOI":"10.1016\/j.pmatsci.2020.100732","article-title":"Materials roles for promoting angiogenesis in tissue regeneration","volume":"117","author":"Lee","year":"2021","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib47","first-page":"1","volume":"vol. 2","author":"It\u014d","year":"2017"},{"key":"10.1016\/j.bioactmat.2025.04.023_bib48","doi-asserted-by":"crossref","first-page":"109669","DOI":"10.1016\/j.compositesb.2022.109669","article-title":"Sodium lignosulfonate cross-linked bioprosthetic heart valve materials for enhanced cytocompatibility, improved hemocompatibility, and reduced calcification","volume":"234","author":"Zhang","year":"2022","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib49","doi-asserted-by":"crossref","first-page":"112153","DOI":"10.1016\/j.diabres.2025.112153","article-title":"Advanced radiation-crosslinked CM-chitosan\/gelatin hydrogel for diabetic ulcer treatment with reducing application frequency","volume":"223","author":"Li","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib50","first-page":"710","article-title":"Treatment of multiple adjacent recessions with the modified coronally advanced tunnel or laterally closed tunnel in conjunction with cross-linked hyaluronic acid and subepithelial connective tissue graft: a report of 15 cases","volume":"51","author":"Lanzrein","year":"2020","journal-title":"Quintessence Int."},{"key":"10.1016\/j.bioactmat.2025.04.023_bib51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/prd.12446","article-title":"Clinical and patient-reported outcomes of tissue engineering strategies for periodontal and peri-implant reconstruction","volume":"91","author":"Tavelli","year":"2000","journal-title":"Periodontol"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25001719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25001719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:24:14Z","timestamp":1762626254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25001719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":51,"alternative-id":["S2452199X25001719"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.04.023","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}