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Immunol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib147","first-page":"178","article-title":"Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells, Immunol","volume":"97","author":"Zimmermann-Geller","year":"2019","journal-title":"Cell Biol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib148","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41573-023-00671-z","article-title":"Targeting angiogenesis in oncology, ophthalmology and beyond","volume":"22","author":"Cao","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib149","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.7150\/ijbs.70958","article-title":"Vegf\/vegfr-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment","volume":"18","author":"Zhao","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10456-015-9487-0","article-title":"Targeting vegf-a with a vaccine decreases inflammation and joint destruction in experimental arthritis","volume":"19","author":"Semerano","year":"2016","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib151","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172018","article-title":"Flt-1 gene polymorphisms and protein expression profile in rheumatoid arthritis","volume":"12","author":"Paradowska-Gorycka","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib152","first-page":"1482","article-title":"Splice variants vegf121 and vegf165 of the angiogenic peptide vascular endothelial cell growth factor are expressed in the synovial tissue of patients with rheumatoid arthritis","volume":"28","author":"Pufe","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib153","article-title":"Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage","volume":"10","author":"Ma","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100954","article-title":"Vegfr1 signaling in retinal angiogenesis and microinflammation","volume":"84","author":"Uemura","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib155","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1002\/ptr.7130","article-title":"Geniposide downregulates the vegf\/sphk1\/s1p pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro","volume":"35","author":"Wang","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154068","article-title":"Geniposide alleviates vegf-induced angiogenesis by inhibiting vegfr2\/pkc\/erk1\/2-mediated sphk1 translocation","volume":"100","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib157","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2147\/DDDT.S330947","article-title":"Network pharmacology and molecular docking study of the Chinese miao medicine sidaxue in the treatment of rheumatoid arthritis","volume":"16","author":"Wu","year":"2022","journal-title":"Drug Des. 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Biol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib161","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ijbiomac.2022.01.113","article-title":"Targeting the pdgf\/pdgfr signaling pathway for cancer therapy: a review","volume":"202","author":"Zou","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib162","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31291","article-title":"Targeting endothelial pdgfr-beta facilitates angiogenesis-associated bone formation through the pak1\/nicd axis","volume":"239","author":"Lin","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib163","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s10067-020-05109-0","article-title":"Evaluation of plasma cytokine protein array profile: the highlighted pdgf-bb in rheumatoid arthritis","volume":"39","author":"Wang","year":"2020","journal-title":"Clin. 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Med."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib189","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/ard.62.2.100","article-title":"Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha","volume":"62","author":"Gravallese","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib190","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00296-011-2210-6","article-title":"Angiogenic growth factors in rheumatoid arthritis","volume":"33","author":"Schroeder","year":"2013","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib191","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3899\/jrheum.090941","article-title":"Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis","volume":"37","author":"Kurosaka","year":"2010","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib192","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib193","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41584-023-00966-w","article-title":"Matrix metalloproteinases in arthritis: towards precision medicine","volume":"19","author":"Grillet","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118625","article-title":"Targeted and mmp-2\/9 responsive peptides for the treatment of rheumatoid arthritis","volume":"569","author":"Li","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib195","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5114\/reum\/168503","article-title":"Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review","volume":"61","author":"Pulik","year":"2023","journal-title":"Reumatologia"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13091653","article-title":"Mmp-13, vegf, and disease activity in a cohort of rheumatoid arthritis patients","volume":"13","author":"Boldeanu","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib197","doi-asserted-by":"crossref","first-page":"145","DOI":"10.31083\/j.fbl2705145","article-title":"Recent advancements of nanotechnology-based strategies for overcoming tumor microenvironment hypoxia","volume":"27","author":"Wu","year":"2022","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib198","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113952","article-title":"A novel treatment modality for rheumatoid arthritis: inflammation-targeted multifunctional metal-organic frameworks with synergistic phototherapy and chemotherapy","volume":"239","author":"Zhao","year":"2024","journal-title":"Colloid Surf. B-Biointerfaces"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215482","article-title":"Nanomaterials relieving hypoxia for enhanced tumor therapy","volume":"499","author":"Hao","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib200","first-page":"2404","article-title":"Association of c-262 polymorphism in catalase gene with rheumatoid arthritis","volume":"72","author":"Tayyab","year":"2022","journal-title":"J. Pakistan Med. Assoc."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.146450","article-title":"Multifunctional platinum-tellurium nanorods modified with hyaluronic acid remove reactive oxygen species to improve the photothermal treatment of rheumatoid arthritis","volume":"475","author":"Ma","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121063","article-title":"Mutual-reinforcing sonodynamic therapy against rheumatoid arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme","volume":"276","author":"Li","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib203","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2024.2380538","article-title":"Surface saturation of drug-loaded hollow manganese dioxide nanoparticles with human serum albumin for treating rheumatoid arthritis","volume":"31","author":"Jia","year":"2024","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib204","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s41565-023-01523-y","article-title":"Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model","volume":"18","author":"Koo","year":"2023","journal-title":"Nat. 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Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib207","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1021\/nn502372n","article-title":"Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide","volume":"8","author":"Zhou","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141484","article-title":"Oxygen supplementation liposomes for rheumatoid arthritis treatment via synergistic phototherapy and repolarization of m1-to-m2 macrophages","volume":"459","author":"Zhang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib209","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1021\/acsnano.4c15740","article-title":"High-throughput screening strategy and metal-organic framework-based multifunctional controlled-release nanomaterial for osteoarthritis therapy","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1107670","article-title":"Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs","volume":"14","author":"Jing","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib211","first-page":"141","article-title":"Nanodrugs alleviate acute kidney injury: manipulate rons at kidney","volume":"22","author":"Chen","year":"2023","journal-title":"Bioact. 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Res."},{"key":"10.1016\/j.bioactmat.2025.04.026_bib215","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202304610","article-title":"Manganese-based immunomodulatory nanocomposite with catalase-like activity and microwave-enhanced ros elimination ability for efficient rheumatoid arthritis therapy","volume":"19","author":"Chen","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2025.04.026_bib216","article-title":"Effect of oral mn-based nanozymes mn(3)o(4) nps on morphological, antioxidation, mucosa, and fecal microbial community in mice colons","author":"Zhang","year":"2025","journal-title":"Food Chem. 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