{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:45:11Z","timestamp":1786985111191,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2019ZT08Y485"],"award-info":[{"award-number":["2019ZT08Y485"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2019JC01Y182"],"award-info":[{"award-number":["2019JC01Y182"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2021YFA1100600"],"award-info":[{"award-number":["2021YFA1100600"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bioactmat.2025.06.041","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T17:48:46Z","timestamp":1751651326000},"page":"962-976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["PKM2+ apoptotic vesicle-mediated systemic senolytics ameliorate chronic periodontitis"],"prefix":"10.1016","volume":"51","author":[{"given":"Meng","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-7500","authenticated-orcid":false,"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jcpe.12808","article-title":"Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes Federation and the European Federation of Periodontology","volume":"45","author":"Sanz","year":"2018","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/prd.12300","article-title":"Periodontitis and rheumatoid arthritis: an update 2012-2017","volume":"83","author":"Bartold","year":"2000","journal-title":"Periodontol"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-023-02747-4","article-title":"IL-1\u03b2 and TNF-\u03b1 play an important role in modulating the risk of periodontitis and Alzheimer's disease","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/prd.12329","article-title":"Periodontal disease and cancer: epidemiologic studies and possible mechanisms","volume":"83","author":"Nwizu","year":"2000","journal-title":"Periodontol"},{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41418-022-01082-0","article-title":"When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death","volume":"30","author":"Bock","year":"2023","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.06.041_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib8","article-title":"Effect of NonSurgical periodontal therapy on plasma levels of IL-17 in chronic periodontitis patients with well controlled Type-II diabetes Mellitus-A clinical Study","volume":"6","author":"Jayakumar Sunandhakumari","year":"2018","journal-title":"Dent J (Basel)"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.06.041_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.disamonth.2018.09.011","article-title":"Effects of periodontal disease on systemic health","volume":"65","author":"Hegde","year":"2019","journal-title":"Dis Mon"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-019-0068-8","article-title":"Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review","volume":"12","author":"Cheng","year":"2020","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib11","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/ar3248","article-title":"Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway","volume":"13","author":"Lo","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.06.041_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.447","article-title":"NLRP3\/IL-1\u03b2 induced myeloid-derived suppressor cells recruitment and PD-L1 upregulation promotes oxaliplatin resistance of hepatocellular carcinoma","volume":"4","author":"Liu","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-030-67171-6_4","article-title":"Apoptotic bodies: mechanism of formation, isolation and functional relevance","volume":"97","author":"Santavanond","year":"2021","journal-title":"Subcell. Biochem."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cmet.2023.11.012","article-title":"Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation","volume":"36","author":"Ou","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib16","first-page":"472","article-title":"Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling","volume":"25","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.06.041_bib17","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41422-018-0070-2","article-title":"Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.06.041_bib18","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1021\/acsnano.1c03517","article-title":"Apoptotic extracellular vesicles ameliorate multiple myeloma by restoring fas-mediated apoptosis","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"issue":"20","key":"10.1016\/j.bioactmat.2025.06.041_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202200306","article-title":"Electrostatic charge-mediated apoptotic vesicle biodistribution attenuates sepsis by switching neutrophil NETosis to apoptosis","volume":"18","author":"Ou","year":"2022","journal-title":"Small"},{"issue":"7","key":"10.1016\/j.bioactmat.2025.06.041_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12109","article-title":"Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes","volume":"10","author":"Zheng","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib22","first-page":"7","article-title":"Pyruvate kinase M2: a potential target for regulating","author":"Alves-Filho","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109279","article-title":"USP25-PKM2-glycolysis axis contributes to ischemia reperfusion-induced acute kidney injury by promoting M1-like macrophage polarization and proinflammatory response","volume":"251","author":"Yang","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib24","series-title":"The Metabolic Signature of Macrophage Responses","author":"Viola","year":"2019"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2012.07.018","article-title":"PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis","volume":"150","author":"Yang","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1158\/0008-5472.CAN-21-0403","article-title":"PKM2 is essential for bladder cancer growth and maintenance","volume":"82","author":"Xia","year":"2022","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.06.041_bib27","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1016\/j.apsb.2021.03.021","article-title":"Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2","volume":"11","author":"Wu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib28","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1158\/0008-5472.CAN-06-2870","article-title":"Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death","volume":"67","author":"Stet\u00e1k","year":"2007","journal-title":"Cancer Res."},{"issue":"24","key":"10.1016\/j.bioactmat.2025.06.041_bib29","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1016\/j.bmcl.2017.11.011","article-title":"Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2","volume":"27","author":"You","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib30","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1038\/s41467-024-50242-y","article-title":"PKM2 aggregation drives metabolism reprograming during aging process","volume":"15","author":"Bie","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12943-018-0791-3","article-title":"Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling","volume":"17","author":"Hsu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.bioactmat.2025.06.041_bib32","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.cell.2022.03.043","article-title":"Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.bioactmat.2025.06.041_bib33","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1016\/j.cell.2024.05.003","article-title":"Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss","volume":"187","author":"Wang","year":"2024","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells14040274","article-title":"Mesenchymal stem\/stromal cells (MSCs) from mouse pelvic vs. long bones exhibit disparate critical quality attributes: implications for translational studies","volume":"14","author":"Boregowda","year":"2025","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.bioactmat.2025.06.041_bib35","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat. Protoc."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/JPER.24-0114","article-title":"B10 cells regulate macrophage polarization to alleviate inflammation and bone loss in periodontitis","volume":"96","author":"Cao","year":"2024","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13287-018-0804-6","article-title":"Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas\/FasL coupling pathway","volume":"9","author":"Yang","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib39","first-page":"51","article-title":"Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering","volume":"34","author":"Gou","year":"2024","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.06.041_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12240","article-title":"Proteomic analysis of MSC-derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions","volume":"11","author":"Zhang","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/cei.13205","article-title":"Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls","volume":"194","author":"Cheng","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.06.041_bib42","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/JLB.5RU1021-524R","article-title":"Circulating inflammatory cell profiling and periodontitis: a systematic review and meta-analysis","volume":"111","author":"Irwandi","year":"2022","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib43","first-page":"294","article-title":"Detection of Th17\/Treg cells and related factors in gingival tissues and peripheral blood of rats with experimental periodontitis","volume":"20","author":"Gao","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib44","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2019-0490","article-title":"Systemic Th17 response in the presence of periodontal inflammation","volume":"28","author":"Su\u00e1rez","year":"2020","journal-title":"J. Appl. Oral Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/prd.12427","article-title":"Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis","volume":"89","author":"Albuquerque-Souza","year":"2000","journal-title":"Periodontol"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib46","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/jre.13128","article-title":"Study on the effect of periodontitis on renal tissue in atherosclerotic mice","volume":"58","author":"Fan","year":"2023","journal-title":"J. Periodontal. Res."},{"issue":"7372","key":"10.1016\/j.bioactmat.2025.06.041_bib47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11190","article-title":"Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL","volume":"7","author":"Yosef","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fimmu.2016.00145","article-title":"Pyruvate kinase M2: a potential target for regulating inflammation","volume":"7","author":"Alves-Filho","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7702681","article-title":"The role of PKM2 in the regulation of mitochondrial function: focus on mitochondrial metabolism, oxidative stress, dynamic, and apoptosis. PKM2 in mitochondrial function","volume":"2022","author":"Gao","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"20","key":"10.1016\/j.bioactmat.2025.06.041_bib51","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.21037\/atm-22-1206","article-title":"Mesenchymal stem cells alleviate aging in vitro and in vivo","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"12","key":"10.1016\/j.bioactmat.2025.06.041_bib52","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1080\/15548627.2020.1717128","article-title":"Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells","volume":"16","author":"Liu","year":"2020","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.bioactmat.2025.06.041_bib53","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1080\/15548627.2020.1821547","article-title":"Autophagy controls mesenchymal stem cell therapy in psychological stress colitis mice","volume":"17","author":"Tian","year":"2021","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.bioactmat.2025.06.041_bib54","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ncb2629","article-title":"ERK1\/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect","volume":"14","author":"Yang","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"97","key":"10.1016\/j.bioactmat.2025.06.041_bib55","doi-asserted-by":"crossref","first-page":"ra73","DOI":"10.1126\/scisignal.2000431","article-title":"Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth","volume":"2","author":"Hitosugi","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115220","article-title":"LPS-induced premature osteocyte senescence: implications in inflammatory alveolar bone loss and periodontal disease pathogenesis","volume":"132","author":"Aquino-Martinez","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bioactmat.2025.06.041_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2015.46","article-title":"Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases","volume":"1","author":"Cheng","year":"2015","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.bioactmat.2025.06.041_bib58","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1136\/ard.2010.148957","article-title":"SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance","volume":"70","author":"Niederer","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib59","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/15548627.2018.1532259","article-title":"PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis","volume":"15","author":"Araya","year":"2019","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.bioactmat.2025.06.041_bib60","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/eji.200535477","article-title":"Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells","volume":"36","author":"Fayad","year":"2006","journal-title":"Eur. J. Immunol."},{"issue":"10","key":"10.1016\/j.bioactmat.2025.06.041_bib61","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nrrheum.2011.123","article-title":"Apoptosis-resistant T cells in SLE: role for the regulatory B subunits of PP2A phosphatase","volume":"7","author":"Buckland","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.490","article-title":"IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy","volume":"8","author":"Kim","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib63","first-page":"43","article-title":"TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells","volume":"4","author":"Qin","year":"2007","journal-title":"Cell. Mol. Immunol."},{"issue":"10","key":"10.1016\/j.bioactmat.2025.06.041_bib64","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/sj.leu.2403457","article-title":"Interleukin-1\u03b2 maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways","volume":"18","author":"Turzanski","year":"2004","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib65","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","article-title":"IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer","volume":"22","author":"Neurath","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091636","article-title":"Pro-inflammatory, Th1, Th2, Th17 cytokines and dendritic cells: a cross-sectional study in chronic periodontitis","volume":"9","author":"Souto","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib67","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","article-title":"Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity","volume":"22","author":"Xiao","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"8","key":"10.1016\/j.bioactmat.2025.06.041_bib68","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat. Med."},{"issue":"23","key":"10.1016\/j.bioactmat.2025.06.041_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400945","article-title":"Targeted clearance of senescent cells via engineered extracellular vesicles reprograms tumor immunosuppressive microenvironment","volume":"13","author":"Ji","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.06.041_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/cells14030226","article-title":"The role of senescence in experimental periodontitis at the causal level: an in vivo study","volume":"14","author":"Chu","year":"2025","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.bioactmat.2025.06.041_bib71","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/00220345231154567","article-title":"The emerging role of accelerated cellular senescence in periodontitis","volume":"102","author":"Aquino-Martinez","year":"2023","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/00220345241299789","article-title":"Dasatinib and Quercetin Limit gingival senescence, inflammation, and bone loss","volume":"104","author":"Rattanaprukskul","year":"2025","journal-title":"J. Dent. Res."},{"issue":"145","key":"10.1016\/j.bioactmat.2025.06.041_bib73","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.3145re8","article-title":"Apoptosis, stem cells, and tissue regeneration","volume":"3","author":"Bergmann","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib74","article-title":"Extracellular vesicles derived from apoptotic cells: an essential link between death and regeneration","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.06.041_bib75","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037036","article-title":"Dysregulation of cell death in human chronic inflammation","volume":"12","author":"Li","year":"2020","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib76","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3389\/fimmu.2018.01486","article-title":"Apoptotic cell-derived extracellular vesicles: more than just debris","volume":"9","author":"Caruso","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib77","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s12274-022-4709-4","article-title":"Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice","volume":"16","author":"Lei","year":"2023","journal-title":"Nano Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.06.041_bib78","doi-asserted-by":"crossref","first-page":"lnad013","DOI":"10.1093\/lifemedi\/lnad013","article-title":"Apoptotic vesicles: emerging concepts and research progress in physiology and therapy","volume":"2","author":"Fu","year":"2023","journal-title":"Life Med"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.06.041_bib79","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13578-019-0317-8","article-title":"PKM2, function and expression and regulation","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.06.041_bib80","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10565-021-09605-0","article-title":"Pyruvate kinase M2 in chronic inflammations: a potpourri of crucial protein-protein interactions","volume":"37","author":"Patel","year":"2021","journal-title":"Cell Biol. Toxicol."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.06.041_bib81","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41419-021-03579-x","article-title":"The role of PKM2 nuclear translocation in the constant activation of the NF-\u03baB signaling pathway in cancer-associated fibroblasts","volume":"12","author":"Gu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioactmat.2025.06.041_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Targeted Ther."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25002798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25002798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:32:40Z","timestamp":1762626760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25002798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":82,"alternative-id":["S2452199X25002798"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.06.041","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PKM2+ apoptotic vesicle-mediated systemic senolytics ameliorate chronic periodontitis","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.06.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}