{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:10:59Z","timestamp":1792512659194,"version":"4.5.0"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","award":["16\/IA\/4584"],"award-info":[{"award-number":["16\/IA\/4584"]}],"id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","award":["JPMXP1323015486"],"award-info":[{"award-number":["JPMXP1323015486"]}],"id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHIJP25H01009"],"award-info":[{"award-number":["KAKENHIJP25H01009"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP23jf0126004"],"award-info":[{"award-number":["JP23jf0126004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP23gm1910004"],"award-info":[{"award-number":["JP23gm1910004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["24zf0127012"],"award-info":[{"award-number":["24zf0127012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000532","name":"Association of Medical Research Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Taighde Eireann - Research Ireland","doi-asserted-by":"publisher","award":["19\/FFP\/6642"],"award-info":[{"award-number":["19\/FFP\/6642"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Taighde Eireann - Research Ireland","doi-asserted-by":"publisher","award":["GOIPG\/2021\/304"],"award-info":[{"award-number":["GOIPG\/2021\/304"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004096","name":"Kyushu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bioactmat.2025.07.018","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T03:19:53Z","timestamp":1754623193000},"page":"855-874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Localised delivery of interleukin-13 from a PLGA microparticle embedded GelMA hydrogel improves functional and histopathological recovery in a mouse contusion spinal cord injury model"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-5781","authenticated-orcid":false,"given":"Ciara M.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7154","authenticated-orcid":false,"given":"Ruth","family":"Colbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-0079","authenticated-orcid":false,"given":"Emmanuelle D.","family":"Aiyegbusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-6966","authenticated-orcid":false,"given":"Ross","family":"O'Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-5242","authenticated-orcid":false,"given":"Jacek K.","family":"Wychowaniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-1944","authenticated-orcid":false,"given":"Klaus-Peter","family":"Knobeloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Prinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot F.","family":"Brougham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-1831","authenticated-orcid":false,"given":"Dearbhaile","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.07.018_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JN.S143236","article-title":"Epidemiology of worldwide spinal cord injury: a literature review","volume":"6","author":"Kang","year":"2018","journal-title":"J. Neurorestoratol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib2","article-title":"Time is spine: what's over the horizon","volume":"35","author":"Pedro","year":"2022","journal-title":"J. Clinic. Orthopaedic. Trauma"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/neu.1990.7.115","article-title":"Methylprednisolone in spinal cord injury: the possible mechanism of action","volume":"7","author":"Hsu","year":"1990","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pneurobio.2013.11.002","article-title":"From basics to clinical: a comprehensive review on spinal cord injury","volume":"114","author":"Silva","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib5","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1172\/JCI90608","article-title":"Cell biology of spinal cord injury and repair","volume":"127","author":"O'Shea","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib7","article-title":"Dissecting the dual role of the glial scar and scar-forming astrocytes in spinal cord injury","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2020.152033","article-title":"Advances in immunotherapy for the treatment of spinal cord injury","volume":"226","author":"Al Mamun","year":"2021","journal-title":"Immunobiology"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4103\/1673-5374.228722","article-title":"Immunomodulation as a neuroprotective strategy after spinal cord injury","volume":"13","author":"Monteiro","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib11","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib12","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbi.2014.11.007","article-title":"Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury","volume":"45","author":"Ma","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ymthe.2019.09.004","article-title":"Transplantation of M2-Deviated microglia promotes recovery of motor function after spinal cord injury in mice","volume":"28","author":"Kobashi","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib17","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.stemcr.2016.11.005","article-title":"Cell-based delivery of Interleukin-13 directs alternative activation of macrophages resulting in improved functional outcome after spinal cord injury","volume":"7","author":"Dooley","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.12.045","article-title":"Macrophage activation and its role in repair and pathology after spinal cord injury","volume":"1619","author":"Gensel","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1189\/jlb.1012512","article-title":"Macrophage phenotypes during tissue repair","volume":"93","author":"Novak","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib21","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.4049\/jimmunol.151.12.7151","article-title":"Modulation of murine macrophage function by IL-13","volume":"151","author":"Doherty","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib22","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/eji.1830240630","article-title":"Interleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma","volume":"24","author":"Doyle","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib23","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.nbd.2013.09.012","article-title":"Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4","volume":"62","author":"Nelissen","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib24","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.7150\/thno.65203","article-title":"Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury","volume":"11","author":"Amo-Aparicio","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu15194184","article-title":"Effects of recombinant IL-13 treatment on gut microbiota composition and functional recovery after hemisection spinal cord injury in mice","volume":"15","author":"Hamad","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12974-016-0756-7","article-title":"Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model","volume":"13","author":"Le Blon","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib27","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.1900909","article-title":"IL-13 ameliorates neuroinflammation and promotes functional recovery after traumatic brain injury","volume":"204","author":"Miao","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12974-022-02458-2","article-title":"Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury","volume":"19","author":"Van Broeckhoven","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib29","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/brain\/awad047","article-title":"Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential","volume":"146","author":"Ribeiro","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2013.08.001","article-title":"Immunopharmacological intervention for successful neural stem cell therapy: new perspectives in CNS neurogenesis and repair","volume":"141","author":"Dooley","year":"2014","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/neuros\/nyaa149","article-title":"Cell therapies for spinal cord injury: trends and challenges of current clinical trials","volume":"87","author":"Bartlett","year":"2020","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108043","article-title":"Functional hydrogels as therapeutic tools for spinal cord injury: new perspectives on immunopharmacological interventions","volume":"234","author":"Walsh","year":"2022","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4103\/1673-5374.290882","article-title":"Hydrogel-based local drug delivery strategies for spinal cord repair","volume":"16","author":"Shultz","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119830","article-title":"A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia\/macrophages repopulation","volume":"237","author":"Ma","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib35","article-title":"Bioinspired hydrogel electrospun fibers for spinal cord regeneration","volume":"29","author":"Chen","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111214","article-title":"Promoting 3D neuronal differentiation in hydrogel for spinal cord regeneration","volume":"194","author":"Zhou","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300951","article-title":"An in vitro and Ex vivo analysis of the potential of GelMA hydrogels as a therapeutic platform for preclinical spinal cord injury","volume":"12","author":"Walsh","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4155\/tde-2020-0099","article-title":"Understanding the burst release phenomenon: toward designing effective nanoparticulate drug-delivery systems","volume":"12","author":"Bhattacharjee","year":"2021","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2020.02.009","article-title":"Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury","volume":"321","author":"Nazemi","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2017.06.030","article-title":"Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury","volume":"261","author":"Santhosh","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib41","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1089\/ten.tea.2015.0471","article-title":"Local delivery of Neurotrophin-3 and Anti-NogoA promotes repair after spinal cord injury","volume":"22","author":"Elliott Donaghue","year":"2016","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib42","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1039\/C6TB01602B","article-title":"Localized and sustained release of brain-derived neurotrophic factor from injectable hydrogel\/microparticle composites fosters spinal learning after spinal cord injury","volume":"4","author":"Khaing","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41590-020-0707-4","article-title":"Novel Hexb-based tools for studying microglia in the CNS","volume":"21","author":"Masuda","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120667","article-title":"Regulation of extracellular matrix assembly and structure by hybrid M1\/M2 macrophages","volume":"269","author":"Witherel","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2019.05.001","article-title":"Controlling the dose-dependent, synergistic and temporal effects of NGF and GDNF by encapsulation in PLGA microparticles for use in nerve guidance conduits for the repair of large peripheral nerve defects","volume":"304","author":"Lackington","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib46","article-title":"Pitfalls of accurate protein determination inside PLGA nanoparticles using the micro BCA assay","volume":"78","author":"Clerici","year":"2021","journal-title":"Proceedings"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib47","first-page":"613","article-title":"Different methods to determine the encapsulation efficiency of protein in PLGA nanoparticles","volume":"28","author":"Amini","year":"2017","journal-title":"Bio Med. Mater. Eng."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib48","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2144\/000112257","article-title":"CellProfiler\u2122: free, versatile software for automated biological image analysis","volume":"42","author":"Lamprecht","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib50","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2013 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib53","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/glia.10357","article-title":"Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo","volume":"46","author":"Shin","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib54","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.4049\/jimmunol.177.2.1323","article-title":"Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia","volume":"177","author":"Yang","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/glia.10057","article-title":"Interleukin-13 and -4 induce death of activated microglia","volume":"38","author":"Yang","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00198","article-title":"Overview of general and discriminating markers of differential microglia phenotypes","volume":"14","author":"Jurga","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.701673","article-title":"Classification of microglial morphological phenotypes using machine learning","volume":"15","author":"Leyh","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib58","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fncel.2019.00472","article-title":"Microglial morphometric parameters correlate with the expression level of IL-1\u03b2, and allow identifying different activated morphotypes","volume":"13","author":"Fern\u00e1ndez-Arjona","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fncel.2017.00235","article-title":"Microglia morphological categorization in a rat model of neuroinflammation by hierarchical cluster and principal components analysis","volume":"11","author":"Fern\u00e1ndez-Arjona","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/cne.21149","article-title":"Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved","volume":"500","author":"Pineau","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib62","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ejpb.2008.02.015","article-title":"Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres","volume":"69","author":"Garbayo","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib63","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijpharm.2012.01.035","article-title":"In vitro sustained release of bioactive anti-NogoA, a molecule in clinical development for treatment of spinal cord injury","volume":"426","author":"Stanwick","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib64","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41467-023-35806-8","article-title":"Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib66","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib67","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib68","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/stem.2360","article-title":"In vivo Interleukin-13-Primed macrophages contribute to reduced alloantigen-specific T cell activation and prolong immunological survival of allogeneic mesenchymal stem cell implants","volume":"34","author":"Hoornaert","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib69","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1002\/eji.201343301","article-title":"Reciprocal modulation of C\/EBP-\u03b1 and C\/EBP-\u03b2 by IL-13 in activated microglia prevents neuronal death","volume":"43","author":"Pan","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib70","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12974-020-02019-5","article-title":"Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation","volume":"17","author":"Honarpisheh","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib71","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12974-018-1212-7","article-title":"Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke","volume":"15","author":"Hamzei Taj","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib72","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.20132477","article-title":"Differential roles of microglia and monocytes in the inflamed central nervous system","volume":"211","author":"Yamasaki","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib73","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1038\/s41467-022-31797-0","article-title":"Microglia coordinate cellular interactions during spinal cord repair in mice","volume":"13","author":"Brennan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib74","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41419-020-2733-4","article-title":"Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice","volume":"11","author":"Fu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib75","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4103\/1673-5374.357912","article-title":"Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury","volume":"18","author":"Zhou","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib76","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1523\/JNEUROSCI.2402-19.2020","article-title":"Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits","volume":"40","author":"Henry","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib77","volume":"16","author":"Chen","year":"2022"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib78","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib79","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s13311-019-00761-0","article-title":"Peripheral administration of IL-13 induces anti-inflammatory microglial\/macrophage responses and provides neuroprotection in ischemic stroke","volume":"16","author":"Kolosowska","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib80","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/elsc.202100040","article-title":"The pro-inflammatory response of macrophages regulated by acid degradation products of poly(lactide-co-glycolide) nanoparticles","volume":"21","author":"Ma","year":"2021","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib81","first-page":"1557","article-title":"The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response","volume":"11","author":"Nicolete","year":"2011","journal-title":"Role Toll-like Receptor. Diseases"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib82","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1440-1681.2007.04638.x","article-title":"Arginase: a critical regulator of nitric oxide synthesis and vascular function","volume":"34","author":"Durante","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib83","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/jnen\/60.10.961","article-title":"Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion","volume":"60","author":"Herx","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib84","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1523\/JNEUROSCI.14-02-00846.1994","article-title":"Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines","volume":"14","author":"Balasingam","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib85","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.sc.3101674","article-title":"Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury","volume":"43","author":"Xu","year":"2005","journal-title":"Spinal Cord"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib86","volume":"15","author":"Yin","year":"2024"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib87","article-title":"Oxidative DNA damage in the pathophysiology of spinal cord injury: seems obvious, but where is the evidence?","volume":"11","author":"Scheijen","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib88","first-page":"690","volume":"14","author":"Socodato","year":"2023"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107796","article-title":"Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology and leads to neurodegeneration","volume":"31","author":"Socodato","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib90","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.4103\/1673-5374.143423","article-title":"Function of microglia and macrophages in secondary damage after spinal cord injury","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib91","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib92","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.devcel.2008.05.003","article-title":"Coordination of actin filament and microtubule dynamics during neurite outgrowth","volume":"15","author":"Schaefer","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib93","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0896-6273(03)00754-2","article-title":"Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow","volume":"40","author":"Zhang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib94","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131355","article-title":"STAT6\/Arg1 promotes microglia\/macrophage efferocytosis and inflammation resolution in stroke mice","volume":"4","author":"Cai","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib95","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2353\/ajpath.2008.070848","article-title":"CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier","volume":"172","author":"Borda","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib96","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/glia.20208","article-title":"CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation","volume":"51","author":"Fabriek","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib97","first-page":"21","volume":"2","author":"Pey","year":"2014"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib98","first-page":"750","volume":"361","author":"Peng","year":"2023"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib99","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ncb1747","article-title":"Nitric oxide-induced nuclear GAPDH activates p300\/CBP and mediates apoptosis","volume":"10","author":"Sen","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib100","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/cdd.2009.137","article-title":"Novel roles for GAPDH in cell death and carcinogenesis","volume":"16","author":"Colell","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib101","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.pharmtox.45.120403.095902","article-title":"Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases","volume":"45","author":"Chuang","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib102","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1242\/jcs.114.9.1643","article-title":"Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress","volume":"114","author":"Dastoor","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib103","first-page":"2606","volume":"26","author":"Tarze","year":"2007"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib104","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1002\/eji.200636625","article-title":"IL-13 induces expression of CD36 in human monocytes through PPARgamma activation","volume":"37","author":"Berry","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib105","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00018-002-8512-9","article-title":"The role of thrombospondin-1 in apoptosis","volume":"59","author":"Friedl","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib106","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1046\/j.1471-4159.1999.0730684.x","article-title":"Arachidonic acid-induced oxidative injury to cultured spinal cord neurons","volume":"73","author":"Toborek","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib107","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5483\/BMBRep.2008.41.8.560","article-title":"Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies","volume":"41","author":"Adibhatla","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib108","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1523\/JNEUROSCI.22-17-07526.2002","article-title":"Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events","volume":"22","author":"Noble","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib109","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s13311-011-0038-0","article-title":"Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury","volume":"8","author":"Zhang","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib110","first-page":"1925","article-title":"Reviving the use of inhibitors of matrix metalloproteases in spinal cord injury: a case for specificity","volume":"18","author":"Ahmed","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib111","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/neu.2007.0438","article-title":"Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury","volume":"25","author":"Yu","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib112","doi-asserted-by":"crossref","first-page":"10107","DOI":"10.1523\/JNEUROSCI.23-31-10107.2003","article-title":"An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice","volume":"23","author":"Wells","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib113","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/jid.2010.361","article-title":"Expression of matrix Metalloproteinase-13 is controlled by IL-13 via PI3K\/Akt3 and PKC-\u03b4 in normal human dermal fibroblasts","volume":"131","author":"Moriya","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib114","first-page":"245","volume":"25","author":"Kadomatsu","year":"2014"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib115","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aab3881","article-title":"The proinflammatory role of HECTD2 in innate immunity and experimental lung injury","volume":"7","author":"Coon","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib116","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1742-2094-9-107","article-title":"Dok2 mediates the CD200Fc attenuation of A\u03b2-induced changes in glia","volume":"9","author":"Lyons","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib117","first-page":"6322","volume":"14","author":"Adrian","year":"2023"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib118","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12964-024-01768-7","article-title":"Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NF\u03baB activation and the pro-inflammatory response","volume":"22","author":"Xie","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib119","volume":"373","author":"Chen","year":"2024"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib120","first-page":"241","volume":"10","author":"Wu","year":"2024"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib121","volume":"10","author":"Zhang","year":"2024"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib122","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/glia.23701","article-title":"Ischemic preconditioning induces cortical microglial proliferation and a transcriptomic program of robust cell cycle activation","volume":"68","author":"McDonough","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib123","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.ajhg.2024.07.008","article-title":"Expanding the genetic and phenotypic landscape of replication factor C complex-related disorders: RFC4 deficiency is linked to a multisystemic disorder","volume":"111","author":"Morimoto","year":"2024","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib124","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/gtmb.2021.0122","article-title":"MAD2L1 functions as a novel diagnostic and predictive biomarker in cholangiocarcinoma","volume":"25","author":"Gao","year":"2021","journal-title":"Genet. Test. Mol. Biomark."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib125","first-page":"489","volume":"425","author":"Stuart","year":"2010"},{"issue":"Suppl 1","key":"10.1016\/j.bioactmat.2025.07.018_bib126","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/onc.2009.40","article-title":"BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes","volume":"27","author":"Chinnadurai","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib127","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1158\/0008-5472.CAN-18-2705","article-title":"Smarcal1 and Zranb3 protect replication forks from myc-induced DNA replication stress","volume":"79","author":"Puccetti","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib128","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.21037\/atm-21-4064","article-title":"Role of spindle pole body component 25 in neurodegeneration","volume":"9","author":"Cui","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.03.050","article-title":"Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies","volume":"323","author":"Chung","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.07.018_bib130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.expneurol.2006.04.020","article-title":"An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury","volume":"201","author":"Piantino","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib131","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202100035","article-title":"Engineering strategies for immunomodulatory cytokine therapies: challenges and clinical progress","volume":"4","author":"Pires","year":"2021","journal-title":"Adv. Therapeut."},{"key":"10.1016\/j.bioactmat.2025.07.018_bib132","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2217\/imt.12.26","article-title":"Particle-mediated delivery of cytokines for immunotherapy","volume":"4","author":"Christian","year":"2012","journal-title":"Immunotherapy"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25003111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25003111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:42:25Z","timestamp":1772912545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25003111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":132,"alternative-id":["S2452199X25003111"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.07.018","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localised delivery of interleukin-13 from a PLGA microparticle embedded GelMA hydrogel improves functional and histopathological recovery in a mouse contusion spinal cord injury model","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}