{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:11:54Z","timestamp":1790741514813,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"The First Hospital of Jilin University","doi-asserted-by":"publisher","award":["2022YYGFZJC005"],"award-info":[{"award-number":["2022YYGFZJC005"]}],"id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073278"],"award-info":[{"award-number":["52073278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373161"],"award-info":[{"award-number":["52373161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2022JBGS10"],"award-info":[{"award-number":["2022JBGS10"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Jilin Province People&apos;s Government Department of Education","doi-asserted-by":"publisher","award":["JJKH20231205KJ"],"award-info":[{"award-number":["JJKH20231205KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["20230101045JC"],"award-info":[{"award-number":["20230101045JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023154","name":"Canadian Red Cross","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002838","name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioactmat.2025.08.002","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:25:53Z","timestamp":1755131153000},"page":"126-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer"],"prefix":"10.1016","volume":"54","author":[{"given":"Heshi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caina","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-3744","authenticated-orcid":false,"given":"Huayu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1158\/1055-9965.EPI-15-0990","article-title":"Systematic review and meta-study synthesis of qualitative studies evaluating facilitators and barriers to participation in colorectal cancer screening","volume":"25","author":"Honein-AbouHaidar","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.critrevonc.2023.103920","article-title":"Cancer stem cells in colorectal cancer: signaling pathways involved in stemness and therapy resistance","volume":"182","author":"Ebrahimi","year":"2023","journal-title":"Crit. Rev. Oncol.-Hematol."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tips.2023.01.003","article-title":"Metastatic colorectal cancer: mechanisms and emerging therapeutics","volume":"44","author":"Shin","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"46","key":"10.1016\/j.bioactmat.2025.08.002_bib4","doi-asserted-by":"crossref","first-page":"32103","DOI":"10.1021\/acsnano.4c10947","article-title":"Bioorthogonal chemistry-guided inhalable nanoprodrug to circumvent cisplatin resistance in orthotopic nonsmall cell lung cancer","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib5","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.21037\/jgo.2019.08.06","article-title":"Hepatic metastasis from colorectal cancer","volume":"10","author":"Kow","year":"2019","journal-title":"J. Gastrointest. Oncol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib6","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41392-022-00922-2","article-title":"Colorectal liver metastasis: molecular mechanism and interventional therapy","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"7069","key":"10.1016\/j.bioactmat.2025.08.002_bib7","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nature04186","article-title":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche","volume":"438","author":"Kaplan","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","article-title":"Extracellular matrix and its therapeutic potential for cancer treatment","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.08.002_bib9","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/acs.nanolett.3c04563","article-title":"Chemoimmunotherapeutic nanogel for pre- and postsurgical treatment of malignant melanoma by reprogramming tumor-associated macrophages","volume":"24","author":"Tang","year":"2024","journal-title":"Nano Lett."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.08.002_bib10","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/s12276-023-01114-w","article-title":"Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy","volume":"55","author":"Choi","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.08.002_bib11","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1158\/0008-5472.CAN-12-2796","article-title":"Acidity generated by the tumor microenvironment drives local invasion","volume":"73","author":"Estrella","year":"2013","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.08.002_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bioactmat.2025.08.002_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108458","article-title":"Integrins in cancer: emerging mechanisms and therapeutic opportunities","volume":"247","author":"Liu","year":"2023","journal-title":"Pharmacol. Therapeut."},{"issue":"728","key":"10.1016\/j.bioactmat.2025.08.002_bib14","doi-asserted-by":"crossref","first-page":"eadg3840","DOI":"10.1126\/scitranslmed.adg3840","article-title":"The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets","volume":"16","author":"Sleeboom","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152590","article-title":"Size-switchable and dual-targeting nanomedicine for cancer chemoimmunotherapy by potentiating deep tumor penetration and antitumor immunity","volume":"493","author":"Tang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.actbio.2022.09.043","article-title":"Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel","volume":"163","author":"Hiraki","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.trecan.2024.11.005","article-title":"Functional heterogeneity of fibroblasts in primary tumors and metastases","volume":"11","author":"Cheng","year":"2024","journal-title":"Trends Cancer"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ccell.2024.02.002","article-title":"PDGFR \u03b1+ITGA11+fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay","volume":"42","author":"Zheng","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41467-023-36334-1","article-title":"Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy","volume":"14","author":"Linares","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3892\/ijo.2016.3779","article-title":"Prometastatic mechanisms of CAF-Mediated EMT regulation in pancreatic cancer cells","volume":"50","author":"Shan","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib21","article-title":"Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts","volume":"5","author":"Chen","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"21","key":"10.1016\/j.bioactmat.2025.08.002_bib22","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1158\/0008-5472.CAN-23-0025","article-title":"Matrix stiffness triggers lipid metabolic cross-talk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases","volume":"83","author":"Zheng","year":"2023","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.bioactmat.2025.08.002_bib23","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1158\/2159-8290.CD-22-1467","article-title":"Oncogenic KRAS drives lipofibrogenesis to promote angiogenesis and Colon cancer progression","volume":"13","author":"Hsu","year":"2023","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-023-02900-0","article-title":"Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1","volume":"42","author":"Zhang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7885","key":"10.1016\/j.bioactmat.2025.08.002_bib25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41586-021-04075-0","article-title":"Dietary palmitic acid promotes a prometastatic memory via schwann cells","volume":"599","author":"Pascual","year":"2021","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioactmat.2025.08.002_bib26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41568-021-00388-4","article-title":"Tumour fatty acid metabolism in the context of therapy resistance and obesity","volume":"21","author":"Hoy","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.08.002_bib27","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221316","article-title":"Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition","volume":"220","author":"Chu","year":"2022","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib28","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gutjnl-2022-327913","article-title":"Novel TCF21high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix","volume":"72","author":"Li","year":"2023","journal-title":"Gut"},{"issue":"38","key":"10.1016\/j.bioactmat.2025.08.002_bib29","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/s41388-021-01988-y","article-title":"Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C\/EBP\u03b2-mediated PDGFB autocrine and paracrine signaling","volume":"40","author":"Du","year":"2021","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib30","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ccell.2020.05.005","article-title":"Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer","volume":"37","author":"Shen","year":"2020","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41392-023-01384-w","article-title":"Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis","volume":"8","author":"Yang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"19","key":"10.1016\/j.bioactmat.2025.08.002_bib32","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1158\/0008-5472.CAN-23-3140","article-title":"AFDN deficiency promotes liver tropism of metastatic colorectal cancer","volume":"84","author":"Liao","year":"2024","journal-title":"Cancer Res."},{"issue":"24","key":"10.1016\/j.bioactmat.2025.08.002_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302613","article-title":"FGF19-induced inflammatory CAF promoted neutrophil extracellular trap formation in the liver metastasis of colorectal cancer","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.apsb.2019.06.004","article-title":"Development and application of hyaluronic acid in tumor targeting drug delivery","volume":"9","author":"Luo","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioactmat.2025.08.002_bib35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jconrel.2015.01.012","article-title":"Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts","volume":"205","author":"Zhong","year":"2015","journal-title":"J. Contr. Release"},{"issue":"20","key":"10.1016\/j.bioactmat.2025.08.002_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202307129","article-title":"Bioengineered hydrogels recapitulate fibroblast heterogeneity in cancer","volume":"11","author":"Ho","year":"2024","journal-title":"Adv. Sci."},{"issue":"12","key":"10.1016\/j.bioactmat.2025.08.002_bib37","article-title":"Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy","volume":"5","author":"Shi","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib38","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/ijc.32193","article-title":"In search of definitions: cancer-Associated fibroblasts and their markers","volume":"146","author":"Nurmik","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bioactmat.2025.08.002_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108119","article-title":"Epigallocatechin-3-gallate (EGCG) inhibits myofibroblast transformation of human Tenon's fibroblasts","volume":"197","author":"Lin","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.actbio.2022.03.023","article-title":"Metal-organic framework-mediated multifunctional nanoparticles for combined chemo-photothermal therapy and enhanced immunotherapy against colorectal cancer","volume":"144","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib41","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jconrel.2022.03.043","article-title":"Strategies to improve the EPR effect: a mechanistic perspective and clinical translation","volume":"345","author":"Ikeda-Imafuku","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.08.002_bib42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jconrel.2020.09.029","article-title":"Nanozyme-mediated Cascade reaction based on metal-organic framework for synergetic chemo-photodynamic tumor therapy","volume":"328","author":"Sheng","year":"2020","journal-title":"J. Contr. Release"},{"issue":"10","key":"10.1016\/j.bioactmat.2025.08.002_bib43","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1021\/acsanm.8b01019","article-title":"Understanding the stability of nanoparticle-protein interactions: effect of particle size on adsorption, conformation and thermodynamic properties of serum albumin proteins","volume":"1","author":"Suvarna","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.08.002_bib44","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.5966\/sctm.2015-0048","article-title":"Concise review: emerging role of cd44 in cancer stem cells: a promising biomarker and therapeutic target","volume":"4","author":"Yan","year":"2015","journal-title":"Stem Cells Transl. Med."},{"issue":"17","key":"10.1016\/j.bioactmat.2025.08.002_bib45","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1158\/0008-5472.CAN-13-0087","article-title":"Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment","volume":"73","author":"Spaeth","year":"2013","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/stem.1556","article-title":"CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment","volume":"32","author":"Kinugasa","year":"2014","journal-title":"Stem Cell."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.08.002_bib47","article-title":"Strategies for enhancing cancer chemodynamic therapy performance","volume":"2","author":"Jana","year":"2022","journal-title":"Explorations"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib48","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/mol.115.099549","article-title":"AMPK inhibits the stimulatory effects of TGF-\u03b2 on Smad2\/3 activity, cell migration, and epithelial-to-mesenchymal transition","volume":"88","author":"Lin","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104468","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes suppress dermal fibroblasts-myofibroblats transition via inhibiting the TGF-\u03b21\/Smad 2\/3 signaling pathway","volume":"115","author":"Hu","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"15","key":"10.1016\/j.bioactmat.2025.08.002_bib50","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.3390\/cancers15153965","article-title":"Crosstalk between cancer cells and cancer-associated fibroblasts mediated by TGF- \u03b21-IGFBP7 signaling promotes the progression of infiltrative gastric cancer","volume":"15","author":"Hong","year":"2023","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.08.002_bib51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/ph18030317","article-title":"The role and mechanism of innate immune regulation in overcoming oxaliplatin resistance and enhancing anti-tumor efficacy in colorectal cancer","volume":"18","author":"Wang","year":"2025","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib52","article-title":"Alteration of chromatin high-order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells","volume":"3","author":"Li","year":"2023","journal-title":"Explorations"},{"key":"10.1016\/j.bioactmat.2025.08.002_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzym. Regul."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib54","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1038\/s41467-022-32101-w","article-title":"Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells","volume":"13","author":"Tan","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.08.002_bib55","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41419-023-06110-6","article-title":"Stromal cells in the tumor microenvironment: accomplices of tumor progression?","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib56","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12935-022-02824-3","article-title":"Oleic acid from cancer-associated fibroblast promotes cancer cell stemness by stearoyl-CoA desaturase under glucose-deficient condition","volume":"22","author":"Hwang","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"23","key":"10.1016\/j.bioactmat.2025.08.002_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315297","article-title":"Ferulic acid and P-Coumaric acid synergistically attenuate non-alcoholic fatty liver disease through HDAC1\/PPARG-mediated free fatty acid uptake","volume":"23","author":"Cui","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib58","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211314","article-title":"CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate","volume":"219","author":"Chen","year":"2022","journal-title":"J. Exp. Med."},{"issue":"7644","key":"10.1016\/j.bioactmat.2025.08.002_bib59","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","article-title":"Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Pan","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.08.002_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/15384047.2019.1685157","article-title":"CXCR4\/TGF-\u03b21 mediated hepatic stellate cells differentiation into carcinoma-associated fibroblasts and promoted liver metastasis of colon cancer","volume":"21","author":"Tan","year":"2020","journal-title":"Cancer Biol. Ther."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib61","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000669","article-title":"Depletion of tumor-reactive HSCs reveals their significance during different stages of liver metastasis","volume":"9","author":"Benedicto","year":"2025","journal-title":"Hepatol. Commun."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib62","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/17474124.2021.1848543","article-title":"The cellular and molecular components involved in pre-metastatic niche formation in colorectal cancer liver metastasis","volume":"15","author":"Yang","year":"2021","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.08.002_bib63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3390\/ijms17050643","article-title":"The role of chemokines in promoting colorectal cancer invasion\/metastasis","volume":"17","author":"Itatani","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib64","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jcmgh.2023.01.006","article-title":"Cancer-associated fibroblasts in hepatocellular carcinoma and cholangiocarcinoma","volume":"15","author":"Ying","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib65","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41467-023-38406-8","article-title":"Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2-\u03b2-catenin cascade to promote liver tumorigenesis","volume":"14","author":"Sinha","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib66","article-title":"FGF19-activated hepatic stellate cells release ANGPTL4 that promotes colorectal cancer liver metastasis","volume":"12","author":"Fan","year":"2024","journal-title":"Adv. Sci."},{"issue":"17","key":"10.1016\/j.bioactmat.2025.08.002_bib67","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.7150\/thno.72853","article-title":"The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases","volume":"12","author":"Giguelay","year":"2022","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.08.002_bib68","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1172\/JCI24652","article-title":"Autocrine PDGFR signaling promotes mammary cancer metastasis","volume":"116","author":"Jechlinger","year":"2006","journal-title":"J. Clin. Investig."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.08.002_bib69","first-page":"869","article-title":"Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells","volume":"29","author":"Yoshizaki","year":"2006","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.08.002_bib70","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1038\/s41467-021-24631-6","article-title":"The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling","volume":"12","author":"Moon","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.08.002_bib71","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3724\/abbs.2023082","article-title":"Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4","volume":"55","author":"Liu","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.bioactmat.2025.08.002_bib72","doi-asserted-by":"crossref","first-page":"425","DOI":"10.34133\/research.0425","article-title":"Golgi protein 73 promotes angiogenesis in hepatocellular carcinoma","volume":"7","author":"Liu","year":"2024","journal-title":"Research"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500355X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500355X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:12:09Z","timestamp":1778890329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X2500355X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":72,"alternative-id":["S2452199X2500355X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.08.002","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}