{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:57:27Z","timestamp":1791827847075,"version":"4.3.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["24ZR1448300"],"award-info":[{"award-number":["24ZR1448300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971832"],"award-info":[{"award-number":["81971832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioactmat.2025.08.040","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T15:56:13Z","timestamp":1757606173000},"page":"850-870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["An injectable hyaluronic acid\u2013silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing"],"prefix":"10.1016","volume":"54","author":[{"given":"Renwen","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mowen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjie","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2404-1117","authenticated-orcid":false,"given":"Zhufeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-9951","authenticated-orcid":false,"given":"Zhiwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-8855","authenticated-orcid":false,"given":"Zhijie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.08.040_bib1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/cells10030655","article-title":"Chronic Diabetic Wounds and Their Treatment with Skin Substitutes","volume":"10","author":"Holl","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib2","first-page":"64","article-title":"Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments","volume":"47","author":"Kim","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib3","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet (Lond. Engl.)"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib4","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3390\/cells9102228","article-title":"Mechanistic actions of microRNAs in diabetic wound healing","volume":"9","author":"Petkovic","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib6","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1002\/dmrr.852","article-title":"The value of debridement and vacuum-assisted closure (V.a.C.) therapy in diabetic foot ulcers","volume":"24","author":"Eneroth","year":"2008","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/1534734616667865","article-title":"Combination of open subtotal calcanectomy and stabilization with external fixation as limb salvage procedure in hindfoot-infected diabetic foot ulcers","volume":"15","author":"Dalla Paola","year":"2016","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib8","doi-asserted-by":"crossref","first-page":"129353","DOI":"10.1016\/j.ijbiomac.2024.129353","article-title":"Doping proanthocyanidins into gel\/zirconium hybrid hydrogel to reshape the microenvironment of diabetic wounds for healing acceleration","volume":"260","author":"Zhu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib9","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1038\/s41467-024-50072-y","article-title":"Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing","volume":"15","author":"Butenko","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib10","doi-asserted-by":"crossref","first-page":"2301885","DOI":"10.1002\/adhm.202301885","article-title":"Multifunctional hydrogels for the healing of diabetic wounds","volume":"13","author":"Xiang","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib11","doi-asserted-by":"crossref","first-page":"32006","DOI":"10.1088\/1748-605X\/add06f","article-title":"Multifunctional nanocomposite hydrogels: an effective approach to promote diabetic wound healing","volume":"20","author":"Hu","year":"2025","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijbiomac.2021.02.133","article-title":"Scar free healing of full thickness diabetic wounds: A unique combination of silver nanoparticles as antimicrobial agent, calcium alginate nanoparticles as hemostatic agent, fresh blood as nutrient\/growth factor supplier and chitosan as base matrix","volume":"178","author":"Choudhary","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib13","doi-asserted-by":"crossref","first-page":"119404","DOI":"10.1016\/j.carbpol.2022.119404","article-title":"hUC-MSCs lyophilized powder loaded polysaccharide ulvan driven functional hydrogel for chronic diabetic wound healing","volume":"288","author":"Ren","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.actbio.2016.03.022","article-title":"Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability","volume":"36","author":"Patil","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib15","doi-asserted-by":"crossref","first-page":"100604","DOI":"10.1016\/j.mtbio.2023.100604","article-title":"Microstructured click hydrogels for cell contact guidance in 3D","volume":"19","author":"Neves","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib16","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1089\/ten.tea.2017.0411","article-title":"Hyaluronic acid dictates chondrocyte morphology and migration in composite gels","volume":"24","author":"Mohan","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib17","doi-asserted-by":"crossref","first-page":"2105325","DOI":"10.1002\/advs.202105325","article-title":"Nonswelling and hydrolytically stable hydrogels uncover cellular mechanosensing in 3D","volume":"9","author":"Long","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib18","doi-asserted-by":"crossref","first-page":"119254","DOI":"10.1016\/j.carbpol.2022.119254","article-title":"Multifunctional polysaccharide hydrogels for skin wound healing prepared by photoinitiator-free crosslinking","volume":"285","author":"Mao","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib19","doi-asserted-by":"crossref","first-page":"114033","DOI":"10.1016\/j.colsurfb.2024.114033","article-title":"Application of bletilla striata polysaccharide hydrogel for wound healing among in diabetes","volume":"241","author":"Li","year":"2024","journal-title":"Colloids Surf., B"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib20","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1039\/C9BM01103J","article-title":"Angiogenesis-promoted bone repair with silicate-shelled hydrogel fiber scaffolds","volume":"7","author":"Dashnyam","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib21","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1039\/D0NR07406C","article-title":"Injectable, self-healing mesoporous silica nanocomposite hydrogels with improved mechanical properties","volume":"13","author":"Zengin","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bcp.2004.09.022","article-title":"The l-arginine\/NO pathway in the early phases of platelet stimulation by collagen","volume":"69","author":"Leoncini","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-511X-4-14","article-title":"Inducible nitric oxide synthase links NF-\u03baB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing","volume":"4","author":"Jia","year":"2005","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib24","doi-asserted-by":"crossref","first-page":"L503","DOI":"10.1152\/ajplung.00328.2014","article-title":"Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs","volume":"308","author":"Grasemann","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib25","article-title":"A mesoporous silica-loaded multi-functional hydrogel enhanced tendon healing via immunomodulatory and pro-regenerative effects","volume":"13","author":"Wan","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib26","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.3390\/nu14224724","article-title":"Puerarin reduces oxidative damage and photoaging caused by UVA radiation in human fibroblasts by regulating Nrf2 and MAPK signaling pathways","volume":"14","author":"Mo","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3390\/bioengineering12040427","article-title":"Self-healing polymeric puerarin hydrogel dressing promotes diabetic wound healing through synergistic immunomodulation and tissue-regenerative remodeling","volume":"12","author":"Geng","year":"2025","journal-title":"Bioengineering"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib28","doi-asserted-by":"crossref","first-page":"rbad036","DOI":"10.1093\/rb\/rbad036","article-title":"An injectable hydrogel combining medicine and matrix with anti-inflammatory and pro-angiogenic properties for potential treatment of myocardial infarction","volume":"10","author":"Feng","year":"2023","journal-title":"Regener. Biomater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib29","article-title":"Engineering bioactive M2 macrophage-polarized, anti-inflammatory, miRNA-based liposomes for functional muscle repair: from exosomal mechanisms to biomaterials","volume":"18","author":"Luo","year":"2022","journal-title":"Small (Weinh. Bergstr. Ger.)"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib30","doi-asserted-by":"crossref","first-page":"5511598","DOI":"10.1155\/2021\/5511598","article-title":"The gene coexpression analysis identifies functional modules dynamically changed after traumatic brain injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib31","doi-asserted-by":"crossref","first-page":"7093844","DOI":"10.1155\/2021\/7093844","article-title":"Untargeted metabolomic profiling of cuprizone-induced demyelination in mouse corpus callosum by UPLC-orbitrap\/MS reveals potential metabolic biomarkers of CNS demyelination disorders","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1158\/2326-6066.CIR-20-0527","article-title":"The prognostic role of macrophage polarization in the colorectal cancer microenvironment","volume":"9","author":"V\u00e4yrynen","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41418-024-01380-9","article-title":"Myeloid Mir34a suppresses colitis-associated colon cancer: characterization of mediators by single-cell RNA sequencing","volume":"32","author":"K\u00f6nig","year":"2025","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib34","doi-asserted-by":"crossref","first-page":"993614","DOI":"10.3389\/fimmu.2022.993614","article-title":"Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage","volume":"13","author":"Wierenga","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib35","doi-asserted-by":"crossref","first-page":"113956","DOI":"10.1016\/j.jconrel.2025.113956","article-title":"Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy","volume":"384","author":"Chen","year":"2025","journal-title":"J. Control. Release: Off. J. Control. Release Soc."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00125-018-4751-7","article-title":"Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the malm\u00f6 diet and cancer-cardiovascular cohort","volume":"62","author":"Bao","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib37","first-page":"138","article-title":"Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration","volume":"51","author":"Li","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib38","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.3390\/ijms26125713","article-title":"Disease-specific novel role of growth differentiation factor 15 in organ fibrosis","volume":"26","author":"Sawant","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib39","doi-asserted-by":"crossref","first-page":"102005","DOI":"10.1016\/j.mtbio.2025.102005","article-title":"A dual-component particulate dressing for simultaneous microenvironment modulation and tissue regeneration in infected diabetic wounds","volume":"33","author":"Li","year":"2025","journal-title":"Mater. Today, Bio"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib40","doi-asserted-by":"crossref","first-page":"101971","DOI":"10.1016\/j.mtbio.2025.101971","article-title":"Design of nano mume fructus charcoal by reshaping inflammatory microenvironment as biofunctional wound nanomedicine","volume":"33","author":"Liang","year":"2025","journal-title":"Mater. Today, Bio"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib41","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","article-title":"Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights","volume":"31","author":"Baltzis","year":"2014","journal-title":"Adv. Ther."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/wrr.13218","article-title":"Single\u2010cell RNA \u2010seq in diabetic foot ulcer wound healing","volume":"32","author":"Dong","year":"2024","journal-title":"Wound Repair Regener"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib43","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.945462","article-title":"Efficacy of cold atmospheric plasma in chronic diabetic foot ulcer management: a case report","volume":"25","author":"Nakayama","year":"2024","journal-title":"Am. J. Case Rep."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib44","doi-asserted-by":"crossref","DOI":"10.2174\/0115733998287694240514110935","article-title":"Deciphering diabetic foot wounds: a comprehensive review on classification, multidrug resistance, microbial insights, management & treatment strategies, and advanced diagnostic tools","volume":"21","author":"Silvia N","year":"2024","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib45","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1021\/acs.molpharmaceut.1c00970","article-title":"Exploration of lipid-based nanocarriers as drug delivery systems in diabetic foot ulcer","volume":"19","author":"Kandregula","year":"2022","journal-title":"Mol. Pharmaceutics"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib46","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/acsbiomaterials.0c01502","article-title":"Injectable desferrioxamine-laden silk nanofiber hydrogels for accelerating diabetic wound healing","volume":"7","author":"Ding","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib47","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/wrr.12310","article-title":"Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing","volume":"23","author":"Goldufsky","year":"2015","journal-title":"Wound Repair Regener"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib48","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1517\/13543784.2014.922951","article-title":"AMP-activated protein kinase activators in diabetic ulcers: from animal studies to phase II drugs under investigation","volume":"23","author":"Lin","year":"2014","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib49","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cger.2013.01.007","article-title":"Clinical management of diabetic ulcers","volume":"29","author":"Thomas","year":"2013","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib50","doi-asserted-by":"crossref","first-page":"120020","DOI":"10.1016\/j.biomaterials.2020.120020","article-title":"Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing","volume":"249","author":"Shiekh","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib51","doi-asserted-by":"crossref","first-page":"tkac003","DOI":"10.1093\/burnst\/tkac003","article-title":"Autophagy and skin wound healing","volume":"10","author":"Ren","year":"2022","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib52","doi-asserted-by":"crossref","first-page":"2200060","DOI":"10.1002\/smll.202200060","article-title":"Sustained exosome\u2010guided macrophage polarization using hydrolytically degradable PEG hydrogels for cutaneous wound healing: identification of key proteins and MiRNAs, and sustained release formulation","volume":"18","author":"Kwak","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib53","doi-asserted-by":"crossref","first-page":"101030","DOI":"10.4252\/wjsc.v17.i2.101030","article-title":"Fetal mice dermal mesenchymal stem cells promote wound healing by inducing M2 type macrophage polarization","volume":"17","author":"Xia","year":"2025","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib54","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/193229681000400409","article-title":"The SNaPTM wound care system: a case series using a novel ultraportable negative pressure wound therapy device for the treatment of diabetic lower extremity wounds","volume":"4","author":"Lerman","year":"2010","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejphar.2014.03.030","article-title":"Protective effects of puerarin against A\u00df40-induced vascular dysfunction in zebrafish and human endothelial cells","volume":"732","author":"Lu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib56","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.intimp.2018.05.034","article-title":"Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators","volume":"61","author":"Ullah","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib57","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijcard.2006.04.062","article-title":"l-arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?","volume":"116","author":"Siasos","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1254\/jjp.66.167","article-title":"Beneficial circulatory effect of L-arginine","volume":"66","author":"Nakaki","year":"1994","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib59","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.pharmtox.41.1.79","article-title":"The clinical pharmacology of L-arginine","volume":"41","author":"B\u00f6ger","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib60","article-title":"Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling","volume":"7","author":"Yu","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.bioactmat.2025.08.040_bib61","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI1699","article-title":"Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling","volume":"101","author":"Rudic","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2025.08.040_bib62","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.ATV.0000207319.28254.8c","article-title":"Endothelial NO synthase deficiency promotes smooth muscle progenitor cells in association with upregulation of stromal cell-derived factor-1\u03b1 in a mouse model of carotid artery ligation","volume":"26","author":"Zhang","year":"2006","journal-title":"Arterioscler., Thromb., Vasc. Biol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:43:39Z","timestamp":1772912619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25004025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"alternative-id":["S2452199X25004025"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.08.040","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An injectable hyaluronic acid\u2013silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.08.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}