{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:09:57Z","timestamp":1792080597237,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373871"],"award-info":[{"award-number":["82373871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574405"],"award-info":[{"award-number":["82574405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2023QYJC017"],"award-info":[{"award-number":["2023QYJC017"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","award":["2023LNJJ12"],"award-info":[{"award-number":["2023LNJJ12"]}],"id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioactmat.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:35:54Z","timestamp":1757543754000},"page":"777-796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction"],"prefix":"10.1016","volume":"54","author":[{"given":"Qiaohui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoxiu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-8963","authenticated-orcid":false,"given":"Kelong","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bioactmat.2025.09.006_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","article-title":"Chronic kidney disease and the global public health agenda: an international consensus","volume":"20","author":"Francis","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.006_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00134-021-06454-7","article-title":"Acute kidney injury in the critically ill: an updated review on pathophysiology and management","volume":"47","author":"Pickkers","year":"2021","journal-title":"Intensive Care Med."},{"issue":"9987","key":"10.1016\/j.bioactmat.2025.09.006_bib3","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.bioactmat.2025.09.006_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41581-024-00875-5","article-title":"Lymphocytes and innate immune cells in acute kidney injury and repair","volume":"20","author":"Lee","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41467-024-55629-5","article-title":"Development and validation of a real-time prediction model for acute kidney injury in hospitalized patients","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.09.006_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202411254","article-title":"Hierarchical targeting nanodrug with holistic DNA protection for effective treatment of acute kidney injury","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103518","article-title":"Protective role of vitamin D receptor against mitochondrial calcium overload from PM2.5-Induced injury in renal tubular cells","volume":"80","author":"Lu","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202208571","article-title":"Mitochondrial-targeted delivery of polyphenol-mediated antioxidases complexes against pyroptosis and inflammatory diseases","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-023-00350-4","article-title":"Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases","volume":"12","author":"Shadfar","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.09.006_bib11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","article-title":"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction","volume":"5","author":"Monzel","year":"2023","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.immuni.2024.12.007","article-title":"Mitochondria and NLRP3: to die or inflame","volume":"58","author":"Yang","year":"2025","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.006_bib14","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1021\/tx300298m","article-title":"The mitochondrial amidoxime reducing component (mARC) is involved in detoxification of N-Hydroxylated base analogues","volume":"25","author":"Krompholz","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.09.006_bib15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41589-019-0249-y","article-title":"Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification","volume":"15","author":"Warnhoff","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.09.006_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41589-019-0257-y","article-title":"Harvesting Moco","volume":"15","author":"Mendel","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102066","article-title":"Glutathione and glutathione-dependent enzymes: from biochemistry to gerontology and successful aging","volume":"92","author":"Lapenna","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102349","article-title":"Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation","volume":"53","author":"Xu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib19","first-page":"381","article-title":"Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment","volume":"21","author":"Huang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"18","key":"10.1016\/j.bioactmat.2025.09.006_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101498","article-title":"Redox-mediated artificial non-enzymatic antioxidant MXene nanoplatforms for acute kidney injury alleviation","volume":"8","author":"Zhao","year":"2021","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"36","key":"10.1016\/j.bioactmat.2025.09.006_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202409351","article-title":"DNA nanotechnology targeting mitochondria: from subcellular molecular imaging to tailor-made therapeutics","volume":"63","author":"Yu","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.006_bib23","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41594-023-01039-y","article-title":"Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1","volume":"30","author":"Parker","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.006_bib24","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s41594-023-01144-y","article-title":"OAT1 structures reveal insights into drug transport in the kidney","volume":"30","author":"Chang","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107647","article-title":"Regulation of organic anion transporters: role in physiology, pathophysiology, and drug elimination","volume":"217","author":"Zhang","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The Organic Anion Transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.09.006_bib27","first-page":"1091","article-title":"Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1","volume":"60","author":"Pombrio","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.bioactmat.2025.09.006_bib29","first-page":"432","article-title":"Recent advances in nanotherapeutics for the treatment and prevention of acute kidney injury","volume":"16","author":"Yu","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.addr.2020.06.006","article-title":"Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment","volume":"158","author":"Zhou","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib31","first-page":"141","article-title":"Nanodrugs alleviate acute kidney injury: manipulate RONS at kidney","volume":"22","author":"Chen","year":"2023","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.006_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.kint.2020.09.033","article-title":"Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis","volume":"99","author":"Boudhabhay","year":"2021","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.006_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41581-023-00769-y","article-title":"Acute kidney injury in patients with burns","volume":"20","author":"Legrand","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.09.006_bib34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.006_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.09.006_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41419-023-05969-9","article-title":"The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis","volume":"14","author":"Guo","year":"2023","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.006_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","article-title":"Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.006_bib38","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1021\/tx300298m","article-title":"The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues","volume":"25","author":"Krompholz","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41420-024-01843-5","article-title":"Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12943-024-02186-6","article-title":"Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform \u2018cold\u2019 tumors into \u2018hot\u2019 tumors","volume":"23","author":"Ying","year":"2024","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.006_bib41","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS\u2013STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-024-01889-y","article-title":"Current advance of nanotechnology in diagnosis and treatment for malignant tumors","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.006_bib43","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1021\/nn900403h","article-title":"Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct","volume":"3","author":"Schanen","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.09.006_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105994","article-title":"Effect of rare earth element lanthanum on lipid deposition and Wnt10b signaling in the liver of male zebrafish","volume":"240","author":"Liu","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114361","article-title":"Nano-bio interactions of 2D molybdenum disulfide","volume":"187","author":"Roy","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2025.09.006_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41467-018-07890-8","article-title":"Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.006_bib47","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1038\/s41467-024-53047-1","article-title":"Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bioactmat.2025.09.006_bib48","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1039\/D4NR05060F","article-title":"Engineered molybdenum disulfide nanosheets as scavengers against oxidative stress inhibit ferroptosis to alleviate acute kidney injury","volume":"17","author":"Zhang","year":"2025","journal-title":"Nanoscale"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:46:36Z","timestamp":1772912796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25004116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S2452199X25004116"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.09.006","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}