{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:36Z","timestamp":1791846396723,"version":"4.3.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023QY13"],"award-info":[{"award-number":["2023QY13"]}],"id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305264"],"award-info":[{"award-number":["82305264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010493","name":"Missouri Botanical Garden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bioactmat.2025.09.030","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:45:52Z","timestamp":1758829552000},"page":"376-390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment"],"prefix":"10.1016","volume":"55","author":[{"given":"Xiang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingdi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2288-0380","authenticated-orcid":false,"given":"Xiaohui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Forouzanfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-073X","authenticated-orcid":false,"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412240","article-title":"An immunomodulatory hydrogel featuring antibacterial and reactive oxygen species scavenging properties for treating periodontitis in diabetes","volume":"37","author":"Ge","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jdsr.2021.09.005","article-title":"Mechanism of alveolar bone destruction in periodontitis \u2014 periodontal bacteria and inflammation","volume":"57","author":"Usui","year":"2021","journal-title":"Japan. Dental Sci. Rev."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cyto.2004.06.005","article-title":"Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections","volume":"28","author":"D'Aiuto","year":"2004","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202570014","article-title":"Controlling alveolar bone loss by hydrogel-based mitigation of oral dysbiosis and bacteria-triggered proinflammatory immune response","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412866","article-title":"Self-assembled eutectogel with cell permeation and multiple anti-inflammatory abilities for treating chronic periodontitis","volume":"37","author":"Cheng","year":"2025","journal-title":"Adv. Mater."},{"issue":"3, Supplement","key":"10.1016\/j.bioactmat.2025.09.030_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1532-3382(12)70019-2","article-title":"Nonsurgical treatment of periodontitis","volume":"12","author":"Sanz","year":"2012","journal-title":"J. Evid. Base Dent. Pract."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib7","first-page":"474","article-title":"Advanced biomaterials for targeting mature biofilms in periodontitis therapy","volume":"48","author":"Tao","year":"2025","journal-title":"Bioact. Mater."},{"issue":"11","key":"10.1016\/j.bioactmat.2025.09.030_bib8","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1039\/D4MH01563K","article-title":"Development of an injectable salicylic acid\u2013choline eutectic hydrogel for enhanced treatment of periodontitis","volume":"12","author":"Zhang","year":"2025","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib9","first-page":"301","article-title":"An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers","volume":"45","author":"Qi","year":"2025","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celbio.2025.100020","article-title":"Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers","volume":"1","author":"Qi","year":"2025","journal-title":"Cell Biomater."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.030_bib11","doi-asserted-by":"crossref","first-page":"11144","DOI":"10.1021\/acsami.1c25014","article-title":"Dendritic hydrogels with robust inherent antibacterial properties for promoting bacteria-infected wound healing","volume":"14","author":"Cheng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.bioactmat.2025.09.030_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/polym15020355","article-title":"Temperature induced gelation and antimicrobial properties of pluronic F127 based systems","volume":"15","author":"Lupu","year":"2023","journal-title":"Polymers"},{"issue":"7","key":"10.1016\/j.bioactmat.2025.09.030_bib13","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/1097-4628(20010214)79:7<1324::AID-APP210>3.0.CO;2-L","article-title":"Antibacterial action of chitosan and carboxymethylated chitosan","volume":"79","author":"Fei Liu","year":"2001","journal-title":"J. Appl. Polym. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib14","first-page":"164","article-title":"Chitosan based bioactive materials in tissue engineering applications-A review","volume":"5","author":"Islam","year":"2020","journal-title":"Bioact. Mater."},{"issue":"21","key":"10.1016\/j.bioactmat.2025.09.030_bib15","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.drudis.2008.07.010","article-title":"Recent approaches for the treatment of periodontitis","volume":"13","author":"Jain","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioactmat.2025.09.030_bib16","first-page":"406","article-title":"Injectable thermosensitive antibiotic-laden chitosan hydrogel for regenerative endodontics","volume":"46","author":"Reis-Prado","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.carbpol.2014.09.094","article-title":"Glycerophosphate-based chitosan thermosensitive hydrogels and their biomedical applications","volume":"117","author":"Zhou","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib18","article-title":"Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127\u2013A critical review","volume":"72","author":"Jaquilin P J","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401190","article-title":"Time-responsive activity of engineered bacteria for local sterilization and biofilm removal in periodontitis","volume":"14","author":"Bai","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib20","first-page":"200","article-title":"L-arginine modified mesoporous bioactive glass with ROS scavenging and NO release for periodontitis treatment","volume":"48","author":"Yao","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib21","first-page":"55","article-title":"cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation","volume":"48","author":"Liu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib22","first-page":"512","article-title":"NIR-responsive bio-system with sequential antibacterial and immunomodulatory effects for the treatment of periodontitis","volume":"51","author":"Qiu","year":"2025","journal-title":"Bioact. Mater."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.030_bib23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.addr.2004.01.012","article-title":"Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis","volume":"56","author":"Paulos","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.030_bib24","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L","article-title":"Selective expression of folate receptor \u03b2 and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis","volume":"42","author":"Nakashima-Matsushita","year":"1999","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.030_bib25","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1002\/jbm.b.34143","article-title":"Development of mesoporous bioactive glass nanoparticles and its use in bone tissue engineering","volume":"106","author":"Kong","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"18","key":"10.1016\/j.bioactmat.2025.09.030_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202314330","article-title":"A novel 3D-printed Bi-layer cranial-brain patch promotes brain injury repair and bone tissue regeneration","volume":"34","author":"Zhou","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.09.030_bib27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1039\/C8TB02938E","article-title":"Dose-dependent modulation effects of bioactive glass particles on macrophages and diabetic wound healing","volume":"7","author":"Xie","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioactmat.2025.09.030_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cis.2017.03.008","article-title":"Sol-gel processing of bioactive glass nanoparticles: a review","volume":"249","author":"Zheng","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biomaterials.2019.03.034","article-title":"Anti-inflammatory actions of folate-functionalized bioactive ion-releasing nanoparticles imply drug-free nanotherapy of inflamed tissues","volume":"207","author":"Kim","year":"2019","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.bioactmat.2025.09.030_bib30","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1021\/acsapm.5c01172","article-title":"A multifunctional hydrogel conduit loaded with miR-29a@Cu-MBG-NH2 for potential applications in peripheral nerve repair","volume":"7","author":"Wei","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150727","article-title":"Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2025.09.030_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.micromeso.2024.113033","article-title":"Folic acid-enhanced magnetic mesoporous bioactive glass against infections in targeted tumor therapy with tetracycline precision loading","volume":"370","author":"Wei","year":"2024","journal-title":"Microporous Mesoporous Mater."},{"issue":"23","key":"10.1016\/j.bioactmat.2025.09.030_bib33","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1039\/c2nr31775c","article-title":"Capacity of mesoporous bioactive glass nanoparticles to deliver therapeutic molecules","volume":"4","author":"El-Fiqi","year":"2012","journal-title":"Nanoscale"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.09.030_bib34","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.actbio.2009.01.040","article-title":"Thermosensitive chitosan\u2013Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration","volume":"5","author":"Park","year":"2009","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.09.030_bib35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13233-010-0405-4","article-title":"Preparation of thermosensitive gelatin-pluronic copolymer for cartilage tissue engineering","volume":"18","author":"Kim","year":"2010","journal-title":"Macromol. Res."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.carbpol.2015.10.050","article-title":"pH-sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel","volume":"137","author":"Ma","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/masy.200550624","article-title":"Thermosensitive chitosans as novel injectable biomaterials","volume":"224","author":"Chung","year":"2005","journal-title":"Macromol. Symp."},{"issue":"12","key":"10.1016\/j.bioactmat.2025.09.030_bib38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.7150\/thno.16614","article-title":"Gelatin-based hydrogel degradation and tissue interaction in vivo: insights from multimodal preclinical imaging in immunocompetent nude mice","volume":"6","author":"Tondera","year":"2016","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.09.030_bib39","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.actbio.2009.09.008","article-title":"Interaction of an ordered mesoporous bioactive glass with osteoblasts, fibroblasts and lymphocytes, demonstrating its biocompatibility as a potential bone graft material","volume":"6","author":"Alcaide","year":"2010","journal-title":"Acta Biomater."},{"issue":"15","key":"10.1016\/j.bioactmat.2025.09.030_bib40","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.biomaterials.2003.09.086","article-title":"The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production","volume":"25","author":"Valerio","year":"2004","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.bioactmat.2025.09.030_bib41","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.biomaterials.2008.04.023","article-title":"On the mechanisms of biocompatibility","volume":"29","author":"Williams","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.09.030_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111613","article-title":"Biomimetic mineralized microenvironment stiffness regulated BMSCs osteogenic differentiation through cytoskeleton mediated mechanical signaling transduction","volume":"119","author":"Chen","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"issue":"39","key":"10.1016\/j.bioactmat.2025.09.030_bib43","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/acs.jafc.3c01851","article-title":"Folic acid protects against ethanol-induced hepatic Mitophagy imbalance by ROS scavenging and attenuating the elevated hcy levels","volume":"71","author":"Zhao","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.030_bib44","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jcpe.13156","article-title":"Characterization of macrophage polarization in periodontal disease","volume":"46","author":"Garaicoa-Pazmino","year":"2019","journal-title":"J. Clin. Periodontol."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.09.030_bib45","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1002\/jcb.27948","article-title":"Synergistic effect of extracellularly supplemented osteopontin and osteocalcin on stem cell proliferation, osteogenic differentiation, and angiogenic properties","volume":"120","author":"Carvalho","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpharm.2016.11.035","article-title":"Development of hydroxyapatite nanoparticles loaded with folic acid to induce osteoblastic differentiation","volume":"516","author":"Santos","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.09.030_bib47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0757.1994.tb00019.x","article-title":"The bacteria of periodontal diseases","volume":"5","author":"Moore","year":"1994","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bioactmat.2025.09.030_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2020.109984","article-title":"Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: current state and perspectives","volume":"138","author":"Li","year":"2020","journal-title":"Eur. Polym. J."},{"issue":"11S","key":"10.1016\/j.bioactmat.2025.09.030_bib49","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1902\/jop.2005.76.11-S.2168","article-title":"Resolution of inflammation in periodontitis","volume":"76","author":"Kantarci","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib50","first-page":"440","article-title":"ROS-balancing-engineered bio-heterojunction hydrogel accelerated the infected bone regeneration based on Sono-chemo dynamic therapy","volume":"52","author":"Xu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.09.030_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actbio.2017.08.044","article-title":"Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration","volume":"66","author":"Huang","year":"2018","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.09.030_bib52","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrd.2016.39","article-title":"Resolution of inflammation: a new therapeutic frontier","volume":"15","author":"Fullerton","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.bioactmat.2025.09.030_bib53","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1902\/jop.2008.080051","article-title":"Doxycycline reduces lipopolysaccharide-induced inflammatory mediator secretion in macrophage and ex vivo human whole blood models","volume":"79","author":"Cazalis","year":"2008","journal-title":"J. Periodontol."},{"issue":"47","key":"10.1016\/j.bioactmat.2025.09.030_bib54","doi-asserted-by":"crossref","first-page":"32932","DOI":"10.1021\/acsnano.4c12519","article-title":"Turn hood into good: recycling silicon from mesoporous silica nanoparticles through magnesium modification to lower toxicity and promote tissue regeneration","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"issue":"29","key":"10.1016\/j.bioactmat.2025.09.030_bib55","doi-asserted-by":"crossref","first-page":"34378","DOI":"10.1021\/acsami.3c03446","article-title":"Selenium-doped mesoporous bioactive glass regulates macrophage metabolism and polarization by scavenging ROS and promotes bone regeneration in vivo","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:19:39Z","timestamp":1773163179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25004372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":55,"alternative-id":["S2452199X25004372"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.09.030","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.09.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}