{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:00Z","timestamp":1791356820034,"version":"4.3.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bioactmat.2025.10.010","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:49:16Z","timestamp":1761187756000},"page":"234-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A \u201ccontrolled assembly\u201d strategy for constructing Coptidis Rhizoma self-assembled nanoparticles to ameliorate inflammatory damage in Atopic dermatitis"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6391-057X","authenticated-orcid":false,"given":"Rui","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6328-8150","authenticated-orcid":false,"given":"Yuwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9477-4169","authenticated-orcid":false,"given":"Run","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.10.010_bib1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(24)02519-4","article-title":"Atopic dermatitis","volume":"405","author":"Guttman-Yassky","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jaad.2023.04.057","article-title":"Emerging treatments for itch in atopic dermatitis: a review","volume":"89","author":"Labib","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.jaci.2025.01.013","article-title":"Update on atopic dermatitis","volume":"155","author":"Meledathu","year":"2025","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jaci.2021.07.036","article-title":"Upadacitinib plus topical corticosteroids in atopic dermatitis: week 52 AD Up study results","volume":"149","author":"Silverberg","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155258","article-title":"Inhibition of inflammation by berberine: molecular mechanism and network pharmacology analysis","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106481","article-title":"Protective effect of berberine in diabetic nephropathy: a systematic review and meta-analysis revealing the mechanism of action","volume":"185","author":"Hu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib9","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.7150\/thno.30787","article-title":"Berberine in cardiovascular and metabolic diseases: from mechanisms to therapeutics","volume":"9","author":"Feng","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104722","article-title":"Berberine pharmacology and the gut microbiota: a hidden therapeutic link","volume":"155","author":"Habtemariam","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib11","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1021\/acsnano.3c01452","article-title":"Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy","volume":"17","author":"Zhou","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/1061186X.2024.2349124","article-title":"pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery","volume":"32","author":"Sun","year":"2024","journal-title":"J. Drug Target."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jconrel.2023.12.026","article-title":"Self-assembled hyaluronic acid nanoparticles for the topical treatment of inflammatory skin diseases: beyond drug carriers","volume":"366","author":"Lee","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib14","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1039\/D0FO02179B","article-title":"Role of particle aggregates in herbal medicine decoction showing they are not useless: considering Coptis chinensis decoction as an example","volume":"11","author":"Wu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108545","article-title":"NLRP3 and cancer: pathogenesis and therapeutic opportunities","volume":"251","author":"Tengesdal","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114070","article-title":"NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation","volume":"43","author":"Yu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101523","article-title":"NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy","volume":"34","author":"Zeng","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib19","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/s41467-020-16043-9","article-title":"N-GSDMD trafficking to neutrophil organelles facilitates IL-1\u03b2 release independently of plasma membrane pores and pyroptosis","volume":"11","author":"Karmakar","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib20","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1016\/j.cell.2024.08.007","article-title":"Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity","volume":"187","author":"Fontana","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib21","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2020.02.002","article-title":"Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib22","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jaci.2021.09.014","article-title":"IL-33 signaling in sensory neurons promotes dry skin itch","volume":"149","author":"Trier","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib23","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02210-2022","article-title":"Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE\/EGFR signalling complex","volume":"62","author":"Strickson","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib24","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41590-022-01255-6","article-title":"Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion","volume":"23","author":"Chen","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41590-022-01255-6","article-title":"Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion","volume":"23","author":"Chen","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib26","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1038\/s41467-023-38209-x","article-title":"Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis","volume":"14","author":"Jia","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.04.029","article-title":"Resibufogenin protects against atherosclerosis in ApoE-\/- mice through blocking NLRP3 inflammasome assembly","author":"Xiaoyang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/7502301","article-title":"Anemoside B4 protects against Acute lung injury by attenuating inflammation through blocking NLRP3 inflammasome activation and TLR4 dimerization","volume":"2020","author":"Yuan","year":"2020","journal-title":"Journal of Immunology Research"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib29","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/j.apsb.2024.03.003","article-title":"Repurposing disulfiram with CuET nanocrystals: enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases","volume":"14","author":"Xu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib30","first-page":"404","article-title":"[Preparation and intestinal absorption mechanism of herpetrione and Herpetospermum caudigerum polysaccharides based self-assembled nanoparticles]","volume":"50","author":"Deng","year":"2025","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcis.2024.03.200","article-title":"Unraveling UVB effects: catalase activity and molecular alterations in the stratum corneum","volume":"666","author":"Labecka","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib32","article-title":"Mechanism investigation of ethosomes transdermal permeation","volume":"X 1","author":"Niu","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib33","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.7150\/thno.98172","article-title":"A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4","volume":"14","author":"Yong","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156407","article-title":"Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-\u03baB signaling pathway","volume":"138","author":"Ni","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154384","article-title":"Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis","volume":"105","author":"Hu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib36","first-page":"118","article-title":"Copper\u2013luteolin nanocomplexes for mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease","volume":"46","author":"Fu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib37","doi-asserted-by":"crossref","first-page":"10677","DOI":"10.1111\/jcmm.15688","article-title":"Danshen (Salvia miltiorrhiza) restricts MD2\/TLR4\u2010MyD88 complex formation and signalling in acute myocardial infarction\u2010induced heart failure","volume":"24","author":"Wang","year":"2020","journal-title":"J Cellular Molecular Medi"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib38","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.apsb.2021.12.023","article-title":"Gentiopicroside targets PAQR3 to activate the PI3K\/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism","volume":"12","author":"Xiao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154469","article-title":"Inhibition of inflammasome activation via sphingolipid pathway in acute lung injury by Huanglian Jiedu decoction: an integrative pharmacology approach","volume":"107","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117561","article-title":"N-butanol extract of Broussonetia papyrifera (L.) L\u2032H\u00e9r. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation","volume":"180","author":"Zeng","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156764","article-title":"Qi-Gu capsule alleviates osteoporosis by inhibiting mesenchymal stem cell senescence via the HIF-1\u03b1\/AMPK axis","volume":"142","author":"Wan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jare.2024.02.008","article-title":"Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism","volume":"68","author":"Liu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib43","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.apsb.2024.12.020","article-title":"Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy","volume":"15","author":"Su","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib44","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.7150\/thno.98400","article-title":"Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation","volume":"14","author":"Wang","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154439","article-title":"Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway","volume":"106","author":"Jiang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2025.10.010_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114841","article-title":"Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats","volume":"285","author":"Chen","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib47","article-title":"Qishen Granule (QSG) inhibits monocytes released from the spleen and protect myocardial function via the TLR4-MyD88-NF-\u03baB p65 pathway in heart failure mice","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116765","article-title":"Reynoutria japonica consisted of emodin-8-\u03b2-D-glucoside ameliorates Dermatophagoides farinae extract-induced atopic dermatitis-like skin inflammation in mice by inhibiting JAK\/STAT signaling","volume":"176","author":"Shim","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioactmat.2025.10.010_bib49","article-title":"Synergistic effects of ginsenoside Rb3 and ferruginol in ischemia-induced myocardial infarction","volume":"23","author":"Chen","year":"2022","journal-title":"IJMS"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25004761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:06:23Z","timestamp":1768842383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25004761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":49,"alternative-id":["S2452199X25004761"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.10.010","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A \u201ccontrolled assembly\u201d strategy for constructing Coptidis Rhizoma self-assembled nanoparticles to ameliorate inflammatory damage in Atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}