{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:34:22Z","timestamp":1790613262638,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172398"],"award-info":[{"award-number":["82172398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2203102"],"award-info":[{"award-number":["XLYC2203102"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bioactmat.2025.11.029","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T21:51:42Z","timestamp":1764712302000},"page":"49-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Additively manufactured Tantalum-titanium alloys with optimized osteogenic and immunomodulatory properties for load-bearing orthopedic implants"],"prefix":"10.1016","volume":"58","author":[{"given":"Junlei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1778-2874","authenticated-orcid":false,"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yada","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinqiao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simiao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.11.029_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121114","article-title":"Resolution of inflammation in bone regeneration: from understandings to therapeutic applications","volume":"277","author":"Newman","year":"2021","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.bioactmat.2025.11.029_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/natrevmats.2016.40","article-title":"Design, clinical translation and immunological response of biomaterials in regenerative medicine","volume":"1","author":"Sadtler","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2025.06.020","article-title":"The Foreign Body Response to biomaterial implants is reduced by co-inhibition of TLR2 and TLR4","author":"Thompson","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2023.03.007","article-title":"Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition","volume":"161","author":"Avery","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2017.59","article-title":"Bone biomaterials and interactions with stem cells","volume":"5","author":"Gao","year":"2017","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.bioactmat.2025.11.029_bib6","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.actbio.2014.06.004","article-title":"Bone and metal: an orthopaedic perspective on osseointegration of metals","volume":"10","author":"Goriainov","year":"2014","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.029_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/(SICI)1097-4636(199810)42:1<20::AID-JBM4>3.0.CO;2-Q","article-title":"Osseointegration of surface\u2010blasted implants made of titanium alloy and cobalt\u2013chromium alloy in a rabbit intramedullary model","volume":"42","author":"Jinno","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.11.029_bib8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tibtech.2009.12.003","article-title":"Classification of osseointegrated implant surfaces: materials, chemistry and topography","volume":"28","author":"Dohan Ehrenfest","year":"2010","journal-title":"Trends Biotechnol."},{"issue":"25","key":"10.1016\/j.bioactmat.2025.11.029_bib9","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1016\/S0142-9612(03)00366-1","article-title":"Characterization of surface oxide films on titanium and adhesion of osteoblast","volume":"24","author":"Feng","year":"2003","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.029_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jbm.820280103","article-title":"The role of hydrated silica, titania, and alumina in inducing apatite on implants","volume":"28","author":"Li","year":"1994","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib11","first-page":"259","article-title":"Direct comparison of additively manufactured porous titanium and tantalum implants towards in vivo osseointegration","volume":"28","author":"Bandyopadhyay","year":"2019","journal-title":"Addit. Manuf."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.11.029_bib12","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/acsbiomaterials.8b01094","article-title":"In vitro and in vivo Study of 3D-Printed porous tantalum scaffolds for repairing bone defects","volume":"5","author":"Guo","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.colcom.2023.100716","article-title":"The effects of Ti and Ta particle surface chemistry on inflammation, osteogenesis and osteoclastogenesis in vitro and in vivo","volume":"54","author":"Huang","year":"2023","journal-title":"Colloid and Interface Science Communications"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.029_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1631\/bdm.2300321","article-title":"Research and clinical applications of selective laser melting tantalum bone plates","volume":"8","author":"Zhao","year":"2025","journal-title":"Bio-Design and Manufacturing"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae057","article-title":"Design, fabrication and clinical characterization of additively manufactured tantalum hip joint prosthesis","volume":"11","author":"Zhao","year":"2024","journal-title":"Regen. Biomater."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.11.029_bib16","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1016\/j.actbio.2010.01.046","article-title":"Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties","volume":"6","author":"Balla","year":"2010","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.11.029_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1179\/1743280414Y.0000000038","article-title":"The role of surface free energy in osteoblast\u2013biomaterial interactions","volume":"59","author":"Gentleman","year":"2014","journal-title":"Int. Mater. Rev."},{"issue":"6","key":"10.1016\/j.bioactmat.2025.11.029_bib18","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.actbio.2009.11.021","article-title":"Direct laser processing of a tantalum coating on titanium for bone replacement structures","volume":"6","author":"Balla","year":"2010","journal-title":"Acta Biomater."},{"issue":"20","key":"10.1016\/j.bioactmat.2025.11.029_bib19","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1016\/j.biomaterials.2006.02.044","article-title":"Combinatorial screen of the effect of surface energy on fibronectin-mediated osteoblast adhesion, spreading and proliferation","volume":"27","author":"Kennedy","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib20","article-title":"3D printing of a titanium-tantalum Gyroid scaffold with superb elastic admissible strain, bioactivity and in-situ bone regeneration capability","volume":"47","author":"Zhao","year":"2021","journal-title":"Addit. Manuf."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib21","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1016\/j.jmrt.2025.05.195","article-title":"Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial","volume":"36","author":"Li","year":"2025","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122756","article-title":"Precision Pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: a proof-of-concept study","volume":"313","author":"Jin","year":"2025","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bioactmat.2025.11.029_bib23","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1016\/j.msec.2013.03.027","article-title":"Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation","volume":"33","author":"Li","year":"2013","journal-title":"Mater. Sci. Eng., C"},{"issue":"6","key":"10.1016\/j.bioactmat.2025.11.029_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066263","article-title":"Porous tantalum coatings prepared by vacuum plasma spraying enhance bmscs osteogenic differentiation and bone regeneration in vitro and in vivo","volume":"8","author":"Tang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.029_bib25","article-title":"Additively manufactured ti\u2013ta\u2013cu alloys for the next-generation load-bearing implants","volume":"6","author":"Bandyopadhyay","year":"2023","journal-title":"Int. J. Extreme Manuf."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib26","first-page":"20","article-title":"3D Printing in alloy design to improve biocompatibility in metallic implants, Mater","volume":"45","author":"Mitra","year":"2021","journal-title":"Today Off."},{"issue":"1\u20132","key":"10.1016\/j.bioactmat.2025.11.029_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.msea.2003.12.011","article-title":"Effects of Ta content on Young's modulus and tensile properties of binary Ti\u2013Ta alloys for biomedical applications","volume":"371","author":"Zhou","year":"2004","journal-title":"Mater. Sci. Eng. A"},{"issue":"3","key":"10.1016\/j.bioactmat.2025.11.029_bib28","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.msec.2008.09.012","article-title":"Ti\u201325Ta alloy with the best mechanical compatibility in Ti\u2013Ta alloys for biomedical applications","volume":"29","author":"Zhou","year":"2009","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.actamat.2016.08.053","article-title":"Evaluation of the tantalum-titanium phase diagram from ab-initio calculations","volume":"120","author":"Barzilai","year":"2016","journal-title":"Acta Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2023.101072","article-title":"Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare","volume":"134","author":"Jia","year":"2023","journal-title":"Prog. Mater. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.029_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mattod.2017.07.001","article-title":"Additive manufacturing: scientific and technological challenges, market uptake and opportunities","volume":"21","author":"Tofail","year":"2018","journal-title":"Mater. Today"},{"issue":"2","key":"10.1016\/j.bioactmat.2025.11.029_bib32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jcot.2018.05.008","article-title":"Current status and challenges of Additive manufacturing in orthopaedics: an overview","volume":"10","author":"Javaid","year":"2019","journal-title":"J. Clin. Orthop. Trauma."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mattod.2021.03.020","article-title":"Directed energy deposition (DED) additive manufacturing: physical characteristics, defects, challenges and applications","volume":"49","author":"Svetlizky","year":"2021","journal-title":"Mater. Today"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.103775","article-title":"Laser powder bed fusion of titanium-tantalum alloys: compositions and designs for biomedical applications","volume":"108","author":"Huang","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib35","series-title":"Selective Laser Melting of Novel titanium-tantalum Alloy as Orthopaedic Biomaterial","author":"Sing","year":"2018"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib36","article-title":"Bioactive and fatigue-resistant Ti\u2013Ta alloy by additive manufacturing for orthopedic applications","volume":"3","author":"Liu","year":"2025","journal-title":"SMMF"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib37","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1016\/j.jmrt.2025.08.165","article-title":"Comparative study of LPBF Ta\u2013Ti alloy: microstructural evolution and deformation behavior","volume":"38","author":"Yang","year":"2025","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jallcom.2025.179682","article-title":"Development of low-modulus Ti-Ta alloys by in-situ synthesis during selective laser melting for implant applications","volume":"1021","author":"Polozov","year":"2025","journal-title":"J. Alloy. Compd."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jmapro.2025.04.041","article-title":"Unveiling the molten pool evolution and defects under different processing parameters in pure tantalum fabricated via laser powder bed fusion","volume":"144","author":"Yang","year":"2025","journal-title":"J. Manuf. Process."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.msea.2024.147088","article-title":"Process optimization, interfacial characteristics, and mechanical properties of titanium-tantalum multi-material structures fabricated via laser powder bed fusion","volume":"913","author":"Song","year":"2024","journal-title":"Mat. Sci. Eng. A-Struct."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nmat3980","article-title":"Harnessing nanotopography and integrin\u2013matrix interactions to influence stem cell fate","volume":"13","author":"Dalby","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib42","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.apsb.2022.09.020","article-title":"Roles of focal adhesion proteins in skeleton and diseases","volume":"13","author":"Chen","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib43","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1002\/jcp.29374","article-title":"Focal adhesion kinase promotes BMP2\u2010induced osteogenic differentiation of human urinary stem cells via AMPK and Wnt signaling pathways","volume":"235","author":"Sun","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112486","article-title":"The influence of zirconium content on the microstructure, mechanical properties, and biocompatibility of in-situ alloying ti-nb-ta based \u03b2 alloys processed by selective laser melting","volume":"131","author":"Kong","year":"2021","journal-title":"Mat. Sci. Eng. C-Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jallcom.2022.168099","article-title":"Powder bed fusion manufacturing of beta-type titanium alloys for biomedical implant applications: a review","volume":"936","author":"Zhang","year":"2023","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2024.101277","article-title":"Towards load-bearing biomedical titanium-based alloys: from essential requirements to future developments","volume":"144","author":"Cui","year":"2024","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.matdes.2018.04.065","article-title":"The biomimetic design and 3D printing of customized mechanical properties porous Ti6Al4V scaffold for load-bearing bone reconstruction","volume":"152","author":"Zhang","year":"2018","journal-title":"Mater. Des."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.actbio.2017.11.003","article-title":"Surface modification of biomaterials and biomedical devices using additive manufacturing","volume":"66","author":"Bose","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2019.100588","article-title":"A review of biomimetic surface functionalization for bone-integrating orthopedic implants: mechanisms, current approaches, and future directions","volume":"106","author":"Stewart","year":"2019","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/jfb6020153","article-title":"Fabrication and characterization of nanoporous niobia, and nanotubular tantala, Titania and Zirconia via anodization","volume":"6","author":"Minagar","year":"2015","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib51","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.actbio.2011.10.023","article-title":"Effects of structural properties of electrospun TiO2 nanofiber meshes on their osteogenic potential","volume":"8","author":"Wang","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib52","doi-asserted-by":"crossref","first-page":"17121","DOI":"10.1021\/acsami.0c02141","article-title":"Engineering biocompatible interfaces via combinations of oxide films and organic self-assembled monolayers","volume":"12","author":"Yuan","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.biomaterials.2004.02.050","article-title":"Quantitative methods for analysis of integrin binding and focal adhesion formation on biomaterial surfaces","volume":"26","author":"Keselowsky","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae057","article-title":"Design, fabrication and clinical characterization of additively manufactured tantalum hip joint prosthesis","volume":"11","author":"Zhao","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121604","article-title":"Immunomodulatory strategies for bone regeneration: a review from the perspective of disease types","volume":"286","author":"Su","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114039","article-title":"Tailoring the physicochemical properties of nanomaterials for immunomodulation","volume":"180","author":"Deng","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.201801106","article-title":"Current advances in immunomodulatory biomaterials for bone regeneration","volume":"8","author":"Lee","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actbio.2024.03.022","article-title":"CD4+ and CD8+ T cells reduce inflammation and promote bone healing in response to titanium implants","volume":"179","author":"Avery","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303814","article-title":"Tantalum particles promote M2 macrophage polarization and regulate local bone metabolism via macrophage\u2010derived exosomes influencing the fates of BMSCs","volume":"13","author":"Yang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41392-024-01934-w","article-title":"The JAK-STAT pathway: from structural biology to cytokine engineering","volume":"9","author":"Lv","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib61","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib62","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12951-022-01549-9","article-title":"Aligned electrospun poly(L-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-\u03baB pathways","volume":"20","author":"Xie","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib63","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib64","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1126\/science.1071924","article-title":"TNF-R1 signaling: a beautiful pathway","volume":"296","author":"Chen","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2025.11.029_bib65","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41419-020-2710-y","article-title":"Spermidine activates RIP1 deubiquitination to inhibit TNF-\u03b1-induced NF-\u03baB\/p65 signaling pathway in osteoarthritis","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib66","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ncb1086","article-title":"A physical and functional map of the human TNF-\u03b1\/NF-\u03baB signal transduction pathway","volume":"6","author":"Bouwmeester","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2025.11.029_bib67","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112725119","article-title":"Targeting ectromelia virus and TNF\/NF-\u03baB or STAT3 signaling for effective treatment of viral pneumonia","volume":"119","author":"Pandey","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25005596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X25005596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:11:09Z","timestamp":1773861069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X25005596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":67,"alternative-id":["S2452199X25005596"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.11.029","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Additively manufactured Tantalum-titanium alloys with optimized osteogenic and immunomodulatory properties for load-bearing orthopedic implants","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.11.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}