{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:43:07Z","timestamp":1784637787619,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ- MSX0747"],"award-info":[{"award-number":["CSTB2023NSCQ- MSX0747"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871368"],"award-info":[{"award-number":["81871368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bioactmat.2025.11.034","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:17:44Z","timestamp":1764767864000},"page":"107-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Machine learning-guided composite ionic liquid-based system for dual-drug delivery targeting redox homeostasis and STAT3\u2013PI3K axis in psoriasis therapy"],"prefix":"10.1016","volume":"58","author":[{"given":"Meng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2025.11.034_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113581","article-title":"Dendritic lipopeptide-based transdermal siRNA delivery systems for effective non-invasive therapy in psoriasis","volume":"381","author":"Ma","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jconrel.2025.01.037","article-title":"Smart core-shell microneedles for psoriasis therapy: in situ self-assembly of calcium ion-coordinated dexamethasone hydrogel","volume":"379","author":"He","year":"2025","journal-title":"J. Contr. Release"},{"issue":"47","key":"10.1016\/j.bioactmat.2025.11.034_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202205847","article-title":"Biologics-loaded photothermally dissolvable hyaluronic acid microneedle patch for psoriasis treatment","volume":"32","author":"Wu","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib4","first-page":"229","article-title":"Compensatory effect-based oxidative stress management microneedle for psoriasis treatment","volume":"46","author":"Wu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2023.09.004","article-title":"Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte","volume":"163","author":"Chen","year":"2023","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.11.034_bib6","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1021\/acsnano.8b02330","article-title":"Nanoparticle-assisted transcutaneous delivery of a signal transducer and activator of transcription 3-inhibiting peptide ameliorates psoriasis-like skin inflammation","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib7","article-title":"Aloperine ameliorates IMQ-induced psoriasis by attenuating Th17 differentiation and facilitating their conversion to treg","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib8","article-title":"Breaking the psoriasis pathological signaling cycle: a novel nanomedicine strategy targeting metabolism and oxidative stress","volume":"32","author":"Wu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib9","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.2147\/IJN.S371183","article-title":"Microneedle patch delivery of methotrexate-loaded albumin nanoparticles to immune cells achieves a potent antipsoriatic effect","volume":"17","author":"Wang","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.11.034_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2015.5","article-title":"Ionic liquids and their solid-state analogues as materials for energy generation and storage","volume":"1","author":"MacFarlane","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"23","key":"10.1016\/j.bioactmat.2025.11.034_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202313023","article-title":"Unexpected energy applications of ionic liquids","volume":"36","author":"Matuszek","year":"2024","journal-title":"Adv. Mater."},{"issue":"26","key":"10.1016\/j.bioactmat.2025.11.034_bib12","article-title":"Ionic liquid interface as a cell scaffold","volume":"36","author":"Ueki","year":"2024","journal-title":"Adv. Mater."},{"issue":"46","key":"10.1016\/j.bioactmat.2025.11.034_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002990","article-title":"Ionic-liquid-based safe adjuvants","volume":"32","author":"Ukidve","year":"2020","journal-title":"Adv. Mater."},{"issue":"34","key":"10.1016\/j.bioactmat.2025.11.034_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202102794","article-title":"Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions","volume":"31","author":"Lu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ensm.2021.05.026","article-title":"EMIMBF4 in ternary liquid mixtures of water, dimethyl sulfoxide and acetonitrile as \u201ctri-solvent-in-salt\u201d electrolytes for high-performance supercapacitors operating at -70 \u00b0C","volume":"40","author":"Lu","year":"2021","journal-title":"Energy Storage Mater."},{"issue":"14","key":"10.1016\/j.bioactmat.2025.11.034_bib16","doi-asserted-by":"crossref","first-page":"17080","DOI":"10.1021\/acsami.3c17091","article-title":"Curcumin-based ionic liquid hydrogel for topical transdermal delivery of curcumin to improve its therapeutic effect on the psoriasis mouse model","volume":"16","author":"Lu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.bioactmat.2025.11.034_bib17","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s13346-024-01705-8","article-title":"Choline-based ionic liquids enhance the dermal delivery of cyclosporine a for potential treatment of psoriasis","volume":"15","author":"Li","year":"2025","journal-title":"Drug Delivery Transl. Res."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib18","article-title":"Retinoid-loaded ionic liquid nanoparticles: decreased irritation, enhanced transdermal delivery and synergistic anti-wrinkle","volume":"44","author":"Xu","year":"2025","journal-title":"Appl. Mater. Today"},{"issue":"8","key":"10.1016\/j.bioactmat.2025.11.034_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202412581","article-title":"Bioactive glycyrrhizic acid ionic liquid self-assembled nanomicelles for enhanced transdermal delivery of anti-photoaging signal peptides","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb6049","article-title":"Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations","volume":"6","author":"Mandal","year":"2020","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.11.034_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.109101","article-title":"Ionic liquid-based in situ dynamically self-assembled cationic lipid nanocomplexes (CLNs) for enhanced intranasal siRNA delivery","volume":"35","author":"Zhang","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jconrel.2023.12.009","article-title":"Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid for treatment of psoriasis-like skin lesions","volume":"365","author":"Li","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbon.2025.120394","article-title":"Machine learning-assisted controllable preparation of multicolor phosphorescent carbon dots","volume":"241","author":"Yan","year":"2025","journal-title":"Carbon"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2024.08.010","article-title":"Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery","volume":"374","author":"Abdalla","year":"2024","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.034_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/acs.jmedchem.2c01339","article-title":"Deciphering nonbioavailable substructures improves the bioavailability of antidepressants by serotonin transporter","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioactmat.2025.11.034_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10654-024-01185-7","article-title":"Machine-learning approaches to predict individualized treatment effect using a randomized controlled trial","volume":"40","author":"Hamaya","year":"2025","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114772","article-title":"How can machine learning and multiscale modeling benefit ocular drug development?","volume":"196","author":"Wang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.bioactmat.2025.11.034_bib28","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1021\/acs.jcim.4c02364","article-title":"Recent advances in the modeling of ionic liquids using artificial neural networks","volume":"65","author":"Racki","year":"2025","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib29","article-title":"Liquid formulations based on ionic liquids in biomedicine","volume":"30","author":"Zhang","year":"2023","journal-title":"Mater. Today Phys."},{"issue":"42","key":"10.1016\/j.bioactmat.2025.11.034_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202304397","article-title":"Enhanced skin permeation of anti-aging peptides using bioactive ionic liquids at low concentrations","volume":"33","author":"Wang","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136027","article-title":"Ionic liquid combined with cationic liposome co-delivers microphthalmia-associated transcription factor small interfering RNA to regulate melanogenesis","volume":"281","author":"Bai","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib32","article-title":"Machine learning enabled customization of performance-oriented hydrogen storage materials for fuel cell systems","volume":"63","author":"Zhou","year":"2023","journal-title":"Energy Storage Mater."},{"issue":"35","key":"10.1016\/j.bioactmat.2025.11.034_bib33","doi-asserted-by":"crossref","first-page":"46123","DOI":"10.1021\/acsami.4c10067","article-title":"Multiple RONS-loaded plasma-activated ice microneedle patches for transdermal treatment of psoriasis","volume":"16","author":"Wu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160972","article-title":"The H2S-releasing multifunctional composite ionic liquid facilitates topical melittin delivery for psoriasis treatment through RONS scavenging and inflammation inhibition","volume":"508","author":"Zeng","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/CCID.S396173","article-title":"Natural plant extract - loganin: a hypothesis for psoriasis treatment through inhibiting oxidative stress and equilibrating immunity via regulation of macrophage polarization","volume":"16","author":"Chen","year":"2023","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.bioactmat.2025.11.034_bib36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/wcms.93","article-title":"PSI4: an open-source electronic structure program","volume":"2","author":"Turney","year":"2012","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.034_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41545-024-00429-z","article-title":"Machine learning prediction of ammonia nitrogen adsorption on biochar with model evaluation and optimization","volume":"8","author":"Liu","year":"2025","journal-title":"npj Clean Water"},{"key":"10.1016\/j.bioactmat.2025.11.034_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138911","article-title":"Unraveling the ecotoxicity of micro(nano)plastics loaded with environmental pollutants using ensemble machine learning","volume":"495","author":"Zhang","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.bioactmat.2025.11.034_bib39","unstructured":"M.J. Frisch, G.W. Trucks, H.B. Schlegel, et al., Gaussian, Inc., Wallingford CT (2013)."},{"issue":"5","key":"10.1016\/j.bioactmat.2025.11.034_bib40","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.034_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"W1","key":"10.1016\/j.bioactmat.2025.11.034_bib42","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gku293","article-title":"SwissTargetPrediction: a web server for target prediction of bioactive small molecules","volume":"42","author":"Gfeller","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.bioactmat.2025.11.034_bib43","doi-asserted-by":"crossref","first-page":"D401","DOI":"10.1093\/nar\/gkt1207","article-title":"STITCH 4: integration of protein-chemical interactions with user data","volume":"42","author":"Kuhn","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2025.11.034_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10822-010-9395-8","article-title":"Computer-aided drug design platform using PyMOL","volume":"25","author":"Lill","year":"2011","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"16","key":"10.1016\/j.bioactmat.2025.11.034_bib45","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.bioactmat.2025.11.034_bib46","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500564X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2500564X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:12:06Z","timestamp":1778890326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X2500564X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":46,"alternative-id":["S2452199X2500564X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.11.034","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning-guided composite ionic liquid-based system for dual-drug delivery targeting redox homeostasis and STAT3\u2013PI3K axis in psoriasis therapy","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2025.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}