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Lett."},{"key":"10.1016\/j.bioactmat.2025.12.019_bib114","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202300357","article-title":"Bioinspired bone seed 3D-Printed scaffold via trapping black phosphorus nanosheet for bone regeneration","volume":"4","author":"Cai","year":"2024","journal-title":"Small Sci."},{"key":"10.1016\/j.bioactmat.2025.12.019_bib115","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202304824","article-title":"Black phosphorus accelerates bone regeneration based on immunoregulation","volume":"11","author":"Qiu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2025.12.019_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.134935","article-title":"Near-infrared-activated nanohybrid coating with black phosphorus\/zinc oxide for efficient biofilm eradication against implant-associated infections","volume":"435","author":"Fang","year":"2022","journal-title":"Chem. Eng. 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Nano Mater."},{"key":"10.1016\/j.bioactmat.2025.12.019_bib297","doi-asserted-by":"crossref","first-page":"17323","DOI":"10.1021\/acsami.4c01956","article-title":"Chronological-programmed black phosphorus hydrogel for responsive modulation of the pathological microenvironment in myocardial infarction","volume":"16","author":"Qiu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2025.12.019_bib298","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12951-024-02685-0","article-title":"Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair","volume":"22","author":"Zhang","year":"2024","journal-title":"J. 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