{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:19:09Z","timestamp":1792091949407,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202302AA310039"],"award-info":[{"award-number":["202302AA310039"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125022"],"award-info":[{"award-number":["82125022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572679"],"award-info":[{"award-number":["82572679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202633"],"award-info":[{"award-number":["82202633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0551300"],"award-info":[{"award-number":["2025ZD0551300"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0551301"],"award-info":[{"award-number":["2025ZD0551301"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioactmat.2026.02.041","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:52:13Z","timestamp":1772509933000},"page":"879-899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques"],"prefix":"10.1016","volume":"61","author":[{"given":"Heng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danlei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-9027","authenticated-orcid":false,"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41569-024-01037-7","article-title":"Efferocytosis in atherosclerosis","volume":"21","author":"Adkar","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.02.041_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41569-023-00979-8","article-title":"Atherosclerotic plaque stabilization and regression: a review of clinical evidence","volume":"21","author":"Sarraju","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.02.041_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.121.054285","article-title":"AtheroSpectrum reveals novel macrophage foam cell gene signatures associated with atherosclerotic cardiovascular disease risk","volume":"145","author":"Li","year":"2022","journal-title":"Circulation"},{"issue":"663","key":"10.1016\/j.bioactmat.2026.02.041_bib4","doi-asserted-by":"crossref","first-page":"eadd2376","DOI":"10.1126\/scitranslmed.add2376","article-title":"Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis","volume":"14","author":"Lin","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.02.041_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41569-022-00769-8","article-title":"Evolving concepts of the vulnerable atherosclerotic plaque and the vulnerable patient: implications for patient care and future research","volume":"20","author":"Gaba","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.02.041_bib6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41569-023-00885-z","article-title":"A role for lipophagy in atherosclerosis","volume":"20","author":"Laval","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib7","doi-asserted-by":"crossref","first-page":"8273","DOI":"10.1038\/s41467-024-52621-x","article-title":"Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in Male mice","volume":"15","author":"Tan","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/15548627.2017.1327942","article-title":"Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux","volume":"14","author":"Jeong","year":"2018","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.02.041_bib9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41556-023-01178-w","article-title":"The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets","volume":"25","author":"Chung","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.02.041_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jare.2023.11.004","article-title":"ASIC1\/RIP1 accelerates atherosclerosis via disrupting lipophagy","volume":"63","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.02.041_bib11","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1080\/15548627.2020.1741202","article-title":"The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis","volume":"17","author":"Pi","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.02.041_bib12","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/CIRCRESAHA.121.320047","article-title":"Autophagy is differentially regulated in Leukocyte and nonleukocyte foam cells during atherosclerosis","volume":"130","author":"Robichaud","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioactmat.2026.02.041_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155617","article-title":"Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1\/PI3K\/AKT signaling pathway","volume":"129","author":"Lin","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib14","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1080\/15548627.2021.1886839","article-title":"Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells","volume":"17","author":"Robichaud","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.416","article-title":"Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.02.041_bib16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41569-022-00676-y","article-title":"Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia","volume":"19","author":"Bor\u00e9n","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"34","key":"10.1016\/j.bioactmat.2026.02.041_bib17","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1093\/eurheartj\/ehab841","article-title":"The dawn of a new era of targeted lipid-lowering therapies","volume":"43","author":"Tokg\u00f6zo\u011flu","year":"2022","journal-title":"Eur. Heart J."},{"issue":"8033","key":"10.1016\/j.bioactmat.2026.02.041_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-024-07993-x","article-title":"Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis","volume":"634","author":"Takaoka","year":"2024","journal-title":"Nature"},{"issue":"10384","key":"10.1016\/j.bioactmat.2026.02.041_bib19","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0140-6736(23)00215-5","article-title":"Inflammation and cholesterol as predictors of cardiovascular events among patients receiving Statin therapy: a collaborative analysis of three randomised trials","volume":"401","author":"Ridker","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCULATIONAHA.118.034645","article-title":"Residual inflammatory risk on treatment with PCSK9 inhibition and Statin therapy","volume":"138","author":"Pradhan","year":"2018","journal-title":"Circulation"},{"issue":"7800","key":"10.1016\/j.bioactmat.2026.02.041_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-020-2027-0","article-title":"Virtual discovery of melatonin receptor ligands to modulate circadian rhythms","volume":"579","author":"Stein","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12449","article-title":"Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis","volume":"64","author":"Zhang","year":"2018","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.02.041_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.tem.2019.11.011","article-title":"Melatonin effects on glucose metabolism: time to unlock the controversy","volume":"31","author":"Garaulet","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.02.041_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12988","article-title":"Melatonin ameliorates atherosclerotic plaque vulnerability by regulating PPAR\u03b4-Associated smooth muscle cell phenotypic switching","volume":"76","author":"Chen","year":"2024","journal-title":"J. Pineal Res."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S1474-4422(23)00363-0","article-title":"Sleep, melatonin, and cardiovascular disease","volume":"22","author":"Covassin","year":"2023","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12581","article-title":"Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor ROR\u03b1-dependent manner","volume":"67","author":"Ding","year":"2019","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib27","article-title":"Melatonin ameliorates ox-LDL-induced lipid accumulation and enhances ABCA1 expression in VSMCs via inhibition of the TRPV1-Ca(2+)-calpain signaling pathway","volume":"1871","author":"Tang","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1039\/C6CS00532B","article-title":"Mesoporous carbon nitrides: synthesis, functionalization, and applications","volume":"46","author":"Lakhi","year":"2017","journal-title":"Chem. Soc. Rev."},{"issue":"38","key":"10.1016\/j.bioactmat.2026.02.041_bib29","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1002\/adma.201602197","article-title":"Metal-Organic-Framework-Derived mesoporous carbon nanospheres containing porphyrin-like metal centers for conformal phototherapy","volume":"28","author":"Wang","year":"2016","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.02.041_bib30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7150\/thno.21927","article-title":"Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2026.02.041_bib31","article-title":"Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib32","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1021\/acsnano.6b07842","article-title":"Molecular imaging of vulnerable atherosclerotic plaques in vivo with osteopontin-specific upconversion nanoprobes","volume":"11","author":"Qiao","year":"2017","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.02.041_bib33","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/CIRCRESAHA.123.322590","article-title":"Proteomic Atlas of atherosclerosis: the contribution of Proteoglycans to sex differences, plaque phenotypes, and outcomes","volume":"133","author":"Theofilatos","year":"2023","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.02.041_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201702793","article-title":"Recent advances in managing atherosclerosis via nanomedicine","volume":"14","author":"Chan","year":"2018","journal-title":"Small"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib35","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/acsnano.0c00245","article-title":"Nanotherapeutic shots through the heart of plaque","volume":"14","author":"Kanthi","year":"2020","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.02.041_bib36","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202403104RR","article-title":"Pro-atherosclerotic effects of osteopontin is contributed to promoting foam cell formation derived from VSMCs by inhibiting cholesterol efflux","volume":"39","author":"Liu","year":"2025","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib37","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1038\/s41467-022-30490-6","article-title":"Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis","volume":"13","author":"Me\u00e7e","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.02.041_bib38","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/s41556-020-0566-0","article-title":"The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells","volume":"22","author":"Miceli","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.02.041_bib39","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s42255-024-01047-2","article-title":"Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance \u03b2-oxidation and tumor cell proliferation","volume":"6","author":"Meng","year":"2024","journal-title":"Nat. Metab."},{"issue":"7983","key":"10.1016\/j.bioactmat.2026.02.041_bib40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-023-06585-5","article-title":"Inhibition of fatty acid oxidation enables heart regeneration in adult mice","volume":"622","author":"Li","year":"2023","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.02.041_bib41","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal \u03b2-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat. Metab."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.02.041_bib42","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41569-021-00538-z","article-title":"High-density lipoproteins, reverse cholesterol transport and atherogenesis","volume":"18","author":"Pownall","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.02.041_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41569-021-00613-5","article-title":"Apolipoproteins in vascular biology and atherosclerotic disease","volume":"19","author":"Mehta","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.02.041_bib44","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jhep.2023.08.023","article-title":"Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux","volume":"79","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.02.041_bib45","first-page":"3900","article-title":"Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice","volume":"117","author":"Yvan-Charvet","year":"2007","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.02.041_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/jpi.12259","article-title":"Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes","volume":"59","author":"Kato","year":"2015","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-079X.2011.00911.x","article-title":"Melatonin promotes differentiation of 3T3-L1 fibroblasts","volume":"52","author":"Gonz\u00e1lez","year":"2012","journal-title":"J. Pineal Res."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.02.041_bib48","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2015.07.039","article-title":"CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt\/mTOR\/SREBP1c and P38\/PPAR\u03b1 pathways","volume":"63","author":"Li","year":"2015","journal-title":"J. Hepatol."},{"issue":"31","key":"10.1016\/j.bioactmat.2026.02.041_bib49","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/eurheartj\/ehaa227","article-title":"Vulnerable plaques and patients: State-Of-The-Art","volume":"41","author":"Tomaniak","year":"2020","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib50","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jacc.2021.01.038","article-title":"Atherosclerotic carotid plaque composition and incident stroke and coronary events","volume":"77","author":"Bos","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib51","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/eurjpc\/zwae281","article-title":"Global burden of cardiovascular diseases: projections from 2025 to 2050","volume":"32","author":"Chong","year":"2025","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.02.041_bib52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/CIRCULATIONAHA.123.066213","article-title":"Inflammation and cholesterol as predictors of cardiovascular events among 13 970 contemporary high-risk patients with Statin intolerance","volume":"149","author":"Ridker","year":"2024","journal-title":"Circulation"},{"issue":"32","key":"10.1016\/j.bioactmat.2026.02.041_bib53","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1093\/eurheartj\/ehaf196","article-title":"Residual cholesterol and inflammatory risk in statin-treated patients undergoing percutaneous coronary intervention","volume":"46","author":"Bay","year":"2025","journal-title":"Eur. Heart J."},{"issue":"15","key":"10.1016\/j.bioactmat.2026.02.041_bib54","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.122.061620","article-title":"Long-term evolocumab in patients with established atherosclerotic cardiovascular disease","volume":"146","author":"O'Donoghue","year":"2022","journal-title":"Circulation"},{"issue":"10355","key":"10.1016\/j.bioactmat.2026.02.041_bib55","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0140-6736(22)01545-8","article-title":"Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials","volume":"400","year":"2022","journal-title":"Lancet"},{"issue":"23 Pt A","key":"10.1016\/j.bioactmat.2026.02.041_bib56","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1016\/j.jacc.2018.09.052","article-title":"Medical therapy for long-term prevention of atherothrombosis following an acute coronary syndrome: JACC state-of-the-art review","volume":"72","author":"Gallone","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.02.041_bib57","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1039\/D2NH00070A","article-title":"Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine","volume":"7","author":"Fan","year":"2022","journal-title":"Nanoscale Horiz."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.02.041_bib58","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s00330-017-5209-x","article-title":"Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring","volume":"28","author":"Lv","year":"2018","journal-title":"Eur. Radiol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.02.041_bib59","article-title":"Ischemic area-targeting and self-monitoring nanoprobes ameliorate myocardial ischemia\/reperfusion injury by scavenging ROS and counteracting cardiac inflammation","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci. (Weinh.)"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:14:19Z","timestamp":1780301659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26001027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":59,"alternative-id":["S2452199X26001027"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.02.041","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}