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A."},{"key":"10.1016\/j.bioactmat.2026.02.060_bib106","doi-asserted-by":"crossref","first-page":"924","DOI":"10.24272\/j.issn.2095-8137.2024.034","article-title":"Rotating magnetic field inhibits A\u03b2 protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice","volume":"45","author":"Guo","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.bioactmat.2026.02.060_bib107","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jconrel.2021.06.003","article-title":"Magnetic-responsive hydrogels: from strategic design to biomedical applications","volume":"335","author":"Li","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.02.060_bib108","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pbiomolbio.2022.11.006","article-title":"Evidence of the static magnetic field effects on bone-related diseases and bone cells","volume":"177","author":"Yang","year":"2023","journal-title":"Prog. Biophys. 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