{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:20:33Z","timestamp":1793661633146,"version":"4.5.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2019kfyXMBZ065"],"award-info":[{"award-number":["2019kfyXMBZ065"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2042023kfyq05"],"award-info":[{"award-number":["2042023kfyq05"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173105"],"award-info":[{"award-number":["52173105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473101"],"award-info":[{"award-number":["52473101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070934"],"award-info":[{"award-number":["82070934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171025"],"award-info":[{"award-number":["82171025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioactmat.2026.03.026","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:03:56Z","timestamp":1774256636000},"page":"569-586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Engineering multifunctional chitosan-based hydrogels for integrated antimicrobial therapy and endogenous stem cell-driven tissue repair in infectious keratitis"],"prefix":"10.1016","volume":"62","author":[{"given":"Wen","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanpeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9112-0248","authenticated-orcid":false,"given":"Mingchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-691X","authenticated-orcid":false,"given":"Huatao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2026.03.026_bib1","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Loss expert group of the global burden of disease, global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib2","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.ophtha.2015.06.007","article-title":"Multidrug-resistant Pseudomonas aeruginosa keratitis: risk factors, clinical characteristics, and outcomes","volume":"122","author":"Vazirani","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jconrel.2020.09.014","article-title":"Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis","volume":"327","author":"Han","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chom.2019.06.002","article-title":"Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms","volume":"26","author":"Yan","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.survophthal.2018.12.003","article-title":"The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance","volume":"64","author":"Ung","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib6","article-title":"Bioadhesives with antimicrobial properties","volume":"35","author":"Nakipoglu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cis.2017.05.012","article-title":"Colloid particle formulations for antimicrobial applications","volume":"249","author":"Halbus","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121394","article-title":"Chitosan scaffolds: expanding Horizons in biomedical applications","volume":"323","author":"Gholap","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117108","article-title":"Chitosan-based nanoparticles against bacterial infections","volume":"251","author":"Rashki","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121344","article-title":"A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing","volume":"322","author":"Liu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202006335","article-title":"Hydrogels as emerging materials for cornea wound healing","volume":"17","author":"Khosravimelal","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib12","article-title":"Concise review: bioengineering of limbal stem cell niche","volume":"10","author":"Soleimani","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100956","article-title":"Human limbal epithelial stem cell regulation, bioengineering and function","volume":"85","author":"Bonnet","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/cmi.2017.107","article-title":"The unique structural and functional features of CXCL12","volume":"15","author":"Janssens","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib15","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2005-04-1417","article-title":"How do stem cells find their way home?","volume":"106","author":"Lapidot","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib16","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/stem.743","article-title":"Limbal epithelial stem\/progenitor cells attract stromal niche cells by SDF-1\/CXCR4 signaling to prevent differentiation","volume":"29","author":"Xie","year":"2011","journal-title":"Stem Cell."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/Beta-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib18","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1038\/s41467-025-59972-z","article-title":"CXCR4(+) mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib19","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.micron.2012.02.014","article-title":"Compliance profile of the human cornea as measured by atomic force microscopy","volume":"43","author":"Last","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140052","article-title":"Enhanced antibacterial and antibiofilm activities of quaternized ultra-highly deacetylated chitosan against multidrug-resistant bacteria","volume":"298","author":"Lu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/acsami.5b07843","article-title":"Facet-controlling agents free synthesis of hematite crystals with high-index planes: excellent photodegradation performance and mechanism insight","volume":"8","author":"Ding","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib22","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.ijbiomac.2022.11.184","article-title":"Injectable wound dressing based on carboxymethyl chitosan triple-network hydrogel for effective wound antibacterial and hemostasis","volume":"225","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202403214","article-title":"Entanglement added to cross-linked chains enables tough gelatin-based hydrogel for Zn metal batteries","volume":"36","author":"Kumankuma-Sarpong","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121144","article-title":"Chitin-based hydrogel loaded with bFGF and SDF-1 for inducing endogenous mesenchymal stem cells homing to improve stress urinary incontinence","volume":"319","author":"Yang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202113383","article-title":"A light-curable and tunable extracellular matrix hydrogel for in situ suture-free corneal repair","volume":"32","author":"Yazdanpanah","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107369","article-title":"Investigating retention time and fluid dynamics of the vehicles in non-invasive topical ocular drug delivery systems","volume":"216","author":"Ghaemmaghamian","year":"2026","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202415353","article-title":"Eye-drop nano-formulation of catalase self-assembled with thiolated chitosan for effective treatment of dry eye disease","volume":"37","author":"Shao","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.7150\/thno.103266","article-title":"Advances in adhesive hydrogels applied for ophthalmology: an overview focused on the treatment","volume":"15","author":"Yan","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1517\/14712598.2011.546338","article-title":"Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine","volume":"11","author":"Lau","year":"2011","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.actbio.2017.08.001","article-title":"Thermosensitive chitosan-based hydrogels releasing stromal cell derived factor-1 alpha recruit MSC for corneal epithelium regeneration","volume":"61","author":"Tang","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202270056","article-title":"Quaternized polysaccharide-based cationic micelles as a macromolecular approach to eradicate multidrug-resistant bacterial infections while mitigating antimicrobial resistance","volume":"18","author":"Xie","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.33","article-title":"Methicillin-resistant Staphylococcus aureus","volume":"4","author":"Lee","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134321","article-title":"Factors influencing the antimicrobial mechanism of chitosan action and its derivatives: a review","volume":"277","author":"Nasaj","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib34","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.3390\/ijms14011854","article-title":"Quaternized chitosan as an antimicrobial agent: antimicrobial activity, mechanism of action and biomedical applications in orthopedics","volume":"14","author":"Tan","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib35","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/acsnano.4c12195","article-title":"Drug in drug: quorum sensing inhibitor in star-shaped antibacterial polypeptides for inhibiting and eradicating corneal bacterial biofilms","volume":"19","author":"Lu","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112450","article-title":"Corneal infection models: tools to investigate the role of biofilms in bacterial keratitis","volume":"9","author":"Urwin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0039-6257(87)90103-2","article-title":"Tobramycin in ophthalmology","volume":"32","author":"Wilhelmus","year":"1987","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of microbial biofilms","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228671","article-title":"Pseudomonas aeruginosa biofilms","volume":"21","author":"Thi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110627","article-title":"Chitosan and their derivatives: antibiofilm drugs against pathogenic bacteria","volume":"185","author":"Khan","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib41","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41579-021-00585-w","article-title":"Antibiofilm activity of host defence peptides: complexity provides opportunities","volume":"19","author":"Hancock","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib42","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrmicro.2017.99","article-title":"Targeting microbial biofilms: current and prospective therapeutic strategies","volume":"15","author":"Koo","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11030300","article-title":"Pathogenesis of the Pseudomonas aeruginosa biofilm: a review","volume":"11","author":"Tuon","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101031","article-title":"Bacterial keratitis: identifying the areas of clinical uncertainty","volume":"89","author":"Tuft","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib45","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35101627","article-title":"Gene expression in Pseudomonas aeruginosa biofilms","volume":"413","author":"Whiteley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.01.057","article-title":"Advances and limitations of drug delivery systems formulated as eye drops","volume":"321","author":"Jumelle","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib47","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1111\/bph.14024","article-title":"Principles of pharmacology in the eye","volume":"174","author":"Awwad","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101809","article-title":"CXCL12\/CXCR4: an amazing challenge and opportunity in the fight against fibrosis","volume":"83","author":"Wu","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101275","article-title":"Cell therapy in the cornea: the emerging role of microenvironment","volume":"102","author":"Suanno","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101011","article-title":"Regenerative therapy for the cornea","volume":"87","author":"Kumar","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jtos.2015.12.006","article-title":"Stem cells in the limbal stroma","volume":"14","author":"Funderburgh","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib52","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/all.15174","article-title":"Epithelial barrier dysfunction in ocular allergy","volume":"77","author":"Singh","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib53","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1350-9462(01)00007-6","article-title":"Characteristics of the human ocular surface epithelium","volume":"20","author":"Kinoshita","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib54","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.preteyeres.2015.07.003","article-title":"Ocular surface reconstruction using stem cell and tissue engineering","volume":"51","author":"Nakamura","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib55","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1021\/acs.chemrev.5c00182","article-title":"Therapeutic hydrogels: properties and biomedical applications","volume":"125","author":"Dong","year":"2025","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jtos.2017.10.006","article-title":"The impact of diabetes on corneal nerve morphology and ocular surface integrity","volume":"16","author":"Markoulli","year":"2018","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib58","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cell.2008.01.041","article-title":"Stem cell trafficking in tissue development, growth, and disease","volume":"132","author":"Laird","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib59","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3389\/fimmu.2020.02109","article-title":"The chemokine receptor CXCR4 in cell proliferation and tissue regeneration","volume":"11","author":"Bianchi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib60","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/cvr\/cvr053","article-title":"VEGF\/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart","volume":"91","author":"Tang","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib61","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib62","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1182\/blood.V76.12.2606.2606","article-title":"Time-dependent alterations in the deformability of human neutrophils in response to chemotactic activation","volume":"76","author":"Frank","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib63","article-title":"Nanofibrous guidance conduits with multiple gradient cues for spinal cord repair","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib64","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.addr.2017.07.011","article-title":"Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration","volume":"120","author":"Pacelli","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib65","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-biophys-110821-071250","article-title":"Orientation of cell polarity by chemical gradients","volume":"51","author":"Ghose","year":"2022","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib66","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tins.2012.06.003","article-title":"Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair","volume":"35","author":"Li","year":"2012","journal-title":"Trends Neurosci."},{"issue":"Pt 18","key":"10.1016\/j.bioactmat.2026.03.026_bib67","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1242\/jcs.111.18.2819","article-title":"Differential regulation of CXCR4 and CCR5 endocytosis","volume":"111","author":"Signoret","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib68","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1136\/jnnp.74.11.1476","article-title":"Human cellular inflammation in the pathology of acute cerebral ischaemia","volume":"74","author":"Price","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib69","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.7150\/ijbs.82317","article-title":"CXCL12-CXCR4\/CXCR7 axis in cancer: from mechanisms to clinical applications","volume":"19","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mam.2013.08.001","article-title":"Altered gene products involved in the malignant reprogramming of cancer stem\/progenitor cells and multitargeted therapies","volume":"39","author":"Mimeault","year":"2014","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib71","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.10-6486","article-title":"Wnt\/beta-catenin signaling regulates proliferation of human cornea epithelial stem\/progenitor cells","volume":"52","author":"Nakatsu","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib72","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1442-9071.2006.01147.x","article-title":"Limbal stem cells: the search for a marker","volume":"34","author":"Chee","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib73","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5966\/sctm.2013-0137","article-title":"Concise review: identifying limbal stem cells: classical concepts and new challenges","volume":"3","author":"Joe","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib74","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/pcn.12242","article-title":"Psychopharmacology of atypical antipsychotic drugs: from the receptor binding profile to neuroprotection and neurogenesis","volume":"69","author":"Kusumi","year":"2015","journal-title":"Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib75","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib76","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib77","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"11","author":"Hur","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib78","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801100","article-title":"Green fabrication of amphiphilic quaternized beta-chitin derivatives with excellent biocompatibility and antibacterial activities for wound healing","author":"Xu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfa.2004.04.051","article-title":"Effect of molecular weight and degree of substitution of quaternary chitosan on its adsorption and flocculation properties for potential retention-aids in alkaline papermaking","volume":"242","author":"Li","year":"2004","journal-title":"Colloids Surf."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib80","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1021\/acs.molpharmaceut.6b01104","article-title":"Biocompatible injectable hydrogel with potent wound healing and antibacterial properties","volume":"14","author":"Hoque","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib81","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3181\/00379727-172-41592","article-title":"Dominant susceptibility effect on the murine corneal response to Pseudomonas aeruginosa","volume":"172","author":"Beisel","year":"1983","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib82","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1097\/ICO.0000000000001050","article-title":"Effect of 1- and 6-Hour-Delayed corneal collagen cross-linking on corneal healing in a rabbit alkali-burn model: clinical and histological observations","volume":"35","author":"Karti","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.bioactmat.2026.03.026_bib83","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1167\/iovs.11-8441","article-title":"Isolation and expansion of human limbal stromal niche cells","volume":"53","author":"Xie","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bioactmat.2026.03.026_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108767","article-title":"Comparison of different methods to isolate mouse limbal epithelial cells","volume":"212","author":"Song","year":"2021","journal-title":"Exp. Eye Res."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:52:21Z","timestamp":1780991541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26001568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":84,"alternative-id":["S2452199X26001568"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.03.026","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering multifunctional chitosan-based hydrogels for integrated antimicrobial therapy and endogenous stem cell-driven tissue repair in infectious keratitis","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}