{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:51:16Z","timestamp":1792234276758,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20250619"],"award-info":[{"award-number":["GZC20250619"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025MD774175"],"award-info":[{"award-number":["2025MD774175"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["CYYY-BSYJSKYCXXM202446"],"award-info":[{"award-number":["CYYY-BSYJSKYCXXM202446"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572756"],"award-info":[{"award-number":["82572756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2411085"],"award-info":[{"award-number":["W2411085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioactmat.2026.03.042","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:04:12Z","timestamp":1775034252000},"page":"798-813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Reconstituted phospholipid membrane-coated Fe2+-Mg2+ displacement nanoparticles block ferroptotic trigger waves"],"prefix":"10.1016","volume":"62","author":[{"given":"Runhan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoji","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8021","key":"10.1016\/j.bioactmat.2026.03.042_bib1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-024-07623-6","article-title":"Emergence of large-scale cell death through ferroptotic trigger waves","volume":"631","author":"Co","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib2","first-page":"273","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism","volume":"171","author":"Stockwell","year":"2017","journal-title":"Redox Biol. Disease, Cell"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.03.042_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7784","key":"10.1016\/j.bioactmat.2026.03.042_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.03.042_bib5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.03.042_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.01.030","article-title":"Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis","volume":"187","author":"Qiu","year":"2024","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.03.042_bib7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib8","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-24-4207","article-title":"Lipid composition alters ferroptosis sensitivity","author":"Park","year":"2025","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.03.042_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2023.03.013","article-title":"SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma","volume":"201","author":"Li","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.03.042_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2020.06.019","article-title":"Dietary lipids induce ferroptosis in Caenorhabditiselegans and human cancer cells","volume":"54","author":"Perez","year":"2020","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.03.042_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202110480","article-title":"Multistability maintains redox homeostasis in human cells","volume":"17","author":"Huang","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217697","article-title":"Glutathione metabolism in ferroptosis and cancer therapy","volume":"621","author":"Xue","year":"2025","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13287-024-03644-0","article-title":"Glutathione supplementation improves fat graft survival by inhibiting ferroptosis via the SLC7A11\/GPX4 axis","volume":"15","author":"Li","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.scib.2022.12.030","article-title":"Topology regulation of nanomedicine for autophagy-augmented ferroptosis and cancer immunotherapy","volume":"68","author":"Hu","year":"2023","journal-title":"Sci. Bull."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.03.042_bib17","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","volume":"26","author":"Dai","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12943-024-01999-9","article-title":"Ferroptotic therapy in cancer: benefits, side effects, and risks","volume":"23","author":"Diao","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioactmat.2026.03.042_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123135","article-title":"Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium","volume":"319","author":"Yu","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12951-022-01405-w","article-title":"Metal ions\/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.03.042_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7603\/s40681-016-0020-6","article-title":"Magnesium deficiency and oxidative stress: an update","volume":"6","author":"Zheltova","year":"2016","journal-title":"Biomedicine"},{"issue":"6724","key":"10.1016\/j.bioactmat.2026.03.042_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.adn7030","article-title":"Ferroptosis-disease perils and therapeutic promise","volume":"386","author":"Brown","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2026.03.042_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101481","article-title":"Iron homeostasis in arthropathies: from pathogenesis to therapeutic potential","volume":"72","author":"Sun","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00198-023-06937-x","article-title":"The influence of iron on bone metabolism disorders","volume":"35","author":"Zhang","year":"2023","journal-title":"Osteoporos. Int."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.03.042_bib25","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.03.042_bib26","article-title":"Ferroptosis in osteocytes as a target for protection against postmenopausal osteoporosis","volume":"11","author":"Jiang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s13018-021-02663-4","article-title":"Iron accumulation deteriorated bone loss in estrogen-deficient rats","volume":"16","author":"Liu","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib28","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s12011-018-1388-9","article-title":"Iron accumulation leads to bone loss by inducing mesenchymal stem cell apoptosis through the activation of Caspase3","volume":"187","author":"Yuan","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib29","article-title":"BMP9 alleviates iron accumulation-induced osteoporosis via the USP10\/FOXO1\/GPX4 axis","author":"Huang","year":"2025","journal-title":"J. Adv. Res."},{"issue":"43","key":"10.1016\/j.bioactmat.2026.03.042_bib30","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.7150\/ijbs.61950","article-title":"Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells","volume":"17","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.03.042_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.110674","article-title":"A Pt@ ZIF-8\/ALN-ac\/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis","volume":"36","author":"Li","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib34","article-title":"MOFs-based nanomaterials for bone repair and regeneration: current status and future perspectives","author":"Huang","year":"2025","journal-title":"Chin. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/mba2.70016","article-title":"Bioengineered nanozymes for orthopedic degenerative diseases: from catalytic mechanisms to multimodal therapy","volume":"4","author":"Peng","year":"2025","journal-title":"MedComm\u2013Biomater. Applicat."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.actbio.2024.04.037","article-title":"Metal\u2013organic frameworks as candidates for tumor sonodynamic therapy: designable structures for targeted multifunctional transformation","volume":"181","author":"Yang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib37","doi-asserted-by":"crossref","first-page":"100037","DOI":"10.1016\/j.preme.2025.100037","article-title":"Surface engineering of nanoparticles for precision medicine","volume":"2","author":"Zheng","year":"2025","journal-title":"precision medicine and engineering, Precis. Med. Eng."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib38","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1038\/s41467-022-35503-y","article-title":"Magnesium hexacyanoferrate nanocatalysts attenuate chemodrug-induced cardiotoxicity through an anti-apoptosis mechanism driven by modulation of ferrous iron","volume":"13","author":"Huo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.148246","article-title":"Ultrasmall Ce-based metal\u2013organic frameworks nanozyme with hydrolytic activity for boosting antibiofilm therapy","volume":"480","author":"Yuan","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118263","article-title":"Bio-based adsorption foam composed of MOF and polyethyleneimine-modified cellulose for selective anionic dye removal","volume":"248","author":"Yuan","year":"2024","journal-title":"Environ. Res."},{"issue":"49","key":"10.1016\/j.bioactmat.2026.03.042_bib41","doi-asserted-by":"crossref","first-page":"54587","DOI":"10.1021\/acsami.2c17358","article-title":"Design of monovalent cerium-based metal organic frameworks as bioinspired superoxide dismutase mimics for ionizing radiation protection","volume":"14","author":"Liu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.03.042_bib42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.03.042_bib43","article-title":"Engineering ultra\u2010small cerium\u2010based metal\u2013organic frameworks nanozymes for efficient antioxidative treatment of dry eye disease","volume":"34","author":"Chen","year":"2024","journal-title":"Adv. Funct. Mater. 6\/2024), Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202414302","article-title":"Simultaneous tailoring of chemical composition and morphology configuration in metal hexacyanoferrate for ultrafast and durable sodium\u2010ion storage","volume":"64","author":"Cheng","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"issue":"30","key":"10.1016\/j.bioactmat.2026.03.042_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202402745","article-title":"Calcium hexacyanoferrate nanozyme enhances plant stress resistance by oxidative stress alleviation and heavy metal removal","volume":"36","author":"Shen","year":"2024","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.03.042_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm.2017.138","article-title":"Understanding the diversity of membrane lipid composition","volume":"19","author":"Harayama","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7823","key":"10.1016\/j.bioactmat.2026.03.042_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.03.042_bib48","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","article-title":"Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification","volume":"102","author":"Ye","year":"2022","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.03.042_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41368-024-00303-1","article-title":"METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs","volume":"16","author":"Jin","year":"2024","journal-title":"Int. J. Oral Sci."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.03.042_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12422","article-title":"Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence","volume":"63","author":"Yang","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib52","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2021.02.025","article-title":"Oxidative stress induces downregulation of TP53INP2 and suppresses osteogenic differentiation of BMSCs during osteoporosis through the autophagy degradation pathway","volume":"166","author":"Yang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"22","key":"10.1016\/j.bioactmat.2026.03.042_bib53","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1111\/jcmm.16974","article-title":"GPX7 facilitates BMSCs osteoblastogenesis via ER stress and mTOR pathway","volume":"25","author":"Hu","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.03.042_bib54","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.bioactmat.2026.03.042_bib55","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMcp2307353","article-title":"Postmenopausal osteoporosis","volume":"389","author":"Walker","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.03.042_bib56","article-title":"Bone grafts in trauma and orthopaedics","volume":"13","author":"Archunan","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7272","key":"10.1016\/j.bioactmat.2026.03.042_bib58","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(63)91089-4","article-title":"Non-union of fractures","volume":"1","author":"Hicks","year":"1963","journal-title":"Lancet"},{"key":"10.1016\/j.bioactmat.2026.03.042_bib59","first-page":"6","article-title":"Orthopedic implants and devices for bone fractures and defects: past, present and perspective","volume":"1","author":"Kim","year":"2020","journal-title":"Eng. Regen."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.03.042_bib60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41419-023-05645-y","article-title":"Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis","volume":"14","author":"Tan","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2013.05.014","article-title":"Cellular metabolic and autophagic pathways: traffic control by redox signaling","volume":"63","author":"Dodson","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.03.042_bib62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s13287-024-04014-6","article-title":"Improvement of osteogenic differentiation potential of placenta-derived mesenchymal stem cells by metformin via AMPK pathway activation","volume":"15","author":"Manochantr","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3894926","article-title":"MicroRNA-16, via FGF2 regulation of the ERK\/MAPK pathway, is involved in the magnesium-promoted osteogenic differentiation of mesenchymal stem cells","volume":"2020","author":"Qi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bioactmat.2026.03.042_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26001817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:44:16Z","timestamp":1780991056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26001817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"alternative-id":["S2452199X26001817"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.03.042","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reconstituted phospholipid membrane-coated Fe2+-Mg2+ displacement nanoparticles block ferroptotic trigger waves","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.03.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}