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Pathol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.04.030_bib154","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.7150\/thno.89180","article-title":"Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles","volume":"14","author":"Jiang","year":"2024","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.04.030_bib155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001455","article-title":"NAMPT-derived NAD+ fuels parp1 to promote skin inflammation through parthanatos cell death","volume":"19","author":"Mart\u00ednez-Morcillo","year":"2021","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.04.030_bib156","first-page":"545","article-title":"Tissue-engineered human psoriatic skin supplemented with cytokines as an in vitro model to study plaque psoriasis, Regen","volume":"11","author":"Pouliot-B\u00e9rub\u00e9","year":"2016","journal-title":"Med"},{"key":"10.1016\/j.bioactmat.2026.04.030_bib157","article-title":"Breaking the psoriasis pathological signaling cycle: a novel nanomedicine strategy targeting metabolism and oxidative stress","volume":"32","author":"Wu","year":"2025","journal-title":"Mater. 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