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Cell Biol."},{"issue":"6899","key":"10.1016\/j.bioactmat.2026.07.017_bib147","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck","volume":"418","author":"Eden","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib148","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6871269","article-title":"Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK\/NF-\u03baB Pathway","volume":"2022","author":"Tu","year":"2022","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.017_bib149","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10664","article-title":"Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration","volume":"7","author":"Marei","year":"2016","journal-title":"Nat. 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Immunol."},{"issue":"7720","key":"10.1016\/j.bioactmat.2026.07.017_bib155","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-018-0444-0","article-title":"RAP2 mediates mechanoresponses of the Hippo pathway","volume":"560","author":"Meng","year":"2018","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.07.017_bib156","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.07.017_bib157","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jot.2024.12.003","article-title":"Role of YAP\/TAZ in bone diseases: A transductor from mechanics to biology","volume":"51","author":"Chen","year":"2025","journal-title":"Journal of Orthopaedic Translation"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib158","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"22","key":"10.1016\/j.bioactmat.2026.07.017_bib159","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211947120","article-title":"Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz","volume":"120","author":"Jones","year":"2023","journal-title":"PNAS"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib160","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.1901033","article-title":"TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching","volume":"204","author":"Scheraga","year":"2020","journal-title":"The Journal of Immunology"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.07.017_bib161","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s42254-025-00874-w","article-title":"Mechanobiology across timescales","volume":"7","author":"Cheng","year":"2025","journal-title":"Nat. Rev. Phys."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.07.017_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116176","article-title":"Matrix-induced nuclear remodeling and mechano-therapeutics","volume":"44","author":"Lee","year":"2025","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.017_bib163","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41581-022-00633-5","article-title":"Trained immunity \u2014 basic concepts and contributions to immunopathology","volume":"19","author":"Ochando","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.017_bib164","article-title":"Macrophage memory emerges from coordinated transcription factor and chromatin dynamics","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Syst"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.07.017_bib165","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cell.2012.03.046","article-title":"LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins","volume":"149","author":"Sosa","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib166","article-title":"A role for nuclear stretching and NPCs changes in the cytoplasmic-nuclear trafficking of YAP: An experimental and numerical modelling approach","volume":"15","author":"Saporito","year":"2022","journal-title":"Mater. 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Immunol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.07.017_bib170","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1165\/rcmb.2023-0456OC","article-title":"TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury","volume":"70","author":"Orsini","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.07.017_bib171","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010463","article-title":"YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix","volume":"12","author":"Bai","year":"2024","journal-title":"J. ImmunoTher. Cancer"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.07.017_bib172","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70121","article-title":"Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation","volume":"59","author":"Li","year":"2026","journal-title":"Cell Proliferation"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.07.017_bib173","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145813","article-title":"Substrate stiffness regulates proinflammatory mediator production through TLR4 activity in macrophages","volume":"10","author":"Previtera","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.017_bib174","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.yexcr.2018.04.005","article-title":"Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor \u03b3 expression, Exp","volume":"367","author":"Okamoto","year":"2018","journal-title":"Cell. Res"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.actbio.2018.02.015","article-title":"Macrophage involvement affects matrix stiffness-related influences on cell osteogenesis under three-dimensional culture conditions","volume":"71","author":"He","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib176","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jmst.2025.02.032","article-title":"Modulating cell stiffness to improve macrophage antibacterial defense: Utilizing spermidine-functionalized black phosphorus nanosheets for periodontitis treatment","volume":"235","author":"Li","year":"2025","journal-title":"Journal of Materials Science & Technology"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2026.218443","article-title":"Uncontrolled Hyperglycemia-Induced Membrane Cholesterol Dysregulation Drives Tumor Immune Evasion by Reducing Hardness of Tumor Cell Plasma Membrane","volume":"648","author":"Yang","year":"2026","journal-title":"Cancer Letters"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib178","article-title":"Shish-kebab structure fiber with nano and micro diameter regulate macrophage polarization for anti-inflammatory and bone differentiation","volume":"23","author":"Zhu","year":"2023","journal-title":"Mater. 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Eng."},{"issue":"8016","key":"10.1016\/j.bioactmat.2026.07.017_bib182","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41586-024-07426-9","article-title":"Adhesive anti-fibrotic interfaces on diverse organs","volume":"630","author":"Wu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib183","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00264-017-3691-z","article-title":"Periprosthetic bone remodelling of short-stem total hip arthroplasty: a systematic review","volume":"42","author":"Yan","year":"2017","journal-title":"International Orthopaedics"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib184","article-title":"Cyclic stretch induced epigenetic activation of periodontal ligament cells, Mater","volume":"26","author":"Bae","year":"2024","journal-title":"Today Bio"},{"issue":"44","key":"10.1016\/j.bioactmat.2026.07.017_bib185","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201909047","article-title":"Shape-Memory Polymers for Biomedical Applications","volume":"30","author":"Delaey","year":"2020","journal-title":"Adv. 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Nanobiotechnol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.07.017_bib188","doi-asserted-by":"crossref","first-page":"18376","DOI":"10.1021\/acsnano.2c06356","article-title":"Decrease in Tumor Interstitial Pressure for Enhanced Drug Intratumoral Delivery and Synergistic Tumor Therapy","volume":"16","author":"Fu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138952","article-title":"Synergistic strategy constructed hydrogel-aerogel biphase gel (HAB-gel) with self-negative-pressure exudate absorption, M2 macrophage\u2010polarized and antibacterial for chronic wound treatment","volume":"451","author":"Zou","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.07.017_bib190","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s40843-024-2917-7","article-title":"Impact of micro-scale regular topography on cell and tissue behaviors","volume":"67","author":"Wang","year":"2024","journal-title":"Sci. China Mater."},{"issue":"17","key":"10.1016\/j.bioactmat.2026.07.017_bib191","doi-asserted-by":"crossref","first-page":"21415","DOI":"10.1021\/acsami.3c18158","article-title":"Designer Micro-\/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization","volume":"16","author":"Asadi Tokmedash","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.07.017_bib193","article-title":"Silk films with distinct surface topography modulate plasma membrane curvature to polarize macrophages","volume":"28","author":"Hu","year":"2024","journal-title":"Mater. 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Sci."},{"key":"10.1016\/j.bioactmat.2026.07.017_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213128","article-title":"Biomimetic surface topography as a potential modulator of macrophages inflammatory response to biomaterials","volume":"141","author":"Monteiro","year":"2022","journal-title":"Biomater. Adv."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.07.017_bib210","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmat4051","article-title":"Interplay of matrix stiffness and protein tethering in stem cell differentiation","volume":"13","author":"Wen","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2026.07.017_bib211","first-page":"608","article-title":"Continuous mechanical-gradient hydrogel with on-demand distributed Mn(2+)\/Mg-doped hydroxyapatite@Fe(3)O(4) for functional osteochondral regeneration","volume":"49","author":"Xu","year":"2025","journal-title":"Bioact. 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