{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:04:23Z","timestamp":1789851863725,"version":"4.0.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515012847"],"award-info":[{"award-number":["2025A1515012847"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202677"],"award-info":[{"award-number":["82202677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401100"],"award-info":[{"award-number":["32401100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioactmat.2026.07.052","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:49:27Z","timestamp":1789634967000},"page":"902-921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair"],"prefix":"10.1016","volume":"67","author":[{"given":"Fanyan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiude","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-5600","authenticated-orcid":false,"given":"Congqin","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.052_bib1a","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307673","article-title":"The Material World of 3D-Bioprinted and Microfluidic-Chip Models of Human Liver Fibrosis","volume":"36","author":"Carvalho","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib1b","first-page":"203","article-title":"A Mg2+\/polydopamine composite hydrogel for the acceleration of infected wound healing","volume":"15","author":"Guo","year":"2022","journal-title":"Bioact. Mater."},{"issue":"13","key":"10.1016\/j.bioactmat.2026.07.052_bib2a","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.3390\/ijms25137137","article-title":"Cutaneous Wound Healing and the Effects of Cannabidiol","volume":"25","author":"Shah","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib2b","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies","volume":"29","author":"Martinengo","year":"2019","journal-title":"Ann. Epidemiol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.07.052_bib3","article-title":"Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: a review","volume":"7","author":"Chin","year":"2024","journal-title":"Health Sci. Rep. Us"},{"issue":"22","key":"10.1016\/j.bioactmat.2026.07.052_bib4a","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201254","article-title":"Micro-Gel Ensembles for Accelerated Healing of Chronic Wound via pH Regulation","volume":"9","author":"Cui","year":"2022","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.052_bib4b","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/wrr.12125","article-title":"The effects of pH on wound healing, biofilms, and antimicrobial efficacy","volume":"22","author":"Percival","year":"2014","journal-title":"Wound Repair Regen."},{"issue":"8","key":"10.1016\/j.bioactmat.2026.07.052_bib5a","article-title":"Systemic antibiotics for treating malignant wounds","author":"Ramasubbu","year":"2017","journal-title":"Cochrane Db Syst. Rev."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.07.052_bib5b","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s10856-019-6319-6","article-title":"A review of accelerated wound healing approaches: biomaterial- assisted tissue remodeling","volume":"30","author":"Nour","year":"2019","journal-title":"J. Mater. Sci. Mater. M"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.07.052_bib6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance-the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.07.052_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10642","article-title":"Growth factors and growth factor gene therapies for treating chronic wounds","volume":"9","author":"Mullin","year":"2023","journal-title":"Bioeng. Transl. Med."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.07.052_bib8a","doi-asserted-by":"crossref","DOI":"10.1063\/5.0060299","article-title":"Metal-based nanoparticles for combating antibiotic resistance","volume":"8","author":"Altun","year":"2021","journal-title":"Appl. Phys. Rev."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib8b","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/14686996.2019.1585131","article-title":"Gelatin-stabilized composites of silver nanoparticles and curcumin: characterization, antibacterial and antioxidant study","volume":"20","author":"Khanh","year":"2019","journal-title":"Sci. Technol. Adv. Mater."},{"issue":"26","key":"10.1016\/j.bioactmat.2026.07.052_bib8c","doi-asserted-by":"crossref","first-page":"17251","DOI":"10.1021\/acsnano.4c04816","article-title":"A Double Network Composite Hydrogel with Self-Regulating Cu2+\/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.07.052_sref4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1049\/iet-nbt.2018.5312","article-title":"Development of nanotechnology for advancement and application in wound healing: a review","volume":"13","author":"Bhattacharya","year":"2019","journal-title":"IET Nanobiotechnol."},{"issue":"52","key":"10.1016\/j.bioactmat.2026.07.052_bib9a","article-title":"Antibacterial Action of Nanoparticles by Lethal Stretching of Bacterial Cell Membranes","volume":"32","author":"Linklater","year":"2020","journal-title":"Adv. Mater."},{"issue":"13","key":"10.1016\/j.bioactmat.2026.07.052_bib9b","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.3390\/ijms25137182","article-title":"Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal","volume":"25","author":"Alfei","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12951-017-0308-z","article-title":"Metal nanoparticles: understanding the mechanisms behind antibacterial activity","volume":"15","author":"Slavin","year":"2017","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.07.052_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nantod.2015.04.002","article-title":"Antibacterial activity of silver nanoparticles: a surface science insight","volume":"10","author":"Le Ouay","year":"2015","journal-title":"Nano Today"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.07.052_bib12","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1007\/s12011-023-03631-1","article-title":"The role of zinc in bone tissue health and Regeneration-a review","volume":"201","author":"Molenda","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/nu10010016","article-title":"Zinc in wound healing modulation","volume":"10","author":"Lin","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib14","first-page":"88","article-title":"Sustained release of magnesium and zinc ions synergistically accelerates wound healing","volume":"26","author":"Yang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2006.00179.x","article-title":"Zinc in wound healing: theoretical, experimental, and clinical aspects","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.052_bib16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5114\/aoms.2016.59591","article-title":"Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results","volume":"14","author":"Moreno-Eutimio","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121652","article-title":"Multi-functional wound dressings based on silicate bioactive materials","volume":"287","author":"Fan","year":"2022","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.07.052_bib18a","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1021\/acsabm.2c00384","article-title":"Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions","volume":"5","author":"Ege","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"issue":"29","key":"10.1016\/j.bioactmat.2026.07.052_bib18b","doi-asserted-by":"crossref","first-page":"37669","DOI":"10.1021\/acsami.4c07035","article-title":"Wound Healing Promotion via Release of Therapeutic Metallic Ions from Phosphate Glass Fibers: An In Vitro and Ex Vivo Study","volume":"16","author":"Hoxha","year":"2024","journal-title":"Acs Appl. Mater. Inter."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.07.052_bib19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/ijag.12252","article-title":"Bioglass and bioactive glasses and their impact on healthcare","volume":"7","author":"Jones","year":"2016","journal-title":"Int. J. Appl. Glass Sci."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkab029","article-title":"Calcium silicate accelerates cutaneous wound healing with enhanced re-epithelialization through EGF\/EGFR\/ERK-mediated promotion of epidermal stem cell functions","volume":"9","author":"Li","year":"2021","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.759702","article-title":"Ectopic mineralization of tissues: mechanisms, risk factors, diseases, and prevention","volume":"9","author":"Kempf","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3\u20134","key":"10.1016\/j.bioactmat.2026.07.052_bib22a","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pcrysgrow.2009.09.001","article-title":"Thermal and chemical methods for producing zinc silicate (willemite): A review","volume":"55","author":"Takesue","year":"2009","journal-title":"Prog. Cryst. Growth Char. Mater."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.07.052_bib22b","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/(SICI)1521-3773(19990517)38:10<1401::AID-ANIE1401>3.0.CO;2-4","article-title":"Zinc silicates:: Very efficient heterogeneous catalysts for the addition of primary alcohols to alkynes and allenes","volume":"38","author":"Breuer","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.07.052_bib23a","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102359","article-title":"Spindle-Like Zinc Silicate Nanoparticles Accelerating Innervated and Vascularized Skin Burn Wound Healing","volume":"11","author":"Zhang","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib23b","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112490","article-title":"Enhanced osteogenesis and angiogenesis of calcium phosphate cement incorporated with zinc silicate by synergy effect of zinc and silicon ions","volume":"131","author":"Lu","year":"2021","journal-title":"Mater. Sci. Eng., C"},{"issue":"22","key":"10.1016\/j.bioactmat.2026.07.052_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201254","article-title":"Micro-gel ensembles for accelerated healing of chronic wound via pH regulation","volume":"9","author":"Cui","year":"2022","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.07.052_bib25a","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/acsnano.6b00181","article-title":"Antibacterial Activity of Ti3C2Tx MXene","volume":"10","author":"Rasool","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib25b","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.addr.2016.04.009","article-title":"Antibacterial applications of graphene-based nanomaterials: Recent achievements and challenges","volume":"105","author":"Ji","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds","volume":"21","author":"Nussbaum","year":"2018","journal-title":"Value Health"},{"issue":"29","key":"10.1016\/j.bioactmat.2026.07.052_bib27a","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1002\/adma.201400815","article-title":"Monodispersed and Ordered Large-Pore Mesoporous Silica Nanospheres with Tunable Pore Structure for Magnetic Functionalization and Gene Delivery","volume":"26","author":"Niu","year":"2014","journal-title":"Adv. Mater."},{"issue":"30","key":"10.1016\/j.bioactmat.2026.07.052_bib27b","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202425826","article-title":"Single\u2010Atom Nickel Encapsulated in Nanosheet\u2010Coiled rGO\u2010CTAB\u2010MoS2 Nanoflowers for High\u2010Efficiency and Long\u2010Term Hydrogen Evolution in Acidic Medium","volume":"35","author":"Liu","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.052_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1039\/C6CS00829A","article-title":"Hierarchically porous materials: synthesis strategies and structure design","volume":"46","author":"Yang","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cej.2017.09.120","article-title":"Hydrothermal synthesis of mesoporous Mg3Si2O5(OH)4 microspheres as high-performance adsorbents for dye removal","volume":"334","author":"Sun","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib30a","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.matchar.2015.08.012","article-title":"Synthesis of zinc phosphate and zinc ammonium phosphate nanostructures with different morphologies through pH control","volume":"108","author":"Zhou","year":"2015","journal-title":"Mater. Charact."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.07.052_bib30b","first-page":"2491","article-title":"A unified topology approach to dot-, rod-, and sheet-MOFs","volume":"7","author":"Noa","year":"2021"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib30c","article-title":"Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution-precipitation reaction","volume":"12","author":"Wang","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf081","article-title":"Heterogeneous zinc\/catechol-derived resin microsphere-functionalized composite hydrogels with antibacterial and anti-inflammatory activities promote bacterial-infected wound healing","volume":"12","author":"Qu","year":"2025","journal-title":"Regen. Biomater."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib32","article-title":"Enhanced activation of retinal progenitor cells by zinc silicate bioceramics for effective functional restoration in retinal degenerative diseases","volume":"6","author":"Sun","year":"2025","journal-title":"View-China"},{"issue":"50","key":"10.1016\/j.bioactmat.2026.07.052_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202507939","article-title":"Copper-doped prussian blue nanozymes: targeted starvation therapy against gram-positive bacteria via the ABC transporter inhibition","volume":"35","author":"Zhang","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib34","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41467-025-56873-z","article-title":"Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism","volume":"16","author":"Khodaparast","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.actbio.2023.10.028","article-title":"Bimetallic oxide Cu-Fe3O4 nanoclusters with multiple enzymatic activities for wound infection treatment and wound healing","volume":"173","author":"Jin","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105611","article-title":"Comparative transcriptome analysis to investigate the mechanism of anti-helicobacter pylori activity of zinc","volume":"168","author":"Fan","year":"2022","journal-title":"Microb. Pathog."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.07.052_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01152-22","article-title":"Transcriptomic and functional approaches unveil the role of tmRNA in zinc acetate mediated levofloxacin sensitivity in Helicobacter pylori","volume":"10","author":"Tao","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.07.052_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205682","article-title":"Zeolitic imidazolate Framework-8 triggers the inhibition of arginine biosynthesis to combat methicillin-resistant","volume":"19","author":"Liu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121663","article-title":"High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis","volume":"287","author":"Jia","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib40","doi-asserted-by":"crossref","first-page":"11789","DOI":"10.2147\/IJN.S474299","article-title":"Comparative study and transcriptomic analysis on the antifungal mechanism of Ag nanoparticles and nanowires against Trichosporon asahii","volume":"19","author":"Han","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib41a","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-\u03baB signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bioactmat.2026.07.052_bib41b","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121768","article-title":"Concurrent antibiosis and anti-inflammation against bacterial pneumonia by zinc hexacyanoferrate nanocatalysts","volume":"289","author":"Liu","year":"2022","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.07.052_bib41c","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/tox.23590","article-title":"NF-\u03baB mediates silica-induced pulmonary inflammation by promoting the release of IL-1\u03b2 in macrophages","volume":"37","author":"Zhang","year":"2022","journal-title":"Environ. Toxicol."},{"issue":"13","key":"10.1016\/j.bioactmat.2026.07.052_bib42a","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202413992","article-title":"Photo-Responsive H2S Composite System Regulates the Nerve Regeneration Microenvironment Through Multiple Pathways","volume":"37","author":"Huo","year":"2025","journal-title":"Adv. Mater."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.07.052_bib42b","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/cns.13918","article-title":"Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1\u03b1\/VEGF signaling pathway in experimental stroke","volume":"28","author":"Li","year":"2022","journal-title":"CNS Neurosci. Ther."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.07.052_bib42c","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1039\/C9BM01103J","article-title":"Angiogenesis-promoted bone repair with silicate-shelled hydrogel fiber scaffolds","volume":"7","author":"Dashnyam","year":"2019","journal-title":"Biomater. Sci."},{"issue":"51","key":"10.1016\/j.bioactmat.2026.07.052_bib42d","doi-asserted-by":"crossref","first-page":"34924","DOI":"10.1021\/acsnano.4c13028","article-title":"Biomimetic Extracellular Vesicles Based on Composite Bioactive Ions for the Treatment of Ischemic Bone Disease","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.07.052_bib43a","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.3390\/ijms25063536","article-title":"Noscapine and Apoptosis in Breast and Other Cancers","volume":"25","author":"Calaf","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.07.052_bib43b","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10495-016-1247-0","article-title":"Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12","volume":"21","author":"de la Cadena","year":"2016","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.07.052_bib44a","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41401-020-00603-2","article-title":"NOD-like receptors in autoimmune diseases","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.bioactmat.2026.07.052_bib44b","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib44c","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106384","article-title":"Multifunctional chitosan-based hydrogel wound dressing loaded with Acanthopanax senticosus and Osmundastrum cinnamomeum: Preparation, characterization and coagulation mechanism","volume":"151","author":"Gou","year":"2024","journal-title":"J. Mech. Behav. Biomed."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.07.052_bib45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.immuni.2015.01.020","article-title":"Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair","volume":"42","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.07.052_bib46a","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1038\/s41467-021-26422-5","article-title":"NRG1\/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration","volume":"12","author":"Laplace-Builh\u00e9","year":"2021","journal-title":"Nat. Commun."},{"issue":"265","key":"10.1016\/j.bioactmat.2026.07.052_bib46b","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"M. Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib47","article-title":"The use of acellular fish skin grafts in burns and complex trauma wounds: a systematic review of clinical data","volume":"11","author":"Pignet","year":"2024","journal-title":"Plast Aesthet Res."},{"key":"10.1016\/j.bioactmat.2026.07.052_bib48a","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124328","article-title":"Sprayable polysaccharide-based biomimetic double dressing with synergistic regulation for wound healing","volume":"335","author":"Xue","year":"2026","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.07.052_bib48b","article-title":"Electrospun photothermal tellurium nanosheet-loaded polycaprolactone\/gelatin nanofibers to promote wound healing","volume":"18","author":"Li","year":"2025","journal-title":"J. Innov. Opt. Heal. Sci."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:34:43Z","timestamp":1789850083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26004494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":73,"alternative-id":["S2452199X26004494"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.07.052","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.07.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}