{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:03:24Z","timestamp":1789671804139,"version":"4.0.1"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3407600"],"award-info":[{"award-number":["2024YFC3407600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB318"],"award-info":[{"award-number":["2024AFB318"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322046"],"award-info":[{"award-number":["82322046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503043"],"award-info":[{"award-number":["82503043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108020"],"award-info":[{"award-number":["82020108020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072198"],"award-info":[{"award-number":["82072198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioactmat.2026.08.018","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:36:42Z","timestamp":1788986202000},"page":"539-560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Porcelain-clay-inspired microsphere hydrogel bioink facilitates bone regeneration via immune-osteogenic regulation"],"prefix":"10.1016","volume":"68","author":[{"given":"Shize","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2026.08.018_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41584-022-00887-0","article-title":"The decisive early phase of bone regeneration","volume":"19","author":"Duda","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","article-title":"Cell communication and relevant signaling pathways in osteogenesis\u2013angiogenesis coupling","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262311642","article-title":"Immune-guided bone healing: the role of osteoimmunity in tissue engineering approaches","volume":"26","author":"Muna\u00f2","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/ten.teb.2014.0677","article-title":"Boon and bane of inflammation in bone tissue regeneration and its link with angiogenesis","volume":"21","author":"Schmidt-Bleek","year":"2015","journal-title":"Tissue Eng., Part B"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib5","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac6700","article-title":"3D bioprinting of osteon-mimetic scaffolds with hierarchical microchannels for vascularized bone tissue regeneration","volume":"14","author":"Sun","year":"2022","journal-title":"Biofabrication"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib6","first-page":"692","article-title":"A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair","volume":"61","author":"Sun","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib7","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.2147\/JIR.S423819","article-title":"Macrophage polarization and the regulation of bone immunity in bone homeostasis","volume":"16","author":"Hu","year":"2023","journal-title":"JIR"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s40779-022-00426-8","article-title":"The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity","volume":"9","author":"Xiong","year":"2022","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.658","article-title":"Macrophage plasticity: signaling pathways, tissue repair, and regeneration","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib11","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: a critical step during wound healing","volume":"73","author":"Land\u00e9n","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature17039","article-title":"Reparative inflammation takes charge of tissue regeneration","volume":"529","author":"Karin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib13","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/ijms24010641","article-title":"Acute inflammation in tissue healing","volume":"24","author":"Soliman","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40779-023-00448-w","article-title":"Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications","volume":"10","author":"Liu","year":"2023","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib15","article-title":"Multifunctional biomedical materials derived from biological membranes","volume":"34","author":"Wang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202423492","article-title":"Biomimetic piezoelectric periosteum\u2010bone integrated implant promotes bone defect repair by remodeling osteogenic microenvironment","volume":"35","author":"Yue","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s40820-019-0330-9","article-title":"Cell membrane coating technology: a promising strategy for biomedical applications","volume":"11","author":"Liu","year":"2019","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biomaterials.2019.01.020","article-title":"A new class of biological materials: cell membrane-derived hydrogel scaffolds","volume":"197","author":"Fan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202003559","article-title":"Recent advances of cell membrane-coated nanomaterials for biomedical applications","volume":"30","author":"Liu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib20","article-title":"Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models","volume":"0","author":"Du","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib21","article-title":"Stem cell membrane-camouflaged targeted delivery system in tumor","volume":"16","author":"Zhang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2022.09.012","article-title":"Stem cell membrane-coated abiotic nanomaterials for biomedical applications","volume":"351","author":"Ferreira-Faria","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib23","article-title":"Harnessing mesenchymal stem cell membrane for construction of drug delivery platforms via optimized biomimetics","volume":"20","author":"Xiao","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202208781","article-title":"Stem cell membrane-coated microribbon scaffolds induce regenerative innate and adaptive immune responses in a critical-size cranial bone defect model","volume":"35","author":"Su","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib25","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1038\/s41467-022-32868-y","article-title":"Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib26","article-title":"Calcium phosphate nanoparticle-immobilized macrophage-derived extracellular vesicle nanohybrid facilitates diabetic bone regeneration","volume":"38","author":"Wu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq7116","article-title":"A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP\/PKA signaling pathway","volume":"8","author":"Yuan","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s40820-024-01557-4","article-title":"Recent strategies and advances in Hydrogel-based delivery platforms for bone regeneration","volume":"17","author":"Wang","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.09.008","article-title":"Extracellular signaling molecules to promote fracture healing and bone regeneration","volume":"94","author":"Hankenson","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41413-025-00487-0","article-title":"Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies","volume":"14","author":"Del Toro Runzer","year":"2026","journal-title":"Bone Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s42242-021-00172-1","article-title":"Injectable bioactive polymethyl methacrylate\u2013hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty","volume":"5","author":"Sun","year":"2022","journal-title":"BioDes. Manuf."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib32","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1089\/ten.tea.2018.0146","article-title":"Effect of the bone morphogenetic Protein-2 doses on the osteogenic potential of human multipotent stromal Cells- containing tissue engineered constructs","volume":"25","author":"Decambron","year":"2019","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121721","article-title":"Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release","volume":"288","author":"Howard","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2015.07.045","article-title":"Surface-mediated delivery of siRNA from fibrin hydrogels for knockdown of the BMP-2 binding antagonist noggin","volume":"25","author":"Kowalczewski","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2015.09.050","article-title":"Chemically modified RNA activated matrices enhance bone regeneration","volume":"218","author":"Elangovan","year":"2015","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib37","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic Protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng., Part B"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201978","article-title":"Lipoplex-functionalized thin-film surface coating based on extracellular matrix components as local gene delivery system to control osteogenic stem cell differentiation","volume":"12","author":"Husteden","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13287-024-03755-8","article-title":"Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats","volume":"15","author":"Deluca","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay1240","article-title":"Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration","volume":"6","author":"Hettiaratchi","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib41","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1525-1594.2009.00988.x","article-title":"The efficacy of bone morphogenetic protein-2 depends on its mode of delivery","volume":"34","author":"La","year":"2010","journal-title":"Artif. Organs"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1089\/ten.tea.2017.0232","article-title":"The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis","volume":"24","author":"Wei","year":"2018","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib43","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1039\/C8BM00701B","article-title":"The immunomodulatory role of sulfated chitosan in BMP-2-mediated bone regeneration","volume":"6","author":"Shu","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121604","article-title":"Immunomodulatory strategies for bone regeneration: a review from the perspective of disease types","volume":"286","author":"Su","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib45","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41467-025-59651-z","article-title":"Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib47","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmat4489","article-title":"Hydrogels with tunable stress relaxation regulate stem cell fate and activity","volume":"15","author":"Chaudhuri","year":"2016","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib48","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrm.2017.108","article-title":"Mechanical forces direct stem cell behaviour in development and regeneration","volume":"18","author":"Vining","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib49","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41577-022-00761-w","article-title":"Tuning immunity through tissue mechanotransduction","volume":"23","author":"Du","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41565-023-01535-8","article-title":"Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases","volume":"19","author":"Mittelheisser","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib51","doi-asserted-by":"crossref","unstructured":"Sun, X. et al. Three-dimensional bioprinted scaffolds loaded with multifunctional magnesium-based metal\u2013organic frameworks improve the senescence microenvironment prompting aged bone defect repair. https:\/\/dx.doi.org\/10.1021\/acsnano.5c03023.","DOI":"10.1021\/acsnano.5c03023"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902026","article-title":"Hydrogel bioink reinforcement for additive manufacturing: a focused review of emerging strategies","volume":"32","author":"Chimene","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib53","first-page":"278","article-title":"3D bioactive composite scaffolds for bone tissue engineering","volume":"3","author":"Turnbull","year":"2018","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41578-019-0148-6","article-title":"Hydrogel microparticles for biomedical applications","volume":"5","author":"Daly","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib55","article-title":"Jammed Microgel inks for 3D printing applications","volume":"6","author":"Highley","year":"2018","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib56","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1038\/s41467-022-30997-y","article-title":"In situ 3D bioprinting with bioconcrete bioink","volume":"13","author":"Xie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40824-022-00325-y","article-title":"High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration","volume":"26","author":"Sun","year":"2022","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib58","article-title":"Hybrid fabrication of perfusable stiffness-flexible integrated scaffold mimicking hierarchical tubular bone","volume":"524","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib60","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/btu031","article-title":"InterProScan 5: genome-scale protein function classification","volume":"30","author":"Jones","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib61","doi-asserted-by":"crossref","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122566","article-title":"Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: towards an optimized regenerative microenvironment","volume":"308","author":"Jiang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib63","article-title":"Porous granular hydrogel scaffolds biofabricated from dual-crosslinked hydrogel microparticles for breast tissue engineering","volume":"33","author":"Guo","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib64","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12951-023-01855-w","article-title":"Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X\/NLRP3 axis","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib65","author":"Thakar"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib66","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1084\/jem.20071132","article-title":"A protein associated with toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses","volume":"204","author":"Takahashi","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8239258","article-title":"Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance","volume":"2016","author":"Sugimoto","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib68","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib69","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/jcp.24861","article-title":"Anti-inflammatory\/tissue repair macrophages enhance the cartilage-forming capacity of human bone marrow-derived mesenchymal stromal cells","volume":"230","author":"Sesia","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15548627.2017.1402992","article-title":"Autophagy balances inflammation in innate immunity","volume":"14","author":"Deretic","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib71","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fcell.2020.00167","article-title":"Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction","volume":"8","author":"Chevriaux","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib73","doi-asserted-by":"crossref","unstructured":"Leclair, P. & Lim, C. J. CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions. Anim. Cells Syst. (Seoul) 24, 243\u2013252.","DOI":"10.1080\/19768354.2020.1818618"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s13402-019-00469-5","article-title":"CD47: role in the immune system and application to cancer therapy","volume":"43","author":"Hayat","year":"2020","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib75","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.cdd.4402184","article-title":"Clearance of apoptotic cells by phagocytes","volume":"15","author":"Erwig","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib76","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.freeradbiomed.2015.04.034","article-title":"Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation","volume":"88","author":"Ishii","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib77","article-title":"Exploring the potential of treating chronic liver disease targeting the PI3K\/Akt pathway and polarization mechanism of macrophages","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib78","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1038\/s41598-017-02840-8","article-title":"Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement","volume":"7","author":"Hori","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib79","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12079-018-0453-7","article-title":"Galectin-3 regulation of wound healing and fibrotic processes: insights for chronic skin wound therapeutics","volume":"12","author":"McLeod","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib80","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/antiox11030555","article-title":"Heme Oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders","volume":"11","author":"Ryter","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib81","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4049\/jimmunol.1103541","article-title":"Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis","volume":"189","author":"Shah","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib82","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00011-022-01595-x","article-title":"Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis","volume":"71","author":"Goswami","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib83","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/CIRCRESAHA.110.226878","article-title":"Liver x receptors in atherosclerosis and inflammation","volume":"108","author":"Im","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib84","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12974-019-1522-4","article-title":"Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation","volume":"16","author":"Ilarregui","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib85","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/ATVBAHA.109.202051","article-title":"Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation","volume":"30","author":"Yancey","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib86","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/ATVBAHA.121.316854","article-title":"Macrophage LRP1 (Low-Density lipoprotein receptor-related protein 1) is required for the effect of CD47 blockade on efferocytosis and atherogenesis-brief report","volume":"42","author":"Mueller","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib87","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/14728222.2019.1656718","article-title":"Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus","volume":"23","author":"Bilsborrow","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib88","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib89","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the Vacuolar H+-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib90","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1096\/fj.201802118R","article-title":"Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis","volume":"33","author":"Sackett","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib91","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1074\/jbc.M109537200","article-title":"Negative regulation of toll-like receptor-mediated signaling by Tollip","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib92","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib93","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy","volume":"51","author":"Ichimura","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib94","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib95","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/549691","article-title":"PPAR\u03b3 and the innate immune System mediate the resolution of inflammation","volume":"2015","author":"Croasdell","year":"2015","journal-title":"PPAR Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib96","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib97","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4161\/gmic.28093","article-title":"SerpinB2 mediated regulation of macrophage function during enteric infection","volume":"5","author":"Shea-Donohue","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.674739","article-title":"The role of GPNMB in inflammation","volume":"12","author":"Saade","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib99","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.addr.2009.01.003","article-title":"Thioredoxin 1 delivery as new therapeutics","volume":"61","author":"Nakamura","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib100","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/mi.2013.63","article-title":"Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury","volume":"7","author":"Zhao","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2024.109199","article-title":"Chitosan: an overview of biological activities, derivatives, properties, and current advancements in biomedical applications","volume":"542","author":"Edo","year":"2024","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib102","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add8570","article-title":"Building block properties govern granular hydrogel mechanics through contact deformations","volume":"8","author":"Emiroglu","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/am.2017.171","article-title":"Novel biomaterial strategies for controlled growth factor delivery for biomedical applications","volume":"9","author":"Wang","year":"2017","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib105","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.tcb.2020.09.009","article-title":"Extracellular vesicle-associated proteins in tissue repair","volume":"30","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib106","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","volume":"12","author":"Salazar","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib107","article-title":"Multifunctional injectable chitosan-based adhesive enhanced by limited oxidation for assisting bone grafting","volume":"36","author":"Li","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib108","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1186\/s12951-024-02996-2","article-title":"A novel multifunctional nanocomposite hydrogel orchestrates the macrophage reprogramming-osteogenesis crosstalk to boost bone defect repair","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139712","article-title":"A photo-thermal dual crosslinked chitosan-based hydrogel membrane for guided bone regeneration","volume":"296","author":"Xiaojie","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.829136","article-title":"Bone mesenchymal stem cell-derived sEV-Encapsulated thermosensitive hydrogels accelerate osteogenesis and angiogenesis by release of exosomal miR-21","volume":"9","author":"Wu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301151","article-title":"Copper ion-modified germanium Phosphorus nanosheets integrated with an electroactive and biodegradable hydrogel for neuro-vascularized bone regeneration","volume":"12","author":"Xu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/biomedicines13020257","article-title":"Functionalized GelMA\/CMCS composite hydrogel incorporating magnesium phosphate cement for bone regeneration","volume":"13","author":"Wang","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib113","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12891-026-09717-w","article-title":"Injectable rhBMP-2-loaded calcium phosphate cement and chitosan composite hydrogel for the repair of osteoporotic bone defects","volume":"27","author":"Cai","year":"2026","journal-title":"BMC Muscoskelet. Disord."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2022.112700","article-title":"Mechanically enhanced composite hydrogel scaffold for in situ bone repairs","volume":"134","author":"Zhang","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib115","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae090","article-title":"Multi-site enhancement of osteogenesis: peptide-functionalized GelMA hydrogels with three-dimensional cultures of human dental pulp stem cells","volume":"11","author":"Liang","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib116","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.2147\/IJN.S321387","article-title":"Nanohydroxyapatite, Nanosilicate-Reinforced injectable, and biomimetic gelatin-methacryloyl hydrogel for bone tissue engineering","volume":"16","author":"Shi","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bioactmat.2026.08.018_bib117","article-title":"Photo-crosslinked bioactive BG\/BMSCs@GelMA hydrogels for bone-defect repairs","volume":"23","author":"Ai","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2026.08.018_bib118","doi-asserted-by":"crossref","first-page":"19951","DOI":"10.1021\/acsami.3c00655","article-title":"Strontium ion-functionalized Nano-Hydroxyapatite\/Chitosan composite microspheres promote osteogenesis and angiogenesis for bone regeneration","volume":"15","author":"Cheng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:11:25Z","timestamp":1789668685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26004810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":118,"alternative-id":["S2452199X26004810"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.018","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porcelain-clay-inspired microsphere hydrogel bioink facilitates bone regeneration via immune-osteogenic regulation","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}