{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:56:09Z","timestamp":1792083369062,"version":"4.4.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372484"],"award-info":[{"award-number":["82372484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302683"],"award-info":[{"award-number":["82302683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272501"],"award-info":[{"award-number":["82272501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108017"],"award-info":[{"award-number":["82120108017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572769"],"award-info":[{"award-number":["82572769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["ML12202923"],"award-info":[{"award-number":["ML12202923"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230215"],"award-info":[{"award-number":["BK20230215"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250123"],"award-info":[{"award-number":["BK20250123"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017534","name":"333 Project of Jiangsu Province","doi-asserted-by":"publisher","award":["2069999"],"award-info":[{"award-number":["2069999"]}],"id":[{"id":"10.13039\/501100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bioactmat.2026.08.041","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:53:20Z","timestamp":1787723600000},"page":"1289-1314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ion-GPS nanocapsules activate calcium-permeable gates in inflammatory microglia for nerve function recovery"],"prefix":"10.1016","volume":"66","author":[{"given":"Yiwei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-1610","authenticated-orcid":false,"given":"Zhengxia","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guhao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-9866","authenticated-orcid":false,"given":"Kun","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.041_bib1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S1474-4422(23)00287-9","article-title":"Global, regional, and national burden of spinal cord injury, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"22","year":"2023","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib2","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","article-title":"Spinal cord repair: advances in biology and technology","volume":"25","author":"Courtine","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104387","article-title":"Navigating the complexities of spinal cord injury: an overview of pathology, treatment strategies and clinical trials","volume":"30","author":"Chopra","year":"2025","journal-title":"Drug Discov. Today"},{"issue":"22","key":"10.1016\/j.bioactmat.2026.08.041_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202517284","article-title":"Mussel inspired hydrogel promotes axon regeneration via Piezo1 modulation and cytoskeleton dynamics in synergy after spinal cord injury","volume":"36","author":"Zheng","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"27","key":"10.1016\/j.bioactmat.2026.08.041_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202002378","article-title":"Melatonin-based and biomimetic scaffold as Muscle\u2013ECM implant for guiding myogenic differentiation of volumetric muscle loss","volume":"30","author":"Xu","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib7","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2413140122","article-title":"Characterizing progenitor cells in developing and injured spinal cord: insights from single-nucleus transcriptomics and lineage tracing","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.041_bib8","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4103\/1673-5374.324858","article-title":"M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury","volume":"17","author":"Yu","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ibra.12048","article-title":"Research progress of endogenous neural stem cells in spinal cord injury","volume":"8","author":"Wang","year":"2022","journal-title":"Ibrain"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jamaneurol.2014.2927","article-title":"Role of endogenous neural stem cells in spinal cord injury and repair","volume":"72","author":"Stenudd","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134370","article-title":"Role of microglia in spinal cord injury","volume":"709","author":"Kroner","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"17","key":"10.1016\/j.bioactmat.2026.08.041_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304087","article-title":"Bioactive nanofiber-hydrogel composite regulates regenerative microenvironment for skeletal muscle regeneration after volumetric muscle loss","volume":"13","author":"Yu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/978-3-030-12457-1_29","article-title":"ER-Mitochondria calcium transfer, organelle contacts and neurodegenerative diseases","volume":"1131","author":"Vallese","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.041_bib16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.molcel.2026.03.002","article-title":"Mechanosensory channels mediate ER Ca(2+) transients to trigger assembly of autophagosome initiation sites for degradation of ER subdomains","volume":"86","author":"Ma","year":"2026","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib17","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1038\/s41467-025-58705-6","article-title":"Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells","volume":"16","author":"Gu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116587","article-title":"The roles of mitochondria-associated membranes in mitochondrial quality control under endoplasmic reticulum stress","volume":"231","author":"Lan","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/ceca.2000.0162","article-title":"Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states","volume":"29","author":"Paschen","year":"2001","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00018-024-05286-0","article-title":"Redox regulation of UPR signalling and mitochondrial ER contact sites","volume":"81","author":"Casas-Martinez","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib21","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/s41418-020-00705-8","article-title":"ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms","volume":"28","author":"Wilson","year":"2021","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib22","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1038\/s41467-025-58722-5","article-title":"GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. Commun."},{"issue":"34","key":"10.1016\/j.bioactmat.2026.08.041_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi2767","article-title":"ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy","volume":"9","author":"Bround","year":"2023","journal-title":"Sci. Adv."},{"issue":"18","key":"10.1016\/j.bioactmat.2026.08.041_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188872","article-title":"cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models","volume":"135","author":"Xiao","year":"2025","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41420-024-01947-y","article-title":"Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy","volume":"10","author":"Su","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biomaterials.2018.03.007","article-title":"Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization","volume":"178","author":"Kang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib27","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2147\/IJN.S402170","article-title":"Mitochondrial calcium nanoregulators reverse the macrophage proinflammatory phenotype through restoring mitochondrial calcium homeostasis for the treatment of osteoarthritis","volume":"18","author":"Lei","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"5806","key":"10.1016\/j.bioactmat.2026.08.041_bib28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/290527a0","article-title":"A non-disruptive technique for loading calcium buffers and indicators into cells","volume":"290","author":"Tsien","year":"1981","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.08.041_bib29","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0278-5846(01)00202-0","article-title":"BAPTA\/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures","volume":"25","author":"Wie","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0006-8993(01)03229-2","article-title":"Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells","volume":"924","author":"Nguyen","year":"2002","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0143-4160(02)00195-1","article-title":"Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress","volume":"33","author":"Paschen","year":"2003","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12640-024-00726-y","article-title":"Curcumin improves hippocampal cell bioenergetics, redox and inflammatory markers, and synaptic proteins, regulating mitochondrial calcium homeostasis","volume":"43","author":"Jara","year":"2025","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102637","article-title":"Hyperoside alleviates toxicity of \u03b2-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP\/PS1 double transgenic Alzheimer's disease mice","volume":"61","author":"Song","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib34","first-page":"59","article-title":"Danshen: a phytochemical and pharmacological overview","volume":"17","author":"Xd","year":"2019","journal-title":"Chin. J. Nat. Med."},{"issue":"12\u201313","key":"10.1016\/j.bioactmat.2026.08.041_bib35","first-page":"1003","article-title":"Effects of Salvia miltiorrhiza on CNS neuronal injury and degeneration: a plausible complementary role of tanshinones and depsides","volume":"81","author":"Bonaccini","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157162","article-title":"Protection against stroke-induced blood-brain barrier disruption by guanxinning injection and its active-component combination via TLR4\/NF-\u03baB\/MMP9-mediated neuroinflammation","volume":"147","author":"Fan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103185","article-title":"Developing targeted antioxidant nanomedicines for ischemic penumbra: novel strategies in treating brain ischemia-reperfusion injury","volume":"73","author":"Hou","year":"2024","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.bioactmat.2026.08.041_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202207826","article-title":"Plant-derived vesicle-like nanoparticles as promising biotherapeutic tools: present and future","volume":"35","author":"Feng","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157087","article-title":"Plant-derived exosomes: unveiling the similarities and disparities between conventional extract and innovative form","volume":"145","author":"Han","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib40","first-page":"171","article-title":"Plant-derived vesicle-like nanoparticles for immunomodulation: mechanisms and applications","volume":"55","author":"Wang","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib41","article-title":"Top-down engineered micron-cell derived nanovesicles encapsulating curcumin targeting the 3R strategy (remove, remodel, repair) for Alzheimer's disease therapy","volume":"34","author":"Chu","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"21\u201322","key":"10.1016\/j.bioactmat.2026.08.041_bib42","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1089\/neu.2024.0047","article-title":"Intravenous administration of Anti-CD47 antibody augments hematoma clearance, mitigates acute neuropathology, and improves cognitive function in a rat model of penetrating traumatic brain injury","volume":"41","author":"Wang","year":"2024","journal-title":"J. Neurotrauma"},{"issue":"42","key":"10.1016\/j.bioactmat.2026.08.041_bib43","article-title":"MicroRNA-Enriched plant-derived exosomes alleviate colitis by modulating systemic immunity, metabolic homeostasis, and gut microbiota","volume":"12","author":"Shi","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.omtn.2018.02.007","article-title":"Gene therapy for neuropathic pain through siRNA-IRF5 gene delivery with homing peptides to microglia","volume":"11","author":"Terashima","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"27","key":"10.1016\/j.bioactmat.2026.08.041_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201322","article-title":"Engineered nanoerythrocytes alleviate central nervous system inflammation by regulating the polarization of inflammatory microglia","volume":"34","author":"Yin","year":"2022","journal-title":"Adv. Mater."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.08.041_bib46","article-title":"Acid-responsive dual-targeted nanoparticles encapsulated aspirin rescue the immune activation and phenotype in autism spectrum disorder","volume":"9","author":"He","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10863-021-09878-4","article-title":"Changes in mitochondrial morphology modulate LPS-induced loss of calcium homeostasis in BV-2 microglial cells","volume":"53","author":"Pereira","year":"2021","journal-title":"J. Bioenerg. Biomembr."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12989-022-00464-z","article-title":"Nitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia","volume":"19","author":"Wu","year":"2022","journal-title":"Part. Fibre Toxicol."},{"issue":"15","key":"10.1016\/j.bioactmat.2026.08.041_bib49","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.041_bib50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/CIRCULATIONAHA.125.073937","article-title":"Junctophilin-2 regulates store-operated calcium entry to drive cardiac fibroblast activation, fibrotic repair, and angiogenesis after myocardial infarction","volume":"152","author":"Wang","year":"2025","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.041_bib51","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.immuni.2017.09.003","article-title":"Store-operated Ca(2+) entry controls clonal expansion of T cells through metabolic reprogramming","volume":"47","author":"Vaeth","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib52","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41590-018-0287-8","article-title":"The Ca(2+) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum","volume":"20","author":"Srikanth","year":"2019","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.041_bib53","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","article-title":"Store-operated calcium channels","volume":"95","author":"Prakriya","year":"2015","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12048","article-title":"A call for Rigor and standardization in plant extracellular vesicle research","volume":"10","author":"Pinedo","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108832","article-title":"Plant-derived nanovesicles and therapeutic application","volume":"269","author":"Jung","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib56","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v5.32945","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J. Extracell. Vesicles"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.041_bib57","doi-asserted-by":"crossref","first-page":"17802","DOI":"10.1021\/acsnano.2c08774","article-title":"Exosomes\u2500Nature's lipid nanoparticles, a rising star in drug delivery and diagnostics","volume":"16","author":"Tenchov","year":"2022","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib58","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1038\/s41467-022-35242-0","article-title":"TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage","volume":"13","author":"Tang","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.041_bib59","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.tcb.2024.02.006","article-title":"ER: a critical hub for STING signaling regulation","volume":"34","author":"Luo","year":"2024","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.041_bib60","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00188-23","article-title":"The papain-like protease of porcine reproductive and respiratory syndrome virus impedes STING translocation from the endoplasmic reticulum to the golgi apparatus by deubiquitinating STIM1","volume":"97","author":"Diao","year":"2023","journal-title":"J. Virol."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.08.041_bib61","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.7150\/thno.44025","article-title":"STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.brainres.2017.11.027","article-title":"Mechanism of salvianolic acid B neuroprotection against ischemia\/reperfusion induced cerebral injury","volume":"1679","author":"Fan","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102260","article-title":"Salvianolic acid B exerts protective effects against A\u03b2-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1\/M2 polarization","volume":"85","author":"Zhao","year":"2023","journal-title":"Tissue Cell"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.041_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101668","article-title":"Salvianolic acid B attenuates toxin-induced neuronal damage via Nrf2-dependent glial cells-mediated protective activity in Parkinson's disease models","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2026.08.041_bib65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2017.07.012","article-title":"Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.041_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70069","article-title":"Nanobody engineered and photosensitiser loaded bacterial outer membrane vesicles potentiate antitumour immunity and immunotherapy","volume":"14","author":"Xia","year":"2025","journal-title":"J. Extracell. Vesicles"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib67","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.apsb.2025.01.015","article-title":"Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease","volume":"15","author":"Wei","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib68","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12951-024-02420-9","article-title":"A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain","volume":"22","author":"Lu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.041_bib69","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1016\/j.ymthe.2025.03.002","article-title":"Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice","volume":"33","author":"Zen","year":"2025","journal-title":"Mol. Ther."},{"issue":"34","key":"10.1016\/j.bioactmat.2026.08.041_bib70","doi-asserted-by":"crossref","first-page":"23014","DOI":"10.1021\/acsnano.4c04674","article-title":"Engineered extracellular vesicle-based nanoformulations that coordinate neuroinflammation and immune homeostasis, enhancing Parkinson's Disease therapy","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"issue":"31","key":"10.1016\/j.bioactmat.2026.08.041_bib71","article-title":"Cordycepin modulates microglial M2 polarization coupled with mitochondrial metabolic reprogramming by targeting HKII and PDK2","volume":"11","author":"Zhong","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib72","article-title":"Ligand-screened cerium-based MOF microcapsules promote nerve regeneration via mitochondrial energy supply","volume":"11","author":"Jiang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"18","key":"10.1016\/j.bioactmat.2026.08.041_bib73","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1158\/0008-5472.CAN-25-0419","article-title":"Mitochondrial calcium uniporter links Acetyl-CoA metabolism and H3K27 acetylation to maintain glioblastoma stem cells","volume":"85","author":"Liu","year":"2025","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.041_bib74","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/stem.767","article-title":"Significance of remyelination by neural stem\/progenitor cells transplanted into the injured spinal cord","volume":"29","author":"Yasuda","year":"2011","journal-title":"Stem Cell."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.041_bib75","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tins.2023.12.003","article-title":"Tuning neural circuits and behaviors by microglia in the adult brain","volume":"47","author":"Zhao","year":"2024","journal-title":"Trends Neurosci."},{"issue":"50","key":"10.1016\/j.bioactmat.2026.08.041_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307624","article-title":"Microenvironment self-adaptive nanomedicine promotes spinal cord repair by suppressing inflammation Cascade and neural apoptosis","volume":"36","author":"Qian","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.041_bib77","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cns.14085","article-title":"Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2\/STAT3 signaling pathway in spinal cord injury","volume":"29","author":"Xiao","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib78","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1177\/0963689718755778","article-title":"Microenvironment imbalance of spinal cord injury","volume":"27","author":"Fan","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1695087","article-title":"Microglia-derived exosomes improve spinal cord functional recovery after injury via inhibiting oxidative stress and promoting the survival and function of endothelia cells","volume":"2021","author":"Peng","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci15020191","article-title":"Sex and strain-specific variations in motor recovery following compression Spinal Cord injury: comparison of sprague-dawley and Wistar rats","volume":"15","author":"Mojarad","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115204","article-title":"Sex-related disparities in mobility, sensory function, and psychological outcomes in Wistar and Sprague-Dawley rats following spinal cord injury","volume":"388","author":"Guo","year":"2025","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib82","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12974-025-03338-1","article-title":"Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury","volume":"22","author":"Kumari","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.041_bib83","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.041_bib84","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/glia.23271","article-title":"Bioenergetic regulation of microglia","volume":"66","author":"Ghosh","year":"2018","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.041_bib85","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbabio.2009.01.005","article-title":"Regulation of mitochondrial dehydrogenases by calcium ions","volume":"1787","author":"Denton","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.041_bib86","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.041_bib87","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bioactmat.2026.08.041_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2019.104411","article-title":"3D structured self-powered PVDF\/PCL scaffolds for peripheral nerve regeneration","volume":"69","author":"Cheng","year":"2020","journal-title":"Nano Energy"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.041_bib89","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41467-017-02598-7","article-title":"An integrated multi-layer 3D-fabrication of PDA\/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration","volume":"9","author":"Qian","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:16:49Z","timestamp":1792081009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26005049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":89,"alternative-id":["S2452199X26005049"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.041","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ion-GPS nanocapsules activate calcium-permeable gates in inflammatory microglia for nerve function recovery","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}