{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:03:02Z","timestamp":1789671782905,"version":"4.0.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007707","name":"National Institute for Insurance against Accidents at Work","doi-asserted-by":"publisher","award":["PR23-CR-P1"],"award-info":[{"award-number":["PR23-CR-P1"]}],"id":[{"id":"10.13039\/501100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioactmat.2026.08.053","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:46:51Z","timestamp":1788252411000},"page":"118-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ultrasound-activated piezoelectric muscle constructs for tissue-engineered regenerative peripheral nerve interfaces"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-5073","authenticated-orcid":false,"given":"Lorenzo","family":"Vannozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Trucco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-3711","authenticated-orcid":false,"given":"Carlotta","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Boccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Schirru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gherardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6662-0067","authenticated-orcid":false,"given":"Waleed Mustafa Ali","family":"Al-ghilan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Parlanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Gemmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-3233","authenticated-orcid":false,"given":"Paolo","family":"Sassu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-8378","authenticated-orcid":false,"given":"Emanuele","family":"Gruppioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-3742","authenticated-orcid":false,"given":"Leonardo","family":"Ricotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2026.08.053_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12984-020-00667-5","article-title":"Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review","volume":"17","author":"Yildiz","year":"2020","journal-title":"J. NeuroEng. Rehabil."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.053_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cps.2020.01.004","article-title":"Regenerative peripheral nerve interfaces for prevention and management of neuromas","volume":"47","author":"Santosa","year":"2020","journal-title":"Clin. Plast. Surg."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.prs.0000421762.53265.54","article-title":"Quantification of regenerative peripheral nerve interface signal transmission","volume":"130.5S-1","author":"Urbanchek","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.053_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/prosthesis7040097","article-title":"Merging neuroscience and engineering through regenerative peripheral nerve interfaces","volume":"7","author":"Wang","year":"2025","journal-title":"Prosthesis"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.053_bib5","article-title":"Regenerative peripheral nerve interfaces for the management of symptomatic hand and digital neuromas","volume":"8","author":"Hooper","year":"2020","journal-title":"Plastic Reconstr. Surg., Glob. Open"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib6","article-title":"Development of a regenerative peripheral nerve interface for control of a neuroprosthetic limb","volume":"1","author":"Urbanchek","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"533","key":"10.1016\/j.bioactmat.2026.08.053_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay2857","article-title":"A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees","volume":"12","author":"Vu","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"Supplement 4S","key":"10.1016\/j.bioactmat.2026.08.053_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/01.prs.0000406317.25436.00","article-title":"Long-term stability of regenerative peripheral nerve interfaces (RPNI)","volume":"128","author":"Urbanchek","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12984-018-0452-1","article-title":"Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand","volume":"15","author":"Frost","year":"2018","journal-title":"J. NeuroEng. Rehabil."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.20517\/2347-9264.2022.26","article-title":"Regenerative peripheral nerve interfaces (RPNIs): current status and future direction","volume":"9","author":"Burke","year":"2022","journal-title":"Plast. Aesthetic Res"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.863969","article-title":"Implantable biomaterials for peripheral nerve regeneration\u2013technology trends and translational tribulations","volume":"10","author":"Sanchez Rezza","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41536-022-00216-9","article-title":"Skeletal muscle differentiation of human iPSCs meets bioengineering strategies: perspectives and challenges","volume":"7","author":"Iberite","year":"2022","journal-title":"npj Regen. Med."},{"issue":"44","key":"10.1016\/j.bioactmat.2026.08.053_bib13","article-title":"Engineered regenerative isolated peripheral nerve interface for targeted reinnervation","volume":"36","author":"Kwon","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib14","first-page":"306","article-title":"Biocompatibility pathways and mechanisms for bioactive materials: the bioactivity zone","volume":"10","author":"Williams","year":"2022","journal-title":"Bioact. Mater."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.053_bib15","first-page":"2704","article-title":"A review of low-intensity pulsed ultrasound for therapeutic applications","volume":"66","author":"Jiang","year":"2018","journal-title":"IEEE (Inst. Electr. Electron. Eng.) Trans. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultrasmedbio.2024.08.016","article-title":"Jingle cell rock: steering cellular activity with low-intensity pulsed ultrasound (LIPUS) to engineer functional tissues in regenerative medicine","author":"Marcotulli","year":"2024","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1080430","article-title":"The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: focusing on the molecular mechanism","volume":"10","author":"Qin","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.053_bib18","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1021\/acsnano.1c03087","article-title":"Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption","volume":"15","author":"Cafarelli","year":"2021","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.053_bib19","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/jfb14100504","article-title":"Musculoskeletal biomaterials: stimulated and synergized with low intensity pulsed ultrasound","volume":"14","author":"Jia","year":"2023","journal-title":"J. Funct. Biomater."},{"issue":"22","key":"10.1016\/j.bioactmat.2026.08.053_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303180","article-title":"Ultrasound\u2010sensitive intelligent nanosystems: a promising strategy for the treatment of neurological diseases","volume":"36","author":"Pan","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.053_bib21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1039\/C8CS00583D","article-title":"Barium titanate at the nanoscale: controlled synthesis and dielectric and ferroelectric properties","volume":"48","author":"Jiang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib22","article-title":"A comprehensive review on barium titanate nanoparticles as a persuasive piezoelectric material for biomedical applications: prospects and challenges","volume":"19.12","author":"Sood","year":"2023","journal-title":"Small"},{"issue":"18","key":"10.1016\/j.bioactmat.2026.08.053_bib23","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1039\/D1BM01853A","article-title":"Piezoelectric nanocomposite bioink and ultrasound stimulation modulate early skeletal myogenesis","volume":"10","author":"Paci","year":"2022","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib24","article-title":"3D bioprinted human skeletal muscle constructs for muscle function restoration","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib25","article-title":"Mechanically programming anisotropy in engineered muscle with actuating extracellular matrices","volume":"1.4","author":"Rios","year":"2023","journal-title":"Device"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/aisy.202400989","article-title":"Monolithic biohybrid flexure mechanism actuated by bioengineered skeletal muscle tissue","author":"Bartolucci","year":"2025","journal-title":"Adv. Intell. Syst."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.053_bib27","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1021\/acsbiomaterials.4c02468","article-title":"Micropatterned styrene\u2013butadiene\u2013styrene thin films doped with barium titanate nanoparticles: effects on myoblast differentiation","volume":"11","author":"Boccoli","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"19","key":"10.1016\/j.bioactmat.2026.08.053_bib28","doi-asserted-by":"crossref","first-page":"21398","DOI":"10.1021\/acsami.0c00154","article-title":"Novel ultrathin films based on a blend of PEG-b-PCL and PLLA and doped with ZnO nanoparticles","volume":"12","author":"Vannozzi","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.053_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202400439","article-title":"Biodegradable piezoelectric micro\u2010and nanomaterials for regenerative medicine, targeted therapy, and microrobotics","volume":"5","author":"Vannozzi","year":"2025","journal-title":"Small Sci."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib30","article-title":"In vivo efficacy of an injectable piezoelectric nanocomposite hydrogel and low-intensity pulsed ultrasound in two preclinical models of osteoarthritis","author":"Tschon","year":"2025","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.053_bib31","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/smll.201201390","article-title":"Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking","volume":"9","author":"Duan","year":"2013","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.053_bib32","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1021\/acsnano.3c08738","article-title":"Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts chondrogenic differentiation in vitro, in both a normal and inflammatory milieu","volume":"18","author":"Ricotti","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib33","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1038\/s41598-017-03723-8","article-title":"Investigating the life expectancy and proteolytic degradation of engineered skeletal muscle biological machines","volume":"7","author":"Cvetkovic","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.actbio.2015.06.033","article-title":"A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain","volume":"24","author":"Heher","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib35","article-title":"Ultrasound-activated piezoelectric hydrogel promotes functional muscle repair by orchestrating myogenesis and reinnervation","author":"Lyu","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245618","article-title":"Myogenin is required for assembly of the transcription machinery on muscle genes during skeletal muscle differentiation","volume":"16","author":"Adhikari","year":"2021","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.053_bib37","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/ac1b6b","article-title":"Physiologic signaling and viability of the muscle cuff regenerative peripheral nerve interface (MC-RPNI) for intact peripheral nerves","volume":"18","author":"Kubiak","year":"2021","journal-title":"J. Neural. Eng."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.053_bib38","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3390\/ijms25021141","article-title":"Regenerative peripheral nerve interfaces (rpnis) in animal models and their applications: a systematic review","volume":"25","author":"Gonz\u00e1lez-Prieto","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.053_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/mus.27138","article-title":"Regenerative peripheral nerve interface free muscle graft mass and function","volume":"63","author":"Hu","year":"2021","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.053_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.injury.2020.10.070","article-title":"Heterologous fibrin biopolymer associated to a single suture stitch enables the return of neuromuscular junction to its mature pattern after peripheral nerve injury","volume":"52","author":"Pinto","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib41","article-title":"Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review","volume":"30","author":"Muller","year":"2024","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.053_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202300255","article-title":"Piezoelectric nanomaterial\u2010mediated physical signals regulate cell differentiation for regenerative medicine","volume":"4","author":"Li","year":"2024","journal-title":"Small Sci."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12984-018-0474-8","article-title":"Safety of long-term electrical peripheral nerve stimulation: review of the state of the art","volume":"16","author":"G\u00fcnter","year":"2019","journal-title":"J. NeuroEng. Rehabil."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.08.053_bib44","doi-asserted-by":"crossref","first-page":"18236","DOI":"10.1021\/acsami.4c02303","article-title":"Ionic rectification by dynamic regulation of the electric double layer at the hydrogel interface","volume":"16","author":"Ouyang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib45","article-title":"The effects of sintering temperature on dielectric constant of Barium Titanate (BaTiO3)","volume":"107","author":"Sandi","year":"2016"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib46","doi-asserted-by":"crossref","first-page":"B43","DOI":"10.1093\/gerona\/51A.1.B43","article-title":"The regeneration of noninnervated muscle grafts and marcaine-treated muscles in young and old rats","volume":"51","author":"Carlson","year":"1996","journal-title":"J. Gerontol., Ser. A Biol. Sci. Med. Sci."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.053_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166294","article-title":"Controlled heat stress promotes myofibrillogenesis during myogenesis","volume":"11","author":"Guo","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.053_bib48","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1152\/japplphysiol.00989.2011","article-title":"Mild heat stress induces mitochondrial biogenesis in C2C12 myotubes","volume":"112","author":"Liu","year":"2012","journal-title":"J. Appl. Physiol."},{"issue":"1\u20134","key":"10.1016\/j.bioactmat.2026.08.053_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0167-2738(97)00074-X","article-title":"Electrical conductivity studies in hydrogels","volume":"97","author":"Pissis","year":"1997","journal-title":"Solid State Ionics"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.colsurfa.2018.05.011","article-title":"Sucrose solutions alter the electric capacitance and dielectric permittivity of lipid bilayers","volume":"557","author":"Vitkova","year":"2018","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib51","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.1990.259.1.C3","article-title":"Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone","volume":"259","author":"Nelson","year":"1990","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"24","key":"10.1016\/j.bioactmat.2026.08.053_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413615","article-title":"Ion channels and transporters in muscle cell differentiation","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.053_bib53","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1039\/D2BM01733D","article-title":"\u201cUltrasound-mediated piezoelectric nanoparticle modulation of intrinsic cardiac autonomic nervous system for rate control in atrial fibrillation","volume":"11","author":"Han","year":"2023","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/acsami.9b17222","article-title":"Surface charge-mediated cell\u2013surface interaction on piezoelectric materials","volume":"12","author":"Ribeiro","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.053_bib55","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1111\/j.1538-7836.2006.02081.x","article-title":"Molecular weight fibrinogen variants determine angiogenesis rate in a fibrin matrix in vitro and in vivo","volume":"4","author":"Kaijzel","year":"2006","journal-title":"J. Thromb. Haemostasis"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.053_bib56","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.115.306477","article-title":"Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates left ventricular dysfunction in a mouse model of acute myocardial infarction","volume":"36","author":"Shindo","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.053_bib57","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3390\/biom11111731","article-title":"Piezoelectric signals in vascularized bone regeneration","volume":"11","author":"D'Alessandro","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122803","article-title":"Ultrasound-responsive microfibers promoted infected wound healing with neuro-vascularization by segmented sonodynamic therapy and electrical stimulation","volume":"313","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.053_bib59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn.2018.13","article-title":"Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics","volume":"19","author":"Petersen","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2025.1568004","article-title":"Combined strategy of \u03b1 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth","volume":"19","author":"Cimpean","year":"2025","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.053_bib61","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1021\/acs.biomac.3c00311","article-title":"Electrospun piezoelectric scaffold with external mechanical stimulation for promoting regeneration of peripheral nerve injury","volume":"24","author":"Zhang","year":"2023","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.053_bib62","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1021\/nn101985a","article-title":"Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation","volume":"4","author":"Ciofani","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2022.107707","article-title":"Ultrasound-driven in vivo electrical stimulation based on biodegradable piezoelectric nanogenerators for enhancing and monitoring the nerve tissue repair","volume":"102","author":"Wu","year":"2022","journal-title":"Nano Energy"},{"key":"10.1016\/j.bioactmat.2026.08.053_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-015-5414-6","article-title":"Absence of systemic toxicity in mouse model towards BaTiO 3 nanoparticulate based eluate treatment","volume":"26","author":"Dubey","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib65","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4142\/jvs.2015.16.1.57","article-title":"Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease","volume":"16","author":"Pa\u00dflack","year":"2015","journal-title":"J. Vet. Sci."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib66","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/2193-1801-3-343","article-title":"Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in the equine liver and kidneys","volume":"3","author":"Pa\u00dflack","year":"2014","journal-title":"SpringerPlus"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib67","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00216-008-2449-2","article-title":"Titanium levels in the organs and blood of rats with a titanium implant, in the absence of wear, as determined by double-focusing ICP-MS","volume":"393","author":"Sarmiento-Gonz\u00e1lez","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bioactmat.2026.08.053_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2026.116244","article-title":"Visible light-mediated crosslinked methacrylated gellan gum nanocomposite hydrogel: physicochemical characterization and in vivo safety","author":"Codispoti","year":"2026","journal-title":"Mater. Des."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.053_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68405-4","article-title":"Uranium-free X solution: a new generation contrast agent for biological samples ultrastructure","volume":"10","author":"Moscardini","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.053_bib70","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.ultrasmedbio.2017.03.003","article-title":"Optimal ultrasound exposure conditions for maximizing C2C12 muscle cell proliferation and differentiation","volume":"43","author":"Salgarella","year":"2017","journal-title":"Ultrasound Med. Biol."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.08.053_bib71","article-title":"Functional skeletal muscle regeneration with thermally drawn porous fibers and reprogrammed muscle progenitors for volumetric muscle injury","volume":"33","author":"Jin","year":"2021","journal-title":"Adv. Mater."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:07:33Z","timestamp":1789668453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26005165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":71,"alternative-id":["S2452199X26005165"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.053","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound-activated piezoelectric muscle constructs for tissue-engineered regenerative peripheral nerve interfaces","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}