{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:54:41Z","timestamp":1791064481817,"version":"4.1.0"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2025Z012"],"award-info":[{"award-number":["WJ2025Z012"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","award":["AI2024A03"],"award-info":[{"award-number":["AI2024A03"]}],"id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706102"],"award-info":[{"award-number":["2023YFB4706102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","award":["2024BCB036"],"award-info":[{"award-number":["2024BCB036"]}],"id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025BRB023"],"award-info":[{"award-number":["2025BRB023"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioactmat.2026.08.060","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:34:36Z","timestamp":1788881676000},"page":"485-502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics"],"prefix":"10.1016","volume":"68","author":[{"given":"Duo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangxuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/21621918251359554","article-title":"Human wound and its burden: updated 2025 compendium of estimates","volume":"14","author":"Sen","year":"2025","journal-title":"Adv. Wound Care"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2025-111730","article-title":"Barriers to and enablers of prophylactic compression use by people at risk of venous leg ulcer recurrence: a qualitative study","volume":"16","author":"Alkahtani","year":"2026","journal-title":"BMJ Open"},{"issue":"24","key":"10.1016\/j.bioactmat.2026.08.060_bib3","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"9498","key":"10.1016\/j.bioactmat.2026.08.060_bib4","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.14859","article-title":"Characteristics and outcomes of diabetic foot ulcers treated with surgical debridement and standardized wound care","volume":"21","author":"Moghaddam Ahmadi","year":"2024","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaad.2015.08.070","article-title":"Wound healing and treating wounds: chronic wound care and management","volume":"74","author":"Powers","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s41401-022-01013-2","article-title":"GDF11 promotes wound healing in diabetic mice via stimulating HIF-1a-VEGF\/SDF-1a-mediated endothelial progenitor cell mobilization and neovascularization","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaf015","article-title":"Nanomedicine-based immunotherapy for tissue regeneration","volume":"13","author":"Li","year":"2025","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122585","article-title":"Microenvironment-sensitive nanozymes for tissue regeneration","volume":"309","author":"Xiong","year":"2024","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40779-024-00573-0","article-title":"Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration","volume":"11","author":"Xiong","year":"2024","journal-title":"Milit. Med. Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202302587","article-title":"Metal-organic frameworks and their composites for chronic wound healing: from bench to bedside","volume":"36","author":"Xiong","year":"2024","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib12","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1039\/D3CS00673E","article-title":"Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications","volume":"53","author":"Wu","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123560","article-title":"MXenzyme-reinforced hydrogel enhances stem cell therapy through multidimensional regulation in rheumatoid arthritis management","volume":"325","author":"Zhao","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmt.2025.100120","article-title":"Microenvironment-feedback hydrogel for precise sequential repair of acute infectious wounds","volume":"12","author":"Tang","year":"2025","journal-title":"Biomedical Technology"},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.70014","article-title":"Antibacterial and proangiogenic hydrogel microneedle patches for wound healing","volume":"4","author":"Zhang","year":"2025","journal-title":"Smart Med"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.060_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202204798","article-title":"Computational biomaterials: computational simulations for biomedicine","volume":"35","author":"Dai","year":"2023","journal-title":"Adv. Mater."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tibtech.2024.11.011","article-title":"Artificial intelligence in biomaterials: a call for unified biocompatibility standards","volume":"43","author":"Mozafari","year":"2025","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202102703","article-title":"Machine learning-driven biomaterials evolution","volume":"34","author":"Suwardi","year":"2022","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib19","article-title":"Mechanobiological dynamics-inspired mechanomodulatory biomaterials","volume":"13","author":"Yang","year":"2026","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"19","key":"10.1016\/j.bioactmat.2026.08.060_bib20","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1039\/D5MH00719D","article-title":"Artificial intelligence-driven revolution in nanozyme design: from serendipity to rational engineering","volume":"12","author":"Yu","year":"2025","journal-title":"Mater. Horiz."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib21","article-title":"Machine learning-assisted high-throughput screening of nanozymes for ulcerative colitis","volume":"37","author":"Zhao","year":"2025","journal-title":"Adv. mat. (Deerfield Beach, Fla.)"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib22","article-title":"Clear-box machine learning for virtual screening of 2D nanozymes to target tumor hydrogen peroxide","volume":"12","author":"Gao","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"16","key":"10.1016\/j.bioactmat.2026.08.060_bib23","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1039\/D5MH00746A","article-title":"Bioinspired rational design of nanozymes","volume":"12","author":"Chen","year":"2025","journal-title":"Mater. Horiz."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"8","key":"10.1016\/j.bioactmat.2026.08.060_bib25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pena","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib26","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/jre.12912","article-title":"Hyperglycemia modulates M1\/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis","volume":"56","author":"Zhang","year":"2021","journal-title":"J. Periodontal. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib28","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2017.05.022","article-title":"Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice","volume":"67","author":"Ma","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119833","article-title":"Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner","volume":"239","author":"Mahon","year":"2020","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12137","article-title":"Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-\u03b2 upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury","volume":"10","author":"Nakazaki","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib31","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","article-title":"Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/1753-0407.70205","article-title":"Insights into macrophage polarization and M1\/M2 balance in diabetic foot ulcers","volume":"18","author":"Zhang","year":"2026","journal-title":"J. Diabetes"},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169138","article-title":"Macrophage RAGE activation is proinflammatory in NASH","volume":"9","author":"Parthasarathy","year":"2024","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41420-023-01425-x","article-title":"High glucose-induced STING activation inhibits diabetic wound healing through promoting M1 polarization of macrophages","volume":"9","author":"Geng","year":"2023","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s10020-022-00525-1","article-title":"Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1\u03b1 in diabetic kidney disease","volume":"28","author":"Jia","year":"2022","journal-title":"Mol Med"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28086","article-title":"Epigenetic modification: a novel insight into diabetic wound healing","volume":"10","author":"Ju","year":"2024","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib37","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4049\/jimmunol.2100695","article-title":"Advanced glycation end products (AGEs) inhibit macrophage efferocytosis of apoptotic \u03b2 cells through binding to the receptor for AGEs","volume":"208","author":"Mao","year":"2022","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40779-025-00611-5","article-title":"Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment","volume":"12","author":"Zhang","year":"2025","journal-title":"Milit. Med. Res."},{"issue":"36","key":"10.1016\/j.bioactmat.2026.08.060_bib39","doi-asserted-by":"crossref","first-page":"32606","DOI":"10.1021\/acsnano.5c10123","article-title":"ZnCe-LDO nanozyme-based multifunctional hydrogel promotes bone regeneration by inflammatory macrophage reprogramming and Piezo1 activation","volume":"19","author":"Xiao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib40","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.2147\/IJN.S382796","article-title":"Recent advances in nanozymes for bacteria-infected wound therapy","volume":"17","author":"Mo","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400677","article-title":"Nanozymes as antibacterial agents: new concerns in design and enhancement strategies","volume":"26","author":"Yan","year":"2025","journal-title":"Chembiochem"},{"issue":"Pt 1","key":"10.1016\/j.bioactmat.2026.08.060_bib42","article-title":"Cu\/Mn bimetallic nanozyme enhanced carboxymethyl chitosan\/oxidized sodium alginate-based hydrogel promotes diabetic wound healing by regulating macrophage polarization through NF-kappaB\/JAK-STAT pathway","volume":"343","author":"Zhang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.bioactmat.2026.08.060_bib43","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41565-024-01660-y","article-title":"Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds","volume":"19","author":"Wei","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib44","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s42003-024-07219-w","article-title":"Cellular and molecular roles of reactive oxygen species in wound healing","volume":"7","author":"Hunt","year":"2024","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/antiox10020313","article-title":"Functions of ROS in macrophages and antimicrobial immunity","volume":"10","author":"Herb","year":"2021","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41392-025-02401-w","article-title":"Diabetes and its complications: molecular mechanisms, prevention and treatment","volume":"11","author":"Zhao","year":"2026","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib48","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.3390\/ijms24119352","article-title":"Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections","volume":"24","author":"Gonz\u00e1lez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.060_bib49","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2017.7263","article-title":"Redox signaling in diabetic wound healing regulates extracellular matrix deposition","volume":"27","author":"Kunkemoeller","year":"2017","journal-title":"Antioxid. Redox Signaling"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib50","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2573660","article-title":"Ferroptosis and macrophage efferocytosis in periodontitis: biological insights and therapeutic advances","volume":"16","author":"Chen","year":"2025","journal-title":"Virulence"},{"issue":"10\u201312","key":"10.1016\/j.bioactmat.2026.08.060_bib51","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signaling"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.060_bib52","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/antiox11071394","article-title":"Macrophage polarization and reprogramming in acute inflammation: a redox perspective","volume":"11","author":"P\u00e9rez","year":"2022","journal-title":"Antioxidants-Basel"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib53","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fimmu.2014.00448","article-title":"Granule protein processing and regulated secretion in neutrophils","volume":"5","author":"Sheshachalam","year":"2014","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib54","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib55","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2353\/ajpath.2006.060128","article-title":"Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin","volume":"169","author":"Quan","year":"2006","journal-title":"Am. J. Pathol."},{"issue":"40","key":"10.1016\/j.bioactmat.2026.08.060_bib56","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.2174\/1381612824666190114164117","article-title":"Oxidative stress and the epigenetics of cell senescence: insights from progeroid syndromes","volume":"24","author":"Rom\u00e1-Mateo","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib57","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/antiox15050548","article-title":"Oxidative-stress-associated molecular signatures in immune-mediated diseases: a systematic review integrating machine learning and systems biology approaches","volume":"15","author":"Mittal","year":"2026","journal-title":"Antioxidants-Basel"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1550","article-title":"Systems biology of angiogenesis signaling: computational models and omics","volume":"14","author":"Zhang","year":"2022","journal-title":"Wires Mechanisms of Disease"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib59","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/ijms25010050","article-title":"Targeting signalling pathways in chronic wound healing","volume":"25","author":"Bonnici","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib60","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.3390\/ijms17111822","article-title":"Extracellular matrix, a hard player in angiogenesis","volume":"17","author":"Mongiat","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bioactmat.2026.08.060_bib61","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41374-021-00598-2","article-title":"LncRNA GAS5 activates the HIF1A\/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers","volume":"101","author":"Peng","year":"2021","journal-title":"Lab. Invest."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib62","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4239\/wjd.v14.i4.364","article-title":"Therapeutic role of growth factors in treating diabetic wound","volume":"14","author":"Zheng","year":"2023","journal-title":"World J. Diabetes"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib63","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib64","article-title":"Enhancing angiogenesis: innovative drug delivery systems to facilitate diabetic wound healing","volume":"170","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.060_bib65","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and wound angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1284981","article-title":"Research progress on the mechanism of angiogenesis in wound repair and regeneration","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8852759","article-title":"The role of oxidative stress and antioxidants in diabetic wound healing","volume":"2021","author":"Deng","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib68","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/0115733998356905250706203510","article-title":"Mechanisms and interventions of diabetic wound healing","volume":"22","author":"Feng","year":"2026","journal-title":"Curr. Diabetes Rev."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib69","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/wrr.12415","article-title":"Pericytes: a newly recognized player in wound healing","volume":"24","author":"Bodnar","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib70","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1089\/wound.2020.1319","article-title":"Advanced wound diagnostics: toward transforming wound care into precision medicine","volume":"11","author":"Weigelt","year":"2022","journal-title":"Adv. Wound Care"},{"issue":"26","key":"10.1016\/j.bioactmat.2026.08.060_bib71","doi-asserted-by":"crossref","first-page":"37353","DOI":"10.1021\/acsami.5c08400","article-title":"Rational design of nanozymes for tumor therapy\u2500a perspective","volume":"17","author":"Zhong","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib72","article-title":"ROS-responsive drug delivery systems for chronic wound healing: advances, challenges, and translational perspectives","volume":"13","author":"Xiong","year":"2026","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114897","article-title":"High-entropy nanozyme biosensors: machine learning-assisted design and stimulus-responsive applications","volume":"255","author":"Xiong","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-96815-9","article-title":"Artificial intelligence driven platform for rapid catalytic performance assessment of nanozymes","volume":"15","author":"Xuan","year":"2025","journal-title":"Sci. Rep."},{"issue":"42","key":"10.1016\/j.bioactmat.2026.08.060_bib75","article-title":"Electron transfer-tailored D-Band center to boost nanozyme catalysis for interpretable machine learning-empowered intelligent biosensing","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.118107","article-title":"Machine learning-assisted multi-channel nanozyme sensor arrays for multiple pesticide tracking, tracing and metabolism analysis","volume":"292","author":"Song","year":"2026","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.060_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202105673","article-title":"DiZyme: open-access expandable resource for quantitative prediction of nanozyme catalytic activity","volume":"18","author":"Razlivina","year":"2022","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib78","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.1038\/s41467-021-27194-8","article-title":"Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"issue":"27","key":"10.1016\/j.bioactmat.2026.08.060_bib79","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201736","article-title":"Prediction and design of nanozymes using explainable machine learning","volume":"34","author":"Wei","year":"2022","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib80","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41467-023-35828-2","article-title":"Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme","volume":"14","author":"Gao","year":"2023","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.bioactmat.2026.08.060_bib81","doi-asserted-by":"crossref","first-page":"13062","DOI":"10.1021\/acsnano.3c04378","article-title":"Rational design strategies for nanozymes","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib82","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210848","article-title":"Machine-learning-assisted nanozyme design: lessons from materials and engineered enzymes","volume":"36","author":"Zhuang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126679","article-title":"Deep convolutional neural network-based 3D fluorescence sensor array for sugar identification in serum based on the oxidase-mimicking property of CuO nanoparticles","volume":"280","author":"Noreldeen","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1483986","article-title":"Advances in machine learning-enhanced nanozymes","volume":"12","author":"Park","year":"2024","journal-title":"Front. Chem."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib85","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s43588-022-00349-3","article-title":"A universal graph deep learning interatomic potential for the periodic table","volume":"2","author":"Chen","year":"2022","journal-title":"Nat. Comput. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib86","article-title":"Nanozymes design via cost-sensitive machine learning for antibacterial applications","volume":"522","author":"Li","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib87","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41524-020-00362-y","article-title":"A critical examination of compound stability predictions from machine-learned formation energies","volume":"6","author":"Bartel","year":"2020","journal-title":"npj Comput. Mater."},{"issue":"23","key":"10.1016\/j.bioactmat.2026.08.060_bib88","doi-asserted-by":"crossref","first-page":"10475","DOI":"10.1007\/s10853-022-06915-4","article-title":"Review of computational approaches to predict the thermodynamic stability of inorganic solids","volume":"57","author":"Bartel","year":"2022","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib89","article-title":"Advancing materials discovery through artificial intelligence","volume":"47","author":"Otyepka","year":"2025","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib90","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1038\/s41467-025-61778-y","article-title":"Accurate prediction of synthesizability and precursors of 3D crystal structures via large language models","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.bioactmat.2026.08.060_bib91","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1039\/D4MH00432A","article-title":"Probabilistic prediction of material stability: integrating convex hulls into active learning","volume":"11","author":"Novick","year":"2024","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114468","article-title":"Design and performance analysis of multi-enzyme activity-doped nanozymes assisted by machine learning","volume":"248","author":"Ge","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"40","key":"10.1016\/j.bioactmat.2026.08.060_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202507126","article-title":"Discovery of surface-engineered nanoparticles that boost enzyme activity via high-throughput screening and machine learning","volume":"21","author":"Sun","year":"2025","journal-title":"Small"},{"issue":"48","key":"10.1016\/j.bioactmat.2026.08.060_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202509992","article-title":"Two birds, one stone: smart MOF nanozymes for dual catalysis and theranostics","volume":"21","author":"Dheyab","year":"2025","journal-title":"Small"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332640","article-title":"Information-theoretic multi-scale geometric pre-training for enhanced molecular property prediction","volume":"20","author":"Hu","year":"2025","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib96","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1039\/D4BM01371A","article-title":"Single-atom nanozymes with intelligent response to pathological microenvironments for bacterially infected wound healing","volume":"13","author":"Wan","year":"2025","journal-title":"Biomater. Sci."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib97","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1021\/acsnano.5c20192","article-title":"Single-atom nanozyme driven lactate reversal fuels oxidative metabolism and represses lactylation to heal diabetic wounds","volume":"20","author":"Wu","year":"2026","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib98","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/bios15060344","article-title":"Machine-learning-assisted nanozyme-based sensor arrays: construction, empowerment, and applications","volume":"15","author":"Liu","year":"2025","journal-title":"Biosensors"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib99","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1039\/D4BM00169A","article-title":"Machine learning in nanozymes: from design to application","volume":"12","author":"Gao","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117533","article-title":"Histidine-engineered Cu-BTC nanozyme with enhanced laccase-like activity combining the machine learning for precise recognition of beta-lactam antibiotics","volume":"283","author":"Xu","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib101","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10726-024-09915-8","article-title":"Group decision making in multiobjective optimization: a systematic literature review","volume":"34","author":"Pajasmaa","year":"2025","journal-title":"Group Decis. Negot."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib102","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1038\/s41467-026-73672-2","article-title":"Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib103","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1021\/acssensors.3c02147","article-title":"Near-infrared fluorescence probe for indication of the pathological stages of wound healing process and its clinical application","volume":"9","author":"Luo","year":"2024","journal-title":"ACS Sens."},{"issue":"7601","key":"10.1016\/j.bioactmat.2026.08.060_bib104","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature17439","article-title":"Machine-learning-assisted materials discovery using failed experiments","volume":"533","author":"Raccuglia","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib105","article-title":"Stimuli-responsive nanozymes for wound healing: from design strategies to therapeutic advances","volume":"33","author":"Wei","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"39","key":"10.1016\/j.bioactmat.2026.08.060_bib106","doi-asserted-by":"crossref","first-page":"21668","DOI":"10.1021\/acs.analchem.5c04419","article-title":"Programmable bimetallic MOF nanozyme composite with microenvironment-adaptive Cascade catalysis for wearable glucose biosensing and accelerated diabetic wound healing","volume":"97","author":"Yu","year":"2025","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.bioactmat.2026.08.060_bib107","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1039\/D5MH00966A","article-title":"Rational design of dual-atom nanozymes for deep infection healing guided by an interpretable intrinsic descriptor","volume":"12","author":"Xia","year":"2025","journal-title":"Mater. Horiz."},{"issue":"30","key":"10.1016\/j.bioactmat.2026.08.060_bib108","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202502752","article-title":"pH-Switchable multi-enzyme-mimicking via liquid metal nanozyme","volume":"21","author":"Shen","year":"2025","journal-title":"Small"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib109","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1039\/D2TB02661A","article-title":"Engineering ROS-scavenging Prussian blue nanozymes for efficient atherosclerosis nanotherapy","volume":"11","author":"Chen","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"36","key":"10.1016\/j.bioactmat.2026.08.060_bib110","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ad572a","article-title":"Advances in metal-organic framework-based nanozymes in ROS scavenging medicine","volume":"35","author":"Xu","year":"2024","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib111","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s12951-025-03558-w","article-title":"Advanced wound healing with stimuli-responsive nanozymes: mechanisms, design and applications","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.060_bib112","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/gels11070483","article-title":"Advances in nanohybrid hydrogels for wound healing: from functional mechanisms to translational prospects","volume":"11","author":"Mo","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib113","doi-asserted-by":"crossref","first-page":"8907","DOI":"10.2147\/IJN.S517671","article-title":"Nanozymes for accelerating the foot wound healing: a review","volume":"20","author":"Lv","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib114","article-title":"Nanozymes for regenerative medicine","volume":"6","author":"Mou","year":"2022","journal-title":"Small Methods"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcancer.2026.01.002","article-title":"Integrative spatial omics and artificial intelligence: transforming cancer research with omics data and AI","volume":"119","author":"McKenzie","year":"2026","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib116","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/biomedicines14020261","article-title":"Artificial intelligence drives advances in multi-omics analysis and precision medicine for sepsis","volume":"14","author":"Shen","year":"2026","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib117","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.71578","article-title":"Digital biomarkers for precision early detection of lung cancer: integrating AI-Driven multi-omics into clinical pathways","volume":"15","author":"Bu","year":"2026","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib118","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.annonc.2023.10.125","article-title":"Artificial intelligence for predictive biomarker discovery in immuno-oncology: a systematic review","volume":"35","author":"Prelaj","year":"2024","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib119","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3390\/ijms27020801","article-title":"AI-Based prediction of gene expression in single-cell and multiscale genomics and transcriptomics","volume":"27","author":"P\u0103l\u0103\u015ftea","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1053\/j.gastro.2025.02.035","article-title":"Machine learning and artificial intelligence in the multi-omics approach to gut microbiota","volume":"169","author":"Rozera","year":"2025","journal-title":"Gastroenterology"},{"issue":"21","key":"10.1016\/j.bioactmat.2026.08.060_bib121","first-page":"1952","article-title":"Review of machine learning and deep learning models for toxicity prediction","volume":"248","author":"Guo","year":"2023","journal-title":"Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib122","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2023.2208777","article-title":"FGFR2 modulates the Akt\/Nrf2\/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction","volume":"45","author":"Jiao","year":"2023","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib123","doi-asserted-by":"crossref","DOI":"10.1155\/jdr\/5751331","article-title":"Targeting oxidative stress and apoptosis via PI3K\/Akt\/Nrf2 pathway: the therapeutic role of Bletilla striata polysaccharide in diabetic wound repair","volume":"2026","author":"Xu","year":"2026","journal-title":"J. Diabetes Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib124","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3892\/ijmm.2025.5567","article-title":"Cell migration in diabetic wound healing: molecular mechanisms and therapeutic strategies","volume":"56","author":"Song","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.csbj.2024.12.030","article-title":"AI-driven multi-omics integration for multi-scale predictive modeling of genotype-environment-phenotype relationships","volume":"27","author":"Wu","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib126","doi-asserted-by":"crossref","DOI":"10.1093\/gpbjnl\/qzaf011","article-title":"Challenges in AI-driven biomedical multimodal data fusion and analysis","volume":"23","author":"Liu","year":"2025","journal-title":"Genomics Proteomics Bioinf."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117741","article-title":"From droplets to diagnosis: AI-driven imaging and system integration in digital nucleic acid amplification testing","volume":"288","author":"Wei","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib128","first-page":"18","article-title":"Nanozyme-based strategies in cancer immunotherapy: overcoming resistance to enhance therapeutic efficacy","volume":"17","author":"Hou","year":"2025","journal-title":"Aging Dis"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib129","article-title":"Surface chemistry of biologically active reducible oxide nanozymes","volume":"36","author":"Neal","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib130","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1039\/C8CS00457A","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)","volume":"48","author":"Wu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102776","article-title":"Artificial intelligence for drug discovery and development in Alzheimer's disease","volume":"85","author":"Qiu","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib132","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf343","article-title":"AI-guided discovery and optimization of antimicrobial peptides through species-aware language model","volume":"26","author":"Bae","year":"2025","journal-title":"Briefings Bioinf."},{"issue":"33","key":"10.1016\/j.bioactmat.2026.08.060_bib133","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2400862121","article-title":"Leveraging coevolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms","volume":"121","author":"Snoeck","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib134","article-title":"Ligand inter-relation analysis via graph theory predicts macrophage response","volume":"37","author":"Kang","year":"2025","journal-title":"Adv. Mater."},{"issue":"41","key":"10.1016\/j.bioactmat.2026.08.060_bib135","doi-asserted-by":"crossref","first-page":"22745","DOI":"10.1021\/acs.analchem.5c04259","article-title":"Deep learning-assisted lens-free holography integrated Pd nanozyme-armed phages for the rapid and extraction-free detection of viable bacteria","volume":"97","author":"Zhan","year":"2025","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib136","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1039\/D5AN01137J","article-title":"Recent advances in MXene nanozymes: synthesis, surface modifications, catalytic properties, and their emerging roles in biosensing and therapeutic applications","volume":"151","author":"Al-Aoh","year":"2026","journal-title":"Analyst"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126094","article-title":"A review on protein corona formation on nanoparticles and prediction of its composition using artificial intelligence tools","volume":"683","author":"Ahmadi","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"43","key":"10.1016\/j.bioactmat.2026.08.060_bib138","doi-asserted-by":"crossref","first-page":"37633","DOI":"10.1021\/acsnano.5c08608","article-title":"Meta-analysis and machine learning prediction of protein Corona composition across nanoparticle systems in biological media","volume":"19","author":"Canchola","year":"2025","journal-title":"ACS Nano"},{"issue":"45","key":"10.1016\/j.bioactmat.2026.08.060_bib139","doi-asserted-by":"crossref","first-page":"25947","DOI":"10.1039\/D5NR03420E","article-title":"Nanozyme-driven remodeling of the immune microenvironment: from catalytic therapy to precise immune regulation","volume":"17","author":"He","year":"2025","journal-title":"Nanoscale"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib140","doi-asserted-by":"crossref","first-page":"14912","DOI":"10.1021\/acsami.4c20322","article-title":"TA-V nanozymes with acid resistance capabilities effectively target and alleviate ulcerative colitis lesions via oral delivery","volume":"17","author":"Jin","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126220","article-title":"Multifunctional nanozyme-embedded hydrogels for advanced diabetic wound management","volume":"685","author":"Yanyu","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"795","key":"10.1016\/j.bioactmat.2026.08.060_bib142","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adt0882","article-title":"A microfluidic wearable device for wound exudate management and analysis in human chronic wounds","volume":"17","author":"Wang","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2026.03.021","article-title":"Spatio-temporal multiscale cell modeling of skin wound healing","author":"Cao","year":"2026","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib147","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s12967-025-06417-2","article-title":"Immunomarker profiling in human chronic wound swabs reveals IL-1 beta\/IL-1RA and CXCL8\/CXCL10 ratios as potential biomarkers for wound healing, infection status and regenerative stage","volume":"23","author":"Rembe","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib148","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v102.325","article-title":"Longitudinal evaluation of biomarkers in wound fluids from venous leg ulcers and split-thickness skin graft donor site wounds treated with a protease-modulating wound dressing","volume":"102","author":"Mikosi\u0144ski","year":"2022","journal-title":"Acta Derm. Venereol."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib149","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1089\/wound.2023.0126","article-title":"Use of serum protein measurements as biomarkers that can predict the outcome of diabetic foot ulceration","volume":"13","author":"Theocharidis","year":"2024","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-45000-7","article-title":"pH profiling reveals progressive wound acidification during healing and higher pH in chronic non-healing wounds: a prospective, multicenter cohort study","volume":"16","author":"Rembe","year":"2026","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.bioactmat.2026.08.060_bib151","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg9614","article-title":"A flexible multiplexed immunosensor for point-of-care in situ wound monitoring","volume":"7","author":"Gao","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib152","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41467-021-27801-8","article-title":"Single cell transcriptomic landscape of diabetic foot ulcers","volume":"13","author":"Theocharidis","year":"2022","journal-title":"Nat. Commun."},{"issue":"858","key":"10.1016\/j.bioactmat.2026.08.060_bib153","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adv4095","article-title":"PTEN acts as a master mediator of nonhealing venous leg ulcers by suppressing immune response, angiogenesis, and lymphangiogenesis","volume":"18","author":"Marjanovic","year":"2026","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2021.107889","article-title":"Monocyte phenotype as a predictive marker for wound healing in diabetes-related foot ulcers","volume":"35","author":"Min","year":"2021","journal-title":"J. Diabet. Complicat."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.stem.2024.11.013","article-title":"Spatiotemporal single-cell roadmap of human skin wound healing","volume":"32","author":"Liu","year":"2025","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib156","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s44303-026-00143-0","article-title":"Predictive modeling of chronic foot ulcer outcomes using longitudinal photoacoustic imaging","volume":"4","author":"Cheng","year":"2026","journal-title":"Npj imaging"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib157","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.chom.2019.03.006","article-title":"Strain- and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy","volume":"25","author":"Kalan","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bioactmat.2026.08.060_bib158","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2026.1812721","article-title":"Anaerobe-associated microbial shifts at infection onset in diabetes-related foot ulcers revealed by longitudinal metagenomics","volume":"16","author":"Radzieta","year":"2026","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib159","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41522-021-00202-x","article-title":"A multiomics approach to identify host-microbe alterations associated with infection severity in diabetic foot infections: a pilot study","volume":"7","author":"Radzieta","year":"2021","journal-title":"npj Biofilms Microbiomes"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.08.060_bib160","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.70717","article-title":"The association of systemic inflammation, wound bioburden and total bacterial counts with healing outcomes in older adults with chronic venous leg ulcers","volume":"22","author":"Kim","year":"2025","journal-title":"Int. Wound J."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib161","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2337\/dc12-1323","article-title":"Granulation response and partial wound closure predict healing in clinical trials on advanced diabetes foot ulcers treated with recombinant human epidermal growth factor","volume":"36","author":"Valenzuela-Silva","year":"2013","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib162","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.7234","article-title":"Development of a method for clinical evaluation of artificial intelligence-based digital wound assessment tools","volume":"4","author":"Howell","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib163","first-page":"870","article-title":"LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial, the lancet","volume":"6","author":"Game","year":"2018","journal-title":"Diabetes & endocrinology"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.060_bib164","article-title":"Glucose-activated programmed hydrogel with self-switchable enzyme-like activity for infected diabetic wound self-adaptive treatment","volume":"37","author":"Yang","year":"2025","journal-title":"Adv. mat. (Deerfield Beach, Fla.)"},{"issue":"16","key":"10.1016\/j.bioactmat.2026.08.060_bib165","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1021\/acsnano.3c04134","article-title":"Ultrasound-augmented multienzyme-like nanozyme hydrogel spray for promoting diabetic wound healing","volume":"17","author":"Shang","year":"2023","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib166","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1038\/s41467-026-72968-7","article-title":"Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration","volume":"17","author":"Kurian","year":"2026","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib144","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tem.2024.04.019","article-title":"Digital twins and artificial intelligence in metabolic disease research","volume":"35","author":"Mosquera-Lopez","year":"2024","journal-title":"Trends Endocrinol. Metabol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib145","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1109\/JBHI.2023.3299028","article-title":"Digital twin in healthcare: a study for chronic wound management","volume":"27","author":"Sarp","year":"2023","journal-title":"IEEE J. Biomed. Health Inform."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.08.060_bib146","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s43588-024-00603-w","article-title":"Advancements and challenges of digital twins in industry","volume":"4","author":"Tao","year":"2024","journal-title":"Nat. Comput. Sci."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.060_bib167","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib168","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: cellular mechanisms and pathological outcomes","volume":"10","author":"Wilkinson","year":"2020","journal-title":"Open Biol."},{"issue":"8","key":"10.1016\/j.bioactmat.2026.08.060_bib169","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1021\/acs.accounts.9b00140","article-title":"Nanozymes: from new concepts, mechanisms, and standards to applications","volume":"52","author":"Liang","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"7715","key":"10.1016\/j.bioactmat.2026.08.060_bib170","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41586-018-0337-2","article-title":"Machine learning for molecular and materials science","volume":"559","author":"Butler","year":"2018","journal-title":"Nature"},{"issue":"29","key":"10.1016\/j.bioactmat.2026.08.060_bib171","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1039\/D3TB00803G","article-title":"Recent progress in nanozymes for the treatment of diabetic wounds","volume":"11","author":"Jiang","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.08.060_bib172","doi-asserted-by":"crossref","DOI":"10.1002\/cnx2.70005","article-title":"Machine learning\u2013driven screening of high\u2010activity antitumor nanozymes using an ensemble enzymatic oracle system","volume":"1","author":"Zhang","year":"2025","journal-title":"Cancer Nexus"},{"issue":"21","key":"10.1016\/j.bioactmat.2026.08.060_bib173","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1021\/acs.nanolett.2c03119","article-title":"Machine learning guided discovery of superoxide dismutase nanozymes for androgenetic alopecia","volume":"22","author":"Zhang","year":"2022","journal-title":"Nano Lett."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib174","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1021\/acsmaterialslett.2c00756","article-title":"Machine learning assisted graphdiyne-based nanozyme discovery","volume":"4","author":"Yu","year":"2022","journal-title":"ACS Mater. Lett."},{"key":"10.1016\/j.bioactmat.2026.08.060_bib175","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3762\/bjnano.6.165","article-title":"The eNanoMapper database for nanomaterial safety information","volume":"6","author":"Jeliazkova","year":"2015","journal-title":"Beilstein J. Nanotechnol."},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib176","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70406","article-title":"Diabetic wound repair: from mechanism to therapeutic opportunities","volume":"6","author":"Wang","year":"2025","journal-title":"MedComm"},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib177","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.1021\/jacs.3c13588","article-title":"Data-driven evolutionary design of multienzyme-like nanozymes","volume":"146","author":"Jiang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"15","key":"10.1016\/j.bioactmat.2026.08.060_bib178","article-title":"Amyloid-templated ceria nanozyme reinforced microneedle for diabetic wound treatments","volume":"37","author":"Xuan","year":"2025","journal-title":"Adv. mat. (Deerfield Beach, Fla.)"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib179","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1038\/s41467-025-61261-8","article-title":"A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.08.060_bib180","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/wound.2021.0073","article-title":"Predicting chronic wound healing time using machine learning","volume":"11","author":"Berezo","year":"2022","journal-title":"Adv. Wound Care"},{"issue":"24","key":"10.1016\/j.bioactmat.2026.08.060_bib181","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg6670","article-title":"Battery-free and AI-enabled multiplexed sensor patches for wound monitoring","volume":"9","author":"Zheng","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib182","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1186\/s12967-025-07330-4","article-title":"Emerging versatile nanozymes for the therapeutic and diagnostic applications of diseases","volume":"23","author":"Jin","year":"2025","journal-title":"J. Transl. Med."},{"issue":"30","key":"10.1016\/j.bioactmat.2026.08.060_bib183","article-title":"Microenvironment-activated nanozyme-armed bacteriophages efficiently combat bacterial infection","volume":"35","author":"Jin","year":"2023","journal-title":"Adv. mat. (Deerfield Beach, Fla.)"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib184","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s44385-025-00038-6","article-title":"Towards adaptive bioelectronic wound therapy with integrated real-time diagnostics and machine learning-driven closed-loop control","volume":"2","author":"Li","year":"2025","journal-title":"npj biomedical innovations"},{"issue":"6677","key":"10.1016\/j.bioactmat.2026.08.060_bib185","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi1407","article-title":"Autonomous, multiproperty-driven molecular discovery: from predictions to measurements and back","volume":"382","author":"Koscher","year":"2023","journal-title":"Science (New York, N.Y.)"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib186","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/bios15090571","article-title":"Deep learning-enhanced nanozyme-based biosensors for next-generation medical diagnostics","volume":"15","author":"Lee","year":"2025","journal-title":"Biosensors (Basel)"},{"issue":"9","key":"10.1016\/j.bioactmat.2026.08.060_bib187","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1021\/acs.joc.3c00844","article-title":"Negative data in data sets for machine learning training","volume":"88","author":"Maloney","year":"2023","journal-title":"J. Org. Chem."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.08.060_bib188","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/s41596-024-01034-7","article-title":"Optimizing the standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes","volume":"19","author":"Zheng","year":"2024","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.08.060_bib189","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav5490","article-title":"Single-atom nanozymes","volume":"5","author":"Huang","year":"2019","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib190","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1038\/s41598-022-08361-3","article-title":"Investigating the microbial and metalloprotease sequestration properties of superabsorbent wound dressings","volume":"12","author":"Singh","year":"2022","journal-title":"Sci. Rep."},{"issue":"46","key":"10.1016\/j.bioactmat.2026.08.060_bib191","doi-asserted-by":"crossref","first-page":"32045","DOI":"10.1021\/acsnano.4c10381","article-title":"Extracellular matrix limits nanoparticle diffusion and cellular uptake in a tissue-specific manner","volume":"18","author":"Cahn","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib192","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12911-020-01332-6","article-title":"Precise4Q consortium, explainability for artificial intelligence in healthcare: a multidisciplinary perspective","volume":"20","author":"Amann","year":"2020","journal-title":"BMC Med. Inf. Decis. Making"},{"issue":"48","key":"10.1016\/j.bioactmat.2026.08.060_bib193","doi-asserted-by":"crossref","first-page":"32431","DOI":"10.1021\/acsomega.1c03752","article-title":"Uncertainty prediction for machine learning models of material properties","volume":"6","author":"Tavazza","year":"2021","journal-title":"ACS Omega"},{"issue":"46","key":"10.1016\/j.bioactmat.2026.08.060_bib194","article-title":"Safety landscape of therapeutic nanozymes and future research directions","volume":"11","author":"Tagaras","year":"2024","journal-title":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib195","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.08.060_bib196","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00204-023-03471-x","article-title":"Artificial intelligence and machine learning disciplines with the potential to improve the nanotoxicology and nanomedicine fields: a comprehensive review","volume":"97","author":"Singh","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"11","key":"10.1016\/j.bioactmat.2026.08.060_bib197","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41565-024-01754-7","article-title":"A translational framework to DELIVER nanomedicines to the clinic","volume":"19","author":"Joyce","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib198","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41591-024-03434-4","article-title":"Artificial intelligence in drug development","volume":"31","author":"Zhang","year":"2025","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.08.060_bib199","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers","volume":"46","author":"McDermott","year":"2023","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.bioactmat.2026.08.060_bib200","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202305249","article-title":"Nanozymes","volume":"36","author":"Gao","year":"2024","journal-title":"Adv. Mater."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:33:59Z","timestamp":1791063239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26005232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":200,"alternative-id":["S2452199X26005232"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.060","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}