{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:09:52Z","timestamp":1789751392804,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2024SCUQJTX010"],"award-info":[{"award-number":["2024SCUQJTX010"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571568"],"award-info":[{"award-number":["32571568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271395"],"award-info":[{"award-number":["32271395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501184"],"award-info":[{"award-number":["32501184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioactmat.2026.09.014","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:57:20Z","timestamp":1789538240000},"page":"716-733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multienzymatic hybrid bio-heterojunction for synergistic microenvironment reprogramming and selenoprotein-activated mitochondrial bioenergetics in diabetic osseointegration"],"prefix":"10.1016","volume":"68","author":[{"given":"Meihua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangrui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-4042","authenticated-orcid":false,"given":"Yao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2026.09.014_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/stcltm\/szad092","article-title":"Advances in material-based strategies for diabetic bone regeneration","volume":"13","author":"Li","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib2","doi-asserted-by":"crossref","first-page":"14726","DOI":"10.1021\/acsnano.4c03626","article-title":"Extracellular matrix-mimetic intrinsic versatile coating derived from marine adhesive protein promotes diabetic wound healing through regulating the microenvironment","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib3","article-title":"Ultrathin WOx nanoribbons with moderate ROS clearance and antibacterial abilities efficiently induce M2 macrophage polarization for diabetic bone defect repair","volume":"34","author":"Wang","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib4","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.7150\/thno.97335","article-title":"Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib5","article-title":"Biomimetic hydrogen\u2010generating piezoelectric hydrogel for dual glucose regulation and mitophagy activation in diabetes\u2010induced IVDD","volume":"35","author":"Liu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib6","article-title":"Susceptibility for some infectious diseases in patients with diabetes: the key role of glycemia","volume":"9","author":"Reyes","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1042362","article-title":"The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool","volume":"13","author":"Sohail","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4093\/dmj.2023.0213","article-title":"Dysfunctional mitochondria clearance in situ: mitophagy in obesity and diabetes-associated cardiometabolic diseases","volume":"48","author":"Tang","year":"2024","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib9","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1021\/acsnano.3c09814","article-title":"A dual role of mesenchymal stem cell derived small extracellular vesicles on TRPC6 protein and mitochondria to promote diabetic wound healing","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123640","article-title":"A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism","volume":"326","author":"Jin","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202507747","article-title":"CsPbBr3 perovskite-based heterostructures in photocatalysis: mechanisms, stability, and multifunctional performance","volume":"12","author":"Lv","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib12","first-page":"440","article-title":"ROS-balancing-engineered bio-heterojunction hydrogel accelerated the infected bone regeneration based on Sono-chemo dynamic therapy","volume":"52","author":"Xu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib13","article-title":"Construction of multifunctional gauze via the potassium permanganate method for wound management","volume":"510","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202401795","article-title":"Electron spin polarization engineering in ferromagnetic bioheterojunction for sonotherapy of osteomyelitis","volume":"34","author":"Ding","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib15","doi-asserted-by":"crossref","DOI":"10.4028\/b-4W7Te2","article-title":"Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/nu5010097","article-title":"Selenium in bone health: roles in antioxidant protection and cell proliferation","volume":"5","author":"Zeng","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib17","doi-asserted-by":"crossref","first-page":"34378","DOI":"10.1021\/acsami.3c03446","article-title":"Selenium-doped mesoporous bioactive glass regulates macrophage metabolism and polarization by scavenging ROS and promotes bone regeneration in vivo","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib18","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s12276-020-0408-y","article-title":"The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies","volume":"52","author":"Kang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib19","doi-asserted-by":"crossref","first-page":"40440","DOI":"10.1021\/acsnano.5c12637","article-title":"A diselenide-linkage self-assembled nanoprodrug for enhanced osteoarthritis treatment","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib20","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1039\/D0FO03141K","article-title":"Biogenic selenium nanoparticles by Lactobacillus casei ATCC 393 alleviate the intestinal permeability, mitochondrial dysfunction and mitophagy induced by oxidative stress","volume":"12","author":"Yan","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib21","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1021\/acsnano.5c17071","article-title":"Biomimetic selenium-encrusted prussian blue nanozyme for myocardial infarction by coordinated enhancement of mitophagy and reactive oxygen species scavenging","volume":"20","author":"Ling","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/s12951-024-02890-x","article-title":"Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells","volume":"22","author":"He","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300880","article-title":"Selenium nanodots (SENDs) as antioxidants and antioxidant\u2010prodrugs to rescue islet \u03b2 cells in type 2 diabetes mellitus by restoring mitophagy and alleviating endoplasmic reticulum stress","volume":"10","author":"Huang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2025.10.277","article-title":"Glutathione selenium nanoparticles alleviate oxidative stress-induced reproductive dysfunction by regulating mitochondrial dynamics","volume":"242","author":"Guo","year":"2026","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117301","article-title":"The protection of selenium against cadmium-induced mitophagy via modulating nuclear xenobiotic receptors response and oxidative stress in the liver of rabbits","volume":"285","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113018","article-title":"Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF-\u03baB\/NLRP3 inflammasome-mediated inflammation","volume":"228","author":"Gao","year":"2021","journal-title":"Ecotox Environ. Safe."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adw3834","article-title":"Cascade-targeting pH\/ROS microneedles promote scarless diabetic wound healing by macrophage metaboimmune reprogramming","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202408236","article-title":"Diabetic microenvironment\u2010unlocked bioHJzyme with H2S evolution for robust anti\u2010pathogens and hyperinflammatory wound regeneration through TGF\u2010\u03b2\/Smad pathway","volume":"34","author":"Gao","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202305277","article-title":"Engineered bio\u2010heterojunction confers extra\u2010 and intracellular bacterial ferroptosis and hunger\u2010triggered cell protection for diabetic wound repair","volume":"36","author":"Dai","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib30","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1021\/acsnano.3c10172","article-title":"Targeted light-induced immunomodulatory strategy for implant-associated infections via reversing biofilm-mediated immunosuppression","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib31","article-title":"Endotoxin\u2010capturing nitric oxide\u2010releasing nanoproducers synergistically integrated with photodynamic therapy for bacterial biofilm infections","volume":"35","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib32","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib33","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1038\/s41467-022-32871-3","article-title":"Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2","volume":"13","author":"Feng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.imlet.2016.06.001","article-title":"Corrigendum to human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose","volume":"176","author":"Castro","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib35","article-title":"Youthful stem cell microenvironments: rejuvenating aged bone repair through mitochondrial homeostasis remodeling","volume":"12","author":"Zhou","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.actbio.2021.09.039","article-title":"Upregulation of mitochondrial dynamics is responsible for osteogenic differentiation of mesenchymal stem cells cultured on self-mineralized collagen membranes","volume":"136","author":"Wan","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib39","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1038\/s41418-022-01032-w","article-title":"RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria","volume":"29","author":"Tu","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","article-title":"Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy","volume":"28","author":"Xian","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib41","first-page":"1367","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib42","first-page":"276","article-title":"Translational selenium nanoparticles boost GPx1 activation to reverse HAdV-14 virus-induced oxidative damage","volume":"38","author":"Li","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102831","article-title":"Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma","volume":"65","author":"Lei","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib44","article-title":"BMSC-NFMC model for vascular regulation and interface integration in osteochondral regeneration","volume":"12","author":"Zhou","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib45","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/acsnano.5c07071","article-title":"Neonatal spinal-cord-like scaffold with hierarchical structural and neurogenetic microenvironments for spinal cord injury repair","volume":"20","author":"Bai","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib46","first-page":"685","article-title":"3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification","volume":"58","author":"Ma","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib47","doi-asserted-by":"crossref","first-page":"42388","DOI":"10.1021\/acsami.2c08422","article-title":"Repair of large-scale rib defects based on steel-reinforced concrete-designed biomimetic 3D-printed scaffolds with bone-mineralized microenvironments","volume":"14","author":"Bai","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib48","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2016.10.016","article-title":"Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization","volume":"167","author":"Yang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.09.014_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41413-024-00399-5","article-title":"Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus","volume":"13","author":"Xian","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.bioactmat.2026.09.014_bib50","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/j.biomaterials.2012.04.013","article-title":"The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA)","volume":"33","author":"Krifka","year":"2012","journal-title":"Biomaterials"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:33:32Z","timestamp":1789749212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26005475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":50,"alternative-id":["S2452199X26005475"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.09.014","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multienzymatic hybrid bio-heterojunction for synergistic microenvironment reprogramming and selenoprotein-activated mitochondrial bioenergetics in diabetic osseointegration","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}