{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:32:57Z","timestamp":1793010777632,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012860","name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center","doi-asserted-by":"publisher","award":["P 30 CA01219740"],"award-info":[{"award-number":["P 30 CA01219740"]}],"id":[{"id":"10.13039\/100012860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01CA264102-01"],"award-info":[{"award-number":["1R01CA264102-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 R01 NS119225-01A1"],"award-info":[{"award-number":["1 R01 NS119225-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA299152-01"],"award-info":[{"award-number":["R01CA299152-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.bioactmat.2026.09.016","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:53:53Z","timestamp":1790272433000},"page":"52-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction\u2013associated steatohepatitis"],"prefix":"10.1016","volume":"69","author":[{"given":"Kaige","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Arledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Kuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn A.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-1698","authenticated-orcid":false,"given":"Dawen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bioactmat.2026.09.016_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/jhep.2001.29628","article-title":"Gene expression of tumor necrosis factor \u03b1 and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients","volume":"34","author":"Crespo","year":"2001","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.bioactmat.2026.09.016_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.09.016_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159524","article-title":"Kupffer cells undergo fundamental changes during the development of experimental NASH and are critical in initiating liver damage and inflammation","volume":"11","author":"Reid","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib5","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.29544","article-title":"Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis","volume":"67","author":"Krenkel","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI83885","article-title":"Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9","volume":"126","author":"Garcia-Martinez","year":"2016","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.09.016_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI121842","article-title":"STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis","volume":"129","author":"Yu","year":"2019","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib9","doi-asserted-by":"crossref","first-page":"G1034","DOI":"10.1152\/ajpgi.00431.2020","article-title":"Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease","volume":"320","author":"Xu","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"12","key":"10.1016\/j.bioactmat.2026.09.016_bib10","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri3921","article-title":"STING: infection, inflammation and cancer","volume":"15","author":"Barber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"6121","key":"10.1016\/j.bioactmat.2026.09.016_bib11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41374-019-0342-6","article-title":"STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease","volume":"100","author":"Wang","year":"2020","journal-title":"Lab. Invest."},{"issue":"7237","key":"10.1016\/j.bioactmat.2026.09.016_bib14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"issue":"7575","key":"10.1016\/j.bioactmat.2026.09.016_bib15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.09.016_bib16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib17","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib18","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4049\/jimmunol.171.3.1393","article-title":"Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune Activation1","volume":"171","author":"Gursel","year":"2003","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.bioactmat.2026.09.016_bib19","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.1300530","article-title":"Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation","volume":"191","author":"Kaminski","year":"2013","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/eji.201747338","article-title":"Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes","volume":"48","author":"Steinhagen","year":"2018","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.09.016_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41565-021-01032-w","article-title":"Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion","volume":"17","author":"Liu","year":"2022","journal-title":"Nat. Nanotechnol."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib22","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1007\/s12274-022-5205-6","article-title":"Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer","volume":"16","author":"Liu","year":"2023","journal-title":"Nano Res."},{"issue":"20","key":"10.1016\/j.bioactmat.2026.09.016_bib23","doi-asserted-by":"crossref","first-page":"578","DOI":"10.21037\/atm.2019.09.70","article-title":"Magnesium and liver disease","volume":"7","author":"Liu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bioactmat.2026.09.016_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.semcdb.2020.11.002","article-title":"Magnesium and inflammation: advances and perspectives","volume":"115","author":"Jeanette","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib25","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1038\/s41467-019-13094-5","article-title":"An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bioactmat.2026.09.016_bib26","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ajpath.2014.01.034","article-title":"Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-Fat\/Fructose diet and sedentary lifestyle","volume":"184","author":"Joanna","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2018.10.012","article-title":"Preclinical models for studying NASH-driven HCC: how useful are they?","volume":"29","author":"Mark","year":"2019","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17370-6","article-title":"The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease","volume":"7","author":"Cazanave","year":"2017","journal-title":"Sci. Rep."},{"issue":"650","key":"10.1016\/j.bioactmat.2026.09.016_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo4474","article-title":"Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease","volume":"14","author":"Fujiwara","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ame2.12338","article-title":"Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease","volume":"6","author":"Ding","year":"2023","journal-title":"Animal Model. Exp. Med."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib31","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/s41467-023-36522-z","article-title":"Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus","volume":"14","author":"Miao","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioactmat.2026.09.016_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41418-019-0366-x","article-title":"Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib33","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib34","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.29742","article-title":"Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1\u2013mediated p62\/sequestosome 1 phosphorylation","volume":"68","author":"Cho","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib35","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/ATVBAHA.123.320612","article-title":"Macrophage-derived GSDMD plays an essential role in atherosclerosis and cross talk between macrophages via the Mitochondria-STING-IRF3\/NF-\u03baB axis","volume":"44","author":"Fan","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112185","article-title":"NF-\u03baB activation enhances STING signaling by altering microtubule-mediated STING trafficking","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bioactmat.2026.09.016_bib37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1039\/C4TB01611D","article-title":"Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. 10.1039\/C4TB01611D","volume":"3","author":"Wang","year":"2015","journal-title":"J. Mater. Chem. B"},{"issue":"4, Part 1","key":"10.1016\/j.bioactmat.2026.09.016_bib38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/jhep.2001.27805","article-title":"Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats","volume":"34","author":"Barbro","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.bioactmat.2026.09.016_bib39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biomaterials.2016.11.009","article-title":"Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles","volume":"114","author":"Can","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2026.09.016_bib40","article-title":"Application of nanoparticles in the treatment of acute lung injury: current situation and future directions","volume":"34","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib41","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a Trem2-Dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.immuni.2022.11.013","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.bioactmat.2026.09.016_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135197","article-title":"TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis","volume":"131","author":"Hou","year":"2021","journal-title":"J. Clin. Investig."},{"issue":"7783","key":"10.1016\/j.bioactmat.2026.09.016_bib44","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bioactmat.2026.09.016_bib45","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/hep.32620","article-title":"Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness","volume":"77","author":"Indira Chandran","year":"2022","journal-title":"Hepatology"},{"issue":"82","key":"10.1016\/j.bioactmat.2026.09.016_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci. Immunol."},{"issue":"572","key":"10.1016\/j.bioactmat.2026.09.016_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba4448","article-title":"Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis","volume":"12","author":"Govaere","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib48","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.molcel.2019.07.028","article-title":"Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis","volume":"75","author":"Xiong","year":"2019","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jhep.2021.01.043","article-title":"Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH","volume":"75","author":"Jorge","year":"2021","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.bioactmat.2026.09.016_bib50","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2026.09.016_bib52","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ncomms2339","article-title":"Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors","volume":"3","author":"Rossol","year":"2012","journal-title":"Nat. Commun."},{"issue":"7329","key":"10.1016\/j.bioactmat.2026.09.016_bib53","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioactmat.2026.09.016_bib54","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1111\/bph.15427","article-title":"Activation of thyroid hormone receptor-\u03b2 improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis","volume":"178","author":"Kannt","year":"2021","journal-title":"Br. J. Pharmacol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26005499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T09:38:10Z","timestamp":1793007490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26005499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":54,"alternative-id":["S2452199X26005499"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.09.016","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction\u2013associated steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}