{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:34:34Z","timestamp":1788366874434,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bioadv.2022.213223","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T12:13:51Z","timestamp":1669637631000},"page":"213223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Silk fibroin bioscaffold from Bombyx mori and Antheraea assamensis elicits a distinct host response and macrophage activation paradigm in vivo and in vitro"],"prefix":"10.1016","volume":"145","author":[{"given":"G.","family":"Janani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Badylak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman B.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2022.213223_bb0005","doi-asserted-by":"crossref","first-page":"1800465","DOI":"10.1002\/adhm.201800465","volume":"8","author":"Holland","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0010","doi-asserted-by":"crossref","first-page":"5460","DOI":"10.1021\/acsabm.9b00576","volume":"2","author":"Janani","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.progpolymsci.2013.09.002","volume":"39","author":"Kundu","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0020","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jbiosc.2008.12.012","volume":"107","author":"Aramwit","year":"2009","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0025","first-page":"1","volume":"5","author":"Gupta","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2022.213223_bb0030","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1021\/acsbiomaterials.9b01162","volume":"5","author":"Janani","year":"2019","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0035","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.12886","volume":"1358","author":"Jewell","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000096893","volume":"63","author":"Spelzini","year":"2007","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.bioadv.2022.213223_bb0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/bip.22024","volume":"97","author":"Kundu","year":"2012","journal-title":"Biopolymers"},{"key":"10.1016\/j.bioadv.2022.213223_bb0050","first-page":"85","volume":"83","author":"Konwarh","year":"2017","journal-title":"Proc. Indian Natl. Sci. Acad."},{"key":"10.1016\/j.bioadv.2022.213223_bb0055","doi-asserted-by":"crossref","first-page":"24401","DOI":"10.1021\/acsami.1c00719","volume":"13","author":"Janani","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2022.213223_bb0060","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actbio.2017.11.053","volume":"67","author":"Janani","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0065","doi-asserted-by":"crossref","first-page":"2102031","DOI":"10.1002\/adhm.202102031","volume":"11","author":"Moses","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0070","doi-asserted-by":"crossref","first-page":"2100750","DOI":"10.1002\/adhm.202100750","volume":"10","author":"Gupta","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0075","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1039\/D1BM00840D","volume":"9","author":"Antmen","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0080","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.addr.2017.05.010","volume":"122","author":"Spiller","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioadv.2022.213223_bb0090","doi-asserted-by":"crossref","first-page":"1700289","DOI":"10.1002\/adhm.201700289","volume":"6","author":"Cha","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0095","doi-asserted-by":"crossref","first-page":"2002328","DOI":"10.1002\/advs.202002328","volume":"8","author":"Xiang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biomaterials.2004.02.047","volume":"26","author":"Meinel","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0105","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1021\/acsbiomaterials.0c00175","volume":"6","author":"Wang","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0110","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1039\/D1BM00936B","volume":"9","author":"Gorenkova","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biomaterials.2015.08.039","volume":"71","author":"Thurber","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0120","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biomaterials.2015.09.027","volume":"73","author":"Reeves","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0125","series-title":"Wound Regeneration and Repair","first-page":"3","article-title":"An in vivo model system for evaluation of the host response to biomaterials","author":"Sicari","year":"2013"},{"key":"10.1016\/j.bioadv.2022.213223_bb0130","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.actbio.2011.11.031","volume":"8","author":"Brown","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0135","doi-asserted-by":"crossref","first-page":"1801451","DOI":"10.1002\/adhm.201801451","volume":"8","author":"Witherel","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.2005.11.1","volume":"11","author":"Wilson","year":"2005","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0145","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","volume":"32","author":"Franz","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0150","first-page":"13","volume":"3","author":"Molina","year":"2019","journal-title":"J. Immunol. Regen. Med."},{"key":"10.1016\/j.bioadv.2022.213223_bb0155","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0736-0266(03)00163-3","volume":"22","author":"Musahl","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bioadv.2022.213223_bb0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2106\/00004623-200703000-00020","volume":"89","author":"Gilbert","year":"2007","journal-title":"JBJS"},{"key":"10.1016\/j.bioadv.2022.213223_bb0165","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jceh.2014.03.043","volume":"5","author":"Faulk","year":"2015","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0170","first-page":"48","volume":"4","author":"Garidel","year":"2006","journal-title":"Bioprocess. Int."},{"key":"10.1016\/j.bioadv.2022.213223_bb0175","first-page":"3138","volume":"218","author":"Boulet-Audet","year":"2015","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0180","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1089\/ten.2006.0437","volume":"13","author":"Sellaro","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0185","first-page":"26","volume":"3","author":"Hussey","year":"2019","journal-title":"J. Immunol. Regen. Med."},{"key":"10.1016\/j.bioadv.2022.213223_bb0190","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1007\/s10439-019-02408-9","volume":"48","author":"Cramer","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0195","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0200","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.actbio.2016.01.038","volume":"33","author":"Dearth","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0205","series-title":"Seminars in Immunology","first-page":"2","author":"Huleihel","year":"2017"},{"key":"10.1016\/j.bioadv.2022.213223_bb0210","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.biomaterials.2008.04.023","volume":"29","author":"Williams","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0215","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1016\/j.biomaterials.2014.06.057","volume":"35","author":"Faulk","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fbioe.2019.00087","volume":"7","author":"Wissing","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0225","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/acsbiomaterials.9b01781","volume":"6","author":"Umuhoza","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0230","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/10\/1\/015003","volume":"10","author":"You","year":"2014","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0235","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.3390\/ijms23052826","volume":"23","author":"Casarin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2022.213223_bb0240","first-page":"505","volume":"53","author":"Kobayashi","year":"2005","journal-title":"Arch. Immunol. Ther. Exp. Eng. Ed."},{"key":"10.1016\/j.bioadv.2022.213223_bb0245","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.3390\/ma8095269","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0250","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1089\/ten.tea.2011.0748","volume":"19","author":"Song","year":"2013","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.bioadv.2022.213223_bb0255","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1016\/j.actbio.2014.04.003","volume":"10","author":"Fearing","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0260","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ten.tea.2008.0419","volume":"15","author":"Valentin","year":"2009","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.bioadv.2022.213223_bb0265","volume":"276","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0270","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1016\/j.biomaterials.2013.02.065","volume":"34","author":"Garg","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0275","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1021\/acsbiomaterials.8b01194","volume":"5","author":"Gupta","year":"2018","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0280","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jlb.65.3.313","volume":"65","author":"Lowell","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0285","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1016\/j.biomaterials.2014.02.012","volume":"35","author":"Spiller","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2022.213223_bb0290","volume":"1","author":"Agrawal","year":"2012","journal-title":"Open J. Regen. Med."},{"key":"10.1016\/j.bioadv.2022.213223_bb0295","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2017.01.056","volume":"53","author":"Julier","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0300","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/jbm.a.36605","volume":"107","author":"Abebayehu","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2022.213223_bb0305","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1753425919838322","volume":"26","author":"Gruber","year":"2020","journal-title":"Innate Immun."},{"key":"10.1016\/j.bioadv.2022.213223_bb0310","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-bioeng-062117-121224","volume":"21","author":"Jain","year":"2019","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2022.213223_bb0315","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00249-015-1096-8","volume":"45","author":"Adlerz","year":"2016","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bioadv.2022.213223_bb0320","first-page":"31","volume":"10","author":"Lock","year":"2019","journal-title":"J. Funct. Mater."},{"key":"10.1016\/j.bioadv.2022.213223_bb0325","series-title":"F1000prime Reports","volume":"6","author":"Martinez","year":"2014"},{"key":"10.1016\/j.bioadv.2022.213223_bb0330","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bioadv.2022.213223_bb0335","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1021\/acs.biomac.0c00090","volume":"21","author":"Guo","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2022.213223_bb0340","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1189\/jlb.1012512","volume":"93","author":"Novak","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioadv.2022.213223_bb0345","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/816460","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bioadv.2022.213223_bb0350","series-title":"Host Response to Biomaterials","first-page":"53","article-title":"Host response to naturally derived biomaterials","author":"Lopresti","year":"2015"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950822005003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950822005003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:45:05Z","timestamp":1757425505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950822005003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":70,"alternative-id":["S2772950822005003"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2022.213223","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silk fibroin bioscaffold from Bombyx mori and Antheraea assamensis elicits a distinct host response and macrophage activation paradigm in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2022.213223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"213223"}}