{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:17:03Z","timestamp":1792120623128,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.bioadv.2023.213331","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T19:23:26Z","timestamp":1675884206000},"page":"213331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function"],"prefix":"10.1016","volume":"147","author":[{"given":"Vignesh K.","family":"Rangasami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Asawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Teramura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Le Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6ns","family":"Hilborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oommen P.","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oommen P.","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2023.213331_bb0005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1210\/er.2008-0031","article-title":"Ethical issues in stem cell research","volume":"30","author":"Lo","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bioadv.2023.213331_bb0010","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.118.313664","article-title":"Adult stem cells: successful standard for regenerative medicine","volume":"124","author":"Prentice","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2023.213331_bb0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2012.12.134","article-title":"Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism","volume":"431","author":"Tatsumi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioadv.2023.213331_bb0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.molmed.2018.12.006","article-title":"Intravascular mesenchymal stromal\/stem cell therapy product diversification: time for new clinical guidelines","volume":"25","author":"Moll","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bioadv.2023.213331_bb0025","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1182\/blood-2012-03-420612","article-title":"Mesenchymal stem cells are injured by complement after their contact with serum","volume":"120","author":"Li","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bioadv.2023.213331_bb0030","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1021\/acs.biomac.1c00070","article-title":"Pluronic micelle-mediated tissue factor silencing enhances hemocompatibility, stemness, differentiation potential, and paracrine signaling of mesenchymal stem cells","volume":"22","author":"Rangasami","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2023.213331_bb0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.actbio.2016.02.018","article-title":"Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes","volume":"35","author":"Asif","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2023.213331_bb0040","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/ma11050849","article-title":"Layer-by-layer heparinization of the cell surface by using heparin-binding peptide functionalized human serum albumin","volume":"11","author":"Song","year":"2018","journal-title":"Materials"},{"key":"10.1016\/j.bioadv.2023.213331_bb0045","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1021\/acsami.6b14584","article-title":"Cell adhesion induced using surface modification with cell-penetrating peptide-conjugated Poly(ethylene glycol)-lipid: a new cell glue for 3D cell-based structures","volume":"9","author":"Teramura","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2023.213331_bb0050","article-title":"Surface-anchored nanogel coating endows stem cells with stress resistance and reparative potency via turning down the cytokine-receptor binding pathways","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2023.213331_bb0055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/mabi.200700061","article-title":"Nanoencapsulation of stem cells within polyelectrolyte multilayer shells","volume":"7","author":"Veerabadran","year":"2007","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bioadv.2023.213331_bb0060","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1021\/acsabm.0c01473","article-title":"Polymer cell surface coating enhances mesenchymal stem cell retention and cardiac protection","volume":"4","author":"Peng","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2023.213331_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202008167","article-title":"Cell surface functionalization with heparin-conjugated lipid to suppress blood activation","volume":"31","author":"Asawa","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioadv.2023.213331_bb0070","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.biomaterials.2012.10.040","article-title":"Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating","volume":"34","author":"Nilsson","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2023.213331_bb0075","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1039\/C9PY00305C","article-title":"Layer-by-layer assembly of nanofilms to control cell functions","volume":"10","author":"Zeng","year":"2019","journal-title":"Polym. Chem."},{"key":"10.1016\/j.bioadv.2023.213331_bb0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biomaterials.2017.03.001","article-title":"A VEGF delivery system targeting MI improves angiogenesis and cardiac function based on the tropism of MSCs and layer-by-layer self-assembly","volume":"127","author":"Liu","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2023.213331_bb0085","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1021\/am504456t","article-title":"The effect of layer-by-layer assembly coating on the proliferation and differentiation of neural stem cells","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2023.213331_bb0090","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1021\/acs.biomac.9b00786","article-title":"A layer-by-layer single-cell coating technique to produce injectable beating mini heart tissues via microfluidics","volume":"20","author":"Guerzoni","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2023.213331_bb0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.actbio.2017.05.052","article-title":"Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII","volume":"58","author":"Gravastrand","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2023.213331_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/ten.teb.2019.0256","article-title":"Engineering and functionalization of gelatin biomaterials: from cell culture to medical applications","volume":"26","author":"Bello","year":"2020","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bioadv.2023.213331_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fbioe.2018.00116","article-title":"Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-\u03b1, by human mononuclear cells","volume":"6","author":"Donaldson","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/910743","article-title":"Heparin and related drugs: beyond anticoagulant activity","volume":"2013","author":"Page","year":"2013","journal-title":"ISRN Pharmacol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1056\/NEJM199307083290204","article-title":"Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin","volume":"329","author":"Ahmed","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioadv.2023.213331_bb0120","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/bj2520515","article-title":"Inhibition of leucocyte elastase by heparin and its derivatives","volume":"252","author":"Redini","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioadv.2023.213331_bb0125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jlb.59.3.389","article-title":"Adhesion mechanisms involved in C5a-induced eosinophil homotypic aggregation","volume":"59","author":"Teixeira","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0014-2999(92)90437-9","article-title":"Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G","volume":"216","author":"Evangelista","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0135","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jtv.2010.03.003","article-title":"Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second-degree burns treated in a public pediatric hospital","volume":"19","author":"Chacon","year":"2010","journal-title":"J. Tissue Viability"},{"key":"10.1016\/j.bioadv.2023.213331_bb0140","article-title":"Heparin-derived theranostic nanoprobes overcome the blood\u2013brain barrier and target glioma in murine model","author":"Samanta","year":"2022","journal-title":"Adv. Ther. (Weinh.)"},{"key":"10.1016\/j.bioadv.2023.213331_bb0145","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1016\/j.biomaterials.2012.04.022","article-title":"Enzymatic degradation of heparin-modified hydrogels and its effect on bioactivity","volume":"33","author":"Nilasaroya","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2023.213331_bb0150","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1111\/febs.12184","article-title":"Heparanase in inflammation and inflammation-associated cancer","volume":"280","author":"Meirovitz","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.bioadv.2023.213331_bb0155","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s10029-006-0146-7","article-title":"Collagenase and surgical disease","volume":"10","author":"Donahue","year":"2006","journal-title":"Hernia"},{"key":"10.1016\/j.bioadv.2023.213331_bb0160","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1039\/D2TB00759B","article-title":"Heparin-coated iron oxide nanoparticles: application as a liver contrast agent, toxicity and pharmacokinetics","volume":"10","author":"Fakhardo","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2023.213331_bb0165","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.jcyt.2019.03.515","article-title":"Effect of heparin on proliferation mesencymal stem cell","volume":"21","author":"Susanto","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bioadv.2023.213331_bb0170","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1089\/dna.2016.3237","article-title":"Gelatin directly enhances neurogenic differentiation potential in bone marrow-derived mesenchymal stem cells without stimulation of neural progenitor cell proliferation","volume":"35","author":"Lee","year":"2016","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0175","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbagen.2005.08.003","article-title":"Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance","volume":"1726","author":"Yu","year":"2005","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bioadv.2023.213331_bb0180","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/ndt\/gft243","article-title":"Heparin\/heparan sulphate interactions with complement\u2014a possible target for reduction of renal function loss?","volume":"29","author":"Zaferani","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bioadv.2023.213331_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioadv.2023.213331_bb0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/jsre.2000.5892","article-title":"Bioactive interleukin-8 is expressed in wounds and enhances wound healing","volume":"93","author":"Rennekampff","year":"2000","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bioadv.2023.213331_bb0195","first-page":"6275","article-title":"Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis","volume":"11","author":"Zhang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bioadv.2023.213331_bb0200","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2174\/1574888X09666140616125446","article-title":"SendOrders for Reprintsto reprints@benthamscience.net the roles of mesenchymal stem cells in tissue repair and disease modification","volume":"9","author":"Li","year":"2014","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bioadv.2023.213331_bb0205","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1089\/scd.2011.0289","article-title":"Hypoxic preconditioning enhances survival of human adipose-derived stem cells and conditions endothelial cells in vitro","volume":"21","author":"Stubbs","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bioadv.2023.213331_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002058","article-title":"Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate","volume":"10","author":"Samal","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2023.213331_bb0215","first-page":"1667","article-title":"VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms","volume":"17","author":"Ge","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioadv.2023.213331_bb0220","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2249.2009.03874.x","article-title":"Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells","volume":"156","author":"English","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0225","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-\u03b3-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0230","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3389\/fimmu.2020.01076","article-title":"Immunosuppressive property of MSCs mediated by cell surface receptors","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2023.213331_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0596-5","article-title":"IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo","volume":"13","author":"Casella","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioadv.2023.213331_bb0240","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049290","article-title":"Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration","volume":"14","author":"Liu","year":"2021","journal-title":"Dis. Model. Mech."},{"issue":"Suppl. 3","key":"10.1016\/j.bioadv.2023.213331_bb0245","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1034\/j.1399-3046.7.s3.13.x","article-title":"Bone marrow stem cells regenerate infarcted myocardium","volume":"7","author":"Orlic","year":"2003","journal-title":"Pediatr. Transplant."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950823000547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950823000547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:46:45Z","timestamp":1757425605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950823000547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":49,"alternative-id":["S2772950823000547"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213331","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"213331"}}