{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:54:45Z","timestamp":1786535685574,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202771"],"award-info":[{"award-number":["82202771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711334"],"award-info":[{"award-number":["2022M711334"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022TQ0121"],"award-info":[{"award-number":["2022TQ0121"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bioadv.2023.213413","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T02:14:32Z","timestamp":1680315272000},"page":"213413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Hippo\/YAP1 inhibition by verteporfin attenuates osteophyte formation in a mouse surgical osteoarthritis model"],"prefix":"10.1016","volume":"149","author":[{"given":"Tao","family":"Gui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwei","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfeng","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengang","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bioadv.2023.213413_bb0005","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"8","key":"10.1016\/j.bioadv.2023.213413_bb0010","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bioadv.2023.213413_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.joca.2003.09.003","article-title":"Are osteophytes good or bad?","volume":"12","author":"Menkes","year":"2004","journal-title":"Osteoarthr. Cart"},{"issue":"3","key":"10.1016\/j.bioadv.2023.213413_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: relevance and biology","volume":"15","author":"Van Der Kraan","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.bioadv.2023.213413_bb0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01409983","article-title":"The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee","volume":"16","author":"Van Osch","year":"1996","journal-title":"Rheumatol. Int."},{"issue":"6","key":"10.1016\/j.bioadv.2023.213413_bb0030","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.1780330612","article-title":"The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees","volume":"33","author":"Pottenger","year":"1990","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.bioadv.2023.213413_bb0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1063-4584(05)80323-1","article-title":"Association of pain with radiological changes in different compartments and views of the knee joint","volume":"4","author":"Cicuttini","year":"1996","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.bioadv.2023.213413_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00115550-199924040-00012","article-title":"Lumbar spine pain originating from vertebral osteophytes","volume":"24","author":"Lamer","year":"1999","journal-title":"Reg. Anesth. Pain Med."},{"issue":"2","key":"10.1016\/j.bioadv.2023.213413_bb0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2214\/ajr.174.2.1740449","article-title":"Cervical osteophytes impinging on the pharynx: importance of size and concurrent disorders for development of aspiration","volume":"174","author":"Strasser","year":"2000","journal-title":"Am. J. Roentgenol."},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03416-1","article-title":"Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.bioadv.2023.213413_bb0055","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/jcb.25863","article-title":"The BET bromodomain inhibitor JQ1 suppresses chondrosarcoma cell growth via regulation of YAP\/p21\/c-Myc signaling","volume":"118","author":"Zhang","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07022-2","article-title":"Reciprocal inhibition of YAP\/TAZ and NF-\u03baB regulates osteoarthritic cartilage degradation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bioadv.2023.213413_bb0065","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10735-013-9502-y","article-title":"YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity","volume":"44","author":"Zhong","year":"2013","journal-title":"J. Mol. Histol."},{"issue":"112014","key":"10.1016\/j.bioadv.2023.213413_bb0070","article-title":"CD47-mediated DTIC-loaded chitosan oligosaccharide-grafted nGO for synergistic chemo-photothermal therapy against malignant melanoma","volume":"123","author":"Zhan","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"issue":"8867","key":"10.1016\/j.bioadv.2023.213413_bb0075","article-title":"Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy","volume":"12","author":"Huang","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"26","key":"10.1016\/j.bioadv.2023.213413_bb0080","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1016\/j.biomaterials.2013.04.057","article-title":"Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates","volume":"34","author":"Huang","year":"2013","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.bioadv.2023.213413_bb0085","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00253-010-2747-4","article-title":"Photoinactivation effects of hematoporphyrin monomethyl ether on Gram-positive and-negative bacteria detected by atomic force microscopy","volume":"88","author":"Jin","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"121437","key":"10.1016\/j.bioadv.2023.213413_bb0090","article-title":"Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy","volume":"283","author":"Gui","year":"2022","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.bioadv.2023.213413_bb0095","doi-asserted-by":"crossref","first-page":"13177","DOI":"10.1002\/jcb.28592","article-title":"Elevated expression of ICAM-1 in synovium is associated with early inflammatory response for cartilage degeneration in type 2 diabetes mellitus","volume":"120","author":"Gui","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bioadv.2023.213413_bb0100","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative\u2013recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"12","key":"10.1016\/j.bioadv.2023.213413_bb0105","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13\u2013deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-9-518","article-title":"The influence of aminophylline on the nanostructure and nanomechanics of T lymphocytes: an AFM study","volume":"9","author":"Huang","year":"2014","journal-title":"Nanoscale Res. Lett."},{"issue":"4","key":"10.1016\/j.bioadv.2023.213413_bb0115","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00424-007-0414-0","article-title":"AFM as a tool to probe and manipulate cellular processes","volume":"456","author":"Lamontagne","year":"2008","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"issue":"4","key":"10.1016\/j.bioadv.2023.213413_bb0125","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/sca.21279","article-title":"Detection of CD28\/CD86 co-stimulatory molecules and surface properties of T and dendritic cells: an AFM study","volume":"38","author":"Huang","year":"2016","journal-title":"Scanning"},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/joca.1998.0159","article-title":"Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?","volume":"7","author":"Hunziker","year":"1999","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.bioadv.2023.213413_bb0135","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.bioadv.2023.213413_bb0140","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1007\/s11999-016-4732-4","article-title":"Classifications in brief: Kellgren-Lawrence classification of osteoarthritis","volume":"474","author":"Kohn","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.bioadv.2023.213413_bb0145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ard.34.1.12","article-title":"Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques","volume":"34","author":"Gilbertson","year":"1975","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.bioadv.2023.213413_bb0150","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/ard.2005.045971","article-title":"Expression of transforming growth factor-\u03b2 (TGF\u03b2) and the TGF\u03b2 signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation","volume":"65","author":"Davidson","year":"2006","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.bioadv.2023.213413_bb0155","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1210\/endo.140.10.7053","article-title":"Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor","volume":"140","author":"Okazaki","year":"1999","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.bioadv.2023.213413_bb0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00418-003-0519-2","article-title":"PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes","volume":"119","author":"Huch","year":"2003","journal-title":"Histochem. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.bioadv.2023.213413_bb0165","first-page":"23","article-title":"The origin (s) of the periarticular osteophytes of osteoarthritic knee joints","volume":"27","author":"Oni","year":"1998","journal-title":"Afr. J. Med. Med. Sci."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277295082300136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277295082300136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:49:47Z","timestamp":1757425787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277295082300136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":33,"alternative-id":["S277295082300136X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213413","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippo\/YAP1 inhibition by verteporfin attenuates osteophyte formation in a mouse surgical osteoarthritis model","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"213413"}}