{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:57:06Z","timestamp":1793321826112,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.bioadv.2023.213542","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T06:25:00Z","timestamp":1688106300000},"page":"213542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Myricetin encapsulated chitosan nanoformulation for management of type 2 diabetes: Preparation, optimization, characterization and in vivo activity"],"prefix":"10.1016","volume":"153","author":[{"given":"Mansi","family":"Upadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna V.","family":"Hosur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod S.","family":"Mali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahmeshwar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2023.213542_bb0005","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bioadv.2023.213542_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119357","article-title":"Treatment of insulin resistance in obesity-associated type 2 diabetes mellitus through adiponectin gene therapy","volume":"583","author":"Banerjee","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2125.1999.00092.x","article-title":"The UK prospective diabetes study (UKPDS): clinical and therapeutic implications for type 2 diabetes","volume":"48","author":"King","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bioadv.2023.213542_bb0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.bioadv.2023.213542_bb0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5001\/omj.2012.68","article-title":"Type 2 diabetes mellitus: a review of current trends","volume":"27","author":"Olokoba","year":"2012","journal-title":"Oman Med. J."},{"key":"10.1016\/j.bioadv.2023.213542_bb0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fendo.2017.00006","article-title":"Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management","volume":"8","author":"Chaudhury","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bioadv.2023.213542_bb0035","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/nrdp.2015.19","article-title":"Type 2 diabetes mellitus","volume":"1","author":"DeFronzo","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bioadv.2023.213542_bb0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ptr.6821","article-title":"Diabetes and plant-derived natural products: from ethnopharmacological approaches to their potential for modern drug discovery and development","volume":"35","author":"Jugran","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bioadv.2023.213542_bb0045","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/biom9090430","article-title":"Flavonoids and their anti-diabetic effects: cellular mechanisms and effects to improve blood sugar levels","volume":"9","author":"AL-Ishaq","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioadv.2023.213542_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/pharmaceutics14010101","article-title":"The role of natural products on diabetes mellitus treatment: a systematic review of randomized controlled trials","volume":"14","author":"Viv\u00f3-Barrachina","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2023.213542_bb0055","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/nu8050310","article-title":"The possible role of flavonoids in the prevention of diabetic complications","volume":"8","author":"Testa","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.bioadv.2023.213542_bb0060","series-title":"Drug Delivery Systems for Metabolic Disorders","first-page":"459","article-title":"Role of nutraceuticals in metabolic syndrome","author":"Mishra","year":"2022"},{"key":"10.1016\/j.bioadv.2023.213542_bb0065","doi-asserted-by":"crossref","first-page":"71754","DOI":"10.18632\/oncotarget.12330","article-title":"Myricetin, a potent natural agent for treatment of diabetic skin damage by modulating TIMP\/MMPs balance and oxidative stress","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.bioadv.2023.213542_bb0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11130-013-0349-x","article-title":"Biological activities of extracts from Chinese bayberry (Myrica rubra Sieb. et Zucc.): a review","volume":"68","author":"Sun","year":"2013","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.bioadv.2023.213542_bb0075","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.lfs.2007.08.045","article-title":"Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats","volume":"81","author":"Liu","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bioadv.2023.213542_bb0080","doi-asserted-by":"crossref","first-page":"544","DOI":"10.4162\/nrp.2014.8.5.544","article-title":"Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet","volume":"8","author":"Choi","year":"2014","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.bioadv.2023.213542_bb0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/hsz-2020-0176","article-title":"Myricetin protects pancreatic \u03b2-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function","volume":"402","author":"Dubey","year":"2021","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bioadv.2023.213542_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(94)00324-X","article-title":"Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery","volume":"116","author":"Brannon-Peppas","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2013.07.034","article-title":"Chitosan nanoparticles: preparation, size evolution and stability","volume":"455","author":"Rampino","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0100","series-title":"Advanced Drug Delivery Systems in the Management of Cancer","first-page":"319","article-title":"Advancement on nanoparticle-based drug delivery systems for cancer therapy","author":"Mishra","year":"2021"},{"key":"10.1016\/j.bioadv.2023.213542_bb0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0168-3659(00)00361-8","article-title":"Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency","volume":"70","author":"Mao","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2023.213542_bb0110","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.msec.2012.09.001","article-title":"Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model","volume":"33","author":"Mukhopadhyay","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2023.213542_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2009.09.004","article-title":"Biodegradation, biodistribution and toxicity of chitosan","volume":"62","author":"Kean","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioadv.2023.213542_bb0120","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1039\/C1CS15239D","article-title":"Polysaccharides as building blocks for nanotherapeutics","volume":"41","author":"Mizrahy","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioadv.2023.213542_bb0125","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.biopha.2018.07.106","article-title":"In vitro and in vivo anticancer efficacy potential of quercetin loaded polymeric nanoparticles","volume":"106","author":"Baksi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2023.213542_bb0130","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3109\/1061186X.2015.1086359","article-title":"Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids","volume":"23","author":"Yildiz","year":"2015","journal-title":"J. Drug Target."},{"key":"10.1016\/j.bioadv.2023.213542_bb0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/bcpt.12342","article-title":"Mucus as a barrier to drug delivery - understanding and mimicking the barrier properties","volume":"116","author":"Boegh","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioadv.2023.213542_bb0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.microc.2009.02.001","article-title":"The effect of the molecular weight of chitosan nanoparticles and its application on drug delivery","volume":"92","author":"Yang","year":"2009","journal-title":"Microchem. J."},{"key":"10.1016\/j.bioadv.2023.213542_bb0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.biotechadv.2011.05.009","article-title":"Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice","volume":"30","author":"Akhtar","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bioadv.2023.213542_bb0150","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1021\/mp300162j","article-title":"Insight on the formation of chitosan nanoparticles through ionotropic gelation with tripolyphosphate","volume":"9","author":"Koukaras","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0155","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.ijbiomac.2018.09.185","article-title":"Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios","volume":"120","author":"Hejjaji","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2023.213542_bb0160","series-title":"Design of Experiments for Pharmaceutical Product Development","first-page":"27","article-title":"Response surface designs and their applications in pharmaceutical development","author":"Beg","year":"2021"},{"key":"10.1016\/j.bioadv.2023.213542_bb0165","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jiec.2015.03.008","article-title":"Optimization of color and COD removal from livestock wastewater by electrocoagulation process: application of Box\u2013Behnken design (BBD)","volume":"28","author":"Tak","year":"2015","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.bioadv.2023.213542_bb0170","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fbp.2008.06.004","article-title":"Application of Box-Behnken design in optimisation for polysaccharides extraction from cultured mycelium of Cordyceps sinensis","volume":"87","author":"Dong","year":"2009","journal-title":"Food Bioprod. Process."},{"key":"10.1016\/j.bioadv.2023.213542_bb0175","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.jscs.2013.11.001","article-title":"An experimental design approach for optimization of spectrophotometric method for estimation of cefixime trihydrate using ninhydrin as derivatizing reagent in bulk and pharmaceutical formulation","volume":"21","author":"Wani","year":"2017","journal-title":"J. Saudi Chem. Soc."},{"key":"10.1016\/j.bioadv.2023.213542_bb0180","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.matdes.2015.07.176","article-title":"Optimization of nickel oxide nanoparticle synthesis through the sol\u2013gel method using Box\u2013Behnken design","volume":"86","author":"Ba-Abbad","year":"2015","journal-title":"Mater. Des."},{"key":"10.1016\/j.bioadv.2023.213542_bb0185","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.desal.2009.03.010","article-title":"Optimization of an azo dye batch adsorption parameters using Box\u2013Behnken design","volume":"249","author":"Tripathi","year":"2009","journal-title":"Desalination"},{"key":"10.1016\/j.bioadv.2023.213542_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128775","article-title":"Haematology and serum biochemistry parameters and variations in the Eurasian beaver (Castor fiber)","volume":"10","author":"Girling","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2023.213542_bb0195","article-title":"Natural polymers composed mucoadhesive interpenetrating buoyant hydrogel beads of capecitabine: development, characterization and in vivo scintigraphy","volume":"55","author":"Upadhyay","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioadv.2023.213542_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120874","article-title":"Mucoadhesive and mucopenetrating chitosan nanoparticles for glycopeptide antibiotic administration","volume":"606","author":"Abruzzo","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fuel.2006.06.010","article-title":"Application of Box\u2013Behnken design and response surface methodology for modeling of some Turkish coals","volume":"86","author":"Aslan","year":"2007","journal-title":"Fuel"},{"key":"10.1016\/j.bioadv.2023.213542_bb0215","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.carbpol.2011.01.044","article-title":"The effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP) \u2013 chitosan nanoparticles","volume":"84","author":"Morris","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2023.213542_bb0220","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S1872-2040(07)60015-2","article-title":"Preparation and characterization of the fluorescent chitosan nanoparticle probe","volume":"34","author":"Zhao","year":"2006","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.bioadv.2023.213542_bb0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-5173(03)00408-3","article-title":"Ultrasonication of chitosan and chitosan nanoparticles","volume":"265","author":"Tang","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0230","series-title":"Sonochemistry and Sonoluminescence in Colloidal Systems, in: Sonochemistry and Sonoluminescence","first-page":"345","author":"Grieser","year":"1999"},{"key":"10.1016\/j.bioadv.2023.213542_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120963","article-title":"Chitosan alginate nanoparticles as a platform for the treatment of diabetic and non-diabetic pressure ulcers: formulation and in vitro\/in vivo evaluation","volume":"607","author":"Sheir","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121382","article-title":"Chitosan nanoparticles facilitate improved intestinal permeation and oral pharmacokinetics of the mast cell stabiliser cromoglycate","volume":"612","author":"Joyce","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0245","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ijbiomac.2018.04.123","article-title":"Development of biopolymers based interpenetrating polymeric network of capecitabine: a drug delivery vehicle to extend the release of the model drug","volume":"115","author":"Upadhyay","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2023.213542_bb0250","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/00914037.2018.1434651","article-title":"Influence of probe-sonication process on drug entrapment efficiency of liposomes loaded with a hydrophobic drug","volume":"68","author":"He","year":"2019","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.bioadv.2023.213542_bb0255","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2019.12.014","article-title":"A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes","volume":"318","author":"He","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2023.213542_bb0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/02652048.2019.1604846","article-title":"Self-assembly pH-sensitive chitosan\/alginate coated polyelectrolyte complexes for oral delivery of insulin","volume":"36","author":"Chen","year":"2019","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.bioadv.2023.213542_bb0265","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.aquaculture.2012.06.012","article-title":"Synthesis and characterization of CS\/TPP nanoparticles for oral delivery of gene in fish","volume":"358\u2013359","author":"Vimal","year":"2012","journal-title":"Aquaculture."},{"key":"10.1016\/j.bioadv.2023.213542_bb0270","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1080\/03639045.2017.1349782","article-title":"Screening of ionically crosslinked chitosan-tripolyphosphate microspheres using Plackett\u2013Burman factorial design for the treatment of intrapocket infections","volume":"43","author":"Yadav","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioadv.2023.213542_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109958","article-title":"Locust bean gum and sodium alginate based interpenetrating polymeric network microbeads encapsulating Capecitabine: Improved pharmacokinetics, cytotoxicity &in vivo antitumor activity","volume":"104","author":"Upadhyay","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2023.213542_bb0280","first-page":"167","article-title":"Differential scanning calorimetry techniques: applications in biology and nanoscience","volume":"21","author":"Gill","year":"2010","journal-title":"J. Biomol. Tech."},{"key":"10.1016\/j.bioadv.2023.213542_bb0285","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0144-8617(01)00320-4","article-title":"Characterization of chitin, chitosan and their carboxymethyl derivatives by differential scanning calorimetry","volume":"49","author":"Kittur","year":"2002","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2023.213542_bb0290","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.3390\/foods11233841","article-title":"Physicochemical, thermal, and morphological properties of chitosan nanoparticles produced by ionic gelation","volume":"11","author":"Alehosseini","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.bioadv.2023.213542_bb0295","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1208\/s12248-012-9345-6","article-title":"Stability of amorphous pharmaceutical solids: crystal growth mechanisms and effect of polymer additives","volume":"14","author":"Sun","year":"2012","journal-title":"AAPS J."},{"key":"10.1016\/j.bioadv.2023.213542_bb0300","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jconrel.2020.10.047","article-title":"Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease","volume":"329","author":"Wang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2023.213542_bb0305","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/diabetology2020004","article-title":"Diabetes mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management","volume":"2","author":"Alam","year":"2021","journal-title":"Diabetology"},{"key":"10.1016\/j.bioadv.2023.213542_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115506","article-title":"Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment","volume":"229","author":"Mumuni","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2023.213542_bb0315","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.freeradbiomed.2007.10.047","article-title":"Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress","volume":"44","author":"Mastrocola","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioadv.2023.213542_bb0320","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/BF00405106","article-title":"Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice","volume":"33","author":"Swanston-Flatt","year":"1990","journal-title":"Diabetologia."},{"key":"10.1016\/j.bioadv.2023.213542_bb0325","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.3390\/molecules23081848","article-title":"Histopathology of the liver, kidney, and spleen of mice exposed to gold nanoparticles","volume":"23","author":"Ibrahim","year":"2018","journal-title":"Molecules."},{"key":"10.1016\/j.bioadv.2023.213542_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2021.100093","article-title":"Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats","volume":"10","author":"Pegah","year":"2021","journal-title":"Metabol. Open"},{"key":"10.1016\/j.bioadv.2023.213542_bb0335","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12906-017-1762-8","article-title":"Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin","volume":"17","author":"Nurdiana","year":"2017","journal-title":"BMC Complement. Altern. Med."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950823002650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950823002650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:54:04Z","timestamp":1706586844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950823002650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":66,"alternative-id":["S2772950823002650"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213542","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myricetin encapsulated chitosan nanoformulation for management of type 2 diabetes: Preparation, optimization, characterization and in vivo activity","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2023.213542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"213542"}}