{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:24:23Z","timestamp":1788931463390,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bioadv.2024.213954","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T06:53:25Z","timestamp":1720248805000},"page":"213954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Tuning bio-aerogel properties. Part 3: Exploring silica-pectin composite aerogels for drug delivery"],"prefix":"10.1016","volume":"163","author":[{"given":"Sophie","family":"Groult","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sytze","family":"Buwalda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Budtova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2024.213954_bb0005","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1002\/anie.201709014","article-title":"Biopolymer aerogels and foams: chemistry, properties, and applications","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioadv.2024.213954_bb0010","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.3390\/polym12122779","article-title":"Biorefinery approach for aerogels","volume":"12","author":"Budtova","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2024.213954_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118130","article-title":"Polysaccharide-based aerogels for thermal insulation and superinsulation: an overview","volume":"266","author":"Zou","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2019.105597","article-title":"Fabrication of bioaerogels from camelina seed mucilage for food applications","volume":"102","author":"Ubeyitogullari","year":"2020","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.bioadv.2024.213954_bb0025","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/catal11080872","article-title":"A bio-based alginate aerogel as an ionic liquid support for the efficient synthesis of cyclic carbonates from CO2 and epoxides","volume":"11","author":"Paninho","year":"2021","journal-title":"Catalysts"},{"key":"10.1016\/j.bioadv.2024.213954_bb0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10934529.2023.2188847","article-title":"Environmentally friendly starch\/alginate aerogels for copper adsorption from aqueous media. A microstructural and kinetic study","volume":"58","author":"Lencina","year":"2023","journal-title":"J. Environ. Sci. Health, Part A"},{"key":"10.1016\/j.bioadv.2024.213954_bb0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/pharmaceutics12050449","article-title":"New trends in bio-based aerogels","volume":"12","author":"Nita","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2024.213954_bb0040","doi-asserted-by":"crossref","first-page":"2204681","DOI":"10.1002\/advs.202204681","article-title":"Aerogel-based biomaterials for biomedical applications: from fabrication methods to disease-targeting applications","volume":"10","author":"Karamikamkar","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2024.213954_bb0045","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1021\/acs.biomac.2c01408","article-title":"Release kinetics of dexamethasone phosphate from porous chitosan: comparison of aerogels and cryogels","volume":"24","author":"Chartier","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2024.213954_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121536","article-title":"Vancomycin-loaded methylcellulose aerogel scaffolds for advanced bone tissue engineering","volume":"324","author":"Iglesias-Mejuto","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.carbpol.2018.10.012","article-title":"Vancomycin-loaded chitosan aerogel particles for chronic wound applications","volume":"204","author":"L\u00f3pez-Iglesias","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijbiomac.2021.06.088","article-title":"Pectin in biomedical and drug delivery applications: a review","volume":"185","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2024.213954_bb0065","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1016\/j.actbio.2012.11.031","article-title":"Silica-coated calcium pectinate beads for colonic drug delivery","volume":"9","author":"Assifaoui","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2024.213954_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carbpol.2016.09.048","article-title":"Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract","volume":"157","author":"Vityazev","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0075","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.eurpolymj.2018.08.048","article-title":"Tuning structure and properties of pectin aerogels","volume":"108","author":"Groult","year":"2018","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioadv.2024.213954_bb0080","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1021\/bm500345u","article-title":"Aeropectin: fully biomass-based mechanically strong and thermal superinsulating aerogel","volume":"15","author":"Rudaz","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2024.213954_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120604","article-title":"Pectin-based aerogel particles for drug delivery: effect of pectin composition on aerogel structure and release properties","volume":"306","author":"M\u00e9ndez","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0090","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.carbpol.2014.10.045","article-title":"Polysaccharide-based aerogel microspheres for oral drug delivery","volume":"117","author":"Garc\u00eda-Gonz\u00e1lez","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0095","series-title":"Pectin-Based Aerogels: Advanced Materials for Thermal Insulation and Drug Delivery Applications","author":"Groult","year":"2019"},{"key":"10.1016\/j.bioadv.2024.213954_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212732","article-title":"Tuning bio-aerogel properties for controlling drug delivery. Part 2: cellulose-pectin composite aerogels","volume":"135","author":"Groult","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2024.213954_bb0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3390\/polym15020407","article-title":"Hybrid polylactic-acid\u2013pectin aerogels: synthesis, structural properties, and drug release","volume":"15","author":"Horvat","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2024.213954_bb0110","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.carbpol.2016.04.031","article-title":"Prilling and supercritical drying: a successful duo to produce core-shell polysaccharide aerogel beads for wound healing","volume":"147","author":"De Cicco","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0115","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3390\/molecules25051187","article-title":"Preparation and characterization of chitosan-coated pectin aerogels: curcumin case study","volume":"25","author":"Panti\u0107","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2024.213954_bb0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.carbpol.2017.03.008","article-title":"Novel ethanol-induced pectin\u2013xanthan aerogel coatings for orthopedic applications","volume":"166","author":"Horvat","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0125","doi-asserted-by":"crossref","first-page":"14490","DOI":"10.1002\/ange.201507328","article-title":"Strong, thermally superinsulating biopolymer\u2013silica aerogel hybrids by cogelation of silicic acid with pectin","volume":"127","author":"Zhao","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioadv.2024.213954_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-52974-0","article-title":"Preparation and characterization of polysaccharide-silica hybrid aerogels","volume":"9","author":"Horvat","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2024.213954_bb0135","doi-asserted-by":"crossref","first-page":"1909539","DOI":"10.1002\/adfm.201909539","article-title":"Sol\u2013gel-based advanced porous silica materials for biomedical applications","volume":"30","author":"Lei","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioadv.2024.213954_bb0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.carbpol.2018.05.026","article-title":"Thermal conductivity\/structure correlations in thermal super-insulating pectin aerogels","volume":"196","author":"Groult","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.carbpol.2015.01.022","article-title":"Cellulose\u2013silica aerogels","volume":"122","author":"Demilecamps","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0150","series-title":"Handbook of Aqueous Solubility Data","author":"Yalkowsky","year":"2016"},{"key":"10.1016\/j.bioadv.2024.213954_bb0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.supflu.2004.12.010","article-title":"Precipitation and phase behavior of theophylline in solvent\u2013supercritical CO2 mixtures","volume":"35","author":"Subra","year":"2005","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.bioadv.2024.213954_bb0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-3812(94)80070-7","article-title":"Solubilities of the xanthines caffeine, theophylline and theobromine in supercritical carbon dioxide","volume":"95","author":"Johannsen","year":"1994","journal-title":"Fluid Phase Equilib."},{"key":"10.1016\/j.bioadv.2024.213954_bb0165","series-title":"A\u00e9rogels - Aspects fondamentaux, Techniques de l\u2019Ing\u00e9nieur AF3609 V1","first-page":"1","author":"Phalippou","year":"2004"},{"key":"10.1016\/j.bioadv.2024.213954_bb0170","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jps.2600740209","article-title":"Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts II: salicylic acid, theophylline, and benzoic acid","volume":"74","author":"Serajuddin","year":"1985","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2024.213954_bb0175","series-title":"CRC Handbook of Chemistry and Physics","author":"Lide","year":"2006"},{"key":"10.1016\/j.bioadv.2024.213954_bb0180","article-title":"Tuning bio-aerogel properties for controlling theophylline delivery. Part 1: pectin aerogels","volume":"C 126","author":"Groult","year":"2021","journal-title":"Mater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2024.213954_bb0185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","article-title":"Mechanisms of solute release from porous hydrophilic polymers","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.213954_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2021.110386","article-title":"Pectin hydrogels, aerogels, cryogels and xerogels: influence of drying on structural and release properties","volume":"149","author":"Groult","year":"2021","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioadv.2024.213954_bb0195","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0254-0584(98)00217-X","article-title":"Comparison of some physical properties of silica aerogel monoliths synthesized by different precursors","volume":"57","author":"Wagh","year":"1999","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.bioadv.2024.213954_bb0200","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1351\/PAC-CON-11-11-18","article-title":"Design and properties of biopolymer\u2013silica hybrid materials: the example of pectin-based biodegradable hydrogels","volume":"84","author":"Agoudjil","year":"2012","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.bioadv.2024.213954_bb0205","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.micromeso.2015.11.048","article-title":"pH sensitive mesoporous materials for immediate or controlled release of NSAID","volume":"224","author":"Tkalec","year":"2016","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.bioadv.2024.213954_bb0210","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.carbpol.2014.06.054","article-title":"Characterisation of biodegradable pectin aerogels and their potential use as drug carriers","volume":"113","author":"Veronovski","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.213954_bb0215","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.jnoncrysol.2009.08.038","article-title":"Polysaccharide-based aerogels as drug carriers","volume":"355","author":"Mehling","year":"2009","journal-title":"J. Non Cryst. Solids"},{"key":"10.1016\/j.bioadv.2024.213954_bb0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.supflu.2015.06.009","article-title":"Fast production of high-methoxyl pectin aerogels for enhancing the bioavailability of low-soluble drugs","volume":"106","author":"Tkalec","year":"2015","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.bioadv.2024.213954_bb0225","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jnoncrysol.2017.11.037","article-title":"Encapsulation and drug release of poorly water soluble nifedipine from bio-carriers","volume":"481","author":"Horvat","year":"2018","journal-title":"J. Non Cryst. Solids"},{"key":"10.1016\/j.bioadv.2024.213954_bb0230","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnoncrysol.2004.06.031","article-title":"Feasibility study of hydrophilic and hydrophobic silica aerogels as drug delivery systems","volume":"350","author":"Smirnova","year":"2004","journal-title":"J. Non Cryst. Solids"},{"key":"10.1016\/j.bioadv.2024.213954_bb0235","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1081\/PDT-200035804","article-title":"Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels","volume":"9","author":"Smirnova","year":"2005","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.bioadv.2024.213954_bb0240","doi-asserted-by":"crossref","first-page":"86","DOI":"10.14356\/kona.2005012","article-title":"Aerogels: tailor-made carriers for immediate and prolonged drug release","volume":"23","author":"Smirnova","year":"2005","journal-title":"Kona Powder Part. J."},{"key":"10.1016\/j.bioadv.2024.213954_bb0245","doi-asserted-by":"crossref","first-page":"371","DOI":"10.35812\/CelluloseChemTechnol.2022.56.33","article-title":"Preparation and properties of novel biocompatible pectin\/silica calcium phosphate hybrids","volume":"56","author":"Abouzeid","year":"2022","journal-title":"Cell. Chem. Technol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824001973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824001973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T22:16:37Z","timestamp":1722723397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950824001973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":49,"alternative-id":["S2772950824001973"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.213954","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuning bio-aerogel properties. Part 3: Exploring silica-pectin composite aerogels for drug delivery","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.213954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"213954"}}