{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:11:23Z","timestamp":1780085483860,"version":"3.54.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"am","delay-in-days":270,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI168475"],"award-info":[{"award-number":["R01AI168475"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bioadv.2024.214005","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:07:24Z","timestamp":1724717244000},"page":"214005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Sustained dual delivery of metronidazole and viable Lactobacillus crispatus from 3D-printed silicone shells"],"prefix":"10.1016","volume":"165","author":[{"given":"Anthony J.","family":"Kyser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Y.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Fotouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie","family":"Aagard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann B.","family":"Frieboes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2024.214005_bb0005","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s41564-022-01177-x","article-title":"Sexually transmitted infections and female reproductive health","volume":"7","author":"Van Gerwen","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060670","article-title":"Composition of the vaginal microbiota in women of reproductive age\u2013sensitive and specific molecular diagnosis of bacterial vaginosis is possible?","volume":"8","author":"Shipitsyna","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2024.214005_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0246953","article-title":"Lactic acid-containing products for bacterial vaginosis and their impact on the vaginal microbiota: a systematic review","volume":"16","author":"Plummer","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2024.214005_bb0020","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fcimb.2020.00354","article-title":"Bacterial vaginosis: current diagnostic avenues and future opportunities","volume":"10","author":"Redelinghuys","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2018.11.046","article-title":"Bacterial vaginosis: an insight into the prevalence, alter- native treatments regimen and it\u2019s associated resistance patterns","volume":"127","author":"Javed","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bioadv.2024.214005_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2023.1100029","article-title":"Bacterial vaginosis: a review of approaches to treatment and prevention","volume":"5","author":"Abbe","year":"2023","journal-title":"Front. Reprod. Health"},{"key":"10.1016\/j.bioadv.2024.214005_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001251","article-title":"Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples","volume":"9","author":"Cohen","year":"2012","journal-title":"PLoS Med."},{"key":"10.1016\/j.bioadv.2024.214005_bb0040","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/QAD.0000000000001768","article-title":"Vaginal microbiota and susceptibility to HIV","volume":"32","author":"Eastment","year":"2018","journal-title":"Aids"},{"key":"10.1016\/j.bioadv.2024.214005_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.927131","article-title":"Role of immunity and vaginal microbiome in clearance and persistence of human papillomavirus infection","volume":"12","author":"Ntuli","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/infdis\/jiad142","article-title":"Bacterial vaginosis and spontaneous clearance of Chlamydia trachomatis in the longitudinal study of vaginal flora","volume":"228","author":"Brown","year":"2023","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bioadv.2024.214005_bb0055","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1086\/657320","article-title":"Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection","volume":"202","author":"Brotman","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bioadv.2024.214005_bb0060","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1177\/0956462418785451","article-title":"2018 European (IUSTI\/WHO) International Union against sexually trans- mitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge","volume":"29","author":"Sherrard","year":"2018","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.bioadv.2024.214005_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119659","article-title":"Bacterial vaginosis: standard treatments and alternative strategies","volume":"587","author":"Tom\u00e1s","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.anaerobe.2017.05.005","article-title":"Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole, tinidazole and clindamycin","volume":"47","author":"Petrina","year":"2017","journal-title":"Anaerobe"},{"key":"10.1016\/j.bioadv.2024.214005_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224964","article-title":"Acceptability of and treatment preferences for recurrent bacterial vaginosis\u2014topical lactic acid gel or oral metronidazole antibiotic: qualitative findings from the VITA trial","volume":"14","author":"Anstey Watkins","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2024.214005_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-0691.2008.02112.x","article-title":"Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis","volume":"15","author":"Mastromarino","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bioadv.2024.214005_bb0085","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3109\/03639045.2014.963864","article-title":"Vaginal suppositories containing Lactobacillus acidophilus: development and characterization","volume":"41","author":"Rodrigues","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0090","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1471-0528.2008.01882.x","article-title":"The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis","volume":"115","author":"Petricevic","year":"2008","journal-title":"Bjog"},{"key":"10.1016\/j.bioadv.2024.214005_bb0095","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.micinf.2006.01.003","article-title":"Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial","volume":"8","author":"Anukam","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bioadv.2024.214005_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14112337","article-title":"Formulation and optimization of metronidazole and Lactobacillus spp. layered suppositories via a three-variable, five-level central composite design for the management of bacterial vaginosis","volume":"14","author":"Ilomuanya","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2024.214005_bb0105","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1056\/NEJMoa1915254","article-title":"Randomized trial of Lactin-V to prevent recurrence of bacterial vaginosis","volume":"382","author":"Cohen","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioadv.2024.214005_bb0110","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3390\/pharmaceutics13091453","article-title":"Predicting drug release from 3D printed oral medicines based on the surface area to volume ratio of tablet geometry","volume":"13","author":"Windolf","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2024.214005_bb0115","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1208\/s12249-018-1017-0","article-title":"3D-printed network structures as controlled-release drug delivery systems: dose adjustment, API release analysis and prediction","volume":"19","author":"Korte","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2024.214005_bb0120","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jconrel.2023.04.023","article-title":"Fabrication and characterization of bioprints with Lactobacillus crispatus for vaginal application","volume":"357","author":"Kyser","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2024.214005_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.fhfh.2022.100088","article-title":"An easy and robust method of preparation of capsules for delivering probiotic bacteria by a 3D bioprinting","volume":"2","author":"Mallick","year":"2022","journal-title":"Food Hydrocoll. Health"},{"key":"10.1016\/j.bioadv.2024.214005_bb0130","article-title":"Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy","volume":"301","author":"Young Isabella","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2024.214005_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123054","article-title":"Formulation and characterization of pressure-assisted microsyringe 3D-printed scaffolds for controlled intravaginal antibiotic release","volume":"641","author":"Kyser","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0140","article-title":"Development of 3D-printed vaginal devices containing metronidazole for alternative bacterial vaginosis treatment","volume":"5","author":"Utomo","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.bioadv.2024.214005_bb0145","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.3390\/v14112501","article-title":"3D-printed EVA devices for antiviral delivery and herpes virus control in genital infection","volume":"14","author":"De Carvalho Rodrigues","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.bioadv.2024.214005_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120290","article-title":"3D printed clotrimazole intravaginal ring for the treatment of recurrent vaginal candidiasis","volume":"596","author":"Tiboni","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejpb.2022.04.001","article-title":"Toward a new generation of vaginal pessaries via 3D-printing: concomitant mechanical support and drug delivery","volume":"174","author":"Eder","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0160","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/polym14040763","article-title":"Development of 3D printed biodegradable mesh with antimicrobial properties for pelvic organ prolapse","volume":"14","author":"Ren","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2024.214005_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112523","article-title":"Melt-extrusion 3D printing of resorbable levofloxacin-loaded meshes: emerging strategy for urogynaecological applications","volume":"131","author":"Corduas","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2024.214005_bb0170","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/pharmaceutics14020437","article-title":"Design, preparation and in vitro evaluation of core\u2013shell fused deposition modelling 3D-printed verapamil hydrochloride pulsatile tablets","volume":"14","author":"Li","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2024.214005_bb0175","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2017.10.003","article-title":"Anti-tuberculosis drug combination for controlled oral delivery using 3D printed compartmental dosage forms: from drug product design to in vivo testing","volume":"268","author":"Genina","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2024.214005_bb0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.addr.2016.01.015","article-title":"Microbicide vaginal rings: technological challenges and clinical development","volume":"103","author":"Malcolm","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioadv.2024.214005_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111615","article-title":"Silicone-based bioscaffolds for cellular therapies","volume":"119","author":"Razavi","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2024.214005_bb0190","doi-asserted-by":"crossref","first-page":"11559","DOI":"10.1021\/acs.langmuir.8b02039","article-title":"Glycerol\u2013silicone elastomers as active matrices with controllable release profiles","volume":"34","author":"Mazurek","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.bioadv.2024.214005_bb0195","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ejps.2012.12.002","article-title":"A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action","volume":"48","author":"Fetherston","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2024.214005_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.02.003","article-title":"Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES","volume":"298","author":"McBride","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2024.214005_bb0205","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijpharm.2018.08.051","article-title":"Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques","volume":"550","author":"Murphy","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","article-title":"Alginate: properties and biomedical applications","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.bioadv.2024.214005_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2022.130155","article-title":"Fe3O4 embedded-carrageenan\/sodium alginate hydrogels for the removal of basic dyes","volume":"654","author":"Sharma","year":"2022","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.bioadv.2024.214005_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124417","article-title":"Carrageenan\/sodium alginate double-network hydrogel with enhanced mechanical properties, anti-swelling, and adsorption capacity","volume":"237","author":"Yu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.bioadv.2024.214005_bb0225","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3390\/polym12102377","article-title":"Kappa-carrageenan-based dual crosslinkable bioink for extrusion type bioprinting","volume":"12","author":"Lim","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2024.214005_bb0230","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/bm400853d","article-title":"Biofilm-like Lactobacillus rhamnosus probiotics encapsulated in alginate and carrageenan microcapsules exhibiting enhanced thermotolerance and freeze-drying resistance","volume":"14","author":"Cheow","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2024.214005_bb0235","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijbiomac.2017.01.016","article-title":"Development of novel carboxymethyl cellulose\/k-carrageenan blends as an enteric delivery vehicle for probiotic bacteria","volume":"97","author":"Dafe","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0240","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.3168\/jds.2021-21245","article-title":"Whey protein isolate- and carrageenan-based edible films as carriers of different probiotic bacteria","volume":"105","author":"Sogut","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bioadv.2024.214005_bb0245","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1208\/s12249-016-0628-6","article-title":"The novelty in fabrication of poly vinyl alcohol\/\u03ba-carrageenan hydrogel with Lactobacillus bulgaricus extract as anti-inflammatory wound dressing agent","volume":"18","author":"El-Fawal","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2024.214005_bb0250","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/adhm.201200317","article-title":"Photocrosslinkable Kappa-carrageenan hydrogels for tissue engineering applications","volume":"2","author":"Mihaila","year":"2013","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2024.214005_bb0255","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1211\/jpp.62.04.0004","article-title":"Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties","volume":"62","author":"Carvalho","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0260","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijpharm.2014.08.054","article-title":"Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398","volume":"475","author":"Grammen","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0265","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1128\/AAC.02446-14","article-title":"Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis","volume":"58","author":"Sundara Rajan","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioadv.2024.214005_bb0270","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.msec.2016.04.068","article-title":"Cell proliferation on PVA\/sodium alginate and PVA\/poly(\u03b3-glutamic acid) electrospun fiber","volume":"66","author":"Yang","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2024.214005_bb0275","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.ijbiomac.2022.09.275","article-title":"kappa-Carrageenan and PVA blends as bioinks to 3D print scaffolds for cartilage reconstruction","volume":"222","author":"Muscolino","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0280","doi-asserted-by":"crossref","DOI":"10.1063\/5.0102035","article-title":"Development of air-assisted atomization device for the delivery of cells in viscous biological ink prepared with sodium alginate","volume":"94","author":"Yan","year":"2023","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.bioadv.2024.214005_bb0285","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1039\/D1BM00695A","article-title":"Pre-shear bioprinting of highly oriented porous hydrogel microfibers to construct anisotropic tissues","volume":"9","author":"Shao","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2024.214005_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/polym11121924","article-title":"3D bioprinting of novel biocompatible scaffolds for endothelial cell repair","volume":"11","author":"Wu","year":"2019","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.bioadv.2024.214005_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059539","article-title":"Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis","volume":"8","author":"Gilbert","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2024.214005_bb0300","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1074\/jbc.M113.453654","article-title":"Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis","volume":"288","author":"Lewis","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioadv.2024.214005_bb0305","doi-asserted-by":"crossref","first-page":"40","DOI":"10.14227\/DT250318P40","article-title":"Simulated genital tract fluids and their applicability in drug release\/dissolution testing of vaginal dosage forms","volume":"25","author":"Tietz","year":"2018","journal-title":"Dissolut. Technol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0310","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.anaerobe.2018.10.004","article-title":"Metronidazole resistance and nim genes in anaerobes: a review","volume":"55","author":"Alauzet","year":"2019","journal-title":"Anaerobe"},{"key":"10.1016\/j.bioadv.2024.214005_bb0315","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jpba.2005.11.008","article-title":"Comparison of UV spectrophotometric method and high performance liquid chromatography for the analysis of flunarizine and its application for the dissolution test","volume":"41","author":"Busaranon","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bioadv.2024.214005_bb0320","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jbm.b.33357","article-title":"Evaluation of metronidazole-loaded poly(3-hydroxybutyrate) membranes to potential application in periodontitis treatment","volume":"104","author":"Da Silva","year":"2016","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.bioadv.2024.214005_bb0325","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jconrel.2004.03.029","article-title":"Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterial","volume":"97","author":"Malcolm","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2024.214005_bb0330","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jbm.b.34742","article-title":"Facile fabrication of elastic, macro-porous, and fast vascularized silicone orbital implant","volume":"109","author":"Xu","year":"2021","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.bioadv.2024.214005_bb0335","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejpb.2023.05.019","article-title":"The processes behind drug loading and release in porous drug delivery systems","volume":"189","author":"Farzan","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0340","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1080\/17425247.2019.1660318","article-title":"Shaping the future: recent advances of 3D printing in drug delivery and healthcare","volume":"16","author":"Trenfield","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.bioadv.2024.214005_bb0345","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/bioengineering9030109","article-title":"3D bioprinting of novel \u03ba-carrageenan bioinks: an algae-derived polysaccharide","volume":"9","author":"Marques","year":"2022","journal-title":"Bioengineering"},{"key":"10.1016\/j.bioadv.2024.214005_bb0350","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3934\/microbiol.2018.1.140","article-title":"Bacterial autoaggregation","volume":"4","author":"Trunk","year":"2018","journal-title":"AIMS Microbiol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217401","article-title":"Enhanced biological removal of intermittent VOCs and deciphering the roles of sodium alginate and polyvinyl alcohol in biofilm formation","volume":"14","author":"Feng","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2024.214005_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2019.107883","article-title":"Properties of a commercial kappa-carrageenan food ingredient and its durable superabsorbent hydrogels","volume":"487","author":"Berton","year":"2020","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioadv.2024.214005_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131758","article-title":"Enhanced probiotic viability in innovative double-network emulsion gels: synergistic effects of the whey protein concentrate-xanthan gum complex and kappa-carrageenan","volume":"270","author":"Shen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0370","first-page":"229","article-title":"Bacterial vaginosis: a review on clinical trials with probiotics","volume":"36","author":"Mastromarino","year":"2013","journal-title":"New Microbiol."},{"key":"10.1016\/j.bioadv.2024.214005_bb0375","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.msec.2014.08.026","article-title":"Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis","volume":"44","author":"Singh","year":"2014","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2024.214005_bb0380","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0885328214528256","article-title":"Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis","volume":"29","author":"Pathak","year":"2014","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bioadv.2024.214005_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120071","article-title":"Development of polycaprolactone-based metronidazole matrices for intravaginal extended drug delivery using a mechanochemically prepared therapeutic deep eutectic system","volume":"593","author":"Li","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0390","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ejpb.2006.02.005","article-title":"Release and diffusional modeling of metronidazole lipid matrices","volume":"63","author":"Ozyazici","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2024.214005_bb0395","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1021\/acs.biomac.2c00186","article-title":"Metronidazole delivery nanosystem able to reduce the pathogenicity of bacteria in colorectal infection","volume":"23","author":"Oliveira","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2024.214005_bb0400","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/jbm.b.34827","article-title":"Mucoadhesive hyaluronic acid-based films for vaginal delivery of metronidazole","volume":"109","author":"Gerton","year":"2021","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.bioadv.2024.214005_bb0405","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1128\/AAC.02542-13","article-title":"Sustained delivery of commensal bacteria from pod-intravaginal rings","volume":"58","author":"Gunawardana","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioadv.2024.214005_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.bea.2023.100078","article-title":"Release kinetics of metronidazole from 3D printed silicone scaffolds for sustained application to the female reproductive tract","volume":"5","author":"Herold","year":"2023","journal-title":"Biomed. Eng. Adv."},{"key":"10.1016\/j.bioadv.2024.214005_bb0415","article-title":"Computational modeling of probiotic recovery from 3D-bioprinted scaffolds for localized vaginal application","volume":"11","author":"Rai","year":"2023","journal-title":"Ann. 3D Print. Med."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824002486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824002486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:23:23Z","timestamp":1726449803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950824002486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":83,"alternative-id":["S2772950824002486"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214005","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained dual delivery of metronidazole and viable Lactobacillus crispatus from 3D-printed silicone shells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214005"}}