{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:07:58Z","timestamp":1787965678987,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bioadv.2024.214037","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T22:03:55Z","timestamp":1725833035000},"page":"214037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["A facile way to fabricate a thrombin immobilized composite sponge with dual hemostatic effects for acute hemorrhage control"],"prefix":"10.1016","volume":"166","author":[{"given":"Dandan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bioadv.2024.214037_bb0005","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/acsabm.0c00160","article-title":"Evaluation of viscoelastic properties, blood coagulation, and cellular responses of a temperature-sensitive gel for hemostatic application","volume":"3","author":"Jun","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214037_bb0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.bioadv.2024.214037_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112430","article-title":"Poly (aspartic acid) based self-healing hydrogel with blood coagulation characteristic for rapid hemostasis and wound healing applications","volume":"214","author":"Chen","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioadv.2024.214037_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101165","article-title":"Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy","volume":"39","author":"Cao","year":"2021","journal-title":"Nano Today"},{"issue":"11","key":"10.1016\/j.bioadv.2024.214037_bb0025","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1002\/jbm.a.35052","article-title":"Hemostatic strategies for traumatic and surgical bleeding","volume":"102","author":"Behrens","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"9","key":"10.1016\/j.bioadv.2024.214037_bb0030","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1016\/j.actbio.2012.05.001","article-title":"Rapidly curable chitosan\u2013PEG hydrogels as tissue adhesives for hemostasis and wound healing","volume":"8","author":"Lih","year":"2012","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214037_bb0035","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1038\/s41467-018-04998-9","article-title":"Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2024.214037_bb0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.msec.2017.03.276","article-title":"Porous chitosan microspheres for application as quick in vitro and in vivo hemostat","volume":"77","author":"Li","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"7","key":"10.1016\/j.bioadv.2024.214037_bb0045","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1039\/D2BM02049A","article-title":"A natural polyphenol-functionalized chitosan\/gelatin sponge for accelerating hemostasis and infected wound healing","volume":"11","author":"Sun","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2024.214037_bb0050","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biomaterials.2019.03.008","article-title":"Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing","volume":"204","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2024.214037_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2016.02.034","article-title":"The effects of crosslinkers on physical, mechanical, and cytotoxic properties of gelatin sponge prepared via in-situ gas foaming method as a tissue engineering scaffold","volume":"63","author":"Poursamar","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.bioadv.2024.214037_bb0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1021\/acsami.3c15517","article-title":"A Janus gelatin sponge with a Procoagulant nanoparticle-embedded surface for Coagulopathic hemostasis","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.bioadv.2024.214037_bb0065","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jbm.a.35940","article-title":"Silk fibroin based carrier system for delivery of fibrinogen and thrombin as coagulant supplements","volume":"105","author":"Teuschl","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"3","key":"10.1016\/j.bioadv.2024.214037_bb0070","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/acsbiomaterials.0c00069","article-title":"Surface-adaptive and on-demand antibacterial sponge for synergistic rapid hemostasis and wound disinfection","volume":"6","author":"Che","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bioadv.2024.214037_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118881","article-title":"Poly (vinyl alcohol)-alginate as potential matrix for various applications: a focused review","volume":"277","author":"Kumar","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.214037_bb0080","first-page":"228","article-title":"Shape-adaptive composite foams with high expansion and absorption used for massive hemorrhage control and irregular wound treatment, applied","volume":"13","author":"Wang","year":"2018","journal-title":"Mater. Today"},{"issue":"32","key":"10.1016\/j.bioadv.2024.214037_bb0085","doi-asserted-by":"crossref","first-page":"10579","DOI":"10.1021\/acssuschemeng.2c02060","article-title":"Facile synthesis and integration of poly(vinyl alcohol) sponge-supported metal Nanocatalysts on a microfluidic Chip enable a new continuous flow multireactor Nanocatalysis platform for high efficiency and reusability catalysis","volume":"10","author":"Hu","year":"2022","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.bioadv.2024.214037_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131977","article-title":"High-strength anti-bacterial composite cryogel for lethal noncompressible hemorrhage hemostasis: synergistic physical hemostasis and chemical hemostasis","volume":"427","author":"Huang","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.bioadv.2024.214037_bb0095","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1039\/D0TB02480E","article-title":"Fabricating poly(vinyl alcohol)\/gelatin composite sponges with high absorbency and water-triggered expansion for noncompressible hemorrhage and wound healing","volume":"9","author":"Yang","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2024.214037_bb0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.carbpol.2018.12.056","article-title":"Enhancement of hemostatic property of plant derived oxidized nanocellulose-silk fibroin based scaffolds by thrombin loading","volume":"208","author":"Shefa","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.214037_bb0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10143-017-0856-6","article-title":"Incidence of thromboembolic events after use of gelatin-thrombin-based hemostatic matrix during intracranial tumor surgery","volume":"41","author":"Gazzeri","year":"2018","journal-title":"Neurosurg. Rev."},{"issue":"18","key":"10.1016\/j.bioadv.2024.214037_bb0110","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1039\/D1BM00917F","article-title":"Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin","volume":"9","author":"Shi","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2024.214037_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.colsurfb.2017.10.021","article-title":"Synergy in thrombin-graphene sponge for improved hemostatic efficacy and facile utilization","volume":"161","author":"Li","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"10","key":"10.1016\/j.bioadv.2024.214037_bb0120","doi-asserted-by":"crossref","first-page":"7643","DOI":"10.1021\/acsabm.1c00882","article-title":"Thrombin embedded in eMPs@Thr\/sponge with enhanced Procoagulant ability for uncompressible and massive hemorrhage control","volume":"4","author":"Liu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2024.214037_bb0125","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.jcis.2023.08.177","article-title":"Reinforcing and toughening bacterial cellulose\/MXene films assisted by interfacial multiple cross-linking for electromagnetic interference shielding and photothermal response","volume":"652","author":"Luo","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2024.214037_bb0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.compscitech.2015.08.004","article-title":"Hydrophilic nanofiber of bacterial cellulose guided the changes in the micro-structure and mechanical properties of nf-BC\/PVA composites hydrogels","volume":"118","author":"Qiao","year":"2015","journal-title":"Compos. Sci. Technol."},{"key":"10.1016\/j.bioadv.2024.214037_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.129136","article-title":"A hemostatic sponge derived from skin secretion of Andrias davidianus and nanocellulose","volume":"416","author":"Zheng","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2024.214037_bb0140","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.carbpol.2013.10.093","article-title":"In situ synthesis of silver-nanoparticles\/bacterial cellulose composites for slow-released antimicrobial wound dressing","volume":"102","author":"Wu","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.214037_bb0145","first-page":"471","article-title":"A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing","volume":"17","author":"Zou","year":"2022","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.bioadv.2024.214037_bb0150","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nprot.2009.238","article-title":"A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone","volume":"5","author":"Zhu","year":"2010","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.bioadv.2024.214037_bb0155","first-page":"2089","article-title":"Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment","volume":"6","author":"Wang","year":"2021","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214037_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1757-7241-21-29","article-title":"Thrombelastography (TEG\u00ae): practical considerations on its clinical use in trauma resuscitation","volume":"21","author":"da Luz","year":"2013","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"10.1016\/j.bioadv.2024.214037_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.compositesb.2017.06.023","article-title":"Preparation of a novel sodium alginate\/polyvinyl formal composite with a double crosslinking interpenetrating network for multifunctional biomedical application","volume":"121","author":"Wang","year":"2017","journal-title":"Compos. Part B Eng."},{"issue":"32","key":"10.1016\/j.bioadv.2024.214037_bb0170","doi-asserted-by":"crossref","first-page":"18498","DOI":"10.1039\/C9RA02994J","article-title":"Interaction of the synthetic antithrombotic peptide P10 with thrombin: a spectroscopy study","volume":"9","author":"Chen","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2024.214037_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112770","article-title":"A keratin\/chitosan sponge with excellent hemostatic performance for uncontrolled bleeding","volume":"218","author":"Yan","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioadv.2024.214037_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143758","article-title":"An ultrafast water absorption composite cryogel containing Iron-doped bioactive glass with rapid hemostatic ability for non-compressible and coagulopathic bleeding","volume":"469","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2024.214037_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119924","article-title":"An antibacterial hemostatic AuNPs@corn stalk\/chitin composite sponge with shape recovery for promoting wound healing","volume":"296","author":"Zheng","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2024.214037_bb0190","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.msec.2017.10.007","article-title":"Hemostatic porous sponges of cross-linked hyaluronic acid\/cationized dextran by one self-foaming process","volume":"83","author":"Liu","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2024.214037_bb0195","first-page":"231","article-title":"Advances in haemostatic sponges: characteristics and the underlying mechanisms for rapid haemostasis","volume":"27","author":"Nepal","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2024.214037_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126329","article-title":"Injectable dry cryogels with excellent blood-sucking expansion and blood clotting to cease hemorrhage for lethal deep-wounds, coagulopathy and tissue regeneration","volume":"403","author":"Zhao","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2024.214037_bb0205","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.carbpol.2017.12.033","article-title":"Preparation of composite hydroxybutyl chitosan sponge and its role in promoting wound healing","volume":"184","author":"Hu","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"10","key":"10.1016\/j.bioadv.2024.214037_bb0210","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1177\/0885328216636320","article-title":"The effect of fiber size and pore size on cell proliferation and infiltration in PLLA scaffolds on bone tissue engineering","volume":"30","author":"Wang","year":"2016","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bioadv.2024.214037_bb0215","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.carbpol.2019.05.028","article-title":"N-alkylated chitosan\/graphene oxide porous sponge for rapid and effective hemostasis in emergency situations","volume":"219","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"11","key":"10.1016\/j.bioadv.2024.214037_bb0220","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1039\/C8TB03181A","article-title":"Synthetic poly(vinyl alcohol)\u2013chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility","volume":"7","author":"Zhao","year":"2019","journal-title":"J. Mater. Chem. B"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824002802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950824002802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:47:32Z","timestamp":1733132852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950824002802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":44,"alternative-id":["S2772950824002802"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214037","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A facile way to fabricate a thrombin immobilized composite sponge with dual hemostatic effects for acute hemorrhage control","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214037"}}