{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:01:56Z","timestamp":1792519316657,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008095","name":"Yanshan University","doi-asserted-by":"publisher","award":["UH202209"],"award-info":[{"award-number":["UH202209"]}],"id":[{"id":"10.13039\/501100008095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022203004"],"award-info":[{"award-number":["H2022203004"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020107010"],"award-info":[{"award-number":["H2020107010"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bioadv.2024.214082","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:50:27Z","timestamp":1729619427000},"page":"214082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["pH responsive and zwitterionic micelle for enhanced cellular uptake and antitumor performance"],"prefix":"10.1016","volume":"167","author":[{"given":"Lu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifa","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bioadv.2024.214082_bb0005","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.7326\/M22-1139","article-title":"Evaluation of harms reporting in US cancer screening guidelines","volume":"175","author":"Kamineni","year":"2022","journal-title":"Ann. Intern. Med."},{"issue":"17","key":"10.1016\/j.bioadv.2024.214082_bb0010","first-page":"370","article-title":"Epidemiological characteristics of occupational cancers reported - China, 2006-2020","volume":"4","author":"Li","year":"2022","journal-title":"China Cdc Weekly"},{"issue":"3","key":"10.1016\/j.bioadv.2024.214082_bb0015","doi-asserted-by":"crossref","first-page":"E549","DOI":"10.1097\/SLA.0000000000005051","article-title":"Dataset for pathology reporting of colorectal cancer: recommendations from the international collaboration on cancer reporting (ICCR)","volume":"275","author":"Loughrey","year":"2022","journal-title":"Ann. Surg."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/ph14010013","article-title":"Overcoming hypoxia-induced chemoresistance in cancer using a novel glycoconjugate of methotrexate","volume":"14","author":"Wozniak","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"20","key":"10.1016\/j.bioadv.2024.214082_bb0025","doi-asserted-by":"crossref","first-page":"22673","DOI":"10.1021\/acsami.0c05724","article-title":"Response of pH-sensitive doxorubicin nanoparticles on complex tumor microenvironments by tailoring multiple physicochemical properties","volume":"12","author":"Chen","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2024.214082_bb0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.actbio.2022.02.036","article-title":"A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment","volume":"143","author":"Quynh","year":"2022","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0035","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1080\/21655979.2021.1879566","article-title":"Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas","volume":"12","author":"Zou","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.bioadv.2024.214082_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110288","article-title":"Synthesis of core-crosslinked zwitterionic polymer nano aggregates and pH\/redox responsiveness in drug controlled release","volume":"106","author":"Zhang","year":"2020","journal-title":"Materials Science and Engineering C-Materials for Biological Applications"},{"key":"10.1016\/j.bioadv.2024.214082_bb0045","first-page":"230","article-title":"Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy","volume":"16648714","author":"Cheng","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01230-6","article-title":"Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy","volume":"15","author":"Zhao","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioadv.2024.214082_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213606","article-title":"Sialic acid-decorated liposomes enhance the anti-cancer efficacy of docetaxel in tumor-associated macrophages","volume":"154","author":"Tran","year":"2023","journal-title":"Biomaterials Advances"},{"issue":"7","key":"10.1016\/j.bioadv.2024.214082_bb0060","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/acs.biomac.1c00530","article-title":"Thermoresponsive carbohydrate-b-polypeptoid polymer vesicles with selective solute permeability and permeable factors for solutes","volume":"22","author":"Okuno","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2024.214082_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114622","article-title":"Intelligent triggering of nanomicelles based on a ROS-activated anticancer prodrug and photodynamic therapy (PDT)-synergistic therapy for lung cancers","volume":"241","author":"Chen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioadv.2024.214082_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213118","article-title":"Dendrimer-based delivery of macromolecules for the treatment of brain tumor","volume":"141","author":"Choudhury","year":"2022","journal-title":"Biomaterials Advances"},{"key":"10.1016\/j.bioadv.2024.214082_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213735","article-title":"Dual stimuli-responsive delivery system for self-regulated colon-targeted delivery of poorly water-soluble drugs","volume":"157","author":"Rabeh","year":"2024","journal-title":"Biomaterials Advances"},{"key":"10.1016\/j.bioadv.2024.214082_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213330","article-title":"Electrospun UV-cross-linked polyvinylpyrrolidone fibers modified with polycaprolactone \/polyethersulfone microspheres for drug delivery","volume":"147","author":"Mirek","year":"2023","journal-title":"Biomaterials Advances"},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08674","article-title":"Drug release study of the chitosan-based nanoparticles","volume":"8","author":"Herdiana","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.bioadv.2024.214082_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.surfcoat.2021.126831","article-title":"Controlled drug release of parylene-coated pramipexole nanofibers for transdermal applications","volume":"409","author":"Tort","year":"2021","journal-title":"Surf. Coat. Technol."},{"issue":"16","key":"10.1016\/j.bioadv.2024.214082_bb0095","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1021\/acs.langmuir.2c00512","article-title":"Surface hydration and antifouling activity of zwitterionic polymers","volume":"38","author":"Chen","year":"2022","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2944","article-title":"Zwitterionic polymers in drug delivery: a review","volume":"35","author":"Harijan","year":"2022","journal-title":"J. Mol. Recognit."},{"issue":"15","key":"10.1016\/j.bioadv.2024.214082_bb0105","doi-asserted-by":"crossref","first-page":"18348","DOI":"10.1021\/acsami.1c02789","article-title":"Tailoring the surface chemistry of anion exchange membranes with zwitterions: toward antifouling RED membranes","volume":"13","author":"Pintossi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.bioadv.2024.214082_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202203460","article-title":"Long-acting insulin-zwitterionic polymer conjugate mitigates hypoglycemia","volume":"29","author":"Zeng","year":"2023","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.bioadv.2024.214082_bb0115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bioactmat.2022.12.028","article-title":"Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture","volume":"24","author":"Liu","year":"2023","journal-title":"Bioactive materials"},{"key":"10.1016\/j.bioadv.2024.214082_bb0120","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ijbiomac.2022.03.216","article-title":"The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen","volume":"209","author":"Jiang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"23","key":"10.1016\/j.bioadv.2024.214082_bb0125","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1021\/acs.chemrev.2c00344","article-title":"Zwitterionic biomaterials","volume":"122","author":"Li","year":"2022","journal-title":"Chem. Rev."},{"issue":"29","key":"10.1016\/j.bioadv.2024.214082_bb0130","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1039\/D2TB01061E","article-title":"Phosphorylcholine zwitterionic shell-detachable mixed micelles for enhanced cancerous cellular uptakes and increased DOX release","volume":"10","author":"Cao","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2024.214082_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1230585","article-title":"Dual functionalized hyaluronic acid micelles loading paclitaxel for the therapy of breast cancer","volume":"11","author":"Liu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0140","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.apsb.2021.05.003","article-title":"GSH-sensitive polymeric prodrug: synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine","volume":"12","author":"Luo","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0145","article-title":"Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy","volume":"13","author":"Gao","year":"2022","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.bioadv.2024.214082_bb0150","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1080\/09205063.2020.1792046","article-title":"Acetal-linked polymeric prodrug micelles based on aliphatic polycarbonates for paclitaxel delivery: preparation, characterization,<i>in vitro<\/i>release and anti-proliferation effects","volume":"31","author":"Zhou","year":"2020","journal-title":"Journal of Biomaterials Science-Polymer Edition"},{"key":"10.1016\/j.bioadv.2024.214082_bb0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.colsurfb.2015.12.025","article-title":"Acetal-linked polymeric prodrug micelles for enhanced curcumin delivery","volume":"140","author":"Li","year":"2016","journal-title":"Colloids and Surfaces B-Biointerfaces"},{"key":"10.1016\/j.bioadv.2024.214082_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120502","article-title":"\u201cstealth\u201d dendrimers with encapsulation of indocyanine green for photothermal and photodynamic therapy of cancer","volume":"600","author":"Cui","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.bioadv.2024.214082_bb0165","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00396-015-3822-2","article-title":"Reduction-responsive zwitterionic nanogels based on carboxymethyl chitosan for enhancing cellular uptake in drug release","volume":"294","author":"Zhang","year":"2016","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.bioadv.2024.214082_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123513","article-title":"Pd nanoparticles stabilized by bitter gourd polysaccharide with peroxidase properties for H2O2 detection","volume":"233","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2024.214082_bb0175","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jcis.2021.07.076","article-title":"Inducing pH control over the critical micelle concentration of zwitterionic surfactants via polyacids adsorption: effect of chain length and structure","volume":"606","author":"Mella","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"19","key":"10.1016\/j.bioadv.2024.214082_bb0180","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.1021\/acsami.7b03317","article-title":"Bioreducible polymer nanocarrier based on multivalent choline phosphate for enhanced cellular uptake and intracellular delivery of doxorubicin","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"38","key":"10.1016\/j.bioadv.2024.214082_bb0185","doi-asserted-by":"crossref","first-page":"14347","DOI":"10.1039\/C7NR03129G","article-title":"Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo","volume":"9","author":"Wen","year":"2017","journal-title":"Nanoscale"},{"issue":"13","key":"10.1016\/j.bioadv.2024.214082_bb0190","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1021\/acs.langmuir.0c00206","article-title":"Zwitterionic unimolecular micelles with pH and temperature response: cenhanced in vivo circulation stability and tumor therapeutic efficiency","volume":"36","author":"Liu","year":"2020","journal-title":"Langmuir"},{"key":"10.1016\/j.bioadv.2024.214082_bb0195","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.actbio.2017.10.034","article-title":"Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells","volume":"65","author":"Ou","year":"2018","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.bioadv.2024.214082_bb0200","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41565-020-0693-6","article-title":"Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions","volume":"15","author":"Han","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"6","key":"10.1016\/j.bioadv.2024.214082_bb0205","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/acs.molpharmaceut.1c00518","article-title":"Zwitterionic block copolymer prodrug micelles for pH responsive drug delivery and hypoxia-specific chemotherapy","volume":"19","author":"Zhao","year":"2022","journal-title":"Mol. Pharm."},{"issue":"13","key":"10.1016\/j.bioadv.2024.214082_bb0210","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1021\/acs.langmuir.3c00159","article-title":"Zwitterionic targeting doxorubicin-loaded micelles assembled by amphiphilic dendrimers with enhanced antitumor performance","volume":"39","author":"Zhang","year":"2023","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.bioadv.2024.214082_bb0215","first-page":"58","article-title":"Self-assembly of dual-sensitive mPEG-PDPA-P(AAm-co-AN) for drug delivery","volume":"36","author":"Song","year":"2023","journal-title":"Journal of Functional Polymer"},{"key":"10.1016\/j.bioadv.2024.214082_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2023.105773","article-title":"pH-responsive star-shaped poly (\u03b5-carprolactone)-co-poly maleic anhydride micelles for synergistic breast cancer combination chemotherapy","volume":"193","author":"Rahmani","year":"2023","journal-title":"React. Funct. Polym."},{"issue":"12","key":"10.1016\/j.bioadv.2024.214082_bb0225","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/adfm.201301309","article-title":"Steric protected and illumination- activated tumor targeting accessory for endowing drug- delivery systems with tumor selectivity","volume":"24","author":"Yuan","year":"2014","journal-title":"Adv. Funct. Mater."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277295082400325X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277295082400325X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T16:48:43Z","timestamp":1733762923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277295082400325X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":45,"alternative-id":["S277295082400325X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214082","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH responsive and zwitterionic micelle for enhanced cellular uptake and antitumor performance","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2024.214082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214082"}}