{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:31:04Z","timestamp":1790130664712,"version":"4.0.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042023kf0103"],"award-info":[{"award-number":["2042023kf0103"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016359","name":"Zhongnan Hospital of Wuhan University","doi-asserted-by":"publisher","award":["ZNJC202242"],"award-info":[{"award-number":["ZNJC202242"]}],"id":[{"id":"10.13039\/501100016359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bioadv.2025.214308","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:01:34Z","timestamp":1744124494000},"page":"214308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Bioactive Zn ingredients endow Ti-Zn composites with exceptional mechanical and osteogenic properties as biomedical implants"],"prefix":"10.1016","volume":"174","author":[{"given":"Li","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-shun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2025.214308_bb0005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10","article-title":"Bone tissue engineering: recent advances and challenges","volume":"40","author":"Amini","year":"2012","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2025.214308_bb0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.bioeng.8.061505.095721","article-title":"Biomechanical and molecular regulation of bone remodeling","volume":"8","author":"Robling","year":"2006","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2025.214308_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2024.101277","article-title":"Towards load-bearing biomedical titanium-based alloys: from essential requirements to future developments","volume":"144","author":"Cui","year":"2024","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0020","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0142-9612(97)00146-4","article-title":"Titanium alloys in total joint replacement-a materials science perspective","volume":"19","author":"Long","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0025","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.msec.2019.04.064","article-title":"Review on titanium and titanium based alloys as biomaterials for orthopaedic applications","volume":"102","author":"Kaur","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2025.214308_bb0030","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jse.2017.12.020","article-title":"Stress shielding of the humerus in press-fit anatomic shoulder arthroplasty: review and recommendations for evaluation","volume":"27","author":"Denard","year":"2018","journal-title":"J. Shoulder Elb. Surg."},{"key":"10.1016\/j.bioadv.2025.214308_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.10.001","article-title":"Metallic implant biomaterials","volume":"87","author":"Chen","year":"2015","journal-title":"Mater. Sci. Eng. R"},{"key":"10.1016\/j.bioadv.2025.214308_bb0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jmst.2021.01.015","article-title":"A novel biomedical titanium alloy with high antibacterial property and low elastic modulus","volume":"81","author":"Cai","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.bioadv.2025.214308_bb0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1557\/jmr.2020.90","article-title":"Processing a biocompatible Ti-35Nb-7Zr-5Ta alloy by selective laser melting","volume":"35","author":"Batalha","year":"2020","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.bioadv.2025.214308_bb0050","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1021\/acsabm.1c00059","article-title":"Enhanced physicochemical and biological properties of a low-temperature copperized layer on gradient nanograined pure titanium","volume":"4","author":"Qiu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.msec.2018.06.024","article-title":"Antibacterial activities and biocompatibilities of Ti-Ag alloys prepared by spark plasma sintering and acid etching","volume":"92","author":"Lei","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2025.214308_bb0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actbio.2016.08.013","article-title":"Novel bioactive materials developed by simulated body fluid evaluation: surface-modified Ti metal and its alloys","volume":"44","author":"Kokubo","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2020.146107","article-title":"A titanium surface modified with zinc-containing nanowires: enhancing biocompatibility and antibacterial property in vitro","volume":"515","author":"Shao","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.01.001","article-title":"Biodegradable metals","volume":"77","author":"Zheng","year":"2014","journal-title":"Mater. Sci. Eng. R"},{"key":"10.1016\/j.bioadv.2025.214308_bb0075","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1016\/j.biomaterials.2006.05.029","article-title":"Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta","volume":"27","author":"Peuster","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0080","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.actbio.2020.11.032","article-title":"Cancellous bone-like porous Fe@Zn scaffolds with core-shell-structured skeletons for biodegradable bone implants","volume":"121","author":"He","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0085","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41467-019-14153-7","article-title":"Alloying design of biodegradable zinc as promising bone implants for load-bearing applications","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2025.214308_bb0090","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jmst.2015.12.018","article-title":"Bio-adaption between magnesium alloy stent and the blood vessel: a review","volume":"32","author":"Ma","year":"2016","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.bioadv.2025.214308_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchar.2022.111748","article-title":"Partially biodegradable Ti\u2013Mg composites prepared by microwave sintering for biomedical application","volume":"185","author":"Lai","year":"2022","journal-title":"Mater. Charact."},{"key":"10.1016\/j.bioadv.2025.214308_bb0100","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: a review","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biomaterials.2017.08.022","article-title":"Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model","volume":"145","author":"Yang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.01.035","article-title":"The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: a comprehensive review","volume":"87","author":"Venezuela","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.actbio.2019.10.034","article-title":"Additively manufactured biodegradable porous zinc","volume":"101","author":"Li","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120905","article-title":"Zn0.8Li0.1Sr\u2014a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: in vitro and in vivo studies","volume":"275","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0125","first-page":"1588","article-title":"Biodegradable Zn\u2013Sr alloy for bone regeneration in rat femoral condyle defect model: in vitro and in vivo studies","volume":"6","author":"Jia","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.bioadv.2025.214308_bb0130","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2020.03.009","article-title":"In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications","volume":"108","author":"Jia","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0135","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.actbio.2020.09.041","article-title":"Biodegradable Zn\u2013Cu alloys show antibacterial activity against MRSA bone infection by inhibiting pathogen adhesion and biofilm formation","volume":"117","author":"Qu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0140","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1038\/s41467-024-47189-5","article-title":"Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2025.214308_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121663","article-title":"High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis","volume":"287","author":"Jia","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214308_bb0150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.actbio.2022.03.055","article-title":"Additive manufacturing of Zn-Mg alloy porous scaffolds with enhanced osseointegration: in vitro and in vivo studies","volume":"145","author":"Qin","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0155","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Additively manufactured Zn-2Mg alloy porous scaffolds with customizable biodegradable performance and enhanced osteogenic ability","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0160","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jmst.2022.09.017","article-title":"Biodegradable Zn-0.5Li alloy rib plate: processing procedure development and in vitro performance evaluation","volume":"141","author":"Sun","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.bioadv.2025.214308_bb0165","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.actbio.2022.01.049","article-title":"Processing optimization, mechanical properties, corrosion behavior and cytocompatibility of additively manufactured Zn-0.7Li biodegradable metals","volume":"142","author":"Qin","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.msec.2015.06.010","article-title":"Powder metallurgical low-modulus Ti-Mg alloys for biomedical applications","volume":"56","author":"Liu","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2025.214308_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2021.108743","article-title":"Mg-Ti composites fabricated by a novel one-step high-pressure sintering: the correlation between microstructures and mechanical properties","volume":"215","author":"Cai","year":"2021","journal-title":"Compos B Eng"},{"key":"10.1016\/j.bioadv.2025.214308_bb0180","first-page":"37","article-title":"Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application","volume":"4","author":"Ouyang","year":"2019","journal-title":"Bioact Mater"},{"key":"10.1016\/j.bioadv.2025.214308_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intermet.2022.107794","article-title":"Investigation on diffusion characteristics and mechanical properties of Ti\u2013Zn system","volume":"154","author":"Tan","year":"2023","journal-title":"Intermetallics"},{"key":"10.1016\/j.bioadv.2025.214308_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jallcom.2022.167555","article-title":"Novel bioactive Ti-Zn alloys with high strength and low modulus for biomedical applications","volume":"931","author":"Qi","year":"2023","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioadv.2025.214308_bb0195","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/09506608.2017.1366003","article-title":"Powder metallurgy of titanium\u2013past, present, and future","volume":"63","author":"Fang","year":"2018","journal-title":"Int. Mater. Rev."},{"key":"10.1016\/j.bioadv.2025.214308_bb0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11669-008-9271-6","article-title":"Ti-Zn (titanium-zinc)","volume":"29","author":"Okamoto","year":"2008","journal-title":"J. Phase Equilib. Diffus."},{"key":"10.1016\/j.bioadv.2025.214308_bb0205","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s12598-023-02558-9","article-title":"Preparation of tungsten-particle-reinforced Zr-based bulk metallic glass composites by two-step spark plasma sintering: microstructure evolution, densification mechanism and mechanical properties","volume":"43","author":"Ma","year":"2024","journal-title":"Rare Metals"},{"key":"10.1016\/j.bioadv.2025.214308_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.intermet.2024.108437","article-title":"Dissimilar low-temperature diffusion bonding of copper and titanium using a Zn interlayer: interfacial microstructure and mechanical properties","volume":"173","author":"Feng","year":"2024","journal-title":"Intermetallics"},{"key":"10.1016\/j.bioadv.2025.214308_bb0215","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1177\/0885328218811052","article-title":"Microstructure, mechanical properties, and preliminary biocompatibility evaluation of binary Ti\u2013Zr alloys for dental application","volume":"33","author":"Wang","year":"2019","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bioadv.2025.214308_bb0220","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/adem.200800041","article-title":"Characterization of Ti-Ta alloys synthesized by cold crucible levitation melting","volume":"10","author":"Gordin","year":"2008","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.msea.2018.12.104","article-title":"Investigation of the structure and mechanical properties of additively manufactured Ti-6Al-4V biomedical scaffolds designed with a Schwartz primitive unit-cell","volume":"745","author":"Soro","year":"2019","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.bioadv.2025.214308_bb0230","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.matchar.2011.03.006","article-title":"Microstructure and mechanical behaviour of Ti-6Al-7Nb alloy produced by selective laser melting","volume":"62","author":"Chlebus","year":"2011","journal-title":"Mater. Charact."},{"key":"10.1016\/j.bioadv.2025.214308_bb0235","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/met12081391","article-title":"Synthesis, characterization and antimicrobial studies of Ti-40Nb-10Ag implant biomaterials","volume":"12","author":"Zhu","year":"2022","journal-title":"Metals"},{"key":"10.1016\/j.bioadv.2025.214308_bb0240","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.matlet.2019.07.008","article-title":"Characterization of a new Ti-13Nb-13Zr-10Cu alloy with enhanced antibacterial activity for biomedical applications","volume":"253","author":"Ke","year":"2019","journal-title":"Mater. Lett."},{"key":"10.1016\/j.bioadv.2025.214308_bb0245","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jallcom.2006.08.163","article-title":"Bulk ultra-fine eutectic structure in Ti-Fe-base alloys","volume":"434-435","author":"Das","year":"2007","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioadv.2025.214308_bb0250","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jallcom.2016.10.017","article-title":"Effects of Zn concentration and heat treatment on the microstructure, mechanical properties and corrosion behavior of as-extruded Mg-Zn alloys produced by powder metallurgy","volume":"693","author":"Yan","year":"2017","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioadv.2025.214308_bb0255","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10853-010-4843-3","article-title":"The effects of calcium and yttrium additions on the microstructure, mechanical properties and biocompatibility of biodegradable magnesium alloys","volume":"46","author":"Li","year":"2011","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0260","article-title":"Additive manufacturing of dense WE43 Mg alloy by laser powder bed fusion","volume":"33","author":"Hyer","year":"2020","journal-title":"Addit. Manuf."},{"key":"10.1016\/j.bioadv.2025.214308_bb0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actamat.2017.03.075","article-title":"Deformation twinning in rolled WE43-T5 rare earth magnesium alloy: influence on strain hardening and texture evolution","volume":"131","author":"Jahedi","year":"2017","journal-title":"Acta Mater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0270","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1016\/j.actamat.2005.03.037","article-title":"The influence of shock-pulse shape on the structure\/property behavior of copper and 316 L austenitic stainless steel","volume":"53","author":"Sencer","year":"2005","journal-title":"Acta Mater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0275","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/met10010060","article-title":"Ductile compressive behavior of biomedical alloys","volume":"10","author":"Affolter","year":"2020","journal-title":"Metals"},{"key":"10.1016\/j.bioadv.2025.214308_bb0280","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.msea.2017.04.088","article-title":"Elevated tensile properties of Ti-O alloy with a novel core-shell structure","volume":"696","author":"Zhang","year":"2017","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.bioadv.2025.214308_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.msea.2024.147417","article-title":"Synergistically enhanced strength and ductility in TiAl\/Nb composites via core-shell structure design","volume":"918","author":"Shen","year":"2024","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.bioadv.2025.214308_bb0290","doi-asserted-by":"crossref","DOI":"10.1080\/17452759.2024.2317780","article-title":"Heterogeneous grain structure in biodegradable Zn prepared via mechanical alloying and laser powder bed fusion for strength-plasticity synergy","volume":"19","author":"Shuai","year":"2024","journal-title":"Virtual Phys. Prototyp."},{"key":"10.1016\/j.bioadv.2025.214308_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2022.109731","article-title":"Exceptional mechanical properties of aluminum matrix composites with heterogeneous structure induced by in-situ graphene nanosheet-Cu hybrids","volume":"234","author":"Pu","year":"2022","journal-title":"Compos B Eng"},{"key":"10.1016\/j.bioadv.2025.214308_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.msea.2023.145160","article-title":"High temperature softening mechanism of powder metallurgy TA15 alloy","volume":"877","author":"Li","year":"2023","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.bioadv.2025.214308_bb0305","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/ab45ae","article-title":"The anisotropic properties and Debye temperatures of Ti-Zn compounds: a first-principles calculation","volume":"6","author":"Yan","year":"2019","journal-title":"Mater Res Express"},{"key":"10.1016\/j.bioadv.2025.214308_bb0310","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1016\/j.actamat.2006.04.038","article-title":"Phase stability and cohesive properties of Ti\u2013Zn intermetallics: first-principles calculations and experimental results","volume":"54","author":"Ghosh","year":"2006","journal-title":"Acta Mater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0315","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.corsci.2017.02.019","article-title":"Corrosion of AlxCoCrFeNi high-entropy alloys: Al-content and potential scan-rate dependent pitting behavior","volume":"119","author":"Shi","year":"2017","journal-title":"Corros. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0320","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.actbio.2023.07.004","article-title":"Controlled nano Cu precipitation through age treatment: a method to enhance the biodegradation, mechanical, antimicrobial properties and biocompatibility of Fe-20Mn-3Cu alloys","volume":"168","author":"Mandal","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0325","first-page":"12","article-title":"Additively manufactured pure zinc porous scaffolds for critical-sized bone defects of rabbit femur","volume":"19","author":"Xia","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.bioadv.2025.214308_bb0330","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actbio.2014.11.048","article-title":"Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates?","volume":"13","author":"Sanchez","year":"2015","journal-title":"A review, Acta Biomater"},{"key":"10.1016\/j.bioadv.2025.214308_bb0335","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.msea.2005.02.094","article-title":"The role of macrostructural morphology and grain size on the corrosion resistance of Zn and Al castings","volume":"402","author":"Os\u00f3rio","year":"2005","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.bioadv.2025.214308_bb0340","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.actbio.2023.02.029","article-title":"The enhancement of mechanical properties and uniform degradation of electrodeposited Fe-Zn alloys by multilayered design for biodegradable stent applications","volume":"161","author":"Xu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214308_bb0345","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1007\/s11665-016-2322-y","article-title":"Mechanism for corrosion prevention by a mechanical plating of uniform zinc-Iron alloy","volume":"25","author":"Kasai","year":"2016","journal-title":"J. Mater. Eng. Perform."},{"key":"10.1016\/j.bioadv.2025.214308_bb0350","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10856-018-6050-8","article-title":"Investigation on the in vitro cytocompatibility of Mg-Zn-Y-Nd-Zr alloys as degradable orthopaedic implant materials","volume":"29","author":"Song","year":"2018","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2025.214308_bb0355","first-page":"400","article-title":"Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel","volume":"32","author":"Yang","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.bioadv.2025.214308_bb0360","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.colsurfb.2013.03.019","article-title":"In situ synthesis and antibacterial activity of copper nanoparticle loaded natural montmorillonite clay based on contact inhibition and ion release","volume":"108","author":"Bagchi","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2025.214308_bb0365","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jbmr.3225","article-title":"Alkaline phosphatase: discovery and naming of our favorite enzyme","volume":"33","author":"Siller","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bioadv.2025.214308_bb0370","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.3390\/ijms23105776","article-title":"Whole aspect of Runx2 functions in skeletal development","volume":"23","author":"Komori","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2025.214308_bb0375","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s12276-020-0471-4","article-title":"RUNX2-modifying enzymes: therapeutic targets for bone diseases","volume":"52","author":"Kim","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioadv.2025.214308_bb0380","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3803\/EnM.2023.1895","article-title":"Osteocalcin: beyond bones","volume":"39","author":"Nowicki","year":"2024","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.bioadv.2025.214308_bb0385","article-title":"Mechanical stretch induced osteogenesis on human annulus fibrosus cells through upregulation of BMP-2\/6 heterodimer and activation of P38 and SMAD1\/5\/8 signaling pathways","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bioadv.2025.214308_bb0390","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.18632\/aging.102833","article-title":"Inflammatory macrophages facilitate mechanical stress-induced osteogenesis","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825001359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825001359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:34:18Z","timestamp":1762648458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950825001359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":78,"alternative-id":["S2772950825001359"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214308","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactive Zn ingredients endow Ti-Zn composites with exceptional mechanical and osteogenic properties as biomedical implants","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214308"}}