{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:09:02Z","timestamp":1778310542087,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002838","name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002838","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS006"],"award-info":[{"award-number":["YDZJ202301ZYTS006"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioadv.2025.214411","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:55:14Z","timestamp":1752623714000},"page":"214411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["An early rapamycin-releasing nerve wrap with dual function for nerve regeneration and adhesion prevention"],"prefix":"10.1016","volume":"177","author":[{"given":"Naiyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2025.214411_bb0005","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jnr.24538","article-title":"Peripheral nerve injury and myelination: Potential therapeutic strategies","volume":"98","author":"Modrak","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bioadv.2025.214411_bb0010","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1039\/C8BM00260F","article-title":"Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration","volume":"6","author":"Du","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2025.214411_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114261","article-title":"The reduction of imidazole propionate induced by intermittent fasting promotes recovery of peripheral nerve injury by enhancing migration of Schwann cells","volume":"442","author":"Tang","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bioadv.2025.214411_bb0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00005373-199807000-00025","article-title":"Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries","volume":"45","author":"Noble","year":"1998","journal-title":"J. Trauma"},{"key":"10.1016\/j.bioadv.2025.214411_bb0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.hcl.2015.01.007","article-title":"Management and complications of traumatic peripheral nerve injuries","volume":"31","author":"Houdek","year":"2015","journal-title":"Hand Clin."},{"key":"10.1016\/j.bioadv.2025.214411_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/698256","article-title":"Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies","volume":"2014","author":"Grinsell","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioadv.2025.214411_bb0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1445-1433.2004.03125.x","article-title":"Traumatic (or amputation) neuroma","volume":"74","author":"Janes","year":"2004","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.bioadv.2025.214411_bb0040","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/micr.1920140909","article-title":"Axonal regeneration rate through cross-face nerve grafts","volume":"14","author":"Braam","year":"1993","journal-title":"Microsurgery"},{"key":"10.1016\/j.bioadv.2025.214411_bb0045","first-page":"339","article-title":"Axon regeneration in the peripheral and central nervous systems","volume":"48","author":"Huebner","year":"2009","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.bioadv.2025.214411_bb0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Gomez-Sanchez","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioadv.2025.214411_bb0055","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1073\/pnas.1910292116","article-title":"Myelin sheath structure and regeneration in peripheral nerve injury repair","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2025.214411_bb0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41593-018-0324-9","article-title":"Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury","volume":"22","author":"Zhou","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214411_bb0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.nbd.2014.06.023","article-title":"Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice","volume":"70","author":"Nicks","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bioadv.2025.214411_bb0070","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12031-015-0672-9","article-title":"Autophagy promotes peripheral nerve regeneration and motor recovery following sciatic nerve crush injury in rats","volume":"58","author":"Huang","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214411_bb0075","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3892\/etm.2015.2201","article-title":"Preparation of a liposomal delivery system and its in vitro release of rapamycin","volume":"9","author":"Miao","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bioadv.2025.214411_bb0080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.hbpd.2022.10.004","article-title":"A mixed blessing for liver transplantation patients - Rapamycin","volume":"22","author":"Fan","year":"2023","journal-title":"Hepatobiliar. Pancreat. Dis. Int."},{"key":"10.1016\/j.bioadv.2025.214411_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109095","article-title":"Immunologic and dose dependent effects of rapamycin and its evolving role in chemoprevention","volume":"245","author":"O'Shea","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bioadv.2025.214411_bb0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2014.03.026","article-title":"PEG-PLGA copolymers: their structure and structure-influenced drug delivery applications","volume":"183","author":"Zhang","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2025.214411_bb0095","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.msec.2015.11.026","article-title":"Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering","volume":"59","author":"Zhao","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2025.214411_bb0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actbio.2021.03.067","article-title":"Recent advances in PLGA-based biomaterials for bone tissue regeneration","volume":"127","author":"Jin","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2025.214411_bb0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fchem.2020.00407","article-title":"Rapamycin-loaded mPEG-PLGA nanoparticles ameliorate hepatic steatosis and liver injury in non-alcoholic fatty liver disease","volume":"8","author":"Zhao","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioadv.2025.214411_bb0110","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10856-007-2007-z","article-title":"Preparation and characterization of biodegradable anti-adhesive membrane for peritoneal wound healing","volume":"18","author":"Park","year":"2007","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2025.214411_bb0115","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10544-019-0425-6","article-title":"20(S)-Ginsenoside Rg3-loaded electrospun membranes to prevent postoperative peritoneal adhesion","volume":"21","author":"Qiu","year":"2019","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.bioadv.2025.214411_bb0120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4103\/NRR.NRR-D-22-01198","article-title":"A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair","volume":"20","author":"Daeschler","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioadv.2025.214411_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116981","article-title":"An electrospun nerve wrap comprising Bletilla striata polysaccharide with dual function for nerve regeneration and scar prevention","volume":"250","author":"Chen","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2025.214411_bb0130","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13046-018-0965-2","article-title":"Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts","volume":"37","author":"Zhou","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2025.214411_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00006534-198901000-00024","article-title":"Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat","volume":"83","author":"Bain","year":"1989","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bioadv.2025.214411_bb0140","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/00006123-199605000-00025","article-title":"Reduction of extraneural scarring by ADCON-T\/N after surgical intervention","volume":"38","author":"Petersen","year":"1996","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bioadv.2025.214411_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111427","article-title":"Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: in-vitro and in-vivo studies","volume":"118","author":"Hasanpour","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2025.214411_bb0150","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jmbbm.2016.09.004","article-title":"Relationships between mechanical properties and drug release from electrospun fibers of PCL and PLGA blends","volume":"65","author":"Chou","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bioadv.2025.214411_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/polym15092072","article-title":"Hydrophobic drug carrier from polycaprolactone-b-poly(ethylene glycol) star-shaped polymers hydrogel blend as potential for wound healing application","volume":"15","author":"Ahmad Shariff","year":"2023","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.bioadv.2025.214411_bb0160","doi-asserted-by":"crossref","first-page":"34413","DOI":"10.1021\/acsomega.4c01963","article-title":"One-step physical and chemical dual-reinforcement with hydrophobic drug delivery in gelatin hydrogels for antibacterial wound healing","volume":"9","author":"An","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioadv.2025.214411_bb0165","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11095-021-03017-9","article-title":"Enhancement of the mechanical and drug-releasing properties of Poloxamer 407 hydrogels with casein","volume":"38","author":"Tundisi","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bioadv.2025.214411_bb0170","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.3171\/foc.2004.16.5.2","article-title":"Pathophysiology of peripheral nerve injury: a brief review","volume":"16","author":"Burnett","year":"2004","journal-title":"Neurosurg. Focus."},{"key":"10.1016\/j.bioadv.2025.214411_bb0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1742-2094-8-110","article-title":"Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury","volume":"8","author":"Gaudet","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bioadv.2025.214411_bb0180","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12031-018-1056-8","article-title":"Schwann-cell autophagy, functional recovery, and scar reduction after peripheral nerve repair","volume":"64","author":"Ko","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214411_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12090788","article-title":"mTORC1 mediates the processes of lysine regulating satellite cells proliferation, apoptosis, and autophagy","volume":"12","author":"Liu","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bioadv.2025.214411_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109621","article-title":"Development of a conduit of PLGA-gelatin aligned nanofibers produced by electrospinning for peripheral nerve regeneration","volume":"348","author":"Pozzobon","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioadv.2025.214411_bb0195","article-title":"Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration","volume":"26","author":"Liu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2025.214411_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/jpm13101431","article-title":"Shielding the nerve: a systematic review of nerve wrapping to prevent adhesions in the rat sciatic nerve model","volume":"13","author":"Mayrhofer-Schmid","year":"2023","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.bioadv.2025.214411_bb0205","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/01.prs.0000176893.44656.8e","article-title":"Enhancement of perineurial repair and inhibition of nerve adhesion by viscous injectable pure alginate sol","volume":"116","author":"Ohsumi","year":"2005","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bioadv.2025.214411_bb0210","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tripleo.2009.06.030","article-title":"Scar less: a review of methods of scar reduction at sites of peripheral nerve repair","volume":"109","author":"Ngeow","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.bioadv.2025.214411_bb0215","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/glia.22957","article-title":"Autophagic myelin destruction by Schwann cells during Wallerian degeneration and segmental demyelination","volume":"64","author":"Jang","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.bioadv.2025.214411_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228652","article-title":"Peripheral nerve regeneration and muscle reinnervation","volume":"21","author":"Gordon","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825002389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825002389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T03:05:28Z","timestamp":1766027128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950825002389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S2772950825002389"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214411","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An early rapamycin-releasing nerve wrap with dual function for nerve regeneration and adhesion prevention","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"214411"}}