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Sci."},{"key":"10.1016\/j.bioadv.2025.214470_bb0355","series-title":"DNA Repair Protocols","first-page":"613","article-title":"Histone H2AX phosphorylation: a marker for DNA damage","author":"Sharma","year":"2012"},{"key":"10.1016\/j.bioadv.2025.214470_bb0360","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1021\/es300433x","article-title":"Flow cytometric evaluation of nanoparticles using side-scattered light and reactive oxygen species-mediated fluorescence\u2013correlation with genotoxicity","volume":"46","author":"Toduka","year":"2012","journal-title":"Environ. Sci. 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Macromol."},{"key":"10.1016\/j.bioadv.2025.214470_bb0390","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10495-020-01594-5","article-title":"Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma","volume":"25","author":"Omoruyi","year":"2020","journal-title":"Apoptosis"},{"key":"10.1016\/j.bioadv.2025.214470_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010074","article-title":"Influence of green synthesized zinc oxide nanoparticles on molecular interaction and comparative binding of azure dye with chymotrypsin: novel nano-conjugate for cancer phototherapy","volume":"15","author":"Singh","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2025.214470_bb0400","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13046-019-1226-8","article-title":"Inhibition of ERK1\/2 in cancer-associated pancreatic stellate cells suppresses cancer\u2013stromal interaction and metastasis","volume":"38","author":"Yan","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2025.214470_bb0405","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1557\/s43578-024-01304-w","article-title":"Novel pH responsive hesperidin nanoformulation exerts anticancer activity on lung adenocarcinoma cells by targeting Akt\/mTOR and MEK\/ERK pathways","volume":"39","author":"Pavan","year":"2024","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.bioadv.2025.214470_bb0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1021\/acs.molpharmaceut.0c00499","article-title":"pH-sensitive nanodrug carriers for codelivery of ERK inhibitor and gemcitabine enhance the inhibition of tumor growth in pancreatic cancer","volume":"18","author":"Ray","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioadv.2025.214470_bb0415","unstructured":"Molecular mechanisms and clinical applications of angiogenesis Nature, (n.d.). https:\/\/www.nature.com\/articles\/nature10144 (accessed July 20, 2025)."},{"key":"10.1016\/j.bioadv.2025.214470_bb0420","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1182\/blood-2007-09-113837","article-title":"Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet \u03b1 granules and differentially released","volume":"111","author":"Italiano","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bioadv.2025.214470_bb0425","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/cancers13051093","article-title":"The chicken chorioallantoic membrane tumor assay as a relevant in vivo model to study the impact of hypoxia on tumor progression and metastasis","volume":"13","author":"Harper","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bioadv.2025.214470_bb0430","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/cpr.12296","article-title":"Gold nanoparticle\u2013conjugated quercetin inhibits epithelial\u2013mesenchymal transition, angiogenesis and invasiveness via EGFR \/ VEGFR \u22122-mediated pathway in breast cancer","volume":"49","author":"Balakrishnan","year":"2016","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bioadv.2025.214470_bb0435","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4161\/cbt.12.7.15980","article-title":"Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1), vascular endothelial growth factor (VEGF) and angiogenesis","volume":"12","author":"Paradziej-\u0141ukowicz","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bioadv.2025.214470_bb0440","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026014","article-title":"Molecular basis of Bcl-XL-p53 interaction: insights from molecular dynamics simulations","volume":"6","author":"Bharatham","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2025.214470_bb0445","doi-asserted-by":"crossref","first-page":"12441","DOI":"10.1039\/C9RA01657K","article-title":"Importance of protein flexibility in ranking ERK2 Type I 1\/2 inhibitor affinities: a computational study","volume":"9","author":"Niu","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2025.214470_bb0450","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9494548","article-title":"A network pharmacology-based study on the mechanism of Dibutyl phthalate of Ocimum basilicum L. against Alzheimer\u2019s disease through the AKT\/GSK-3\u03b2 pathway","volume":"2022","author":"Simayi","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioadv.2025.214470_bb0455","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17020144","article-title":"Insights into protein-ligand interactions: mechanisms, models, and methods","volume":"17","author":"Du","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2025.214470_bb0460","doi-asserted-by":"crossref","first-page":"14675","DOI":"10.1073\/pnas.95.25.14675","article-title":"Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability","volume":"95","author":"Nikolova","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2025.214470_bb0465","first-page":"1","article-title":"Targeting p53 pathways: mechanisms, structures and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Sig. Transduct. Target. 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