{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:44:31Z","timestamp":1793385871321,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bioadv.2025.214619","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T22:52:31Z","timestamp":1763938351000},"page":"214619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheimer's disease: Modulating oxidative stress and neuroinflammation"],"prefix":"10.1016","volume":"181","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioadv.2025.214619_bb0005","article-title":"Long non-coding RNA CASC15 enhances learning and memory in mice by promoting synaptic plasticity in hippocampal neurons","volume":"4","author":"Zou","year":"2024","journal-title":"Exploration (Beijing)"},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/INMD.20230027","article-title":"Recent advances in photobiomodulation therapy for brain diseases","volume":"2","author":"Dong","year":"2024","journal-title":"Interdiscip. Med."},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1039\/D2NA00625A","article-title":"Advanced nanomaterials for modulating Alzheimer\u2019s related amyloid aggregation","volume":"5","author":"Shao","year":"2023","journal-title":"Nanoscale Adv."},{"issue":"36","key":"10.1016\/j.bioadv.2025.214619_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022021","article-title":"The comparative effectiveness of traditional Chinese medicine exercise therapies in elderly people with mild cognitive impairment: a protocol for a network meta-analysis","volume":"99","author":"Su","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13046-021-01830-z","article-title":"Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway","volume":"40","author":"Wang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2025.214619_bb0030","doi-asserted-by":"crossref","first-page":"8869526","DOI":"10.1155\/2020\/8869526","article-title":"Acute effects of two different species of amyloid-\u03b2 on oscillatory activity and synaptic plasticity in the commissural CA3-CA1 circuit of the hippocampus","volume":"2020","author":"Gauthier-Uma\u00f1a","year":"2020","journal-title":"Neural Plast."},{"issue":"48","key":"10.1016\/j.bioadv.2025.214619_bb0035","doi-asserted-by":"crossref","first-page":"33032","DOI":"10.1021\/acsnano.4c05693","article-title":"Multi targeted therapy for Alzheimer\u2019s disease by guanidinium-modified calixarene and cyclodextrin co-assembly loaded with insulin","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2025.214619_bb0040","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fphar.2019.00395","article-title":"Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer\u2019s disease through activation of BDNF-TrkB signaling pathway","volume":"10","author":"Luo","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bioadv.2025.214619_bb0045","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/antiox10091439","article-title":"Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer\u2019s disease: the role of antioxidants in prevention and treatment","volume":"10","author":"Juszczyk","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioadv.2025.214619_bb0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fncel.2020.00062","article-title":"Resveratrol preincubation enhances the therapeutic efficacy of hUC-MSCs by improving cell migration and modulating neuroinflammation mediated by MAPK signaling in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.bioadv.2025.214619_bb0055","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1249\/MSS.0000000000002294","article-title":"Effects of exercise training on anxious-depressive-like behavior in Alzheimer rat","volume":"52","author":"Wu","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bioadv.2025.214619_bb0060","doi-asserted-by":"crossref","first-page":"2125643","DOI":"10.1155\/2016\/2125643","article-title":"Syntaxin 5 overexpression and \u03b2-amyloid 1-42 accumulation in endoplasmic reticulum of hippocampal cells in rat brain induced by ozone exposure","volume":"2016","author":"Hern\u00e1ndez-Zimbr\u00f3n","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioadv.2025.214619_bb0065","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2024.08.031","article-title":"Icariin targets p53 to protect against ceramide-induced neuronal senescence: implication in Alzheimer\u2019s disease","volume":"224","author":"Wu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0070","first-page":"174","article-title":"Clusterin overexpression protects against western diet-induced obesity and NAFLD","volume":"10","author":"Park","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.bioadv.2025.214619_bb0075","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"(Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-021-00704-3","article-title":"Baicalein inhibits heparin-induced tau aggregation by initializing non-toxic tau oligomer formation","volume":"19","author":"Sonawane","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioadv.2025.214619_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106092","article-title":"Baicalein attenuates neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2\/NF-\u03baB expressions and regulation of metabolic abnormality","volume":"79","author":"Yan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0090","series-title":"Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3\/Caspase-1\/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson\u2019s Disease","author":"Rui","year":"2020"},{"issue":"8","key":"10.1016\/j.bioadv.2025.214619_bb0095","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/biom15081188","article-title":"Apelin-13-mediated upregulation of METTL3 ameliorates Alzheimer\u2019s disease via inhibiting neuroinflammation through m6A-dependent regulation of lncRNA BDNF-AS","volume":"15","author":"Han","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioadv.2025.214619_bb0100","series-title":"Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities","first-page":"47","article-title":"Transporter systems and metabolism at the blood\u2013brain barrier and blood\u2013CSF barrier","author":"Verma","year":"2024"},{"key":"10.1016\/j.bioadv.2025.214619_bb0105","series-title":"Alzheimer's Disease and Advanced Drug Delivery Strategies","first-page":"265","article-title":"Nanoformulations targeting Alzheimer's disease","author":"Kapoor","year":"2024"},{"key":"10.1016\/j.bioadv.2025.214619_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.340967","article-title":"Mitochondria-targeting fluorescent sensor with high photostability and permeability for visualizing viscosity in mitochondrial malfunction, inflammation, and AD models","volume":"1250","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bioadv.2025.214619_bb0115","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0120","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1089\/scd.2007.0024","article-title":"Immune regulation by mesenchymal stem cells derived from adult spleen and thymus","volume":"16","author":"Krampera","year":"2007","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bioadv.2025.214619_bb0125","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1517\/14712598.2015.1051528","article-title":"Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy","volume":"15","author":"Li","year":"2015","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bioadv.2025.214619_bb0130","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes\u2013vesicular carriers for intercellular communication","volume":"21","author":"Simons","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0135","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.bioadv.2025.214619_bb0140","doi-asserted-by":"crossref","first-page":"8146","DOI":"10.4049\/jimmunol.180.12.8146","article-title":"Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor","volume":"180","author":"Saunderson","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2012.06.001","article-title":"Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling","volume":"147","author":"Mokarizadeh","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bioadv.2025.214619_bb0150","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2019.01.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion","volume":"197","author":"Mathew","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214619_bb0160","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1021\/acsnano.3c13150","article-title":"Biomimetic nanovesicles as a dual gene delivery system for the synergistic gene therapy of Alzheimer\u2019s disease","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2025.214619_bb0165","doi-asserted-by":"crossref","first-page":"20240095","DOI":"10.1002\/EXP.20240095","article-title":"Synthetic biology-based engineering cells for drug delivery","volume":"5","author":"Yi","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.bioadv.2025.214619_bb0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuint.2017.02.001","article-title":"Crosstalk of metabolic factors and neurogenic signaling in adult neurogenesis: implication of metabolic regulation for mental and neurological diseases","volume":"106","author":"Gao","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bioadv.2025.214619_bb0175","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1111\/jcmm.15378","article-title":"Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK\/mTOR-mediated autophagy flux pathway","volume":"24","author":"Gu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2025.214619_bb0180","doi-asserted-by":"crossref","first-page":"33734","DOI":"10.1021\/acsnano.5c00694","article-title":"Biomimetic nanoregulators mediated tyrosine hydroxylase mRNA and stimulator of interferon genes antagonist codelivery for synergistic therapy on Parkinson\u2019s disease","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2025.214619_bb0185","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.2174\/0929867325666180406120051","article-title":"Targeting AMPK in diabetes and diabetic complications: energy homeostasis, autophagy and mitochondrial health","volume":"26","author":"Madhavi","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioadv.2025.214619_bb0190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fct.2012.11.002","article-title":"Tartary buckwheat improves cognition and memory function in an in vivo amyloid-\u03b2-induced Alzheimer model","volume":"53","author":"Choi","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0195","first-page":"152","article-title":"Curcumin promotes proliferation of adult neural stem cells and the birth of neurons in Alzheimer\u2019s disease mice via notch signaling pathway","volume":"21","author":"Li","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bioadv.2025.214619_bb0200","article-title":"Deferoxamine preconditioning enhances the protective effects of stem cells in streptozotocin-induced Alzheimer\u2019s disease","volume":"287","author":"Asl","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12906-018-2237-2","article-title":"Huatuo Zaizao pill ameliorates cognitive impairment of APP\/PS1 transgenic mice by improving synaptic plasticity and reducing a\u03b2 deposition","volume":"18","author":"Zhang","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.bioadv.2025.214619_bb0210","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1038\/srep07608","article-title":"Combining two repurposed drugs as a promising approach for Alzheimer\u2019s disease therapy","volume":"5","author":"Chumakov","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2025.214619_bb0215","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.3390\/ijms21093291","article-title":"Infusion of plasma from exercised mice ameliorates cognitive dysfunction by increasing hippocampal neuroplasticity and mitochondrial functions in 3xTg-AD mice","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0220","first-page":"2376","article-title":"FasL on decidual macrophages mediates trophoblast apoptosis: a potential cause of recurrent miscarriage","volume":"43","author":"Ding","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bioadv.2025.214619_bb0225","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/srep01197","article-title":"Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes","volume":"3","author":"Katsuda","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2025.214619_bb0230","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/10717544.2020.1762262","article-title":"Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles","volume":"27","author":"Qi","year":"2020","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioadv.2025.214619_bb0235","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.omtn.2019.10.002","article-title":"Intranasal administration of miR-146a agomir rescued the pathological process and cognitive impairment in an AD mouse model","volume":"18","author":"Mai","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bioadv.2025.214619_bb0240","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3892\/mmr.2021.11931","article-title":"Ginsenoside Rg1 improves cognitive capability and affects the microbiota of the large intestine in a tree shrew model for Alzheimer\u2019s disease","volume":"23","author":"Guo","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioadv.2025.214619_bb0245","article-title":"Isobaric tags for relative and absolute quantitation identification of blood proteins relevant to paroxetine response in patients with major depressive disorder","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104974","article-title":"Exosome-based approaches in the management of Alzheimer\u2019s disease","volume":"144","author":"Kandimalla","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bioadv.2025.214619_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0260","doi-asserted-by":"crossref","first-page":"1601712","DOI":"10.3389\/fphar.2025.1601712","article-title":"Unveiling the therapeutic potential of natural products in Alzheimer\u2019s disease: insights from in vitro, in vivo, and clinical studies","volume":"16","author":"Aktary","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0265","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3858\/emm.2010.42.12.084","article-title":"Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction","volume":"42","author":"Choi","year":"2010","journal-title":"Exp. Mol. Med."},{"issue":"18","key":"10.1016\/j.bioadv.2025.214619_bb0270","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1021\/acschemneuro.5c00493","article-title":"Donepezil and Memantine derivatives for dual-function and prodrug applications in Alzheimer\u2019s disease","volume":"16","author":"Terpstra","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0275","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201700600R","article-title":"Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP\/PS1 mice","volume":"32","author":"Cui","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.bioadv.2025.214619_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12979-019-0150-2","article-title":"RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer\u2019s disease","volume":"16","author":"Cui","year":"2019","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.bioadv.2025.214619_bb0285","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fncel.2020.00062","article-title":"Resveratrol preincubation enhances the therapeutic efficacy of hUC-MSCs by improving cell migration and modulating neuroinflammation mediated by MAPK signaling in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0290","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1038\/s41598-019-43537-4","article-title":"High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer\u2019s disease mice","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2025.214619_bb0295","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fncel.2019.00538","article-title":"Increased inflammation and unchanged density of synaptic vesicle glycoprotein 2A (SV2A) in the postmortem frontal cortex of Alzheimer\u2019s disease patients","volume":"13","author":"Metaxas","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioadv.2025.214619_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24030587","article-title":"New multitarget hybrids bearing tacrine and phenylbenzothiazole motifs as potential drug candidates for Alzheimer\u2019s disease","volume":"24","author":"Rajeshwari","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2025.214619_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055774","article-title":"Ferulic acid is a nutraceutical \u03b2-secretase modulator that improves behavioral impairment and Alzheimer-like pathology in transgenic mice","volume":"8","author":"Mori","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2025.214619_bb0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1051\/bmdcn\/2019090423","article-title":"Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials","volume":"9","author":"Alizadeh","year":"2019","journal-title":"Biomed. (Taipei)"},{"key":"10.1016\/j.bioadv.2025.214619_bb0315","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13098-021-00638-3","article-title":"Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats","volume":"13","author":"Miao","year":"2021","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bioadv.2025.214619_bb0320","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1567202620666230303144323","article-title":"Curcumin alleviates oxidative stress, neuroinflammation, and promotes behavioral recovery after traumatic brain injury","volume":"20","author":"Chen","year":"2023","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.bioadv.2025.214619_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103015","article-title":"Putative mechanisms responsible for the antihyperglycemic action of lactobacillus paracasei HII01 in experimental type 2 diabetic rats","volume":"12","author":"Toejing","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bioadv.2025.214619_bb0330","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.2147\/DMSO.S276184","article-title":"Mogroside IIIE alleviates high glucose-induced inflammation, oxidative stress, and apoptosis of podocytes by the activation of AMPK\/SIRT1 signaling pathway","volume":"13","author":"Xue","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.bioadv.2025.214619_bb0335","doi-asserted-by":"crossref","first-page":"7920540","DOI":"10.1155\/2019\/7920540","article-title":"Mechanisms of aerobic exercise upregulating the expression of hippocampal synaptic plasticity-associated proteins in diabetic rats","volume":"2019","author":"Li","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.bioadv.2025.214619_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159381","article-title":"Metformin prevents nigrostriatal dopamine degeneration independent of AMPK activation in dopamine neurons","volume":"11","author":"Bayliss","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2025.214619_bb0345","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1172\/JCI133982","article-title":"Brain-specific repression of AMPK\u03b11 alleviates pathophysiology in Alzheimer\u2019s model mice","volume":"130","author":"Zimmermann","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioadv.2025.214619_bb0350","first-page":"1167","article-title":"Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK\/uncoupling protein 2 pathway, cell Physiol","volume":"32","author":"Pu","year":"2013","journal-title":"Biochem"},{"key":"10.1016\/j.bioadv.2025.214619_bb0355","article-title":"Curcumin suppresses apoptosis and inflammation in hypoxia\/reperfusion-exposed neurons via Wnt signaling pathway","volume":"26","author":"Zhou","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bioadv.2025.214619_bb0360","article-title":"Untargeted metabolomics analysis of the hippocampus and cerebral cortex identified the neuroprotective mechanisms of Bushen Tiansui formula in an A\u03b225-35-induced rat model of Alzheimer\u2019s disease","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2025.214619_bb0365","doi-asserted-by":"crossref","first-page":"1468561","DOI":"10.3389\/fmed.2024.1468561","article-title":"Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer\u2019s disease: a computational biology approach","volume":"11","author":"Xiang","year":"2024","journal-title":"Front. Med."},{"issue":"7","key":"10.1016\/j.bioadv.2025.214619_bb0370","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00018-023-04841-5","article-title":"Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes","volume":"80","author":"Pantazopoulou","year":"2023","journal-title":"Cell Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.bioadv.2025.214619_bb0375","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12085","article-title":"Biodistribution of extracellular vesicles following administration into animals: a systematic review","volume":"10","author":"Kang","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bioadv.2025.214619_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.949724","article-title":"Safety and biodistribution of exosomes derived from human induced pluripotent stem cells","volume":"10","author":"Gu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0385","doi-asserted-by":"crossref","first-page":"31003","DOI":"10.1038\/s41598-024-82108-0","article-title":"Assessment of retention and attenuation of motor-learning memory by repeated rotor-rod analyses","volume":"14","author":"Kakizawa","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bioadv.2025.214619_bb0390","doi-asserted-by":"crossref","first-page":"uiae019","DOI":"10.1093\/joccuh\/uiae019","article-title":"Subchronic toxicity study of indium\u2013tin oxide nanoparticles following intratracheal administration into the lungs of rats","volume":"66","author":"Matsumura","year":"2024","journal-title":"J. Occup. Health"},{"issue":"7","key":"10.1016\/j.bioadv.2025.214619_bb0395","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3390\/pharmaceutics17070888","article-title":"Nanotechnology approaches for mitigating biologic immunogenicity: a literature review","volume":"17","author":"Alanazi","year":"2025","journal-title":"Pharmaceutics"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825004467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825004467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:34:43Z","timestamp":1767098083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950825004467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":79,"alternative-id":["S2772950825004467"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214619","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheimer's disease: Modulating oxidative stress and neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214619"}}